Angiotensin-Converting Enzyme 2: The First Decade by Nicola E. Clarke, Anthony J. Turner

“…As a result there has been huge interest in ACE2 over the past decade as a potential therapeutic for lowering blood pressure, especially elevation resulting from excess Ang II. …”
Get full text

Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography by Yan Zhao, Keita Fukao, Songji Zhao, Ayahisa Watanabe, Tadateru Hamada, Kazuaki Yamasaki, Yoichi Shimizu, Naoki Kubo, Naoyuki Ukon, Toru Nakano, Nagara Tamaki, Yuji Kuge

“…Noninvasive imaging by 18 F-FDG PET is useful for evaluating the therapeutic effects of irbesartan and reflects inflammation, a key factor involved in the therapeutic effects.…”
Get full text

The combined use of scRNA-seq and network propagation highlights key features of pan-cancer Tumor-Infiltrating T cells. by Adèle Mangelinck, Elodie Molitor, Ibtissam Marchiq, Lamine Alaoui, Matthieu Bouaziz, Renan Andrade-Pereira, Hélène Darville, Etienne Becht, Céline Lefebvre

“…Improving the selectivity and effectiveness of drugs represents a crucial issue for future therapeutic developments in immuno-oncology. Traditional bulk transcriptomics faces limitations in this context for the early phase of target discovery as resulting gene expression levels represent the average measure from multiple cell populations. …”
Get full text

Schwann Cells in Neuromuscular Disorders: A Spotlight on Amyotrophic Lateral Sclerosis by Kathryn R. Moss, Smita Saxena

“…Furthermore, advancements in understanding Schwann cell pathology in ALS combined with lessons learned from studying Charcot–Marie–Tooth disease Type 1 (CMT1) suggest potential therapeutic strategies targeting these cells may support nerve repair and slow disease progression. …”
Get full text

Non-coding RNAs and exosomal ncRNAs in colorectal cancer by Yalda Zhoulideh

“…A better understanding of the roles of ncRNAs and exogenous ncRNAs may lead to the development of new therapeutic strategies for this disease.…”
Get full text

Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma by Lin Zhang, Haoming Jiang, Haichao Ma

“…The immunosuppressive environment, dominated by M2 macrophages, contributes to immune evasion and poor therapeutic outcomes, though recent findings suggest the potential for reprogramming these cells to enhance immune responses. …”
Get full text

Biogenic nanoparticles as a promising drug delivery system by Rehab M. Abdel-Megeed

“…The biological technique of generating nanoparticles has advantages over chemical, physical, and biological methods, including low-toxicity and friendly to the environment, thereby providing a viable option for therapeutic applications as s promising drug delivery system. …”
Get full text

Microencapsulation Techniques in HIV Pediatric Formulations: Advances and Future Outlook by Nnamdi Ikemefuna Okafor

“…This is because adult and pediatric HIV treatments follow a similar therapeutic approach. Due to the dearth of clinically licensed pediatric antiretroviral drug (ARVD) therapy, children with HIV worldwide are prescribed unlicensed drugs each year. …”
Get full text

Intravitreal steroid implants in the management of noninfectious intermediate and posterior uveitis by Sarjak M Shah, Priya Prabhu, Jyotirmay Biswas

“…Dexamethasone implants favor the therapeutic goal of prevention of recurrences, whereas the use of fluocinolone implants helps to attain better visual outcomes due to their longer duration of action. …”
Get full text

Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives by Anandarajagopal Kalusalingam, Kamaliah Kamal, Abdullah Khan, Bama Menon, Ching Siang Tan, Venkateshan Narayanan, Sattanathan Kumar, Khang Wen Goh, Kah Seng Lee, Jactty Chew, Long Chiau Ming

“…The review will be valuable for researchers involved in medicinal plant research and drug discovery, offering potential for use alongside modern therapeutic agents. However, clinical studies are essential to validate its therapeutic applications. …”
Get full text

Genetic Hearing Loss and Gene Therapy by Nathanial T Carpena, Min Young Lee

“…These defective genes will ultimately be important therapeutic targets. However, the auditory system is extremely complex which requires tremendous advances in gene therapy including gene vectors, routes of administration, and therapeutic approaches. …”
Get full text

Developing a Strategy for Interventional Molecular Imaging of Oxidized Low-Density Lipoprotein in Atherosclerosis by Samata S. Pandey MSc, Dorian O. Haskard DM, FRCP, FMedSci, Ramzi Y. Khamis MB, ChB, PhD, MRCP

“…The identification of vulnerable coronary artery atherosclerotic plaques offers the prospect of either localized or systematic therapeutic targeting in order to prevent myocardial infarction. …”
Get full text

Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm by Koichi Yoshimura, Hiroki Aoki

“…Previously, we identified c-Jun N-terminal kinase (JNK), a pro-inflammatory signaling molecule, as a therapeutic target for AAA. Abnormal activation of JNK in AAA tissue regulates multiple pathological processes in a coordinated manner. …”
Get full text

A review on the potential of Bruton’s tyrosine kinase (Btk) inhibitor – Ibrutinib for treatment of Multiple Myeloma (MM) by Sze-Ting Bong, Lydia Ngiik-Shiew Law, Jodi Woan-Fei Law

“…To date, clinical trials of ibrutinib as therapeutic alternative for MM have produced promising results, particularly as combination therapy with other agents such as dexamethasone and carfilzomib. …”
Get full text

INTEGRATION OF TRADITIONAL CHINESE MEDICINE INTO MODERN PHYSICAL THERAPY by Mihuță Andreea, Cojocariu Adrian

“…It also offers patients a wide range of therapeutic options, promotes self-knowledge and responsibility in taking care of their own health.…”
Get full text

Phytochemicals, Nutritional and Elemental Composition of different plant parts of Rinorea oblongifolia (C.H Wright) C. Marquand ex Chipp by Adeniyi Ohunayo, Olusola Elekofehinti, Muftau Kolawole Oladunmoye, Anthony Kayode Onifade

“…These findings support oblongifolia’s potential for nutritional supplements and therapeutic uses, with further research needed to investigate mechanisms and standardize extraction protocols. …”
Get full text

La Vallée de l’Arve à l’épreuve de la santé environnementale : entre imaginaire thérapeutique et éco-anxiété by Alexandre Savioz

“…Though this contrasts sharply with past therapeutic representations of the mountains as mentioned above, current fears around air quality in the Arve Valley find themselves echoed in broader societal debates around environmental health and eco-anxiety.…”
Get full text

Spines, Plasticity, and Cognition in Alzheimer's Model Mice by Tara Spires-Jones, Shira Knafo

“…Understanding the underpinnings of dementia in AD will be essential to develop and evaluate therapeutic approaches for this widespread and devastating disease.…”
Get full text

Preparation and Synergistic Anti-Tumor Effect of Iridium Oxide Nanocomposites under Microscope by Xudong He, Feng Xiang, Zhangyi Xu

“…Iridium oxide nanocomposite DOX combined with SDT can obtain a good therapeutic effect, which has positive feedback on the efficacy of chemotherapy and the therapeutic effect of cancer surgery.…”
Get full text

Oligodendrocyte precursor cell-derived exosomes combined with cell therapy promote clinical recovery by immunomodulation and gliosis attenuation by Sarah Ingrid Pinto Santos, Santiago José Ortiz-Peñuela, Alessandro de Paula Filho, Ana Laura Midori Rossi Tomiyama, Lilian de Oliveira Coser, Juliano Coelho da Silveira, Daniele dos Santos Martins, Adriano Polican Ciena, Alexandre Leite Rodrigues de Oliveira, Carlos Eduardo Ambrósio

“…This study aimed to evaluate the therapeutic efficacy of the combination of NSCs and EVs derived from oligodendrocyte precursor cells (OPCs) in an animal model of multiple sclerosis. …”
Get full text