Crisdesalazine alleviates inflammation in an experimental autoimmune encephalomyelitis multiple sclerosis mouse model by regulating the immune system by Su-Min Park, Yong-Hun Oh, Ga-Hyun Lim, Ju-Hyun An, Jin-Hwan Lee, Byoung-Joo Gwag, So-Jung Won, Kyoung-Won Seo, Hwa-Young Youn

“…This is the first study to directly demonstrate the therapeutic effects of a microsomal prostaglandin E2 synthase-1 inhibitor in an EAE model and its ability to alter macrophage polarization, suggesting that it may be a new therapeutic option for the treatment of patients affected by multiple sclerosis and other autoimmune diseases.…”
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Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk by Andreas Pasch, Willi Jahnen-Dechent, Edward R. Smith

“…Phosphate is an important cardiovascular risk factor and lowering elevated blood phosphate concentrations is a main therapeutic target in kidney patients. Phosphate is subject to the blood mineral buffering system which controls the precipitation of calcium and phosphate. …”
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Improving Imitation Skills in Children with Autism Spectrum Disorder Using the NAO Robot and a Human Action Recognition by Abeer Alnafjan, Maha Alghamdi, Noura Alhakbani, Yousef Al-Ohali

“…<b>Conclusions:</b> Our findings suggest that integrating robotics into therapeutic practices can effectively enhance the imitation skills of children with ASD, offering valuable support to therapists.…”
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Theophylline Revisited. Mechanisms, Challenges, and New Horizons by Jakub Szarłowicz, Michał Mazur, Dorota Waz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

“…However, its narrow therapeutic index and variability in pharmacokinetics remain significant challenges. …”
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Acoustic ecology as therapy? by Louise Rossiter

“…As a musician, I have been interested in the potential effects and benefits of music as a therapeutic tool. I have also been in a fortunate position to experience the deployment of music as a 'hands on' tool to interact with children and young people within both communities and residential care settings.…”

CASE PRESENTATION by Goga Iolanda, Cioc Enache, Boghici Elena-Monica, Moraru Mihaela, Nichita Monica-Adriana, Dumitrescu Elena, Pirlea Andrei-Daniel, Zob Daniela-Luminiţa

“…A case report Clinical and therapeutic particularities in dermatofibrosarcoma protuberans – a case report Multiple myeloma presenting as sellar plasmacytoma and focal and segmental glomerulosclerosis – case report…”
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Approche spatiale d’un centre hospitalier, le CHU pédiatrique de Ouagadougou (Burkina Faso) by Aude Nikiema

“…The objective is to include elements which compose the therapeutic landscape and to define a model of organization.…”
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Inflammatory Bowel Disease Patients Are Frequently Nonadherent to Scheduled Induction and Maintenance Infliximab Therapy: A Canadian Cohort Study by Christopher Ma, Chad J Evaschesen, Grenvil Gracias, Vivian W Huang, Darryl K Fedorak, Karen I Kroeker, Levinus A Dieleman, Brendan P Halloran, Richard N Fedorak

“…Although infliximab has demonstrated efficacy in inducing and maintaining disease remission, adherence to regularly scheduled infliximab infusions is required to maintain therapeutic trough drug levels and prevent the development of anti-infliximab antibodies.…”
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Gaps in the Inpatient Management of Chronic Obstructive Pulmonary Disease Exacerbation and Impact of An Evidence-Based Order Set by Abhijat Kitchlu, Tamer Abdelshaheed, Elizabeth Tullis, Samir Gupta

“…Admission order sets with evidence-based diagnostic and therapeutic guidance have enabled quality improvement and guideline implementation in other conditions.…”
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EVALUATION OF TRANSFORMATIVE SKILLS IN PATIENTS WITH GONARTHROSIS IN PHYSIOTHERAPY PROGRAMS by Rusnac Felicia

“…The integrated approach to psychological and motivational dimensions provides a new perspective on optimizing therapeutic interventions, targeting not only functional recovery but also enhancing patients' capacity to maintain therapeutic progress in the long term.The study highlights the potential of incorporating transformative skillsinto physiotherapy programs, contributing to the development of more effective and personalized strategies for treating gonarthrosis, positively impacting patients' quality of life and the overall efficiency of the recovery process.…”
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Shikonin Induces Glioma Necroptosis, Stemness Decline, and Impedes (Immuno)Proteasome Activity by Xianyun Qin, Lu Zhang, Jilan Liu, Yan Lu, Fuyao Zhou, Feng Jin

“…Presently, standard therapeutic approaches yield limited curative outcomes. …”
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Investigation of the Potential of Nanoparticles as a New Drug Delivery System for Endodontic Treatment by Abdul A. K. Kader, Sandeep Chandran, K. K. Ridhun Unnikrishnan, Nikita A. Mannur, Anusar Gupta, Savadamoorthi Kamatchi Subramani

“…Conclusion: Nanoparticles demonstrate significant potential as a drug delivery system in endodontic treatment, enhancing both the antibacterial efficacy and penetration depth of therapeutic agents.…”
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Targeting Drug Delivery to the Lungs by Inhalation by C. O'Callaghan

“…Since the drug is delivered directly to its required site, only a small quantity is needed for an adequate therapeutic response, and consequently there is a low incidence of systemic side effects compared with oral or intravenous administration. …”
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Future Guides for Biomarkers for Autism Spectrum Disorders by Mai Mohamed Elhassan Mustafa

“…It would be a significant advancement to have biomarkers that can identify children at risk during the presymptomatic period to aid in early diagnosis, confirm behavioral observations, stratify patients into subgroups, and predict therapeutic response.…”
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Insulin in Central Nervous System: More than Just a Peripheral Hormone by Ana I. Duarte, Paula I. Moreira, Catarina R. Oliveira

“…Herewith, we aim to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach.…”
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Nanomaterials for targeted therapy of kidney diseases: Strategies and advances by Zhiwen Wang, Chun Zhang

“…Due to the presence of blood circulation barriers and glomerular filtration barriers, drug therapy for kidney diseases faces challenges such as poor renal targeting, short half-life, and severe systemic side effects, severely hindering therapeutic progress. Therefore, the research and development of kidney-targeted therapeutic agents is of great clinical significance. …”
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Efficacy and Safety of Tripterygium Wilfordii Glycoside Tablets Combined with Acitretin Capsules in the Treatment of Moderate to Severe Plaque Psoriasis: A Randomized Controlled Tr... by Qinghui Fu, Yunjie Zhu, Yiqi Fang, Changbo Dai

“…TWGs combined with acitretin had better therapeutic effects and higher safety in the treatment of MSPP.…”
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Mesenchymal Stem and Progenitor Cells in Regeneration: Tissue Specificity and Regenerative Potential by Rokhsareh Rohban, Thomas Rudolf Pieber

“…MSC have been successfully isolated from various human tissues and they have been shown to offer the possibility to establish novel therapeutic interventions for a variety of hard-to-noncurable diseases. …”
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Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson’s Disease by Katharina E. Rosenbusch, Arjan Kortholt

“…Here, we review the recent progress in elucidating the complex LRRK2 activation mechanism, describe the accumulating evidence that link LRRK2-mediated PD to mitochondrial dysfunction and aberrant autophagy, and discuss possible ways for therapeutically targeting LRRK2.…”
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Therapy of Inflammatory Bowel Disease using New 5-ASA Compounds: An Introduction by Ulrich Klotz

“…Strong evidence has been accumulating that mesalazine (5- aminosalicylic acid, 5-ASA) represents the therapeutic moiety of the standard drug sulphasalazine. …”
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