The protective effects of active ingredients from acrorus tatarinowii on sperm and their molecular mechanisms by Zonglin Lu, Haiyang Zhao, Hui Wang, Xin Wang, Zixue Sun

“…Abstract Purpose To investigate the therapeutic potential of Acrorus tatarinowii in oligoasthenozoospermia and its related mechanism through modulation of the BCL2/Bax/Caspase3 signaling pathway. …”
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Comprehensive Insights into De Quervain’s Tenosynovitis: From Etiology to Rehabilitation by Piotr Charzewski, Agnieszka Starzyk

“…Further research is essential to refine diagnostic and therapeutic strategies, reduce recurrence rates, and improve patient outcomes. …”
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A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

“…Abstract Circadian medicine, the delivery of therapeutic interventions based on an individual’s daily rhythms, has shown improved efficacy and reduced side-effects for various treatments. …”
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Leveraging RIBOTAC technology: Fluorescent RNase L probes for live-cell imaging and function analysis by Elias Khaskia, Raphael I. Benhamou

“…RNA-targeting small molecules, particularly RIBOnuclease TArgeting Chimeras (RIBOTACs), represent a powerful and promising therapeutic approach by selectively degrading RNAs through ribonuclease (RNase) recruitment. …”
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A comprehensive review of the roles of T-cell immunity in preeclampsia by Xu Peng, Ibeh Chinwe Oluchi-Amaka, Joanne Kwak-Kim, Joanne Kwak-Kim, Xiuhua Yang

“…Furthermore, the recent therapeutic approaches centered on targeting T cell immunity in PE are critically appraised.…”
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Anti-Atopic Dermatitis Effect of Seaweed Fulvescens Extract via Inhibiting the STAT1 Pathway by Tae-Young Gil, Yun-Mi Kang, Ye-Jin Eom, Chul-Hee Hong, Hyo-Jin An

“…These results suggested that SF could be a potential therapeutic alternative for the treatment of AD.…”
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Nanoparticle accumulation and penetration in 3D tumor models: the effect of size, shape, and surface charge by Pierre Cybulski, Maria Bravo, Maria Bravo, Jim Jui-Kai Chen, Indra Van Zundert, Sandra Krzyzowska, Farsai Taemaitree, Hiroshi Uji-i, Hiroshi Uji-i, Hiroshi Uji-i, Johan Hofkens, Johan Hofkens, Susana Rocha, Beatrice Fortuni

“…These findings underscore the importance of carefully tailoring NP properties to the complex tumor microenvironment for improved therapeutic outcomes in real tumors.…”
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Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis by Jie Chen, J. Steven Alexander, A. Wayne Orr

“…Recent works highlight a role for integrins in lymphangiogenesis and suggest that integrin inhibitors may serve as therapeutic targets to limit lymphangiogenesis and lymph node metastasis. …”
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Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics by Maria Carolina O. Rodrigues, Antonio Antunes Rodrigues, Loren E. Glover, Julio Voltarelli, Cesario V. Borlongan

“…This paper focuses on this new therapeutic approach highlighting its direct translational and clinical utility in promoting regeneration of not only acute but perhaps also chronic cases of peripheral nerve damage.…”
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Predicting immunotherapy efficacy in endometrial cancer: focus on the tumor microenvironment by Liubov A. Tashireva, Irina V. Larionova, Irina V. Larionova, Nikita A. Ermak, Anastasia A. Maltseva, Ekaterina I. Livanos, Anna Yu. Kalinchuk, Marina N. Stakheyeva, Larisa A. Kolomiets

“…Immunotherapy represents a groundbreaking therapeutic approach, based on the immune system’s intrinsic capacity to interfere with tumor progression, that opens the horizons in the treatment of endometrial cancer. …”
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PARP4 deficiency enhances sensitivity to ATM inhibitor by impairing DNA damage repair in melanoma by Yuehua Li, Yu Liu, Jingjing Ma, Yuqi Yang, Qiao Yue, Guannan Zhu, Weinan Guo, Tianwen Gao, Qiong Shi, Chunying Li

“…This suggests investigating novel therapeutic strategies from the synthetic lethality perspective. …”
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Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis by Qiong-Yi Zhang, Hai-Biao Gong, Man-Ya Jiang, Fujun Jin, Guan Wang, Chang-Yu Yan, Xiang Luo, Wan-Yang Sun, Shu-Hua Ouyang, Yan-Ping Wu, Wen-Jun Duan, Lei Liang, Yun-Feng Cao, Xin-Xin Sun, Meijing Liu, Gen-Long Jiao, Hua-Jun Wang, Kurihara Hiroshi, Xiaogang Wang, Rong-Rong He, Yi-Fang Li

“…Abstract Oxidative stress plays a critical role in postmenopausal osteoporosis, yet its impact on osteoblasts remains underexplored, limiting therapeutic advances. Our study identifies phospholipid peroxidation in osteoblasts as a key feature of postmenopausal osteoporosis. …”
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Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage by Keiki Nagaharu, Masahiro Masuya, Keiki Kawakami, Naoyuki Katayama

“…In addition to conventional therapeutic strategies, romiplostim shows promising efficacy for chronic ITP. …”
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RUNX1 promotes proliferation of cervical cancer through TGFB2-MAPK pathway by Yongqin Jia, Neng Yang, Shuai Tang, Li Deng, Yanzhou Wang, Xiongwei Cai

“…Our study provides new insights into the role of RUNX1 in CC proliferation and suggests RUNX1 as a potential therapeutic target in CC.…”
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Targeting KRAS: from metabolic regulation to cancer treatment by Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

“…Therefore, this review provides an overview of the current understanding of metabolic mechanisms associated with KRAS mutation and related therapeutic strategies, aiming to facilitate the understanding of current challenges in KRAS-driven cancer and to support the investigation of therapeutic strategies.…”
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Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters by Kit-Leong Cheong, Amanullah Sabir, Suresh Veeraperumal, Franck Quero, Rui Li, Qiaoli Zhao, Karsoon Tan, Saiyi Zhong, Udayakumar Veerabagu

“…This study investigates the esterification of laminarin, a β-glucan polysaccharide, using trifluoroacetic anhydride and acetic acid to synthesize laminarin acetyl esters (LA) with potential therapeutic properties. The efficacy of LA was evaluated in an in vivo dextran sulfate sodium induced colitis mouse model. …”
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Current Insight of Peptide-Based Hydrogels for Chronic Wound Healing Applications: A Concise Review by Aifa Asyhira Khairul Nizam, Syafira Masri, Nur Izzah Md Fadilah, Manira Maarof, Mh Busra Fauzi

“…Therefore, to address the socioeconomic burden in taking care of chronic wounds, hydrogel-based therapeutic materials have been proposed. Hydrogels are hydrophilic polymer networks with a 3D structure which allows them to become skin substitutes for chronic wounds. …”
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New Aspects in the Differential Diagnosis and Therapy of Bladder Pain Syndrome/Interstitial Cystitis by Jochen Neuhaus, Thilo Schwalenberg, Lars-Christian Horn, Henry Alexander, Jens-Uwe Stolzenburg

“…Usually, patients are partially or completely resistant to anticholinergic therapy, and therapeutical options are especially restricted in case of BPS/IC. …”
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Regulation and therapy: the role of ferroptosis in DLBCL by Yifan Wang, Yifan Wang, Zhengmei He, Zhengmei He, Xinyu Dong, Xinyu Dong, Yiming Yao, Yiming Yao, Qiuni Chen, Qiuni Chen, Yuye Shi, Yuye Shi, Yuan Deng, Yuan Deng, Quane Zhang, Quane Zhang, Liang Yu, Liang Yu, Liang Yu, Chunling Wang, Chunling Wang, Chunling Wang

“…Its occurrence pathway plays an essential impact on the therapeutic effect of tumors. Numerous studies have shown that modulating critical factors in the ferroptosis pathway can influence the growth of tumor cells in hematological malignancies including DLBCL. …”
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Engineering extracellular vesicles for ROS scavenging and tissue regeneration by Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim

“…Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. …”
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