hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways by Yan Yu, Chengchun Zhu, Xiao Wang, Ying Shi, Yiping Gao, Zhiyi Yu

“…BackgroundBreast cancer remains a leading cause of mortality among women worldwide, with existing therapeutic options often accompanied by significant side effects and a persistent risk of disease recurrence. …”
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Lifetime Attributable Risk in Mammography Screenings in Dubai: The Influence of Breast Thickness and Age on Radiation Exposure by Kaltham Abdulwahid Mohd Noor, Norhashimah Mohd Norsuddin, Iza Nurzawani Che Isa, Muhammad Khalis Abdul Karim

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Phytomedicine nanoformulations for Parkinson's disease by Chinthu V. Saji, K P Mohanakumar, Rajesh A Shenoi

“…In recent years, attentions of both clinicians and patients have shifted to herbal medicines that are rich source of bioactive compounds with therapeutic potential to target multiple pathways involved in PD pathology. …”
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Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer by Ying Ye, Ying Ye, Yi Huang, Yi Huang, Jianbo Pan, Jianbo Pan

“…Bioinformatic analysis indicated that the 15 biomarkers were strongly correlated with the prognosis of lung cancer patients.ConclusionWe confirmed the importance of the decreased autoantibodies in lung cancer, providing new diagnostic and therapeutic strategies.…”
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Deep Learning-based Artificial Intelligence in Audio based Analysis of Swallowing using Cervical Auscultation by Salloum Hazem, Graf Simone, Schilling Berit, Richter Lena, Jeleff-Wölfler Olivia, Feussner Hubertus, Ostler Daniel, Wilhelm Dirk, Fuchtmann Jonas

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Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction by Li T, Yang B, Liu X, Shi D, Wang Z, Chen Y, Shen C

“…Compared to PSN alone, Se@PSN showed superior therapeutic efficacy against IR injury.Conclusion: Se@PSN exhibit great potential in reducing ferroptosis and protecting mitochondrial function, making them a promising therapeutic approach for the treatment of myocardial IR injury. …”
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Efficacy of caerulomycin A in modulating macrophage polarization and cytokine response in a murine model of lipopolysaccharide-induced sepsis by Jun Zhang, Shiyue Tang

“…These findings support further exploration of the potential of caeA as a therapeutic agent for sepsis.…”
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Liposomal Formulations: A Recent Update by Surendra S. Agrawal, Vrinda Baliga, Vaishali Y. Londhe

“…Surface modification methods like PEGylation and ligand conjugation can direct liposomes to disease regions, improving therapeutic efficacy and reducing off-target effects. …”
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Improving general practitioners’ approaches to functional somatic syndromes: a pilot training program with a focus on compassion and communication by Gonthier Ariane, Linder Audrey, Sommer Johanna, Despland Jean-Nicolas, Ambresin Gilles

“…Methods The aim of our scientific team was to develop a training session about functional somatic syndromes for GPs, with the objective to improve the therapeutic attitude of the participants. The first session of the training was constructed as a pilot session, followed by a qualitative study to complete content validation. …”
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Cyanidin and Cyanidin-3-Glucoside Alleviate Peptic Ulcer Disease: Insights from in vitro, and in vivo Studies by Prayoga DK, Aulifa DL, Budiman A, Levita J, Jiranusornkul S

“…These compounds have proven effective in managing other health problems, including peptic ulcers, but more in-depth exploration in clinical settings is required to confirm therapeutic potential in humans. It is necessary to validate the therapeutic efficacy and safety in human populations. …”
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Targeting B and T Lymphocyte Attenuator Regulates Lupus Disease Development in NZB/W Mice by Gherardi L, Aubergeon L, Sayah M, Fauny JD, Dumortier H, Monneaux F

“…Léa Gherardi,* Lucie Aubergeon,* Mélanie Sayah, Jean-Daniel Fauny, Hélène Dumortier, Fanny Monneaux CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, 67084, France*These authors contributed equally to this workCorrespondence: Fanny Monneaux, CNRS UPR3572, Institut de Biologie Moléculaire et Cellulaire, 2 Allée Konrad Roentgen, Strasbourg, 67084, France, Email f.monneaux@ibmc-cnrs.unistra.frPurpose: The co-inhibitory receptor B and T Lymphocyte Attenuator (BTLA) negatively regulates B and T cell activation. …”
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Using Targeted Virotherapy to Treat a Resistant Ewing Sarcoma Model: From the Bedside to the Bench and Back by Hesham Abdelbary, Christopher W. Brown, Joel Werier, John Bell

“…Oncolytic virus therapy (OV) is a novel therapeutic platform whereby viruses can selectively infect as well as replicate in and kill tumor cells, while sparing normal tissues. …”
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Clinical Holistic Medicine: Holistic Pelvic Examination and Holistic Treatment of Infertility by Søren Ventegodt, Mohammed Morad, Joav Merrick

“…There is, therefore, a need for a procedure that is familiar to and safe for the patient, for all work that involves therapeutic touching of sexual organs over and beyond what is standard medical practice. …”
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CircSPG21 ameliorates oxidative stress-induced senescence in nucleus pulposus-derived mesenchymal stem cells and mitigates intervertebral disc degeneration through the miR-217/SIRT... by Yongbo Zhang, Sheng Yang, Xuan You, Zhengguang Li, Liuyang chen, Rui Dai, Hua Sun, Liang Zhang

“…CircSPG21 also ameliorated disc degeneration in the IVDD rat model, highlighting its potential as a therapeutic target. Conclusion CircSPG21 reduces oxidative stress-induced NPMSC senescence through the miR-217/SIRT1 axis and mitophagy, providing new insights into IVDD and identifying circSPG21 as a potential therapeutic target for disc degeneration.…”
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Adjuvant ozone therapy in necrotizing soft tissue infection. Presentation of a case by Isidro Lamote Matos, Jorge Enrique Rodríguez León, Maydelin Pérez Reina, Niuvys Valera Rodríguez

“…This work continues the ozone therapy topic as a complementary and therapeutic technique in patients with this type of infections, as well as its approach in Primary Health Care. …”
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Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models by D. Betty Lew, Christie F. Michael, Tracie Overbeck, W. Scout Robinson, Erin L. Rohman, Jeffrey M. Lehman, Jennifer K. Patel, Brandi Eiseman, Kim S. LeMessurier, Amali E. Samarasinghe, M. Waleed Gaber

“…One of the unmet needs for asthma management is a new therapeutic agent with both anti-inflammatory and anti-smooth muscle (ASM) remodeling effects. …”
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Nocardiose disseminada by Tiago Costa, Luís Rocha, Luciana Silva, Inês Rato, Sara Pinto

“…Nocardiosis, caused by various species of Nocardia, poses diagnostic and therapeutic challenges due to its diverse clinical presentations that often mimic other infections and malignancies. …”
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Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies by Amirata Mohseni, Fatemeh Salehi, Samaneh Rostami, Kaveh Hadiloo, Mehrdad Hashemi, Zahra Baridjavadi, Fatemeh Ahangari, Najibeh Karami, Fatemeh Samani, Safa Tahmasebi, Najma Farahani, Afshin Taheriazam

“…This review discusses the diagnostic role of exosomes in various hematological malignancies and explores the therapeutic potential of immune cell-derived exosomes in these diseases.…”
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ENTPD8 overexpression enhances anti-PD-L1 therapy in hepatocellular carcinoma via miR-214-5p inhibition by Si-qi Zhao, Min-jie Chen, Fei Chen, Zhao-feng Gao, Xiao-ping Li, Ling-yu Hu, Hai-ying Cheng, Jin-yan Xuan, Jian-guo Fei, Zheng-wei Song

“…In vivo, ENTPD8 overexpression combined with anti-PD-L1 treatment enhanced therapeutic efficacy in HCC mouse models. These findings suggest that ENTPD8 may serve as a prognostic marker and therapeutic target for HCC, offering potential strategies for improving treatment outcomes.…”
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Neurogranin in Alzheimer's Disease: Roles in synaptic function, pathology, and potential as a diagnostic biomarker by Rajkumar Bavaharini, Chaitanya Sree Somala, Konda Mani Saravanan, Thirunavukarasou Anand

“…Cortical Amyloid β pathology seems to accelerate the onset of clinical symptoms; therefore, it is potentially valuable for early diagnosis of AD and therapeutic intervention. Synaptic pathology was shown to be an early feature of AD. …”
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