The Ongoing Challenge of Hematopoietic Stem Cell-Based Gene Therapy for β-Thalassemia by Ekati Drakopoulou, Eleni Papanikolaou, Nicholas P. Anagnou

“…Since then, researchers focused on designing efficient and safe vectors, which can successfully deliver the therapeutic transgene, demonstrating no insertional mutagenesis. …”
Get full text

Concurrent presentation of proliferative glomerulonephritis with monoclonal immunoglobulin deposits and light chain proximal tubulopathy: a case report and review of the literature by Jingdong Zhang, Yang Liu, Fengyan Jin, Jia Li, Hui Wang, Fuzhe Ma, Ye Jia, Jinyu Yu, Shan Wu, Shaojie Fu, Zhonggao Xu, Hao Wu

“…These findings contribute to a better understanding of MGRS and may guide future therapeutic strategies for similar cases.…”
Get full text

Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade by Yasir Osman Ali Abdalla, Bavani Subramaniam, Shaik Nyamathulla, Noorasyikin Shamsuddin, Norhafiza M. Arshad, Kein Seong Mun, Khalijah Awang, Noor Hasima Nagoor

“…An understanding of their molecular targets, underlying mechanisms can reveal their anticancer efficacy, help in optimal therapeutic dose selection, to mitigate their side effects and toxicity towards the host. …”
Get full text

Current Treatment of Heart Failure with Preserved Ejection Fraction: Should We Add Life to the Remaining Years or Add Years to the Remaining Life? by Jia Li, Peter Moritz Becher, Stefan Blankenberg, Dirk Westermann

“…In this review, we will focus on the tested as well as the promising therapeutic options that are currently studied in patients with heart failure with preserved ejection fraction, along with a brief discussion of pathophysiological mechanisms and diagnostic options that are helpful to increase our understanding of novel therapeutic strategies.…”
Get full text

A surrogate BSL2-compliant infection model recapitulating key aspects of human Marburg virus disease by Wanying Yang, Wujie Zhou, Bo Liang, Xiaojun Hu, Shen Wang, Zhenshan Wang, Tiecheng Wang, Xianzhu Xia, Na Feng, Yongkun Zhao, Feihu Yan

“…Notably, the pathogenicity was found to be species-specific, age-related, sex-associated, and challenge route-dependent. Subsequently, the therapeutic efficacy of the MR191 monoclonal antibody was validated in this model. …”
Get full text

Development, Validation and Statistical Correlation of RP–LC Methods for Determination of Atazanavir Sulfate in Capsule Dosage Form by A. Behera, D. G. Sankar, S. K. Moitra, S. C. Si

“…To study the effective therapeutic bioavailability of Atazanavir Sulfate (ATV), administered singly or in combination with Ritonavir, a cost effective and rapid method is required. …”
Get full text

Pathological Role of Tonsillar B Cells in IgA Nephropathy by Yusuke Suzuki, Hitoshi Suzuki, Junichiro Nakata, Daisuke Sato, Tadahiro Kajiyama, Tomonari Watanabe, Yasuhiko Tomino

“…This clinical and experimental information may provide important clues for a therapeutic rationale.…”
Get full text

Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration by De-Zhi Zhao, Rui-Lin Yang, Han-Xiao Wei, Kang Yang, Yi-Bing Yang, Nuo-Xin Wang, Qian Zhang, Fang Chen, Tao Zhang

“…Although the current treatment of periodontal disease can achieve good control of inflammation, it is difficult to regenerate the periodontal supporting tissues to achieve a satisfactory therapeutic effect. In recent years, due to the good tissue regeneration ability, the research on Mesenchymal stromal/stem cells (MSCs) and MSC-derived exosomes has been gradually deepened, especially its ability to interact with the microenvironment of the body in the complex immunoregulatory network, which has led to many new perspectives on the therapeutic strategies for many diseases. …”
Get full text

Pancreaticopleural Fistula: A Review of Imaging Diagnosis and Early Endoscopic Intervention by Ali Kord Valeshabad, Jennifer Acostamadiedo, Lekui Xiao, Winnie Mar, Karen L. Xie

“…Early therapeutic ERCP is an effective and relatively safe treatment option for PPF, so invasive surgery may be avoided.…”
Get full text

Sedative and Hypnotic Activities of the Methanolic and Aqueous Extracts of Lavandula officinalis from Morocco by Rachad Alnamer, Katim Alaoui, El Houcine Bouidida, Abdelaziz Benjouad, Yahia Cherrah

“…Stems and flowers of Lavandula officinalis L. have several therapeutic applications in folk medicine in curing or managing a wide range of diseases, including insomnia. …”
Get full text

Immunomodulatory Effects of Tigecycline in Balb/C Mice by Elhayek Shada Y., Fararjeh Mohammad A., Assaf Areej M., Abu-Rish Eman Y., Bustanji Yasser

“…In conclusion, tigecycline is safe at therapeutic and sub-therapeutic doses, but it could still have an immunomodulatory effect at higher doses. …”
Get full text

Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure by Ruifang Lin, Ruifang Lin, Yunfeng Yu, Lixin Du, Zehui Ding, Zehui Ding, Ziyan Wang, Ziyan Wang, Jiaming Wei, Jiaming Wei, Zhihua Guo, Zhihua Guo

“…The active ingredients serve as the foundation for the therapeutic effects of traditional Chinese medicine (TCM). …”
Get full text

Validation of a mouse model with Apoe gene knockout by Petr R. Lebedev

“…Conclusion: ApoE knockout mice represent a promising genetic model for assessing therapeutic approaches to treat cardiovascular diseases. …”
Get full text

<i>Hovenia dulcis Thunb</i>. Honey Exerts Antiviral Effect Against Influenza A Virus Infection Through Mitochondrial Stress-Mediated Enhancement of Innate Immunity by Eun-Bin Kwon, Buyun Kim, Young-Eun Kim, Sung-Joon Na, Sang Mi Han, Soon Ok Woo, Hong Min Choi, Siwon Moon, Young Soo Kim, Jang-Gi Choi

“…To combat influenza A virus (IAV) infection, it is vital to develop effective therapeutic strategies, including immunomodulators. …”
Get full text

miRNA in blood-brain barrier repair: role of extracellular vesicles in stroke recovery by Vojtech Sprincl, Vojtech Sprincl, Nataliya Romanyuk

“…Our findings underscore the need for further research to optimize the therapeutic potential of EVs and establish their efficacy and safety in clinical settings.…”
Get full text

The protective effect and experimental research progress of pleotropic statins in intervertebral disc degeneration by Xianxu Zhang, Shicheng Li, Xin Liu, Zhong Ma, Qiang Zhang, Yuji Zhang, Jiangdong An, Zhiqiang Luo

“…Furthermore, recent advancements in the application of statins for IVDD treatment are discussed, along with the potential of combining statins with other drugs as part of multi-target therapeutic strategies. This review aims to provide a scientific reference for further investigations into the use of statins in the treatment of IVDD.…”
Get full text

Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases by Marjana Brkic, Sriram Balusu, Claude Libert, Roosmarijn E. Vandenbroucke

“…We also discuss MMP inhibition as a possible therapeutic strategy to treat neurodegenerative diseases.…”
Get full text

Role of neuroimmunomodulation by vagus nerve stimulation in rheumatoid arthritis: Are we heading towards a drug-free era? by Prasan Deep Rath, Swetal Pandey, Rahul Bisaralli

“…Progressive clinical research in the field of neuroimmunomodulation has formed a base for the development of a new therapeutic paradigm for various inflammatory diseases, including rheumatoid arthritis (RA). …”
Get full text

Discussion on the mechanism of HER2 resistance in esophagogastric junction and gastric cancer in the era of immunotherapy by Yan Zhang, Wenxuan Fan, Fei Su, Xiaoling Zhang, Yunyi Du, Weiling Li, Yangjun Gao, Wenqing Hu, Jun Zhao

“…Furthermore, the review discusses the Novel therapeutic approaches, including the use of antibody-drug conjugates (ADCs) and combination therapies are assessed for their potential to enhance outcomes. …”
Get full text

MicroRNA Profiling in Cartilage Ageing by Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter Clegg, Yongxiang Fang, Andy Cremers, Pieter Emans, Tim Welting, Mandy Peffers

“…MicroRNAs (miRNA), a class of small noncoding RNAs, are potential therapeutic targets for regulating molecular mechanisms in both disease and ageing. …”
Get full text