A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

“…EpCAM is an attractive therapeutic target because of its expression in most solid tumors. …”
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Macrophage Activities in Myocardial Infarction and Heart Failure by Sophia Esi Duncan, Shan Gao, Michael Sarhene, Joel Wake Coffie, Deng Linhua, Xingru Bao, Zhang Jing, Sheng Li, Rui Guo, Jing Su, Guanwei Fan

“…If researchers in future confirm that macrophages play a vital role in the heart, they can be therapeutically targeted for cardiac healing.…”
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Percutaneous Radiofrequency Ablation of Small (1–2 cm) Hepatocellular Carcinomas Inconspicuous on B-Mode Ultrasonographic Imaging: Usefulness of Combined Fusion Imaging with MRI an... by Min Woo Lee, Hyo Keun Lim, Hyunchul Rhim, Dong Ik Cha, Tae Wook Kang, Kyoung Doo Song, Ji Hye Min, Geum-Youn Gwak, Seonwoo Kim, David S. K. Lu

“…After CEUS-added FI-guided RFA, therapeutic outcomes including rates of technical success, primary technique efficacy, major complications, and local tumor progression were assessed. …”
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Surgical and Non-surgical Treatments in Pleural Empyema by Sami DENİZ, Nimet AKSEL, Özer ÖZDEMİR, Görkem VAYISOĞLU ŞAHİN, Ezgi ÇİMEN ÇELİK, Mutlu Onur GÜÇSAV, Filiz GÜLDAVAL, Ahmet Emin ERBAYCU, Ahmet ÜÇVET

“…We categorized the patients in two groups as therapeutic drainage (group 1) and open surgery (group 2). …”
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Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer by Yuankui Zhu, Yaxi Yang, Linghe Yue, Lei Wan, Xuqian Ma, Qing Yang, Xuan Tian, Yuguan Li, Ke Wang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei, Dianbao Zuo, Mingqian Feng, Mingqian Feng

“…In light of these concerns, there is a growing interest in exploring alternative T cell types, natural killer T (NKT) cells and gammadelta (γδ) T cells, that possess the capacity to lyse tumors while potentially offering a safer therapeutic profile with fewer side effects. These cells present a compelling alternative that warrants a comprehensive evaluation of their therapeutic potential and safety profile. …”
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Bibliometric and visual analysis in the field of electroacupuncture’s analgesia and regulation on negative emotion from 2014 to 2024 by Xubo Huang, Jiajie Gao, Yuxin Ding, Jiali Wang, Junfan Fang, Junfan Fang, Jianqiao Fang, Jianqiao Fang, Junying Du, Junying Du

“…EA, a contemporary adaptation of traditional acupuncture, has gained significant attention for its potential therapeutic benefits in managing chronic pain and mood disorders.MethodsUsing the Web of Science Core Collection as the primary data source, we identified 537 articles related to EA’s therapeutic effects. …”
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Impact of eggshell membrane on metabolism and cell adhesion in oxidatively stressed canine chondrocytes by Juraj Vozar, Nikola Hudakova, Natalia Nosalova, Mykhailo Huniadi, Dana Marcincakova, Slavomir Hornak, Lubica Hornakova, Petra Majerova, Dasa Cizkova, Dasa Cizkova

“…Eggshell membrane (ESM) is a rich source of bioactive compounds, including proteins, peptides, and antioxidants, contributing to its potential therapeutic benefits. These natural antioxidants might help neutralize reactive oxygen species (ROS) and modulate inflammatory responses, which are often linked with chondrocyte damage in osteoarthritis. …”
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A ROS-responsive hydrogel encapsulated with matrix metalloproteinase-13 siRNA nanocarriers to attenuate osteoarthritis progression by Qiuyang Wang, Kai Feng, Guangsheng Wan, Wei Liao, Jing Jin, Peng Wang, Xiaolian Sun, Weijun Wang, Qing Jiang

“…Abstract RNA interference (RNAi) and oxidative stress inhibition therapeutic strategies have been extensively utilized in the treatment of osteoarthritis (OA), the most prevalent degenerative joint disease. …”
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Synchronized autologous T-cell immunotherapy with hyperthermia to previously heavy treated advanced renal cell carcinoma by Jun Ren, Congcong Li, Dazhao Xu, Kun Wan, Chuxiong Zeng, Lina Hu, Xianzhi Guo, Feifei Huo, Xiumei Rong, Xinna Zhou, Tiecheng Wu, Xiaoli Wang, Bo Sun, JingJing Lou, Amy Hobeika, Michael A. Morse, Herbert Kim Lyerly

“…One cycle ACT constituted three infusions of RetroNectin activated killer (RAK)cells at each 28 days interval. One SHAPE-T therapeutic schema included two cycles of 42.6 billion of RAKs plus 10 times of hyperthermia. …”
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Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma by Babita Shashni, Hao Thi Tran, Long Binh Vong, Ren-Jei Chung, Yukio Nagasaki

“…This platform holds promise for improving therapeutic outcomes in lung cancer while minimizing adverse effects.…”
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Comparison between Intra-Articular Injection of Infrapatellar Fat Pad (IPFP) Cell Concentrates and IPFP-Mesenchymal Stem Cells (MSCs) for Cartilage Defect Repair of the Knee Joint... by Yaguang Han, Haobo Li, Rong Zhou, Jun Wu, Ziye Liu, Huan Wang, Jiahua Shao, Yi Chen, Jun Zhu, Qiwei Fu, Qirong Qian, Yiqin Zhou

“…Overall, IPFP-MSCs represent an effective therapeutic strategy for stimulating articular cartilage regeneration. …”
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Clinically Relevant Solution for the Hypothermic Storage and Transportation of Human Multipotent Mesenchymal Stromal Cells by Yuriy Petrenko, Milada Chudickova, Irena Vackova, Tomas Groh, Eliska Kosnarova, Jitka Cejkova, Karolina Turnovcova, Alexander Petrenko, Eva Sykova, Sarka Kubinova

“…After the storage, the preservation of viability, identity, and therapeutically associated properties of MSCs were assessed. …”
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Biomimetic polydopamine loaded with janus kinase inhibitor for synergistic vitiligo therapy via hydrogel microneedles by Chunying Li, Wenwen Wang, Junyi Shao, Sen Zhou, Xiaolin Ji, Youxia Xi, Qiuyang Xu, Yuhan Huang, Jingle Wang, Yilin Wan, Zhiming Li

“…We precisely deliver this therapeutic agent to the dermis using microneedle (MN) patches, aiming to enhance therapeutic efficacy compared to traditional drug administration methods. …”
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Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control by Yun Gao, Xiushan Yin, Xiaomeng Ren

“…In this review, we focus on the main resources of MSCs, underlying therapeutic mechanisms, clinical applications, and efforts made to improve MSC-based cell therapy efficiency.…”
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The role of fecal microbiota transplantation in type 2 diabetes mellitus treatment by Huimei Wang, Shuo Li, Luping Zhang, Nan Zhang

“…Research endeavors have uncovered the remarkable therapeutic efficacy of FMT across diverse diseases, with particular emphasis on its application in addressing type 2 diabetes mellitus (T2DM) and associated com-plications. …”
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Current Bioengineering Methods for Whole Kidney Regeneration by Shuichiro Yamanaka, Takashi Yokoo

“…All these approaches represent potentially promising therapeutic strategies for the treatment of patients with chronic kidney disease. …”
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PROTAC technology for prostate cancer treatment by Zhen Wang, Dingpeng Zhang, Hiroyuki Inuzuka, Wenyi Wei

“…Although androgen deprivation therapy remains the mainstay for early-stage PrCa treatment, efficacy is temporary because many cases advance to castration-resistant PrCa (CRPC), presenting a significant therapeutic hurdle. This review explores key biomarkers for PrCa and the latest therapeutic strategies for CRPC with a particular focus on the innovative proteolysis-targeting chimera (PROTAC) technology. …”
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Human Echinococcosis: A Neglected Disease by António Menezes da Silva

“…Furthermore, the terminology related to the designations around the parasite, its evolution and some therapeutic procedures is not uniform and sometimes inappropriate terms and wrong designations are used based on incorrect concepts. …”
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Dissociation: understanding the dynamics of primary and secondary capacities by Veronica Mateescu

“…This study underscores the need for culturally informed, holistic therapeutic strategies to address the multifaceted impacts of trauma.…”
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Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection by Rajnish Kumar Singh, Ramakrishna Vangala, Atharva S. Torne, Dipayan Bose, Erle S. Robertson

“…Furthermore, in this review, we explore current therapeutic strategies targeting these epigenetic alterations and discuss future directions for research and treatment. …”
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