Tumor-Associated Regulatory T Cells in Non-Small-Cell Lung Cancer: Current Advances and Future Perspectives by Jiaqi Liang, Guoshu Bi, Guangyao Shan, Xing Jin, Yunyi Bian, Qun Wang

“…This review is aimed at elucidating the molecular mechanisms of tumor-associated Tregs in NSCLC and providing therapeutic targets relevant to Tregs.…”
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Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives by Deshuang Zhang, Dongke Xie, Yi Qu, Dezhi Mu, Shaopu Wang

“…This academic review aims to enhance the etiological comprehension of NEC, promote the development of targeted therapeutic interventions, and impart the significant impact of perinatal factors on the formulation of preventive and curative strategies for the disease.…”
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Ethnopharmacology of Psychotria: Potential Use of P. malayana Jack Leaves as Antidiabetic Agent by Sharifah Nurul Akilah Syed Mohamad, Alfi Khatib, Siti Zaiton Mat Soád, Qamar Uddin Ahmed, Zalikha Ibrahim

“…Finally, the review addresses the toxicological studies on the Psychotria species, assessing their safety as therapeutic agents. …”
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Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma by Jie Chen, Chengyu Feng, Yufei Lan, Xiangtian Chen, Zhengqi Peng, Zihan Huang, Ruiqing Wang, Wenxin Zhang, Yingying Ye, Zhilei Mao, Dongyue Pan, Lihua Yang

“…However, the tumor microenvironment (TME)-induced radioresistance often compromises its therapeutic efficacy. Herein, we propose an innovative bidirectional radiosensitization strategy for NPC. …”
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Engineering of SauriCas9 with enhanced specificity by Xiaoqi Zhang, Chen Tao, Miaomiao Li, Sufang Zhang, Puping Liang, Yan Huang, Huihui Liu, Yongming Wang

“…SauriCas9 is a compact Cas9 nuclease showing promise for in vivo therapeutic applications. However, concerns about off-target effects necessitated improvements in specificity. …”
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Sacha Inchi (<i>Plukenetia volubilis</i>): Potential Bioactivity, Extraction Methods, and Microencapsulation Techniques by Sarah Gustia Redjeki, Alfa Fildzah Hulwana, Rizqa Nurul Aulia, Ira Maya, Anis Yohana Chaerunisaa, Sriwidodo Sriwidodo

“…This paper aims to provide a review of the therapeutic potential, extraction methods, and microencapsulation strategies for enhancing the oil’s stability and bioavailability. …”
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Monoclonal Antibodies for Treatment of COVID-19: An Updated Review of Current Evidence by Saurabh Nimesh, Pratibha Kumari, Rohit Kumar, Gosiya Gosiya, Md. Quamuddin, Md. Iftekhar Ahmad

“… The emergence of COVID-19 in December 2019 spurred a global effort to develop effective medical interventions. Therapeutic monoclonal antibodies (mAbs) have emerged as a promising strategy to combat the SARS-CoV-2 virus. …”
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Contradictory Mechanisms of rheumatoid arthritis and hepatitis B virus infection activation by Fenglin Zhu, Miao Wang, Xuhong Zhang, Guoqing Zhao, Hongyan Gao, Lamei Zhou

“…Recently, numerous studies have been conducted on the contradictory therapeutic mechanisms between RA treatment and HBV infection, including aspects of innate immunity, adaptive immunity, and related signalling pathways. …”
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Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease by Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin

“…Abstract Amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD) are diverse in clinical presentation and are caused by complex and multiple factors, including genetic mutations and environmental factors. Numerous therapeutic approaches have been developed based on the genetic causes and potential mechanisms of ALS and HD. …”
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A Simple Methodology for Conversion of Mouse Monoclonal Antibody to Human-Mouse Chimeric Form by Vinh T. Dang, Kedar D. Mandakhalikar, Oi-Wing Ng, Yee-Joo Tan

“…The human-mouse chimeric forms allow detailed analysis of the mechanism of inhibition and the potential for therapeutic applications. Here, a step-by-step description of the conversion process will be described. …”
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Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction by Zhenlei Peng, Qiyu Jia, Junxiong Mao, Xiao Luo, Anqi Huang, Hao Zheng, Shijie Jiang, Qi Ma, Qi Ma, Chuang Ma, Qizhong Yi

“…These neurotransmitters interact within the reward circuitry, creating potential targets for therapeutic intervention. This improved understanding of neurotransmitter systems provides a foundation for developing targeted treatments and helps clinicians select personalized therapeutic approaches.…”
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Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. by I.A. Khabarov, S.D. Sergazy, A.S. Maikenova, A.N. Zhabayeva, O.V. Maslova, S.M. Adekenov

“…New drug-delivery systems acquired vital importance because of higher bioavailability and overall therapeutic efficacy. A review of various studies on the production and application of phytosomal medical forms, which are in the form of hybrid molecules with high solubility in lipid and aqueous environments, is presented in this article. …”
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A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease by Amir R. Afshari, Hamid R. Sadeghnia, Hamid Mollazadeh

“…Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative. …”
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Anti-tumor role and molecular mechanism of vanillic acid by Xunxing Hao, Zhixiao Gao, Mingzhe Hu

“…This paper offers a comprehensive review of VA's anti-tumor effects and underlying mechanisms, aiming to provide some references for scientists and clinical physicians in the research of anti-tumor therapeutic strategies.…”
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SIRT1 Regulates Cognitive Performance and Ability of Learning and Memory in Diabetic and Nondiabetic Models by Yue Cao, Zi Yan, Tong Zhou, Guixia Wang

“…Our findings suggest that SIRT1 might be a potential therapeutic target for the treatment of cognitive impairment induced by type 2 diabetes mellitus.…”
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Targeted nanozyme-enabled treatment of cardiovascular diseases by Lin Liu, Jie Lv, Xiuxiu Wang, Xiao Huang, Chenchen Zhang, Qingqing Pan, Wei Yan, Zhen Qin

“…As a highly regarded therapeutic strategy, nanotechnology offers new perspectives and means for treating CVDs. …”
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Molecular Mechanisms Underlying Hypothermia-Induced Neuroprotection by Yasushi Shintani, Yasuko Terao, Hiroyuki Ohta

“…To predict precise target molecules, we took advantage of the therapeutic time window and duration of hypothermia necessary to exert neuroprotective effects. …”
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Neuroinflammation and Cerebrovascular Disease in Old Age: A Translational Medicine Perspective by Mario Di Napoli, Imtiaz M. Shah

“…A better understanding of stroke pathophysiology in the elderly patient would assist in the development of new therapeutic strategies for this vulnerable age group. …”
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Research Trend in the Efficacy of Korean Medicine Treatment for Frostbite by Kim Hyorim, Lee Dong-Hwan, Jae-Young Lee, Tae-Jun Lee, Sung-Hwan Cho, Ji-Won Park, Hea-Ju Kim, Seol Jung, Hye-Ri Jo

“…Altogether, four studies, including two case studies and two animal experiments, that assessed the therapeutic effects of Korean medicine on frostbite were identified. …”

Endothelial Progenitor Cell Migration-Enhancing Factors in the Secretome of Placental-Derived Mesenchymal Stem Cells by Witchayaporn Kamprom, Pakpoom Kheolamai, Yaowalak U-Pratya, Aungkura Supokawej, Methichit Wattanapanitch, Chuti Laowtammathron, Sittiruk Roytrakul, Surapol Issaragrisil

“…Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. …”
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