NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity by Yixuan Liu, Baoyue Liu, Mingzhu Shi, Tianxiang Ye, Huifang Li

“…Inhibition of the inflammasome presents a promising novel therapeutic target for mitigating geniposide-induced hepatotoxicity.…”
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Molecular Mechanisms, Diagnoses, and Treatments of Respiratory Diseases by Te-Chun Shen

“…The Special Issue “Molecular Mechanisms, Diagnoses, and Treatments of Respiratory Diseases” in the journal <i>Biomedicines</i> compiles critical advancements in the understanding of respiratory diseases, focusing on their molecular mechanisms, diagnostic approaches, and therapeutic strategies [...]…”
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Economic Evaluation of Voriconazole for the Treatment of Candidemia in Canadian Adults by Coleman Rotstein, Lael Cragin, Michel Laverdière, Gary Garber, Eric J Bow, Alissa Scalera, Craig Roberts, Sonja V Sorenson, the Canadian Expert Panel

“…BACKGROUND: Candidemia is a common cause of nosocomial bloodstream infection. When selecting therapeutic treatments for candidemia, cost-effectiveness is an important consideration. …”
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Outcomes of Peginterferon Alpha-2a and Ribavirin Hepatitis C therapy in Aboriginal Canadians by Curtis L Cooper, Robert J Bailey, Vince G Bain, Frank Anderson, Eric M Yoshida, Mel Krajden, Paul Marotta, for the Canadian Pegasys Study Group

“…BACKGROUND: There is little published information on baseline characteristics and therapeutic outcomes in hepatitis C virus (HCV)-infected Aboriginal Canadians. …”
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Cat Scratch Disease: The Story Continues by Mary Anne Opavsky

“…OBJECTIVE: To present a perspective on the current state of knowledge of cat scratch disease (CSD), including the evidence for Bartonella henselae as the etiological agent, epidemiological and clinical characteristics of the disease, available diagnostic tests and current therapeutic options.…”
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The Protective Role of PGC-1α in Cystitis Glandularis: Mitigating Mitochondrial Injury and Inflammation by Min Chen, Yongbo Tang, Yue Fu, Haiwei Hu, Ende Cui, Zhouliang Wen, Wei Zhong, Jimin Su, Bo Ge

“…Targeting the PGC-1α signaling pathway may offer an effective therapeutic intervention for the clinical management of CG.…”
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FTO Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Apoptosis and Autophagy by Pi-Xiao Wang, Ling Zhu, Mei Xiang, Rixin Zhang, Xiaolin Zheng, Zhi Zheng, Kai Li

“…FTO-mediated m6A demethylation modification may be an important therapeutic target for hepatic IRI.…”
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Current Status of New Anticoagulants in the Management of Venous Thromboembolism by Roberto C. Montoya, Ajeet Gajra

“…The current paper will review the characteristics, clinical trial results, and current and potential therapeutic uses of these new agents with a focus on the categories of direct thrombin inhibitors and activated factor X inhibitors.…”
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PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition by Hui Xiao, Longxiao Zhang, Yuan Chen, Chengjun Zhou, Xiao Wang, Dehai Wang, Zhenzhong Liu

“…These findings indicate PKM2 is a potentially useful diagnostic biomarker and therapeutic target in breast cancer.…”
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Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome by Mimouni, Nour El Houda, Giacobini, Paolo

“…However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Müllerian hormone) can contribute to the onset of PCOS in adulthood and lead to the transgenerational transmission of neuroendocrine and metabolic traits through alterations in the DNA methylation process.The originality of the translational findings summarized here involves the identification of potential biomarkers for early diagnosis of the syndrome, in addition to the validation of a promising therapeutic avenue in a preclinical model of PCOS, which can improve the management of patients suffering from the syndrome.…”
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Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system by Roshanak Asgari, Maria Caceres-Valdiviezo, Sally Wu, Laurie Hamel, Bailey E. Humber, Sri Mahavir Agarwal, Paul J. Fletcher, Stephanie Fulton, Margaret K. Hahn, Sandra Pereira

“…Obesity is characterized by expanded adipose tissue mass and consequently, elevated concentrations of leptin in blood. Leptin's therapeutic potential for most forms of obesity is hampered by leptin resistance and a narrow dose–response window. …”
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Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy by Dechuan Sun, Mona Amiri, Qi Meng, Ranjith R. Unnithan, Chris French

“…In this review, we discuss the abnormalities observed in calcium signalling and its potential as a therapeutic target for NDs. Additionally, we highlight recent studies that utilise miniscope technology to investigate the alterations in calcium dynamics associated with NDs.…”
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Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis by Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka

“…Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis. …”
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Peroxisome Proliferator-Activated Receptors in Diabetic Nephropathy by Shinji Kume, Takashi Uzu, Keiji Isshiki, Daisuke Koya

“…Diabetic nephropathy is a leading cause of end-stage renal disease, which is increasing in incidence worldwide, despite intensive treatment approaches such as glycemic and blood pressure control in patients with diabetes mellitus. New therapeutic strategies are needed to prevent the onset of diabetic nephropathy. …”
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scFv Antibody: Principles and Clinical Application by Zuhaida Asra Ahmad, Swee Keong Yeap, Abdul Manaf Ali, Wan Yong Ho, Noorjahan Banu Mohamed Alitheen, Muhajir Hamid

“…Alternatively, antibody fragments could also be applied in the construction of immunotoxins, therapeutic gene delivery, and anticancer intrabodies for therapeutic purposes. …”
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Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management by Menglei Shi, Menglei Shi, Sisi Chen, Sisi Chen, Yutong Feng, Yutong Feng, Shiyuan Wang, Yuyu Xia, Jianlin He

“…The marine ecosystem, distinguished by its distinctive environmental characteristics, is a treasure trove of novel lead compounds possessing unique chemical structures, offering promising avenues for the development of new therapeutic agents or dietary supplement targeting NAFLD. …”
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Transcription factor specificity protein (SP) family in renal physiology and diseases by Wei Zhou, Jiaxi Fang, Qingqing Jia, Hanyan Meng, Fei Liu, Jianhua Mao

“…Our findings provide a comprehensive understanding of SPs in renal health and disease, offering new avenues for targeted therapeutic interventions and precision medicine in nephrology.…”
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Nanoparticles-mediated delivery of herbal extract: Impact on inhibition advanced glycation end-product (AGEs): A systematic review by Astuti Febriana, Akrom, Mustofa

“…This systematic review compiles and analyzes research on the therapeutic efficacy of nanoparticle-mediated delivery systems for herbal extracts aimed at inhibiting the formation of Advanced Glycation End- products. …”
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The neuroscience in breast cancer: Current insights and clinical opportunities by Jia-feng Wang, Meng-chuan Wang, Lei-lei Jiang, Neng-ming Lin

“…Furthermore, the study discussed the potential of nerves as biomarkers for diagnosing and prognosticating breast cancer, and evaluated prospects for improving chemotherapy and immunotherapy therapeutic outcomes in breast cancer treatment. We hope to provide a deeper understanding of the neurobiological underpinnings of breast cancer and pave the way for the discovery of innovative therapeutic targets and prognostic markers.…”
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Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting by David Filgueiras-Rama, Miguel A. Arias, Ángel Iniesta, Eduardo Armada, José L. Merino, Rafael Peinado, J. L. López-Sendón

“…This paper aims at providing readers a brief and specific revision of current knowledge about the mechanisms underlying atrial arrhythmias in OSA and their clinical and therapeutic implications.…”
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