Current concept on pediatric low-grade glioma in the era of molecular diagnosis by Tzu-Chiang Peng, Ching-Ying Wang, Yi-Yen Lee

“…Despite recent advances in surgical technique, chemotherapy, and radiotherapy, it disappointedly relates to significantly profound morbidity compared to other cancers. The current therapeutic strategy leads to a high incidence of adverse effects. …”
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Takayasu Arteritis with Congestive Heart Failure in a 16-year-old Indian Male Child by Manisha Mehra, Poonam Joshi, Ankit Kumar Sahu, Surya Kant Tiwari

“…Despite diagnostic and therapeutic challenges, the patient showed improvement after 3 months. …”
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NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors by Man-Man Qi, Heng-Yue Peng, Tian-Ge Zhang, Yan Li, Meng-Ya Gao, Wen-Bo Sun, Xu-Peng Wang

“…This study investigated the therapeutic effect of intraperitoneal injection of the H2S donor sodium hydrosulfide (NaHS) on neuropathic pain. …”
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Site-Specific Immunosuppression in Vascularized Composite Allotransplantation: Prospects and Potential by Jonas T. Schnider, Matthias Weinstock, Jan A. Plock, Mario G. Solari, Raman Venkataramanan, Xin Xiao Zheng, Vijay S. Gorantla

“…The skin is directly accessible for visual monitoring of acute rejection (AR) and for directed biopsy, timely therapeutic intervention, and management of AR. …”
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T Cell Costimulatory Molecules in Anti-Viral Immunity: Potential Role in Immunotherapeutic Vaccines by Tania H Watts, Edward M Bertram, Jacob Bukczynski, Tao Wen

“…These new developments have important implications for therapeutic vaccine design. In this review the authors discuss the function of T cell costimulatory molecules in immune system activation and their potential for enhancing the efficacy of therapeutic vaccines.…”
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The Role of Mesenchymal Stem Cell Secretome (Extracellular Microvesicles and Exosomes) in Animals’ Musculoskeletal and Neurologic-Related Disorders by Alefe Luiz Caliani Carrera, Bruno Watanabe Minto, Patrícia Malard, Hilana dos Santos Sena Brunel

“…The advances in regenerative medicine are very important for the development of medicine and the discovery of stem cells has shown a greater capacity to raise the level of therapeutic quality while their use becomes more accessible, especially in their mesenchymal form. …”
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Cancer Cachexia: Mechanisms and Clinical Implications by Claire L. Donohoe, Aoife M. Ryan, John V. Reynolds

“…Understanding the complex interplay of tumour and host factors will uncover new therapeutic targets.…”
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Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19 by Aliede E. in ‘t Veld, Manon A. A. Jansen, Luuk C. A. Ciere, Matthijs Moerland

“…Here, we discuss the mechanistic basis for the use of HCQ against SARS-CoV-2 in a prophylactic setting and in a therapeutic setting, at different stages of the disease. …”
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Aging and tumors: a dynamic interaction by Yudi Zhang, Siqiang Zhu, Zhaodong Liu, Yonghao Hu, Yongjian Zhang, Liang Shang, Leping Li

“…Ultimately, the discussion explores the potential application of anti-aging strategies in tumor therapy and considers the possibility of utilizing senescence mechanisms as a novel therapeutic approach for tumors. This research provides novel insights into the complex interplay between senescence and tumor development, suggesting potential strategies for future preventative measures and therapeutic interventions.…”
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The Risk of Tuberculosis Transmission in Solid Organ Transplant: Is It More Than a Theoretical Concern? by Gregory Rose

“…The present case report describes a therapeutic dilemma regarding the transmission of Mycobacterium tuberculosis during transplantation of solid organs, places this phenomenon within the context of the literature, and makes recommendations for screening and therapy.…”
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The use of Positive Psychotherapy tools and concepts in the coming out process of a non-heteronormative (LGBTA) client: A case report by Krzysztof Dembinski

“… This paper explores therapeutic challenges faced by non-heteronormative individuals before coming out, emphasizing the role of Positive and Transcultural Psychotherapy (PPT) in providing support. …”
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Immunomodulation in the Treatment of Refractory Catastrophic Antiphospholipid Syndrome by Karthik Nath, Andrew McCann

“…Prompt therapeutic anticoagulation, antiplatelet, and glucocorticoid therapy was commenced. …”
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NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis by Shin Maeda

“…A better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC.…”
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Modeling of chemo-radiotherapy targeting growing vascular tumors: A continuum-level approach. by Ioannis Lampropoulos, Marina Koutsi, Michail E Kavousanakis

“…The aim of this study is to demonstrate the enhanced efficiency of combined therapeutic strategies for the treatment of growing tumors, based on computational experiments of a continuous-level modeling framework. …”
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Targeting the Mitotic Catastrophe Signaling Pathway in Cancer by Margaret M. Mc Gee

“…Furthermore, the activation of mitotic catastrophe offers significant therapeutic advantage which has been exploited in the action of conventional and targeted anticancer agents. …”
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Challenges and updates in the management of eosinophilic esophagitis by Tsvetelina Velikova

“…There are many challenges regarding the treatment options of EE. Different therapeutic approaches are best at meeting different endpoints. …”
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Use of Bismuth in Irritable Bowel Syndrome by T. A. Ilchishina

“…The use of therapeutic-dosed bismuth preparations is safe and well tolerated by patients.Conclusion. …”
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Effect of photobiomodulation as preventive treatment of diabetic foot ulcer: randomised, controlled, double-blind, clinical trial protocol by Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori, Roselene Lourenço, Silvana Torres Perez, Cinthya Cosme Gutierrez Duran, Alexandre Rocha Santos Padilha, Tainá Caroline dos Santos Malavazzi

“…The boot will be worn once a day for 6 min over 60 days and the participants will also receive therapeutic education. The control group will wear a non-therapeutic LED boot (sham) under the same conditions and will also receive therapeutic education. …”
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Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA by Po-Ku Chen, Joung-Liang Lan, Yi-Ming Chen, Hsin-Hua Chen, Shih-Hsin Chang, Chia-Min Chung, Nurul H. Rutt, Ti-Myen Tan, Raja Nurashirin Raja Mamat, Nur Diana Anuar, Jonathan M. Blackburn, Der-Yuan Chen

“…Anti-drug antibody (ADAb) development is associated with secondary therapeutic failure in biologic-treated rheumatoid arthritis (RA) patients. …”
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Enhancement of anti‐sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2‐targeted CAR by Pui Yeng Lam, Natacha Omer, Josh K. M. Wong, Cui Tu, Louisa Alim, Gustavo R. Rossi, Maria Victorova, Hannah Tompkins, Cheng‐Yu Lin, Ahmed M. Mehdi, Amos Choo, Melissa R. Elliott, Elaina Coleborn, Jane Sun, Timothy Mercer, Orazio Vittorio, Lachlan J. Dobson, Alexander D. McLellan, Andrew Brooks, Zewen Kelvin Tuong, Seth W. Cheetham, Wayne Nicholls, Fernando Souza‐Fonseca‐Guimaraes

“…Despite the critical need, therapeutic advancements have been limited over the past three decades. …”
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