Apigenin suppresses osteoarthritis progression by inhibiting pyroptosis via SIRT1/mTOR pathway-mediated mitophagy by Jiahao Ying, Shijie Li, Anna Ying, Yindong Ding, Xiaoyin Zhu, Jiahao Lin, Kehe Yu

“…Exploring the therapeutic effects and underlying mechanisms of Apigenin (Api) in managing osteoarthritis (OA) was the primary focus of this research. …”
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Chemical Speciation of the System Cu(II)-Indomethacin in Ethanol and Water by UV-Vis Spectrophotometry by Norma Rodríguez-Laguna, Luis I. Reyes-García, Rosario Moya-Hernández, Alberto Rojas-Hernández, Rodolfo Gómez-Balderas

“…It has been proposed that the metal-drug complexes could be in fact the active agents displaying therapeutic effects of drugs. The characterization of the global formation equilibrium of complexes formed between metal ions and species with biological activity such as nonsteroidal anti-inflammatory drugs provides essential information to understand the mechanism of action of drugs. …”
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Benchmarking Standing Stability for Bipedal Robots by Juan A. JUANCASTANO, Eugenio Manuel Espuela, Jaime Ramos Rojas, Enrico Mingo Hoffman, Chengxu Zhou

“…Furthermore, the same benchmarking method was applied to the therapeutic exoskeleton H3, illustrating its potential to optimize mechanical design and therapeutic performance. …”
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Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment by Qibo Huang, Bai Hu, Ping Zhang, Ye Yuan, Shiwei Yue, Xiaoping Chen, Junnan Liang, Zhouping Tang, Bixiang Zhang

“…In this review we present the work supporting that therapeutic agent targeting the nervous system could have significant potential to improve cancer therapy.…”
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Lipedema: exploring pathophysiology and treatment strategies – state of the art by Fabio Kamamoto, Jaqueline Munaretto Timm Baiocchi, Bernardo Nogueira Batista, Renan Diego Américo Ribeiro, Débora Aparecida Oliveira Modena, Vitor Cervantes Gornati

“…Despite increasing recognition, comprehensive understanding, including pathophysiological, clinical, and therapeutic aspects, has not been fully achieved. This review aims to fill gaps in knowledge of this field, to support more informed management of lipedema. …”
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Potential inhibition of CXCL12/SDF-1 by small molecule Hesperetin in management of tobacco associated oral cancer by G. Radha, Ramya Ramadoss, Pradeep Kumar Yadalam, Rajeshkumar Shanmugam

“…Conclusion: Targeting molecular components of the NF-κB signaling pathway through inhibition of CXCL12/SDF-1 could serve as a vital therapeutic adjunct in management of tobacco associated oral cancer. …”
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Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions by Wang-Soo Lee, Jaetaek Kim

“…Several studies have demonstrated that PPAR agonists improve dyslipidemia and glucose control in animals, supporting their potential as a promising therapeutic option to treat diabetes and dyslipidemia. …”
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Exploring Long Noncoding RNAs in Glioblastoma: Regulatory Mechanisms and Clinical Potentials by Tao Zeng, Lei Li, Yan Zhou, Liang Gao

“…Then, their diagnostic, prognostic, and therapeutic implications were also discussed.…”
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Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology by Shengming Ou, Xiaoya Nie, Xiangyu Qiu, Xin Jin, Geyan Wu, Rongxin Zhang, Jinrong Zhu

“…Despite evidence implicating lncRNAs in cancer and inflammation, studies on their mechanisms and therapeutic potential remain scarce. We investigate the mechanisms of lncRNA-mediated regulation of inflammation and cancer immunity, assessing the feasibility and challenges of lncRNAs as therapeutic targets in these conditions.…”
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Protection of Fecal Microbiota Transplantation in a Mouse Model of Multiple Sclerosis by Kanglan Li, Shouchao Wei, Li Hu, Xiaojian Yin, Yingren Mai, Chunmei Jiang, Xiaoping Peng, Xingxing Cao, Zhongkai Huang, Haihong Zhou, Guoda Ma, Zhou Liu, Huiliang Li, Bin Zhao

“…We provide evidence that FMT can rectify altered GM to some extent with a therapeutic effect on EAE. We also found that FMT led to reduced activation of microglia and astrocytes and conferred protection on the blood-brain barrier (BBB), myelin, and axons in EAE. …”
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Case Report: Management of a case of multidrug-resistant Klebsiella pneumoniae infection in a second-kidney transplant patient by Supreeta R. Shettar, Mahadevaiah Neelambike Sumana, Manjunath S. Shetty, Yogeesh D. Maheshwarappa, Reddy G. Raghukanth, Asha Srinivasan, Dharan P. Vamshi, Gautam Kalyatanda, Swamy G. S. Veerabhadra, Shylaja Eshwarappa Chinchana

“…This approach is critical in overcoming the resistance mechanisms inherent to Klebsiella pneumoniae, thereby improving the likelihood of therapeutic success. The findings presented here highlight the potential efficacy of extended meropenem infusion in treating MDR infections, providing a valuable therapeutic option for clinicians facing similar cases. …”
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Treatment of Cervical Pregnancy with Ultrasound-Guided Intragestational Injection of Methotrexate: A Case Report by Angeliki Rouvali, Panagiotis Vlastarakos, Sofoklis Stavros, Maria Giourga, Kalliopi Pappa, Angeliki Gerede, Alexandros Rodolakis, Ekaterini Domali

“…The evolution of ultrasound over the past decades has enabled early diagnosis and has shifted the management from a radical surgical approach towards a stepwise conservative therapeutic approach, when possible.…”
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Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction by Rosario Licitra, Stefania Della Vecchia, Lorenzo Santucci, Rachele Vivarelli, Sara Bernardi, Filippo M. Santorelli, Maria Marchese

“…Trehalose holds promise as a therapeutic agent for CLN8, warranting further research into its neuroprotective mechanisms and clinical applications.…”
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Animal models for transplant immunology: bridging bench to bedside by Minseok Kang, Hwon Kyum Park, Kyeong Sik Kim, Dongho Choi

“…Animal models have not only provided opportunities to understand complex immune mechanisms in transplantation but also served as a platform to assess therapeutic interventions. While small animals have been instrumental in uncovering new therapeutic concepts related to immunosuppression and immune tolerance, the progression to human trials has largely been driven by studies in large animals. …”
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Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms by Lujia Si, Yupu An, Jiahang Zhou, Yu Lai

“…By elucidating these mechanisms, this review contributes to the development of therapeutic approaches that target disorders of the central nervous system.…”
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Potential of ultrasound stimulation and sonogenetics in vision restoration: a narrative review by Jie Ji, Chen Gong, Gengxi Lu, Junhang Zhang, Baoqiang Liu, Xunan Liu, Junhao Lin, Patrick Wang, Biju B. Thomas, Mark S. Humayun, Qifa Zhou

“…We also address how methods such as viral transcription can be utilized to render specific neurons or organs highly responsive to ultrasound, leading to significantly improved therapeutic outcomes.…”
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Metabolomic profiles as a new understanding of disease processes by O. Yu. Zolnikova, M. S. Reshetova, M. N. Ivanova, V. T. Ivashkin

“…These results define new potential therapeutic strategies, making metabolomics useful for a wide range of biomedical and pharmaceutical research.Conclusion. …”
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Disease prediction by network information gain on a single sample basis by Jinling Yan, Peiluan Li, Ying Li, Rong Gao, Cheng Bi, Luonan Chen

“…Moreover, our method was validated by successfully predicting disease deteriorations and identifying their potential therapeutic targets from four real omics datasets, i.e., an influenza dataset and three cancer datasets.…”
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Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies by Pinglian Yang, Xiaoling Rong, Zhechang Gao, Jiaojiao Wang, Zhiping Liu

“…Fundamental studies that elucidate the mechanisms by which metabolic and epigenetic regulation of macrophage polarization influence atherosclerosis will pave the way for novel therapeutic approaches.…”
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Fertility Preservation in Female Patients with Cancer Part II: Royan Institute Clinical Practice Guideline for Girls and Women with Cancer; A Review Study by Azar Yahyaei, Esmat Mashhadi Meighani, Firouzeh Ghaffari

“…The formulation and execution of harmonized guidelines and policies concerning the provision of FPservices, inclusive of therapeutic strategies and standardization of procedures, are crucial to surmount disagreementsregarding the delivery of these therapeutic services and avert delays in cancer treatment. …”
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