Treatment of Radiation Bone Injury with Transplanted hUCB-MSCs via Wnt/β-Catenin by Yufeng Zhang, Huaxin Deng, Zhiqiang Yang, Zhe Chen, Sheng Zhang, Yufan Zhu, Min Yang, Houcheng Zhong, Fuling Zhou, Yuanlong Xie, Lin Cai

“…Our results reveal the inhibitory effect of radiation on osteoblast function. hUCB-MSCs can be used as a therapeutic target for the development of new therapeutic strategies for radiotherapy of bone injury diseases.…”
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Platelet‐derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A‐II by Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang

“…This underscores the need for improved therapeutic approaches that can modulate lipid metabolism and halt the transition from liver steatosis to chronic liver disease. …”
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Crosstalk between non-coding RNAs and programmed cell death in colorectal cancer: implications for targeted therapy by Seyed Reza Taha, Mehdi Karimi, Bahar Mahdavi, Milad Yousefi Tehrani, Ali Bemani, Shahriar Kabirian, Javad Mohammadi, Sina Jabbari, Meysam Hushmand, Alireza Mokhtar, Mohammad Hossein Pourhanifeh

“…The targeted modulation of ncRNA-PCD interactions presents promising avenues for personalized cancer treatment, which may improve patient outcomes by enhancing therapeutic effectiveness and reducing resistance.…”
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Mouse Umbilical Cord Mesenchymal Stem Cell Paracrine Alleviates Renal Fibrosis in Diabetic Nephropathy by Reducing Myofibroblast Transdifferentiation and Cell Proliferation and Upr... by Hongde Li, Pengfei Rong, Xiaoqian Ma, Wei Nie, Yan Chen, Juan Zhang, Qiong Dong, Min Yang, Wei Wang

“…Transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) is currently considered a novel therapeutic strategy for diabetic nephropathy (DN). …”
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In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…We demonstrate that the HCI in vitro assay we devised is a reliable screening method to select candidate molecules for mutation-independent therapeutic approaches for retinal disorders. Moreover, our data indicate that miR-429 represents a potential therapeutic target against photoreceptor degeneration.…”
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Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy by Yawen Wang, Lei Yang, Qing Xu, Taiyu Liu, Hongliang He, Lisha Liu, Lifang Yin

“…Current antifibrotic nanomedicines face significant limitations, including poor penetration into fibrotic tissue, rapid clearance, and suboptimal therapeutic efficacy. The dense fibrotic ECM acts as a major physiological barrier, necessitating the development of a targeted delivery strategy to achieve effective therapeutic outcomes. …”
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Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn’s disease: a single-centre, cross-sectional study by Yoshiaki Takada, Hiroki Kiyohara, Yohei Mikami, Masataka Taguri, Ryoya Sakakibara, Yasuhiro Aoki, Kosaku Nanki, Takaaki Kawaguchi, Yusuke Yoshimatsu, Shinya Sugimoto, Tomohisa Sujino, Kaoru Takabayashi, Naoki Hosoe, Haruhiko Ogata, Motohiko Kato, Yasushi Iwao, Nobuhiro Nakamoto, Takanori Kanai

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Life-Threatening Retroperitoneal Hematoma in a Patient with COVID-19 by Monarch Shah, John Paul Colombo, Sanya Chandna, Haris Rana

“…In this report, we discuss a case of retroperitoneal hemorrhage in a patient treated with therapeutic anticoagulation which ultimately led to the patient’s death. …”
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Contrasting Psychotherapeutic Treatments in Inflammatory Bowel Disease: an Exploratory Review by Carlos Enrique Zerpa

“…The intervention that has the greatest verifiable therapeutic potential, given a better systematization of methodological procedures used, is cognitive behavioral psychotherapy. …”
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Approved antibacterial drugs in the last 10 years: from the bench to the clinic by Miguel García-Castro, Francisco Sarabia, Amelia Díaz-Morilla, Juan Manuel López-Romero

“…Indeed, bacteria have developed various mechanisms of resistance against several therapeutic agents. Consequently, the scientific community is always interested in search of new therapeutic agents, which are able to efficiently kill resistant-bacterial strains. …”
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Remarkable Role of Indoleamine 2,3-Dioxygenase and Tryptophan Metabolites in Infectious Diseases: Potential Role in Macrophage-Mediated Inflammatory Diseases by Yuki Murakami, Masato Hoshi, Yukio Imamura, Yuko Arioka, Yasuko Yamamoto, Kuniaki Saito

“…This paper offers insights into new therapeutic strategies in the modulation of viral infection and several immune-related disorders.…”
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Functional and Structural Features of Organizing the "Sense of Rightness" within the Structure of Personality by Yuliia Bogachenko

“…The study highlights the necessity of new therapeutic methods to support psychological resilience and personality development under modern stress factors, particularly through emphasizing the integration of emotions, self-awareness, and the search for deep meaning in life and the sense of rightness.…”
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Post-translational modifications and bronchopulmonary dysplasia by Kun Yang, Ting He, Xue Sun, Wenbin Dong

“…The aim is to provide novel insights into bronchopulmonary dysplasia's pathogenesis and potential therapeutic targets for clinical management.…”
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The Management of Iron Chelation Therapy: Preliminary Data from a National Registry of Thalassaemic Patients by Adriana Ceci, Laura Mangiarini, Mariagrazia Felisi, Franco Bartoloni, Angela Ciancio, Marcello Capra, Domenico D'Ascola, Paolo Cianciulli, Aldo Filosa

“…This study represents the analysis of the preliminary data collected for the evaluation of current status of the iron chelation practice in the Italian thalassaemic population and describes how therapeutic interventions can widely differ in the different patients' age groups.…”
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The Emerging Role of GC-MSCs in the Gastric Cancer Microenvironment: From Tumor to Tumor Immunity by Zhaoji Pan, Yiqing Tian, Guoping Niu, Chengsong Cao

“…Moreover, we also discuss the potential biomarker and therapeutic role of GC-MSCs. It is anticipated that new and deep insights into the functionality of GC-MSCs and the underlying mechanisms will promote the novel and promising therapeutic strategies against gastric cancer.…”
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Recent research on the bioactivity of polyphenols derived from edible fungi and their potential in chronic disease prevention by Wenbin Yu, Yufei Zhang, Yi Lu, Zhiwei Ouyang, Jiahua Peng, Yayi Tu, Bin He

“…Chronic diseases pose a significant threat to global public health, demanding innovative preventive and therapeutic strategies. Recent research has brought to light the nutritional and bioactive properties of edible fungi, with a particular focus on the bioactivity of mushroom polyphenols. …”
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Bacteria in Cancer Therapy: Renaissance of an Old Concept by Sebastian Felgner, Dino Kocijancic, Michael Frahm, Siegfried Weiss

“…Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. …”
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Improving the Performance of Phase-Change Perfluorocarbon Droplets for Medical Ultrasonography: Current Progress, Challenges, and Prospects by Paul S. Sheeran, Paul A. Dayton

“…In the field of ultrasound, phase-change droplets present an attractive alternative to traditional microbubble agents for many diagnostic and therapeutic applications. Despite the progress, phase-change PFC droplets remain far from clinical implementation due to a number of challenges. …”
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A Spotlight on Chemical Constituents and Pharmacological Activities of Nigella glandulifera Freyn et Sint Seeds by Besma Boubertakh, Xin-Guang Liu, Xiao-Lan Cheng, Ping Li

“…We put also a spotlight on the recently studied therapeutic potentials of such amazing herb seeds as antidiabetes, melanogenesis inhibition, anticancer, anti-inflammatory, antithrombosis, and antiplatelet aggregation effects. …”
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Stereotactic body radiation therapy as initial treatment for head and neck cancer by Sivakamavalli Jeyachandran

“…This study explores SBRT's efficacy, safety, and outcomes as the initial therapeutic modality for HNSCC. SBRT's precision targeting and high doses enable localized tumor control while sparing adjacent healthy tissues, mitigating treatment-related morbidities. …”
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