Photodynamic Therapy (PDT) in drug delivery: Nano-innovations enhancing treatment outcomes by Ahmed N. Al-Jamal, Ali Fawzi Al-Hussainy, Bahira Abdulrazzaq Mohammed, Hadi Hussein Abbas, Issa Mohammed Kadhim, Zahraa Hassan Ward, Debarshi Kar Mahapatra, Tomy Muringayil Joseph, Ehsan kianfar, Sabu Thomas

“…Numerous treatment modalities including PDT have long recognized the need to improve the performance of nanoscale therapeutic frameworks. Photosensitizers (Ps) are NPs used in PDT, selectively targeting malignant tissues for therapeutic effects, while sparing healthy cells. …”
Get full text

A Case Series of Gastrointestinal Tuberculosis in Renal Transplant Patients by Pedro Azevedo, Cristina Freitas, Hugo Silva, Pedro Aguiar, Pedro Farrajota, Manuela Almeida, Sofia Pedroso, La Salete Martins, Leonídio Dias, José Ramón Vizcaíno, António Castro Henriques, António Cabrita

“…Intestinal tuberculosis has a very difficult investigational approach, requiring a high clinical suspicion for its diagnosis. Therapeutic options may be a problem in the context of an immunosuppressed patient, requiring adjustment of maintenance therapy. …”
Get full text

Human Polyomavirus Reactivation: Disease Pathogenesis and Treatment Approaches by Cillian F. De Gascun, Michael J. Carr

“…In spite of this, there remains a dearth of specific therapeutic options for human polyomavirus infections and an incomplete understanding of the relationship between the virus and the host immune system. …”
Get full text

Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy by Songyan Wang, Bing Li, Chunguang Li, Wenpeng Cui, Lining Miao

“…Therefore, increasing attention is being paid to CCN2 as a potential therapeutic target for DN. Up to date, there are also many drugs or agents which have been shown for their protective effects against DN via different mechanisms. …”
Get full text

Towards person-centred maternal and newborn care in Ethiopia: a mixed method study of satisfaction and experiences of care by Tigist Eshetu, Eshcolewyine Fekadu, Ahmed Abdella, Adiyam Mulushoa, Girmay Medhin, Merga Belina, Atalay Alem, Roxanne Keynejad, Tanya Robbins, Nadine Seward, Andrew Shennan, Louise M. Howard, Martin Prince, Jane Sandall, Charlotte Hanlon

Get full text

Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

“…Several therapeutic options are now available, although some differences across countries in drug approval and the optimal therapeutic sequencing associated with each peculiar patient subgroup represent a clinical challenge for oncologists. …”
Get full text

C/EBPβ in Alzheimer’s disease: An integrative regulator of pathological mechanisms by Xiaoting Luo, Junyi Liang, Xue Lei, Fengqi Sun, Minghai Gong, Bin Liu, Zhongguang Zhou

“…With the global aging population, the incidence of AD continues to rise, yet current therapeutic strategies remain limited in their ability to significantly alleviate cognitive impairments. …”
Get full text

Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment by Wenxiu Yuan, Jiaqi Liu, Zhenzhen Zhang, Chengxinyue Ye, Xueman Zhou, Yating Yi, Yange Wu, Yijun Li, Qinlanhui Zhang, Xin Xiong, Hengyi Xiao, Jin Liu, Jun Wang

“…Emerging evidence underscores the therapeutic promise of exosomes in osteoarthritis management. …”
Get full text

Tecovirimat in the management of poxviruses: a narrative review of available evidence by Olalekan John Okesanya, Jerico Bautista Ogaya, Ikponmwosa Jude Ogieuhi, Mohamed Mustaf Ahmed, Bonaventure Michael Ukoaka, Ojoisimi Franca Jamgbadi, Deborah Oluwaseun Shomuyiwa, Don Lucero-Prisno Eliseo, Blessing Olawunmi Amisu, Olakulehin Adebusuyi, William K. Chung, Emery Manirambona, Nimat Bola Idris, Janet Alexis A. De los Santos

“…Clinical trials have shown significant therapeutic potential. Various doses of tecovirimat were used in rabbit and mpox models. …”
Get full text

Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma by Qing Zhang, Kang Tian, Jinjing Xu, Haixu Zhang, Liantao Li, Qiang Fu, Dafei Chai, Huizhong Li, Junnian Zheng

“…The chimeric antigen receptor-modified immune effector cell (CAR-T and CAR-NK) therapies are newly developed adoptive treatments of cancers. However, their therapeutic efficacy against solid tumors is limited. …”
Get full text

Compatibility of Whole Wheat-Based Composite Flour in the Development of Functional Foods by Amani Weerarathna, Matara Arahchige Jagath Wansapala

“…Furthermore, the suitability of composite flours in food products in terms of nutritive and therapeutic value is emphasised. It was found that food products with higher nutritional and therapeutic value and acceptable sensory properties can be formulated by blending different non-wheat flour sources with wheat flour at different ratios. …”
Get full text

Engineered a dual-targeting biomimetic nanomedicine for pancreatic cancer chemoimmunotherapy by Meng Wang, Qida Hu, Junmin Huang, Xinyu Zhao, Shiyi Shao, Fu Zhang, Zhuo Yao, Yuan Ping, Tingbo Liang

“…Abstract The therapeutic effect of chemotherapeutics such as gemcitabine against pancreatic cancer is considerably attenuated by immune-suppressive tumor microenvironment. …”
Get full text

Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes by Virendra Kumar Yadav, Rachna Gupta, Abdullah A. Assiri, Jalal Uddin, Azfar A. Ishaqui, Pankaj Kumar, Khalid M. Orayj, Shazia Tahira, Ashish Patel, Nisha Choudhary

“…The current approach has several limitations, like delayed diagnosis, limited therapeutic delivery, and risks of secondary injuries. …”
Get full text

Biodegradable and Stimuli-Responsive Nanomaterials for Targeted Drug Delivery in Autoimmune Diseases by Nargish Parvin, Sang Woo Joo, Tapas K. Mandal

“…Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation to avoid adverse side effects. …”
Get full text

The Role of Thoracic Medial Branch Blocks in Managing Chronic Mid and Upper Back Pain: A Randomized, Double-Blind, Active-Control Trial with a 2-Year Followup by Laxmaiah Manchikanti, Vijay Singh, Frank J. E. Falco, Kimberly A. Cash, Vidyasagar Pampati, Bert Fellows

“…To determine the clinical effectiveness of therapeutic thoracic facet joint nerve blocks with or without steroids in managing chronic mid back and upper back pain. …”
Get full text

Adeno-associated virus mediated artificial circular RNA for triggering cancer immunotherapy to treat prostate cancer by Chujin Ye, Chujin Ye, Zhiye Liu, Zhiye Liu, Qifan Xie, Qifan Xie, Yanlin Tang, Yanlin Tang, Jiayi Zeng, Jiayi Zeng, Ziwei Feng, Ziwei Feng, Jiumin Liu, Jiumin Liu, Haibiao Xie, Haibiao Xie

“…IntroductionSpecifically regulating endogenous molecules is a potential molecular therapeutic strategy. Naturally occurring circular RNAs (circRNAs) are structurally stable and have been proved to serve as highly efficient miR-sponges and protein-sponges in cancer cells.MethodsWe chemically synthesized circRNA (ScircRNA) in vitro to achieve therapeutic dysfunction by targeting specific miRNAs. …”
Get full text

DPSCs Protect Architectural Integrity and Alleviate Intervertebral Disc Degeneration by Regulating Nucleus Pulposus Immune Status by Xiwen Dong, Fanqi Hu, Jing Yi, Yuning Zhang, Chao Liu, Panpan Geng, Han Duan, Chu-Tse Wu, Xuesong Zhang, Hua Wang

“…Intervertebral disc (IVD) degeneration is the primary cause for low back pain that has a high prevalence in modern society and poses enormous economic burden on patients. Few effective therapeutic strategies are available for IVD degeneration treatment. …”
Get full text

Dopamine‐conjugated extracellular vesicles induce autophagy in Parkinson's disease by Jae Hoon Sul, Sol Shin, Hark Kyun Kim, Jihoon Han, Junsik Kim, Soyoung Son, Jungmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jeongmi Lee, Jinsu Park, Donghoon Ahn, Sunyoung Park, Leon F. Palomera, Jeein Lim, Jongho Kim, Chanhee Kim, Seungsu Han, Ka Young Chung, Sangho Lee, Tae‐in Kam, Yunjong Lee, Jeongyun Kim, Jae Hyung Park, Dong‐Gyu Jo

“…These findings collectively indicate that surface modification of EVs with dopamine presents a potent strategy for targeting dopaminergic neurons in the brain. The remarkable therapeutic potential of Dopa‐EVs, demonstrated in PD models, positions them as a highly promising candidate for PD treatment, offering a significant advance over current therapeutic modalities.…”
Get full text

Shielding the Gut: Ghrelin and Ferrostatin-1’s Protective Role Against Sepsis-Induced Intestinal Ferroptosis by Qiliang Hou, Zhimin Dou, Lei Zhu, Bin Li

“…<b>Objective:</b> This study investigates the therapeutic efficacy of ghrelin in alleviating sepsis-induced intestinal damage, focusing on its potential to inhibit ferroptosis and protect intestinal barrier integrity. …”
Get full text

Immunotherapy against glioblastoma using backpack‐activated neutrophils by Tatsuya Fukuta, Ninad Kumbhojkar, Supriya Prakash, Suyog Shaha, A. Da Silva‐Candal, Kyung Soo Park, Samir Mitragotri

“…Hence, therapeutic approaches that stimulate local and systemic immune environments can improve the efficacy of ICIs. …”
Get full text