Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting by Ming Liu, Li Zheng, Yang Zhang, Jinhui Tian

“…The therapeutic effects of PA may vary across different subtypes of TNBC such as TNBC-BL1, TNBC-Metaplastic, and TNBC-BL2. …”
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Amelioration of liver fibrosis with autologous macrophages induced by IL-34-based condition by Yuichi Igarashi, Haruka Wada, Masato Muto, Ryohei Sone, Yoshinori Hasegawa, Ken-ichiro Seino

“…Using these models, we evaluated the therapeutic capacity of macrophages induced by interleukin 34-based conditions. …”
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Repeated exposure to low doses of light induces retinal damage in vivo in a wavelength-dependent manner by Anaïs Françon, Laurent Jonet, Francine Behar-Cohen, Alicia Torriglia

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An Evaluation of Procedural Training in Canadian Respirology Fellowship Programs: Program Directors’ and Fellows’ Perspectives by David Ryan Stather, Julie Jarand, Gerard A Silvestri, Alain Tremblay

“…BACKGROUND: In recent years, there has been a rapid growth in diagnostic and therapeutic procedures performed by respirologists.…”
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Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression by Yicheng Zhu, Jiaoshun Chen, Chen Chen, Rong Tang, Jin Xu, Si Shi, Xianjun Yu

“…Highlight Distinct mechanical cues in the tumor microenvironment drive tumor behaviors and highlight potential therapeutic targets.…”
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Diagnosis and Treatment of Urinary Tract Complication in Crohn’s Disease: An Experience over 15 Years by Haim Ben-Ami, Yeoshua Ginesin, Doron M Behar, Doron Fisher, Yeouda Edoute, Alexandra Lavy

“…BACKGROUD: Urinary tract complications in Crohn’s disease are common but treatable, and often present diagnostic and therapeutic dilemmas.…”
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Primary spindle cell sarcoma of the hard palate: A rare case report and literature review by Shirley Silva, Daniel Droguett, Dahiana Pulgar, Paola Muñoz

“…Sarcomas, constituting 1% of cancers, pose diagnostic and therapeutic challenges, particularly when rare, such as in the hard palate. …”
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Medical treatment of vitiligo: A narrative review by Anuradha Bishnoi, K.B. Meghana, Davinder Parsad

“…This abstract reviews the latest therapeutic approaches, including the use of Janus kinase inhibitors such as ruxolitinib. …”
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Transcriptome profiling of aged-mice ovaries administered with individual ingredients of Samul-tang by Hyejin Shin, Jihyun Kim, Musun Park, Heeseon Jo, Myunggyo Lee, Seongwon Cha, Haeseung Lee, Sooseong You

“…This dataset provides a resource for investigating the action mechanisms of SM and assist in identifying effective combinations of ingredients that can reproduce the therapeutic effects of SM.…”
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Current state and prospects of using dendritic cell vaccination for cancer immunotherapy by I.Yu. Filin, K.V. Kitaeva, A.A. Rizvanov, V.V. Solovyeva

“…Due to their low toxicity and simple production process, personalized therapeutic vaccines based on dendritic cells are of particular clinical interest. …”
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Chemistry and pharmacological diversity of quinoxaline motifs as anticancer agents by Ajani Olayinka O., Nlebemuo Martins T., Adekoya Joseph A., Ogunniran Kehinde O., Siyanbola Tolutope O., Ajanaku Christiana O.

“…Hence, this review highlights the current versatile routes to accessing functionalized quinoxaline motifs and harnessing their documented therapeutic potentials for anticancer drug development.…”
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Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient by Samuel Chan, Michael T. Burke, David W. Johnson, Ross S. Francis, David W. Mudge

“…The immunosuppressant tacrolimus has a narrow therapeutic window, necessitating therapeutic drug monitoring to maintain efficacy and minimise toxicity. …”
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Physician Global Assessments or Blood tests do not Predict Mucosal Disease Activity in Ulcerative Colitis by Mayur Brahmania, Charles N Bernstein

“…BACKGROUND: Mucosal healing has been proposed as the therapeutic end point in the treatment of patients with ulcerative colitis (UC).…”
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Nasobiliary Drainage by Paul Kortan

“…Placement of nasobiliary tubes has now become a widely accepted method for therapeutic drainage and instillation of solvents into the biliary tree. …”
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Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy by Sadaf Alam, Leena Anjum, Muhammad Haneef

“…Conclusions: NSAIDs are promising therapeutic alternatives in cancer treatment, offering significant chemopreventive and therapeutic benefits. …”
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Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin by Jun Iida, Kazuki Kotani, Kozue Murata, Keisuke Hakamada, Wusiman Maihemuti, Yoshinobu Mandai, Yosuke Hiraoka, Kenji Minatoya, Hidetoshi Masumoto

“…Abstract This study explored the impact of hydrolyzed gelatin (HG) concentration on the retention and therapeutic efficacy of human iPS cell-derived cardiomyocytes (hiPSC-CMs) when injected into the myocardium. …”
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Early Recognition of Foreign Body Aspiration as the Cause of Cardiac Arrest by Muhammad Kashif, Hafiz Rizwan Talib Hashmi, Misbahuddin Khaja

“…This case highlights the importance of early identification of FBA causing cardiac arrest, and we report a positive neurological outcome for postresuscitation therapeutic hypothermia following cardiac arrest due to asphyxia.…”
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Guanidine‐Derived Polymeric Nanoinhibitors Target the Lysosomal V‐ATPase and Activate AMPK Pathway to Ameliorate Liver Lipid Accumulation by Yunfei Zhao, Ke Hu, Fangliang Wang, Lulu Zhao, Yu Su, Jun Chen, Gang Zou, Liming Yang, Li Wei, Mengjiao Deng, Yunyu He, Ping Wang, Xiong Z Ruan, Yaxi Chen, Chao Yu

“…Abstract Current research efforts in polymer and nanotechnology applications are primarily focused on cargo delivery to enhance the therapeutic index, with limited attention being paid to self‐molecularly targeted nanoparticles, which may also exhibit significant therapeutic potential. …”
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Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives by Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary, Deepak Nathiya, Vishal Thakur, Rachna Gupta, Sheersha Pramanik, Pankaj Kumar, Nishant Gupta, Ashish Patel

“…It further discusses the application of gene therapy in conjunction with nanomedicine for targeted therapeutic interventions.…”
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Mechanistic insights into 5-aminolevulinic acid photodynamic therapy for acne vulgaris: targeting lipogenesis via the OLR1-Wnt/β-catenin pathway by Jia Yan, Linglin Zhang, Qingyu Zeng, Yitao Qian, Ke Li, Xiaojing Liu, Yun Wu, Yu Yan, Haiyan Zhang, Szeman Cheung, Jia Liu, Ronald Sroka, Xiuli Wang, Lei Shi

“…Abstract Acne vulgaris, a prevalent chronic inflammatory skin disorder, is often characterized by hyperactive sebaceous glands and excessive sebum production, presenting a significant therapeutic challenge. While 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is clinically effective in treating moderate to severe acne, the molecular mechanisms underlying its therapeutic effects remain largely unexplored. …”
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