Health Canada's use of its priority review process for new drugs: a cohort study by Joel Lexchin

“…Therefore, when Health Canada uses priority reviews, it is important that it accurately identifies products that represent a significant therapeutic advance. The purpose of this study is to compare Health Canada's use of priority reviews to therapeutic ratings from two independent organisations, the Patented Medicine Prices Review Board (PMPRB) and the French drug bulletin Prescrire International, over the period 1 January 1997–31 December 2012.Design Cohort study.Data sources Annual reports of the Therapeutic Products Directorate, and the Biologics and Genetic Therapies Directorate; evaluations of therapeutic innovation from PMPRB and Prescrire International; WHO Collaborating Centre for Drug Statistics Methodology.Interventions Assessments by PMPRB and Prescrire International treated as a gold standard for postmarket therapeutic value.Primary and secondary outcome measures Drug-by-drug comparison between the review status from Health Canada and the therapeutic status from PMPRB/Prescrire using κ values, and positive and negative predictive values. …”
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PPARs in Human Neuroepithelial Tumors: PPAR Ligands as Anticancer Therapies for the Most Common Human Neuroepithelial Tumors by Elisabetta Benedetti, Renato Galzio, Barbara D'Angelo, Maria Paola Cerù, Annamaria Cimini

“…The majority of malignant neuroepithelial tumors have poor prognosis and do not respond to conventional therapeutic protocols, therefore, new therapeutic approaches are needed. …”
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Induced Hypothermia Does Not Harm Hemodynamics after Polytrauma: A Porcine Model by Matthias Weuster, Philipp Mommsen, Roman Pfeifer, Juliane Mohr, Steffen Ruchholtz, Sascha Flohé, Matthias Fröhlich, Claudia Keibl, Andreas Seekamp, Martijn van Griensven, Ingo Witte

“…Future studies should extend therapeutic hypothermia.…”
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Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes by Rebecca Craig-Schapiro, Ge Li, Kevin Chen, Jesus M. Gomez-Salinero, Ryan Nachman, Aleksandra Kopacz, Ryan Schreiner, Xiaojuan Chen, Qiao Zhou, Shahin Rafii, David Redmond

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CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody by Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh, Yao-Ming Huang

“…This engineering approach does not require a priori knowledge of structural and functional mapping of antibody–antigen interaction and thus is generally applicable for therapeutic antibody development when desired ortholog binding is lacking. …”
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Stretchable and body conformable electronics for emerging wearable therapies by Benzhao Huang, Qian Wang, Wei Li, Desheng Kong

“…The therapeutic mechanisms adopted by these devices are then systematically explored. …”
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Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology by Jeffrey K. Actor

“…There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a “firebreak” to slow transmission. …”
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SQUARE-IT: a proposed approach to square the identified research problem in the literature with the objectives, the appropriate clinical research question, and the research hypothe... by Martin Alfuth, Jonas Klemp, Annette Schmidt, Lukas Streese, Nikolai Ramadanov, Robert Prill

“…Using SQUARE-IT as a framework, further elaboration of the approach and addition of other aspects are warranted to advance the discussion and improve methods of evidence-based practice in medical and therapeutic specialties for quality improvement of patient care.…”
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Initial-Stage Primary Intraosseous Squamous Cell Carcinoma Derived from Odontogenic Keratocyst with Unusual Keratoameloblastomatous Change of the Maxilla: A Case Report and Literat... by Kentaro Kikuchi, Fumio Ide, Shota Takizawa, Seiji Suzuki, Hideaki Sakashita, Tie-Jun Li, Kaoru Kusama

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The Effect of Knowledge, Education, Income, and Marriage Age on Iron Deficiency Anemia in Pregnant Women in Taiz City-Yemen by Lamia A. S. Ali, Hermanto Tri Joewono, Widati Fatmaningrum, Riyadh A. S. Thabit, Hebah H. M. Almothana, Fardous G. Alsoufi, Aya Ali Abdullah, Tasnim Mohammed Al-Qadhi, Suha Ali Al Hajj, Samar A. A. Ahmed, Sarah A. D. Alselwi, Habib Thabet, Haitham T. S. Mohammed, Linda Andriani

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CD4 T cell contact drives macrophage cell cycle G0-G1 transition by Petra Mlcochova, Na Zhao, Omar Shabana, Roman Fischer, Ravindra K. Gupta

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Correction: CD4 T cell contact drives macrophage cell cycle G0-G1 transition by Petra Mlcochova, Na Zhao, Omar Shabana, Roman Fischer, Ravindra K. Gupta

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A review on current and future advancements for commercialized microalgae species by Jia Fei Wong, Hui Jing Hong, Su Chern Foo, Michelle Khai Khun Yap, Ji Wei Tan

“…Although studies have proved the therapeutic potentials of high-value bioproducts in microalgae, however, there is still room to understand their potential therapeutic properties on humans’ health, discovering novel microalgae-derived bioactive compounds, as well as translating the lab-based evidence to clinical trial studies. …”
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Daratumumab for autoimmune diseases: a systematic review by Martin Krusche, Ina Kötter, Lennard Ostendorf, Nikolas Ruffer, Marie-Therese Holzer, Tobias B. Huber

“…Therefore, systematic clinical trials of this therapeutic approach are needed.…”
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Extensive Characterization of Mesenchymal Stem Cell Marker Expression on Freshly Isolated and In Vitro Expanded Human Adipose-Derived Stem Cells from Breast Cancer Patients by Premrutai Thitilertdecha, Visnu Lohsiriwat, Poonsin Poungpairoj, Varangkana Tantithavorn, Nattawat Onlamoon

“…Variation in numbers and functions of cells in fat tissues may affect therapeutic outcomes and adverse events after autologous fat tissue grafting in postmastectomy breast cancer patients; however, the relevant information regarding cellular components is still incomplete. …”
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Impairment of Neuroplasticity in the Dorsolateral Prefrontal Cortex by Alcohol by Genane Loheswaran, Mera S. Barr, Reza Zomorrodi, Tarek K. Rajji, Daniel M. Blumberger, Bernard Le Foll, Zafiris J. Daskalakis

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MR imaging findings of neurosarcoidosis by Alejandro M. Bolon-Ojeda, Vania P. Balcazar-Vidal, Jhonatan Gomez-Dominguez

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Cancer vaccines: platforms and current progress by Wanting Lei, Kexun Zhou, Ye Lei, Qiu Li, Hong Zhu

“…Abstract Cancer vaccines, crucial in the immunotherapeutic landscape, are bifurcated into preventive and therapeutic types, both integral to combating oncogenesis. …”
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Exploring the Protective Effects of Xueshuantong Injection on Central Retinal Vein Occlusion by Qiang Chen, Jing Zhang, Xin-Yu Liu, Kai Xu, Hui-Yi Guo, Ya-Min Li, Yu-Qing Guo, Li-Na Liang

“…Color fundus photography, fundus fluorescein angiography, histological examination, TUNEL assay, and immunofluorescence staining were conducted to evaluate the therapeutic effects. Results: The study revealed that both XST and lyophilized XST injections exhibited therapeutic effects against CRVO in rabbits and rats. …”
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Brief communication: gaps and opportunities in HIV research in Venezuela by Jesús A. Morgado, María G. Medina, Rafael N. Guevara, Martín Carballo, Jaime R. Torres, Fhabián S. Carrión-Nessi, David A. Forero-Peña

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