RNA sequence analysis landscape: A comprehensive review of task types, databases, datasets, word embedding methods, and language models by Muhammad Nabeel Asim, Muhammad Ali Ibrahim, Tayyaba Asif, Andreas Dengel

“…To gain insights of biological functions and to detect diseases at early stages and develop potent therapeutics, researchers are performing diverse types RNA sequence analysis tasks. …”
Get full text

Surgical delay-associated mortality risk varies by subtype in loco-regional breast cancer patients in SEER-Medicare by Macall Leslie Salewon, Rashmi Pathak, William C. Dooley, Ronald A. Squires, Hallgeir Rui, Inna Chervoneva, Takemi Tanaka

Get full text

Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis by Rongjiong Zheng, Songsong Xie, Qiong Zhang, Ling Cao, Shaniya Niyazi, Xiaobo Lu, Lihua Sun, Yan Zhou, Yuexin Zhang, Kai Wang

“…These results indicate that peripheral T lymphocyte immunity was involved in patients with brucellosis and represents a target for the preclinical and clinical assessment of novel immunomodulating therapeutics. The patients’ immune function had not completely recovered in a short period of time during convalescence, so long-term follow-up of convalescent patients is needed.…”
Get full text

Ethnotherapeutic Uses and Phytochemical Composition of Physalis peruviana L.: An Overview by Félicien Mushagalusa Kasali, Jonans Tusiimire, Justin Ntokamunda Kadima, Casim Umba Tolo, Anke Weisheit, Amon Ganafa Agaba

Get full text

Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals by Yohji Matsusaka, Rudolf A. Werner, Paula Arias-Loza, Naoko Nose, Takanori Sasaki, Xinyu Chen, Constantin Lapa, Takahiro Higuchi

“…Along with its unique features of SPECT molecular functional imaging is a superior collimator technology that is applicable to medium-sized animal models and thus may promote translational research for diagnostic purposes and development of novel therapeutics.…”
Get full text

NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats by Kevin M. Kim, Amandeep Girdhar, Maria E. Cicardi, Vaishnavi Kankate, Miyuki Hayashi, Ruoyu Yang, Jenny L. Carey, Charlotte M. Fare, James Shorter, Gino Cingolani, Davide Trotti, Lin Guo

“…Thus, NLS-binding deficient Kapβ2 may be implemented as a potential therapeutic for C9-ALS/FTD.…”
Get full text

Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening by Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell

“…Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies, additional anti-viral therapeutics with pan-coronavirus activity are of high interest. …”
Get full text

Distal protein-protein interactions contribute to nirmatrelvir resistance by Eric M. Lewandowski, Xiujun Zhang, Haozhou Tan, Aiden Jaskolka-Brown, Navita Kohaal, Aliaksandra Frazier, Jesper J. Madsen, Lian M. C. Jacobs, Jun Wang, Yu Chen

“…Mpro is a key target of anti-COVID-19 therapeutics such as nirmatrelvir (the active component of Paxlovid). …”
Get full text

Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

Get full text

Effect of Food on the Steady-State Pharmacokinetics of Tenofovir and Emtricitabine plus Efavirenz in Ugandan Adults by Mohammed Lamorde, Pauline Byakika-Kibwika, William S. Tamale, Francis Kiweewa, Mairin Ryan, Alieu Amara, John Tjia, David Back, Saye Khoo, Marta Boffito, Cissy Kityo, Concepta Merry

Get full text

LncRNA PVT1 links estrogen receptor alpha and the polycomb repressive complex 2 in suppression of pro-apoptotic genes in hormone-responsive breast cancer by Viola Melone, Domenico Palumbo, Luigi Palo, Noemi Brusco, Annamaria Salvati, Antonietta Tarallo, Giorgio Giurato, Francesca Rizzo, Giovanni Nassa, Alessandro Weisz, Roberta Tarallo

“…Abstract RNA-based therapeutics highlighted novel approaches to target either coding or noncoding molecules for multiple diseases treatment. …”
Get full text

Phenolic compounds from Chaenomeles speciosa alleviate inflammation in lipopolysaccharide-treated RAW264.7 macrophages via the NF-κB and MAPK pathways by Fuxia Hu, Chao Liu, Fengqin Wang, Changxin Zhou, Maotong Zhu, Dongxiao Sun-Waterhouse, Zhaosheng Wang

“…Therefore, the phenolic extract from C. speciosa is a desirable anti-inflammatory agent for inflammatory conditions to meet the rising demand for natural and cost-effective therapeutics.…”
Get full text

Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

“…While diagnostic and therapeutic approaches are still under debate, RNA sequencing (RNAseq) has emerged as a promising tool to provide deeper insights into the pathophysiology of COVID-19 and guide personalized treatment. …”
Get full text

Protocol for a mixed-methods randomised controlled trial evaluating the psychosocial effects of an expressive arts-based intervention on adults with age-related macular degeneratio... by Qing Li, Temmy Lee Ting Lo, Rainbow Tin Hung Ho, Adrian Ho Yin Wan, Ted Chun Tat Fong, Caitlin Kar Pui Chan, Allen Ming Yan Cheong, Wai Chi Chan

Get full text

Crystallite size and phase purity in Pb1-xSrxTiO3 ferroelectric perovskites for biomedical applications via controlled sintering by Rahmat Doni Widodo, Samsudin Anis, Deni Fajar Fitriyana, Maykel Manawan, Joni Sah, Aji Santiko, Rizalman Bin Mamat, Abdulfatah Abdu Yusuf, Muhammad Imam Ammarullah

“…Controlled sintering in perovskite materials opens new pathways for their application in medical diagnostics and therapeutic technologies.…”
Get full text

Molecular Identification and Antimicrobial Potential of Streptomyces Species from Nepalese Soil by Karan Khadayat, Dawa Dindu Sherpa, Krishna Prakash Malla, Sunil Shrestha, Nabin Rana, Bishnu P. Marasini, Santosh Khanal, Binod Rayamajhee, Bibek Raj Bhattarai, Niranjan Parajuli

“…However, the production of new therapeutics is delayed in recent days. Thus, the isolation of new Streptomyces species has drawn attention. …”
Get full text

Discrete vulnerability to pharmacological CDK2 inhibition is governed by heterogeneity of the cancer cell cycle by Vishnu Kumarasamy, Jianxin Wang, Michelle Roti, Yin Wan, Adam P. Dommer, Hanna Rosenheck, Sivasankar Putta, Alec Trub, John Bisi, Jay Strum, Patrick Roberts, Seth M. Rubin, Costakis Frangou, Karen McLean, Agnieszka K. Witkiewicz, Erik S. Knudsen

“…Overall, this study underscores two fundamentally distinct features of response to CDK2 inhibitors that are conditioned by tumor context and could serve as the basis for differential therapeutic strategies in a wide range of cancers.…”
Get full text

Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors by Alessandro Papale, Ilaria Maria Morella, Marzia Tina Indrigo, Rick Eugene Bernardi, Livia Marrone, Francesca Marchisella, Andrea Brancale, Rainer Spanagel, Riccardo Brambilla, Stefania Fasano

“…Furthermore, a screening of small therapeutics currently in clinical trials for cancer therapy revealed PD325901 as a brain-penetrating drug that blocks ERK signalling in the nanomolar range. …”
Get full text

Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential by Rushikesh Girase, Nayan A. Gujarathi, Amey Sukhia, Sri Sai Nikitha Kota, Tulshidas S. Patil, Abhijeet A. Aher, Yogeeta O. Agrawal, Shreesh Ojha, Charu Sharma, Sameer N. Goyal

“…However, they frequently undergo rapid clearance, reducing circulation time and therapeutic efficacy. Additionally, their stability in the bloodstream is often compromised, resulting in premature drug release. …”
Get full text

Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects approximately 0.46% of the global population. Conventional therapeutics for RA, including disease‐modifying antirheumatic drugs (DMARDs), nonsteroidal anti‐inflammatory drugs (NSAIDs), and corticosteroids, frequently result in unintended adverse effects. …”
Get full text