Curative Effect of AD-MSCs against Cisplatin-Induced Hepatotoxicity in Rats is Potentiated by Azilsartan: Targeting Oxidative Stress, MAPK, and Apoptosis Signaling Pathways by Amany Abdlrehim Bekhit, Olivia N. Beshay, Michael A. Fawzy, Sara Mohamed Naguib Abdel-Hafez, Gaber El-Saber Batiha, Farid S. Ataya, Moustafa Fathy

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Fecal microbiota transplantation to prevent acute graft-versus-host disease: pre-planned interim analysis of donor effect by Swetha Reddi, Liliia Senyshyn, Maryam Ebadi, Daniel Podlesny, Samuel S. Minot, Ted Gooley, Amanda J. Kabage, Geoffrey R. Hill, Stephanie J. Lee, Alexander Khoruts, Armin Rashidi

“…FMT is a holistic microbiota restoration approach that can be performed as a precision therapeutic. ClinicalTrials.gov identifier NCT06026371…”
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Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools by Diana Spiegelberg, Le-Ann Hwang, Khian Hong Pua, Sashwini Chandra Kumar, Xin Yu Koh, Xiao Hui Koh, Ram Kumar Selvaraju, Kanaga Sabapathy, Marika Nestor, David Lane

“…We conclude that molecular imaging with an anti-p53R175H tracer could be a promising approach for cancer diagnostics and could be further applied for patient stratification and treatment response monitoring of mutant p53-targeted therapeutics.…”
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Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents by Jie Dai, Qianyue Li, Ziyi Li, Zhonglin Zang, Yan Luo, Chenghe Zhou

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A Validated Reverse Phase HPLC Analytical Method for Quantitation of Glycoalkaloids in Solanum lycocarpum and Its Extracts by Renata Fabiane Jorge Tiossi, Mariza Abreu Miranda, João Paulo Barreto de Sousa, Fabíola Silva Garcia Praça, Maria Vitória Lopes Badra Bentley, James Dewey McChesney, Jairo Kenupp Bastos

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Enhancement of in vitro transcellular absorption and in vivo oral bioavailability of apigenin by self-nanoemulsifying drug delivery systems by Vilasinee Hirunpanich Sato, Hitoshi Sato, Manaw Sangfuang, Jannarin Nontakham, Varaporn Buraphacheep Junyaprasert, Veerawat Teeranachaideekul, Boontida Morakul

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Design and synthesis of antiproliferative 2-oxoindolin-3-ylidenes incorporating urea function with potential VEGFR-2 inhibitory properties by Dalia R. Aboshouk, M. Adel Youssef, Siva S. Panda, Benson M. Kariuki, Mohamed S. Bekheit, Ahmed R. Hamed, Walid Fayad, Ahmed A. F. Soliman, Adel S. Girgis

“…Abstract Targeted therapy is preferable over other therapeutics due to its limitation of drawbacks and better pharmaceutical outcomes. …”
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A functional approach to analyze the genetic basis for differences in virulence of monkeypox virus clades by Patricia L. Earl, Jeffrey L. Americo, Sara Reynolds, Wei Xiao, Catherine Cotter, Bernard Moss

“…Determination of the genetic basis for these differences could help to develop improved therapeutics and vaccines. The Castaneous (CAST) mouse is highly susceptible to MPXV and virulence differences of MPXV clades are statistically significant mimicking their relative severities in humans. …”
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Vaginal Microbiota Diversity of Patients with Embryonic Miscarriage by Using 16S rDNA High-Throughput Sequencing by Linfen Xu, Lingna Huang, Chengying Lian, Huili Xue, Yanfang Lu, Xiujuan Chen, Yong Xia

“…Overall, our analyses provided potential biomarkers for embryonic miscarriage and elucidated the causative relationship between microbiota and immune responses and may enable the possible diagnosis and therapeutics of early pregnancy loss.…”
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Porous polytrimethylenecarbonate scaffolds: Design considerations and porosity modulation techniques by Klaudia Małgorzata Jurczak, Ruichen Zhang, Wouter L.J. Hinrichs, Dirk W. Grijpma, Richte C.L. Schuurmann, Jean-Paul P.M. de Vries, Patrick van Rijn

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Evaluating the reliability of a microperimetry-based method for assessing visual function in the junctional zone of geographic atrophy lesions by A. Yasin Alibhai, Eric M. Moult, Muhammad Usman Jamil, Khadija Raza, Marco U. Morales, Ramiro Ribeiro, Caroline R. Baumal, James G. Fujimoto, Nadia K. Waheed

“…The approach’s repeatability and compatibility with standard microperimetry grids may make it useful for assessing the effects of GA therapeutics.…”
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Digital health technologies and innovation patterns in diabetes ecosystems by Odile-Florence Giger, Estelle Pfitzer, Wasu Mekniran, Hannes Gebhardt, Elgar Fleisch, Mia Jovanova, Tobias Kowatsch

“…Results Our analyses revealed the emergence of eight organization segments in digital diabetes ecosystems: real-world evidence analytics, healthcare management platforms, clinical decision support, diagnostic and monitoring, digital therapeutics, wellness, online community, and online pharmacy (RQ1). …”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

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Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…The approach should be widely applicable for developing popular LAGA mutant-based biological therapeutics.…”
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The Process of Acclimation to Chronic Hypoxia Leads to Submandibular Gland and Periodontal Alterations: An Insight on the Role of Inflammatory Mediators by Antonela Romina Terrizzi, María Inés Conti, María Pilar Martínez, Javier Fernández-Solari

“…This study may eventually contribute to finding therapeutics to treat the decreased salivary flow, improving in that way oral health.…”
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Approaches and applications in transdermal and transpulmonary gene drug delivery by Anni Zhang, Xuran Zhang, Jiahui Chen, Xianbao Shi, Xijuan Yu, Zhonggui He, Zhonggui He, Jin Sun, Jin Sun, Mengchi Sun, Mengchi Sun, Zhijun Liu

“…Considering the rapid development of gene therapeutics via transdermal and transpulmonary administration, here we aim to summarize the nearest advances in transdermal and transpulmonary gene drug delivery. …”
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Awareness and Perception of Healthcare Providers about Proxy Consent in Critical Care Research by Rania Mahafzah, Karem H. Alzoubi, Omar F. Khabour, Rana Abu-Farha

“…Respondents also agreed that the informed consent process should explain research protocols and procedures (76.6%), therapeutic alternatives (84.1%), potential benefits (41.4%), and potential risks (44.1%) and that participation in the research is voluntary (66.9%). …”
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A novel approach for target deconvolution from phenotype-based screening using knowledge graph by Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun

“…Our findings have the potential to revolutionize drug screening and open new avenues in pharmacological research, increasing the speed and efficiency of pursuing novel therapeutics. The code is available at  https://github.com/Xiong-Jing/PPIKG .…”
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Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling by Ginetta Collo, Laura Cavalleri, Federica Bono, Cristina Mora, Stefania Fedele, Roberto William Invernizzi, Massimo Gennarelli, Giovanna Piovani, Tilo Kunath, Mark J. Millan, Emilio Merlo Pich, PierFranco Spano

“…The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD). …”
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