Giese-type alkylation of dehydroalanine derivatives via silane-mediated alkyl bromide activation by Perry van der Heide, Michele Retini, Fabiola Fanini, Giovanni Piersanti, Francesco Secci, Daniele Mazzarella, Timothy Noël, Alberto Luridiana

“…The rising popularity of bioconjugate therapeutics has led to growing interest in late-stage functionalization (LSF) of peptide scaffolds. α,β-Unsaturated amino acids like dehydroalanine (Dha) derivatives have emerged as particularly useful structures, as the electron-deficient olefin moiety can engage in late-stage functionalization reactions, like a Giese-type reaction. …”
Get full text

Efficacy and safety of CAR-T cell therapy in B-ALL patients previously treated with blinatumomab by Yurou Chu, Biqi Zhou, Rui Gao, Miao Miao, Huiying Qiu, Xiaowen Tang, Ying Wang, Suning Chen, Liqing Kang, Depei Wu, Yang Xu

Get full text

The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells by Po-An Tai MD, PhD, Yen-Lin Liu MD, PhD, Ya-Ting Wen MD, Chien-Min Lin MD, PhD, Thanh-Tuan Huynh MD, PhD, Michael Hsiao DVM, PhD, Alexander T. H. Wu PhD, Li Wei MD, PhD

“…The presence of glioma stem cells (GSCs) can repopulate the tumor posttreatment and resist therapeutics. A better understanding of GSC biology is essential for developing more effective interventions. …”
Get full text

Age-associated alterations in immune and inflammatory responses in captive olive baboons (Papio anubis) by Michele M. Mulholland, Bharti P. Nehete, Ashley DeLise, Angela M. Achorn, Lisa M. Pytka, Pramod N. Nehete, Pramod N. Nehete

“…Though there are phenotypic and functional similarities between baboons and humans, specific differences exist in immune cell expression and immune function of lymphocytes that should be considered for better experimental outcomes in the development of therapeutics and restoring innate and adaptive immune function in aged individuals.…”
Get full text

Alendronate partially rescues the periodontal defects in OIM mouse model of osteogenesis imperfecta by Po-Jung Chen, Ke Wang, Meng-Hsuan Lin, Radhika Sharma, Zana Kalajzic, Mara O’Brien, Sumit Yadav

“…., alendronate) are commonly used therapeutics for the treatment of OI. Our knowledge, in terms of the affects of alendronate treatment on the PDL entheses in OI is also far from complete. …”
Get full text

Generation of thiyl radicals in a spatiotemporal controlled manner by light: Applied for the cis to trans isomerization of unsaturated fatty acids/phospholipids by Biswajit Roy, Ryota Kojima, Obaed Shah, Meg Shieh, Eshani Das, Shahrzad Ezzatpour, Emiko Sato, Yusuke Hirata, Stephen Lindahl, Atsushi Matsuzawa, Hector C. Aguilar, Ming Xian

Get full text

Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations by Sarbani Mishra, Preety Sthutika Swain, Sanghamitra Pati, Budheswar Dehury

“…Our knowledge-based and machine-learning guided docking and physics-based simulations study unveils deep insights into the endogenous ligand recognition by the positive surface ligand binding site and distant core site pave the way for exploration of other small molecules towards development of novel therapeutics against Alzheimer's disease.…”
Get full text

The role of olfactory transport in the penetration of manganese oxide nanoparticles from blood into the brain by A. V. Romashchenko, M. B. Sharapova, К. N. Morozova, E. V. Kiseleva, K. E. Kuper, D. V. Petrovskii

“…The results will add to the understanding of the pathogenesis of various neurodegenerative diseases and help studying the side effects of therapeutics administered intravenously.…”
Get full text

Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain by Chae-Jeong Lee, Seung Hyun Jang, Jiwoo Lim, Hyunju Park, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Soo-Jin Song, Jung-A Shin, Chulhee Choi, Heon Yung Gee, Youn-Hee Choi

“…Exosomes are potent therapeutics or drug delivery vehicles for various materials, including proteins and regulatory genes, to target cells. …”
Get full text

Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum by Mitchell L. Trickey, Mrittika Chowdury, Georgina Bramwell, Natalie A. Counihan, Tania F. de Koning-Ward

“…Conclusions This work provides valuable insight regarding the essentiality of the RhopH1 clag genes to the NPPs functionality and validates the continued investigation of the RhopH complex as a therapeutic target to treat malaria infections.…”
Get full text

Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein by Oscar Herrera-Calderon, Abdulrahman M. Saleh, Andres F. Yepes-Perez, Nada H. Aljarba, Saad Alkahtani, Gaber El-Saber Batiha, Renan Dilton Hañari-Quispe, Haydee Chavez, Josefa Bertha Pari-Olarte, Eddie Loyola-Gonzales, José Santiago Almeida-Galindo, José Francisco Kong-Chirinos, Taoufiq Benali

Get full text

New derivatives of sulfonylhydrazone as potential antitumor agents: Design, synthesis and cheminformatics evaluation by Sabbah Dima A., Al-Azaideh Bara’a A., Talib Wamidh H., Hajjo Rima, Sweidan Kamal, Al-Zuheiri Aya M., Sheikha Ghassan Abu, Shraim Sawsan

Get full text

Measuring Digital Health Literacy in Older Adults: Development and Validation Study by SungMin Kim, Choonghee Park, Sunghyeon Park, Dai-Jin Kim, Ye-Seul Bae, Jae-Heon Kang, Ji-Won Chun

“… BackgroundNew health care services such as smart health care and digital therapeutics have greatly expanded. To effectively use these services, digital health literacy skills, involving the use of digital devices to explore and understand health information, are important. …”
Get full text

Variations and Asymmetry in Sacral Ventral Rami Contributions to the Bladder by Rebeccah R. Overton, Istvan P. Tamas, Emily P. Day, Nagat Frara, Michel A. Pontari, Susan B. Fecho, Steven N. Popoff, Mary F. Barbe

“…<b>Conclusions:</b> This characterization of the anatomical variation in sacral ventral rami contributions to the bladder will ultimately aid in developing therapeutics for patients with bladder dysfunction.…”
Get full text

Regulation of Murine Ovarian Epithelial Carcinoma by Vaccination against the Cytoplasmic Domain of Anti-Müllerian Hormone Receptor II by Cagri Sakalar, Suparna Mazumder, Justin M. Johnson, Cengiz Z. Altuntas, Ritika Jaini, Robert Aguilar, Sathyamangla V. Naga Prasad, Denise C. Connolly, Vincent K. Tuohy

“…AMHR2-CD vaccination significantly inhibited ID8 tumor growth when administered either prophylactically or therapeutically, and protection against EOC growth was passively transferred into naive recipients with AMHR2-CD-primed CD4+ T cells but not with primed B cells. …”
Get full text

Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana by Kwame Yeboah, Jennifer A. Agyekum, Eric Kyei Baafour, Daniel A. Antwi, Afua B. Adjei, Vincent Boima, Ben Gyan

Get full text

Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry by Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen, Chong-Feng Xu

“…Aggregates are recognized as one of the most critical product-related impurities in monoclonal antibody (mAb)-based therapeutics due to their negative impact on the stability and safety of the drugs. …”
Get full text

Meta-analysis examining the association between low platelet monoamine oxidase levels and Zuckerman's sensation seeking scale in a sex dependent manner by Jordan Winfield, Ian A. Mendez, Gabriel A. Frietze

Get full text

Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn by Johannes Reusch, Jan Terje Andersen, Ulrich Rant, Tilman Schlothauer

“…Monoclonal antibodies (mAbs) as therapeutics necessitate favorable pharmacokinetic properties, including extended serum half-life, achieved through pH-dependent binding to the neonatal Fc receptor (FcRn). …”
Get full text

Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs by Jennifer Mumaw, Erin T. Jordan, Corinne Sonnet, Ronke M. Olabisi, Elizabeth A. Olmsted-Davis, Alan R. Davis, John F. Peroni, Jennifer L. West, Franklin West, Yangqing Lu, Steven L. Stice

“…Autologous bone grafting is the most effective treatment for long-bone nonunions, but it poses considerable risks to donors, necessitating the development of alternative therapeutics. Poly(ethylene glycol) (PEG) microencapsulation and BMP2 transgene delivery are being developed together to induce rapid bone formation. …”
Get full text