The colorectal cancer microenvironment: Preclinical progress in identifying targets for cancer therapy by Abdo Meyiah, Faez Iqbal Khan, Dia Aldeen Alfaki, Khaled Murshed, Afsheen Raza, Eyad Elkord

“…Furthermore, targeting stromal and angiogenic factors in the TME may provide new therapeutic options. Overall, understanding and targeting the TME in CRC is a promising approach for improving therapeutic outcomes.…”
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Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction by Lin Li, Guangyu Rong, Xin Gao, Yiyun Cheng, Zhengwang Sun, Xiaopan Cai, Jianru Xiao

“…This co‐assembled fluoropeptide nanoplatform proposed in this study offers a promising approach for targeted and intracellular delivery of peptide therapeutics in the treatment of various diseases.…”
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Targeted SPP1 Inhibition of Tumor‐Associated Myeloid Cells Effectively Decreases Tumor Sizes by Benan Kartal, Christopher S. Garris, Hyung Shik Kim, Rainer H. Kohler, Jasmine Carrothers, Elias A. Halabi, Yoshiko Iwamoto, Anne‐Gaëlle Goubet, Yuxuan Xie, Pratyaksha Wirapati, Mikaël J. Pittet, Ralph Weissleder

“…These findings are important as they offer a promising avenue for developing novel therapeutic strategies targeting TAM.…”
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Comparative study between efficacy of topical tofacitinib 2% ointment versus topical clobetasol propionate 0.05% ointment in hand eczema at a tertiary hospital in central India [ve... by Dr Adarshlata Singh, Drishti Bhatt

“…The findings may contribute to optimized treatment strategies for hand eczema, improving patient outcomes and guiding future research in dermatological therapeutics.…”
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Effects of a flavonoid-enriched orange peel extract against type 2 diabetes in the obese ZDF rat model by Alexander Gosslau, Emmanuel Zachariah, Shiming Li, Chi-Tang Ho

“…Our study emphasize the complexity of anti-diabetic regimen suggesting a treatment with OPE to reduce inflammation in adipose tissue in combination with antidiabetic therapeutics as promising strategy against T2D. Keywords: Type 2 diabetes, Orange peel, Zucker diabetic fatty rats, Chronic inflammation, Obesity…”
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Metabolic Context Regulates Distinct Hypothalamic Transcriptional Responses to Antiaging Interventions by Alexis M. Stranahan, Bronwen Martin, Wayne Chadwick, Sung-Soo Park, Liyun Wang, Kevin G. Becker, William H. WoodIII, Yongqing Zhang, Stuart Maudsley

“…A greater understanding of how genetic background contributes to hypothalamic response mechanisms could pave the way for the development of more nuanced therapeutics for the treatment of metabolic disorders that occur in diverse physiological backgrounds.…”
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Aqueous spice extracts as alternative antimycotics to control highly drug resistant extensive biofilm forming clinical isolates of Candida albicans. by Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Priya Ashrit, Uddagiri Venkanna Babu, Lakavalli Mohan Sharath Kumar, Vasulingam Sampath, Kalidas Shetty, Amruta Purushottam Joglekar, Rashmi Awaknavar

“…The results of this study indicated that the alternate approach in controlling high biofilm-forming, multi-drug resistant clinical isolates of C. albicans M-207 and S-470 using whole aqueous extracts of garlic, clove, and Indian gooseberry is a safe, potential, and cost-effective one that can benefit the health care needs with additional effective therapeutics to treat biofilm infections.…”
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Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient by Nu T. Lu, Jeffrey Raizer, Erwin P. Gabor, Natalie M. Liu, James Q. Vu, Dennis J. Slamon, John L. Barstis

“…We describe the clinical and therapeutic course of a 51-year-old woman with HER-2+ breast cancer who developed leptomeningeal (LM) and spinal cord metastases after 8 years of stable disease on combination therapy with intravenous (IV) trastuzumab. …”
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The Effects of BMP-2, miR-31, miR-106a, and miR-148a on Osteogenic Differentiation of MSCs Derived from Amnion in Comparison with MSCs Derived from the Bone Marrow by Sirikul Manochantr, Kulisara Marupanthorn, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Prakasit Sanguanjit

“…Moreover, the information of miRNA expression and function during osteogenic differentiation may be useful for the development of new therapeutics or enhanced an in vitro culture technique required for stem cell-based therapies in the bone regeneration.…”
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Advances in Microengineered Platforms for Skin Research by Sireesh Kumar Teertam, Vijayasaradhi Setaluri, Jose M. Ayuso

“…Human and animal skin differ significantly, limiting the translational potential of animal-based investigations to advance therapeutics to human skin diseases. Hence, there is a critical need for physiologically relevant human skin models to explore novel treatment strategies. …”
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Bayesian Optimization Of NeuroStimulation (BOONStim) by Lindsay D. Oliver, Jerrold Jeyachandra, Erin W. Dickie, Colin Hawco, Salim Mansour, Stephanie M. Hare, Robert W. Buchanan, Anil K. Malhotra, Daniel M. Blumberger, Zhi-De Deng, Aristotle N. Voineskos

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Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats by El-Shaimaa A. Arafa, Waseem Hassan, Ghulam Murtaza, Manal Ali Buabeid

“…It was concluded that both FC.Cr. and SC.Cr. exhibited remarkable therapeutics potential in HFD-STZ-induced diabetic rats. …”
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Sempervirine inhibits proliferation, invasion and metastasis of ovarian cancer cells and induces ultrastructural changes in vivo by Danni Chen, Yan Tan, Tingting Chen, Qin Wang, Yan Yan, Xiaoya Zhao, Zhongxiao Zhang, Jin Qiu, Jian Zhang

“…Our study suggests that sempervirine is a promising therapeutic agent against ovarian cancer.…”
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Regulation of miRNAs in obesity and diabetes by Eva Maher, Ava O'Meara, Cathy Brougham

“…The identification of dysregulated miRNAs and in particular novel dysregulated miRNAs, may lead to the development of miRNA-based personalised therapeutics for obesity and diabetes.…”
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Hyperexcitability of Cortical Oscillations in Patients with Somatoform Pain Disorder: A Resting-State EEG Study by Qian Ye, Dong Yan, Manlin Yao, Wutao Lou, Weiwei Peng

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Genetic control of N-glycosylation of human blood plasma proteins by S. Zh. Sharapov, A. N. Timoshchuk, Y. S. Aulchenko

“…Observed associations between protein glycosylation levels and human diseases have led to the conclusion that N-glycans can be considered a potential source of biomarkers and therapeutic targets. Although biochemical pathways of glycosylation are well studied, the understanding of the mechanisms underlying general and tissue-specific regulation of these biochemical reactions in vivo is limited. …”
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A versatile cell line for establishing potency of cell type-specific AAV transgenes by Refugio A. Martinez, Yemeserach M. Bishaw, Meagan A. Quinlan, Erin L. Groce, Bryan B. Gore, Ed S. Lein, John K. Mich, Boaz P. Levi

“…Potency assays are essential for adeno-associated virus (AAV) therapy development, allowing simple and quantitative assessments of therapeutic activity, target engagement, vector stability, and activity per batch. …”
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Girolline is a sequence context-selective modulator of eIF5A activity by Tilman Schneider-Poetsch, Yongjun Dang, Wakana Iwasaki, Mayumi Arata, Yuichi Shichino, Ali Al Mourabit, Celine Moriou, Daniel Romo, Jun O. Liu, Takuhiro Ito, Shintaro Iwasaki, Minoru Yoshida

“…Abstract Natural products have a long history of providing probes into protein biosynthesis, with many of these compounds serving as therapeutics. The marine natural product girolline has been described as an inhibitor of protein synthesis. …”
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Fluorescent Particles Based on Aggregation-Induced Emission for Optical Diagnostics of the Central Nervous System by Shan Liu, Jinkuan Liu, Xue Li, Xiaoxin Du, Cheng Yin, Yong Luo, Chenzhong Li

“…We will discuss the evolution and conclude with an outlook on the future challenges and opportunities for AIEgens in clinical diagnostics and therapeutics of CNS disorders.…”
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Commonality of Virulence-Promoting Function in Rhodococcus equi Virulence Associated Proteins (Vaps) by Timothy R. Ganderton, Daniel Ghete, Karen Hogg, Graeme J. Park, Christoph G. Baumann, Anthony J. Wilkinson, Paul R. Pryor

“…These data imply that the molecular mechanism(s) that VapA uses to neutralise lysosomal acidity should also be seen in VapN and K which will help guide researchers in identifying their precise mode of action and aid the future development of targeted therapeutics.…”
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