Possible Potentiation by Certain Antioxidants of the Anti-Inflammatory Effects of Diclofenac in Rats by Samah S. Abbas, Mona F. Schaalan, Ashraf K. Bahgat, Ezzeddin S. El-Denshary

“…In conclusion, the results of these studies suggested to us that the added presence of natural antioxidants could be beneficial as standard anti-inflammatory therapeutics for a patient under diclofenac treatment, albeit that these effects do not appear to significantly build upon those that could be obtained from this common anti-inflammatory agent per se.…”
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Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7) by Pi‐Wan Cheng, Vishwanath‐Reddy Hothpet, Ganapati Bhat, Kristina Bailey, Lei Li, Derrick R. Samuelson

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Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease by Vincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

“…The development of antiviral therapeutics, such as small-molecule inhibitors that target conserved proteins like the enteroviral 3C protease, remains to be achieved. …”
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Human immune system: Exploring diversity across individuals and populations by Kim Han Hoang Nguyen, Nghi Vinh Le, Phuc Hoang Nguyen, Hien Hau Thi Nguyen, Duy Mai Hoang, Chien Dinh Huynh

“…Despite the complexity of the relationship, there remains a gap in understanding the specificity of immune indices across races, immune reference ranges among populations, highlighting the need for deeper understanding of immune diversity for personalized approaches in diagnostics and therapeutics. This review systematically organizes these findings, with the goal of emphasizing the potential of targeted interventions to address health disparities and advance translational research, enabling a more comprehensive strategy. …”
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Stemness-Attenuating miR-503-3p as a Paracrine Factor to Regulate Growth of Cancer Stem Cells by Minkoo Seo, Seung Min Kim, Eun Young Woo, Ki-Cheol Han, Eun Joo Park, Seongyeol Ko, Eun wook Choi, Mihue Jang

“…However, there are no promising therapeutics directed against CSCs. Herein, we found that miR-503-3p inhibited tumor growth via the regulation of CSC proliferation and self-renewal. miR-503-3p, isolated from human adipose stem cell- (ASC-) derived exosomes, suppressed initiation and progression of CSCs as determined by anchorage-dependent (colony formation) and anchorage-independent (tumorsphere formation) assays. …”
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Drug repurposing screen for the rare disease ataxia-telangiectasia by Namrata Jayanth, Gurvan Mahé, Matthew Campbell, Mike Lipkin, Shushant Jain, Rhea van de Bospoort, Jennifer Thornton, Brad Margus, David F. Fischer

“…Over 6,000 compounds from small molecule drug repurposing libraries were subsequently screened in the assay developed, leading to identification of several promising in vitro hits.Using the assay developed and the identified hits opens avenues to investigate potential therapeutics for A-T.…”
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Multifocal Breast Cancer in Young Women with Prolonged Contact between Their Breasts and Their Cellular Phones by John G. West, Nimmi S. Kapoor, Shu-Yuan Liao, June W. Chen, Lisa Bailey, Robert A. Nagourney

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A computational approach to drug design for multiple sclerosis via QSPR modeling, chemical graph theory, and multi-criteria decision analysis by Fozia Bashir Farooq, Nazeran Idrees, Esha Noor, Nouf Abdulrahman Alqahtani, Muhammad Imran

“…This framework can be broadly applied to rationally design new therapeutics for complex diseases.…”
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Effects of Chronic Dopamine D2R Agonist Treatment and Polysialic Acid Depletion on Dendritic Spine Density and Excitatory Neurotransmission in the mPFC of Adult Rats by Esther Castillo-Gómez, Emilio Varea, José Miguel Blasco-Ibáñez, Carlos Crespo, Juan Nacher

“…Dopamine D2 receptors (D2R) in the medial prefrontal cortex (mPFC) are key players in the etiology and therapeutics of schizophrenia. The overactivation of these receptors contributes to mPFC dysfunction. …”
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Exosome-loading miR-205: a two-pronged approach to ocular neovascularization therapy by Hui-ying Zhang, Qiu-yang Zhang, Qing Liu, Si-guo Feng, Yan Ma, Feng-sheng Wang, Yue Zhu, Jin Yao, Biao Yan

“…This innovative approach avoids cytotoxicity while preserving therapeutic efficacy in both cellular and animal models. …”
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Quality of Life in Wilson’s Disease: A Systematic Literature Review by Chakrapani Balijepalli, Kevin Yan, Lakshmi Gullapalli, Stephane Barakat, Helene Chevrou-Severac, Eric Druyts

“…**Discussion:** Although our understanding of the underlying pathophysiology of WD has advanced, and novel therapeutics are on the horizon, our understanding of how WD affects overall QOL remains limited. …”
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Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice by Tomoko Asagami, Joseph K. Belanoff, Junya Azuma, Christine M. Blasey, Robin D. Clark, Philip S. Tsao

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Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics by Anmei Chen, Ying Gong, Shaoquan Wu, Ye Du, Zhijun Liu, Yuhong Jiang, Jiahong Li, Yang-Bao Miao

“…Furthermore, the review explores the potential clinical applications of nano-armored probiotics in precision therapeutics, critically addressing safety and regulatory considerations, and proposing the innovative concept of ‘probiotic intestinal colonization with nano armor’ for brain-targeted therapies. …”
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Proceedings of clinical trials on bile tract cancer by XIONG Yichen, YANG Ziyi, SANG Yuer, GONG Wei

“…All of these are significant for optimizing therapeutic strategies for BTC. BILCAP and ASCOT studies confirm the vital role of adjuvant chemotherapy in resectable BTC. …”
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Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells by Katja Spiess, Mads G. Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Thomas N. Kledal, Mette M. Rosenkilde

“…Immunotoxins as antiviral therapeutics are largely unexplored but have promising prospective due to their high selectivity potential and their unparalleled efficiency. …”
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The curated Lactobacillus acidophilus NCFM genome provides insights into strain specificity and microevolution by Meichen Pan, Sarah O’Flaherty, Ashley Hibberd, Svetlana Gerdes, Wesley Morovic, Rodolphe Barrangou

“…Of particular interest is Lactobacillus acidophilus NCFM, an extensively studied strain that has been widely commercialized for decades and is being used for the delivery of vaccines and therapeutics. Results Here, we revisit the L. acidophilus genome, which was sequenced twenty years ago, and determined the core and pan genomes of 114 publicly available L. acidophilus strains, spanning commercial isolates, academic strains and clones from the scientific literature. …”
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Cell Membrane-Camouflaged Nanoparticles: A Promising Biomimetic Platform for Tumor Therapy by Chengliang Lyu, Wenjin Wang, Yuan Yang, Peilin Guo, Feng Li, Wei Wei

“…Finally, we highlight the current challenges and prospects of these cell membrane camouflaging therapeutics that will contribute to the development.…”
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Phytochemical components and antibacterial activity of two populations of Senecio vulgaris L. essential oils as traditional medicine plant by Fatemeh Hajmoradi, Hamed Fathi, Foozieh Moghadami

“…Conclusion: This research highlights the significance of S. vulgaris as a valuable reservoir of monoterpene-rich oil exhibiting robust antibacterial characteristics, suggesting its potential use in the development of novel and naturally derived therapeutics for bacterial diseases. …”
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A European Approach to Irritable Bowel Syndrome Management by Michel Delvaux, Jacques Frexinos

“…The pathophysiology of IBS is based on multiple factors. Most of the therapeutics proposed for the management of patients with IBS have been developed on the assumption that motility disorders of the gut are the most reliable pathological findings among these patients. …”
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Systemic adverse drug events to topical prostaglandin analogs for treating glaucoma: a retrospective focused pharmacovigilance study by Kannan Sridharan

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