Lipoprotein Signal Peptide as Adjuvants: Leveraging Lipobox-Driven TLR2 Activation in Modern Vaccine Design by Muhammad Umar, Haroon Afzal, Asad Murtaza, Li-Ting Cheng

“…Thus, lipoprotein signal peptides (SPs) demonstrate remarkable versatility as adjuvants in vaccine development, diagnostics, and immune therapeutics, highlighting their essential role in advancing immune-based strategies to combat diverse pathogens.…”
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Navigating the frontier: Comprehensive insights into CRISPR technology advancements, delivery strategies, and ethical considerations in cancer research by Manisha S. Jain, K.S. Srikruthi, Prakash Goudanavar, N Raghavendra Naveen

“…The synthesis of information across these diverse domains contributes to a holistic understanding of CRISPR's current status, challenges, and promising avenues in cancer research and therapeutics.…”
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A bird’s-eye view of the biological mechanism and machine learning prediction approaches for cell-penetrating peptides by Maduravani Ramasundaram, Honglae Sohn, Thirumurthy Madhavan

“…In conclusion, this review will encourage the use of ML algorithms for finding effective CPPs, which will have a positive impact on future research on drug delivery and therapeutics.…”
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Green Synthesis of Gold and Iron Nanoparticles for Targeted Delivery: An In Vitro and In Vivo Study by Beenish Khanzada, Nosheen Akthar, Muhammad Zeeshan Bhatti, Hammad Ismail, Mohammed Alqarni, Bushra Mirza, Gomaa Mostafa-Hedeab, Gaber El-Saber Batiha

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Drug delivery systems for oral cancer treatment: A patent perspective by Mohamed Hassan Dehghan, Abrar Abdul Malik Siddiqui

“…The paper provides an extensive review of patents pertaining to novel therapeutics, formulations, and treatment methods for oral cancer. …”
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5-Methoxytryptophan Alleviates Dextran Sulfate Sodium-Induced Colitis by Inhibiting the Intestinal Epithelial Damage and Inflammatory Response by Yanling Wang, Jun Li, Qinyuan Yang, Zhenhang Zhu, Fang Cheng, Xiangyan Ai, Yang Liu, Dongbao Zhao, Futao Zhao, Peng Cheng

“…Among various available therapeutics, 5-methoxytryptophan (5-MTP) has emerged as one of the protectants by inhibiting inflammatory damage. …”
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Health-Related Quality of Life in the Gender, Race, And Clinical Experience Trial by Judith Feinberg, Michael Saag, Kathleen Squires, Judith Currier, Robert Ryan, Bruce Coate, Joseph Mrus

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Erratum to ‘Role of nanotechnology in neurosurgery: A review of recent advances and their applications’ [World Neurosurgery: X (22C) (2024)100298)] by Javed Iqbal, Evan Courville, Syed Faraz Kazim, Michael Kogan, Meic H. Schmidt, Christian A. Bowers

“…These nanoparticles exhibit significant potential in medicine, including in imaging techniques and diagnostic tools, tissue-engineered constructs, drug delivery systems, pharmaceutical therapeutics, and implants. The association with neurosurgery had been less well established compared to other organ systems but has recently offered the promising future potential for a wide range of utilities, including CNS drug delivery, neuro-regeneration, neuro oncology, neuroimaging, and neuromodulation. …”
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Regulating Immune Responses Induced by PEGylated Messenger RNA–Lipid Nanoparticle Vaccine by Hyein Jo, Jaewhoon Jeoung, Wonho Kim, Dooil Jeoung

“…Messenger RNA (mRNA)-based therapeutics have shown remarkable progress in the treatment and prevention of diseases. …”
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Transposon mediated functional genomic screening for BRAF inhibitor resistance reveals convergent Hippo and MAPK pathway activation events by Li Chen, Iulian Pruteanu-Malinici, Anahita Dastur, Xunqin Yin, Dennie Frederick, Ruslan I. Sadreyev, Cyril H. Benes

“…Many resistance events to targeted therapies have been identified, suggesting a complex path to improve therapeutics. Here, we showed the utility of a piggyBac transposon activation mutagenesis screen for the efficient identification of genes that are resistant to BRAF inhibition in melanoma. …”
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Antibody association in solution: cluster distributions and mechanisms by Sandi Brudar, Leonid Breydo, Elisha Chung, Ken A. Dill, Nasim Ehterami, Ketan Phadnis, Samir Senapati, Mohammed Shameem, Xiaolin Tang, Muhammmad Tayyab, Barbara Hribar-Lee

“…Understanding factors that affect the clustering and association of antibodies molecules in solution is critical to their development as therapeutics. For 19 different monoclonal antibody (mAb) solutions, we measured the viscosities, the second virial coefficients, the Kirkwood-Buff integrals, and the cluster distributions of the antibody molecules as functions of protein concentration. …”
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Identification of Flavonoid C-Glycosides as Promising Antidiabetics Targeting Protein Tyrosine Phosphatase 1B by Athika Rampadarath, Fatai Oladunni Balogun, Charlene Pillay, Saheed Sabiu

“…The lack of clinically approved PTP1B inhibitors has continued to prompt research in plant-derived therapeutics possibly due to their relatively lesser toxicity profiles. …”
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Validation framework for in vivo digital measures by Szczepan W. Baran, Susan E. Bolin, Stefano Gaburro, Marcel M. van Gaalen, Megan R. LaFollette, Chang-Ning Liu, Sean Maguire, Lucas P. J. J. Noldus, Lucas P. J. J. Noldus, Natalie Bratcher-Petersen, Brian R. Berridge

“…The adoption of in vivo digital measures in pharmaceutical research and development (R&D) presents an opportunity to enhance the efficiency and effectiveness of discovering and developing new therapeutics. For clinical measures, the Digital Medicine Society’s (DiMe) V3 Framework is a comprehensive validation framework that encompasses verification, analytical validation, and clinical validation. …”
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Challenging a Misnomer? The Role of Inflammatory Pathways in Inflammatory Breast Cancer by Riley J. Morrow, Nima Etemadi, Belinda Yeo, Matthias Ernst

“…This review summarises the current molecular evidence suggesting that inflammatory signaling pathways are upregulated in this disease, including NF-κB activation and excessive IL-6 production among others, which may provide an avenue for novel therapeutics. The role of the tumor microenvironment, through tumor-associated macrophages, infiltrating lymphocytes, and cancer stem cells is also discussed, suggesting that these tumor extrinsic factors may help account for the differences in behavior between inflammatory breast cancer and noninflammatory breast cancer. …”
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Large Granular Lymphocytic Leukemia: A Report of Response to Rituximab by Uroosa Ibrahim, Sara Parylo, Shiksha Kedia, Shafinaz Hussein, Jean Paul Atallah

“…A response to rituximab in refractory cases such as ours has been reported and may guide us towards exploring other immune-based therapeutics in this rare disease.…”
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Etiology and epizootology of bovine mastitis (analytical review) by A. A. Andreeva, V. A. Evgrafova, M. S. Voronina, O. V. Pruntova, N. B. Shadrova

“…The latter plays a specific role in indicating the direction of further therapeutic measures, since the obtained data facilitate selection of effective antibiotics against certain pathogens. …”
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In Silico Study of Coumarins: Wedelolactone as a Potential Inhibitor of the Spike Protein of the SARS-CoV-2 Variants by Saurav Katuwal, Siddha Raj Upadhyaya, Rishab Marahatha, Asmita Shrestha, Bishnu P. Regmi, Karan Khadayat, Saroj Basnet, Ram Chandra Basnyat, Niranjan Parajuli

“…Despite the rigorous global efforts to control SARS-CoV-2 transmission, it continues to pose a serious threat to humans with the frequent emergence of new variants. Thus, robust therapeutics to combat the virus are a desperate need. …”
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New Insights into the PPARγ Agonists for the Treatment of Diabetic Nephropathy by Zhanjun Jia, Ying Sun, Guangrui Yang, Aihua Zhang, Songming Huang, Kristina Marie Heiney, Yue Zhang

“…At the same time, the new insights into the therapeutic strategies of DN based on the PPARγ agonists were fully addressed.…”
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Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Childr... by Jason Glover, Tsz-Kwong Man, Donald A Barkauskas, David Hall, Tanya Tello, Mary Beth Sullivan, Richard Gorlick, Katherine Janeway, Holcombe Grier, Ching Lau, Jeffrey A Toretsky, Scott C Borinstein, Chand Khanna, Timothy M Fan, COG Osteosarcoma Biology Group

“…In addition the identification and development of novel diagnostics and effective therapeutics remain elusive. The QuadW-COG Childhood Sarcoma Biostatistics and Annotation Office (CSBAO) has developed the High Dimensional Data (HDD) platform to complement the existing physical inventory and to promote in silico hypothesis testing in sarcoma biology. …”
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A Current Overview of Next-Generation Probiotics and Their Prospects in Health and Disease Management by Ke-Yan Loo, Joanne Yuen Heng Thong, Loh Teng-Hern Tan, Vengadesh Letchumanan, Kok-Gan Chan, Learn-Han Lee, Jodi Woan-Fei Law

“…Nevertheless, future research is essential to better elucidate the exact mechanisms, safety profiles, and therapeutic applications of these NGPs.  Graphical abstract: The potential therapeutic applications of NGPs. …”
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