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2741
Pathogenesis of Severe Clinical Pictures of Influenza A (H1 N1). Some answers and new doubts.
Published 2011-04-01“…Meanwhile, the whole diagnosis and therapeutic’s arsenal for the prevention and the care of the critical sick persons, should be put on at the patients’ disposition, especially to those ones that required intensive care.…”
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2742
Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms
Published 2014-01-01“…Taken all together, the results indicated that HAEEO possessed potent anti-inflammatory activity and it may hold therapeutic promise in the management of acute and chronic inflammatory conditions.…”
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2743
Metabolic plasticity in pancreatic cancer: The mitochondrial connection
Published 2025-02-01“…Major Conclusion: Targeting mitochondrial metabolism holds promise for advancing PDAC therapeutics. Ongoing clinical trials underscore the therapeutic potential of modulating key regulators of mitochondrial dynamics and mitophagy. …”
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2744
Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i>
Published 2025-01-01“…Finally, we examine the potential of <i>C. elegans</i> as a platform for testing ETC-targeting drug candidates, including OXPHOS inhibitors, which represent promising avenues in cancer therapeutics. This review underscores the translational relevance of ETC research in <i>C. elegans</i>, bridging fundamental biology and therapeutic innovation.…”
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2745
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2746
Age-Related Changes in Trabecular and Cortical Bone Microstructure
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2747
Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence
Published 2025-02-01“…Integrating single-cell and other omic disease data with clinical and surgical metadata can identify multiple disease subtypes with translation to novel diagnostics and therapeutics. Herein, we present real-world perspectives on endometriosis and the importance of multidisciplinary collaboration in informing molecular, epidemiologic, and cell-specific data in the clinical and surgical contexts.…”
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2748
Proteomics and Its Current Application in Biomedical Area: Concise Review
Published 2024-01-01“…Biomedical researchers tirelessly seek cutting-edge technologies to advance disease diagnosis, drug discovery, and therapeutic interventions, all aimed at enhancing human and animal well-being. …”
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2749
A computational and structural approach to identify malignant non-synonymous FOXM1 single nucleotide polymorphisms in triple-negative breast cancer
Published 2025-01-01“…Thus, although further in-vitro validations are awaited the findings of this in-silico work can be used as a blueprint for malignant nsSNP identification of FOXM1 aiding in clinical TNBC therapeutics.…”
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2750
PROTEOMIC PROFILING OF BLOOD-BASED BIOMARKERS IN THE EARLY DETECTION OF ALZHEIMERS DISEASE
Published 2024-06-01“…Thus, various proteomic tools can be utilized for the identification of biomarkers from blood which can serve not only in early diagnosis but also for the development of new therapeutics targeting AD. …”
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2751
From Plant to Patient: A Historical Perspective and Review of Selected Medicinal Plants in Dermatology
Published 2025-01-01“…This review covers various plant-derived therapeutics (polyphenon E [sincatechins], psoralen, salicylic acid, anthralin, podophyllotoxin, and Filsuvez [birch triterpenes, oleogel-S10]) that have demonstrated scientific evidence of clinical efficacy for dermatologic disorders. …”
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2752
miR-468-3p suppresses osteogenic differentiation of BMSCs by targeting Runx2 and inhibits bone formation
Published 2024-12-01“…Abstract An improved understanding of the molecular actions underpinning bone marrow mesenchymal stem cell (BMSC) differentiation could highlight new therapeutics for osteoporosis (OP). Current evidence indicates that microRNAs (miRNAs) exert critical roles in many biological systems, including osteoblast differentiation. …”
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2753
Cognitive therapy for challenging problems : what to do when the basics don't work /
Published 2005Table of Contents: “…Identifying problems in treatment -- Conceptualizing patients who present challenges -- When a personality disorder challenges treatment -- Developing and using the therapeutic alliance -- Therapeutic relationship problems: case examples -- When therapists have dysfunctional reactions to patients -- Challenges in setting goals -- Challenges in structuring the session -- Challenges in solving problems and in homework -- Challenges in identifying cognitions -- Challenges in modifying thoughts and images -- Challenges in modifying assumptions -- Challenges in modifying core beliefs.…”
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2754
Cilostazol protective effect on nedaplatin-induced genotoxicity in cultured human lymphocytes
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2755
Epidermal growth factor and remarkable correlations in a case series COVID-19
Published 2024-06-01“…In the context of COVID-19, understanding the role of serum concentrations of EGF offered new possibilities for a better understanding of physiopathology and therapeutics. Objective: To explore the behavior of serum EGF values in patients with COVID-19, as well as to determine possible significant correlations between EGF, and analytical and clinical parameters of interest. …”
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2756
Helminth Parasites and the Modulation of Joint Inflammation
Published 2011-01-01“…There is an urgent need to develop better therapeutics for autoimmune and autoinflammatory diseases, of which musculoskeletal disorders such as rheumatoid arthritis are particularly prevalent and debilitating. …”
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2757
mRNA vaccines in the context of cancer treatment: from concept to application
Published 2025-01-01“…Abstract Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing the landscape of cancer therapeutics in an encouraging manner. Among the diverse immunotherapy strategies, mRNA vaccines have ushered in a new era for the therapeutic management of malignant diseases, primarily due to their impressive impact on the COVID-19 pandemic. …”
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2758
Effects of Earthworm (Pheretima communisima) extract on atopic dermatitis: An in vitro and in vivo study
Published 2025-01-01“…These results show that EWE might be therapeutics for the management of AD.…”
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2759
Evaluation of amoebicidal potential of Paneth cell cryptdin-2 against Entamoeba histolytica.
Published 2011-12-01“…In view of the emergence of this possibility, in addition to the associated side effects and mutagenic ability of the currently available anti-amoebic drugs, there is a need to explore newer therapeutics against this disease. In this context, the present study evaluated the amoebicidal potential of cryptdin-2 against E. histolytica.…”
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2760
High-parameter immunophenotyping reveals distinct immune cell profiles in pruritic dogs and cats
Published 2025-01-01“…IntroductionImmunophenotyping is a powerful tool for grading disease severity, aiding in diagnosis, predicting clinical response, and guiding the development of novel therapeutics.MethodsThis pilot study employs high parameter immunophenotyping panels (15 markers for dog, 12 for cat) and leverages unsupervised clustering to identify immune cell populations. …”
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