Standard: Human gastric organoids by Fan Hong, Ronghui Tan, Ting Wang, Nanshan Zhong, Hongling Zhao, Rui-hua Xu, Lin Shen, Yingbin Liu, Xuebiao Yao, Dongxi Xiang, Lijian Hui, Jianping Xiong, Dong Gao, Bing Zhao, Zhifeng Miao, Jie Hao, Yong Li, Shijun Hu, Boqiang Fu, Guoqiang Hua, Lei Wang, Zhao-Lei Zeng, Chong Chen, Jianmin Wu, Changlin Wang, Chunnian Wang, Xianbao Zhan, Chen Song, Chunping Yu, Yingying Yang, Gengming Niu, Yalong Wang, Tongbiao Zhao, Ye-Guang Chen

“…Abstract Organoid technology provides a transformative approach to understand human physiology and pathology, offering valuable insights for scientific research and therapeutic development. Human gastric organoids, in particular, have gained significant interest for applications in disease modeling, drug discovery, and studies of tissue regeneration and homeostasis. …”
Get full text

Solid Pseudopapillary Neoplasm of the Pancreas in Young Male Patients: Three Case Reports by Akira Aso, Eikichi Ihara, Kazuhiko Nakamura, Irina Sudovykh, Tetsuhide Ito, Masafumi Nakamura, Tetsuo Ikeda, Nobuyoshi Takizawa, Yoshinao Oda, Shuji Shimizu

Get full text

Nanoparticle Therapy Is a Promising Approach in the Management and Prevention of Many Diseases: Does It Help in Curing Alzheimer Disease? by Lamyaa M. Kassem, Nada A. Ibrahim, S. Ayesha Farhana

“…Gene delivery vehicles and nanocarriers including neurotrophic factors are promising therapeutics for many NDDs, and they can modulate neuronal survival and synaptic connectivity. …”
Get full text

A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients by Noor R. Abady, Zeana Shakir Al-Al Hindi

“…It is crucial to conduct further research in this area to develop tailored therapeutics.…”
Get full text

Alzheimer's disease and gut-brain axis: Drosophila melanogaster as a model by Samuel de Mattos Alves, Paulo Noronha Lisboa-Filho, Carolina Letícia Zilli Vieira, Marina Piacenti-Silva

“…Here we discuss how the simplicity and extensive genetic tools of Drosophila make it a valuable model for studying these interactions and testing potential therapeutics, including probiotics. Integrating Drosophila studies with other established models may reveal conserved pathways and accelerate the translation of findings into clinical applications.…”
Get full text

Antiatherosclerotic and Cardioprotective Potential of Acacia senegal Seeds in Diet-Induced Atherosclerosis in Rabbits by Heera Ram, Rameshwar Jatwa, Ashok Purohit

“…The findings of the present study reveal that Acacia senegal seed extract ameliorated diet-induced atherosclerosis and could be considered as lead in the development of novel therapeutics.…”
Get full text

Analysis of a Model for the Morphological Structure of Renal Arterial Tree: Fractal Structure by Aurora Espinoza-Valdez, Francisco C. Ordaz-Salazar, Edgardo Ugalde, Ricardo Femat

“…Biomedical systems are suitable candidates for this field because of their importance in life sciences including therapeutics. Here we deal with the analysis of a model recently proposed by Espinoza-Valdez et al. (2010) for the kidney vasculature developed via angiogenesis. …”
Get full text

Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model. by Manuel E Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E Crawford, Stuart Bunting, Mika Aoyagi-Scharber

“…Overall, our data indicate that advanced therapeutics may widen the treatment window for neurodegenerative disorders.…”
Get full text

Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection. by Kiran Bala Sharma, Chandru Subramani, Khashpatika Ganesh, Anshula Sharma, Brohmomoy Basu, Shivani Balyan, Ghanshyam Sharma, Shouri Ka, Arundhati Deb, Mitul Srivastava, Saurabh Chugh, Sapna Sehrawat, Kanchan Bharadwaj, Archana Rout, Pankaj Kumar Sahoo, Suman Saurav, Rajender K Motiani, Ramandeep Singh, Deepti Jain, Shailendra Asthana, Renu Wadhwa, Sudhanshu Vrati

“…The frequent epidemics of CHIKV across the world pose a significant public health burden necessitating the development of effective antiviral therapeutics. A cellular imaging-based high-content screening of natural compounds identified withaferin A (WFA), a steroidal lactone isolated from the plant Withania somnifera, as a potent antiviral against CHIKV. …”
Get full text

Combinatorial Cytotoxic Effects of Gelam Honey and 5-Fluorouracil against Human Adenocarcinoma Colon Cancer HT-29 Cells In Vitro by Syed Ahmad Tajudin T-Johari, Fatimah Hashim, Wan Iryani Ismail, Abdul Manaf Ali

“…Combination of natural products with chemodrugs is becoming a trend in discovering new therapeutics approach for enhancing the cancer treatment process. …”
Get full text

Anticancer potential of coumarins from the Ferulago genus by Mansour Mofasseri, Elham Eini, Saber Mofasseri, Bahram Hanifehpour, Fatemeh Zanbili, Ahmad Poursattar Marjani

“…Cancer treatment needs better therapeutic agents with fewer side effects compared to the present anticancer and antitumor drugs. …”
Get full text

Applications of polymeric nanoparticles in drug delivery for glioblastoma by Shuhan Liu, Shuhan Liu, Shuhan Liu, Shuhan Liu, Bin Tan, Feng Wang, Feng Wang, Ying Yu

“…This review explores the diverse applications of polymeric nanoparticles (NPs) in GBM treatment, including delivery of chemotherapeutics, targeted therapeutics, immunotherapeutics, and other agents for radiosensitization and photodynamic therapy. …”
Get full text

Probiotics in the Management of Atopic Dermatitis for Children: A Case-Based Review by Ashila Putri Disamantiaji, Endang Farihatul Izza, Muhamad Faza Soelaeman, Tannia Sembiring, Melva Louisa

“…This case-based review was done to assess and evaluate the therapeutic efficacy of probiotics supplementation in the management of eczema in children. …”
Get full text

hsa-miR-548d-3p: a potential microRNA to target nucleocapsid and/or capsid genes in multiple members of the Flaviviridae family by H. W. Cayatineto, S. T. Hakim

“…These small molecules are even being used as gene suppressors in antiviral therapeutics, inhibiting viral replication. In the current study, we used bioinformatic tools to predict a possible miRNA sequence that could be complementary to the nucleocapsid (NP) and/or capsid (CP) gene of the Flaviviridae family and provide an inhibitory solution.MethodsBioinformatics is a field of science that includes tremendous computational analysis, logarithms, and sequence alignments. …”
Get full text

AI Methods for Antimicrobial Peptides: Progress and Challenges by Carlos A. Brizuela, Gary Liu, Jonathan M. Stokes, Cesar de laFuente‐Nunez

Get full text

The pharmacognostic profile and pharmacological importance of cordia myxa-a review by Asif yousuf Wani, Rubeena Khaliq, Nazia Kousar, Sarika Pundir

“…Evaluation of pharmacological and therapeutic activities confirmed the Cordia myxa plant's hypotensive, respiratory stimulant, anti-inflammatory, antimicrobial, diuretic and immunomodulatory properties. …”
Get full text

Lipoxins and Annexin-1: Resolution of Inflammation and Regulation of Phagocytosis of Apoptotic Cells by Michael Scannell, Paola Maderna

“…Understanding the role and mechanism of the powerful anti-inflammatory and proresolution actions of endogenous compounds can be a useful tool in the development of potential therapeutics in resolving inflammatory diseases.…”
Get full text

Triterpene esters from Uncaria rhynchophylla hooks as potent HIV-1 protease inhibitors and their molecular docking study by JiSuk Lee

“…This underscores the urgent need for safer, more effective drugs to combat resistant strains and advance acquired immunodeficiency syndrome (AIDS) therapeutics. Eight triterpene esters (1–8) were identified from Uncaria rhynchophylla hooks. …”
Get full text

The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review by Punitha Letchumanan, Kumitaa Theva Das

“…The first-in-human clinical trial of Excision BioTherapeutics’ CRISPR-based HIV cure, EBT-101, demonstrated safety but failed to prevent viral rebound. …”
Get full text

Diagnostic Lessons from a Complex Case of Postintestinal Transplantation Enteropathy by Cian Wade, Philip Allan, Elena Collantes, Srikanth R. Reddy, Peter J. Friend, Georgios Vrakas

“…This case illustrates the importance of developing reliable and specific markers for guiding the diagnosis of rejection and the use of antirejection therapeutics in this rapidly evolving field of transplant surgery.…”
Get full text