Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives by Deyun Chen, Qian Hou, Lingzhi Zhong, Yali Zhao, Meirong Li, Xiaobing Fu

“…In this review, we focus on recent progress in the use of bioactive molecules in skin regenerative medicine, by which desired cell types can be generated in vitro for cell therapy and conventional therapeutics can be developed to repair and regenerate skin in vivo through activation of the endogenous repairing potential. …”
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Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes by Arpeeta Sharma, Pascal N. Bernatchez, Judy B. de Haan

“…Thus, in this review, we discuss novel therapeutic targets that either upregulate EDNO production or increase antioxidant enzyme capacity in an effort to limit oxidative stress and restore endothelial function. …”
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Computational analysis of the effect of a binding protein (RbpA) on the dynamics of Mycobacterium tuberculosis RNA polymerase assembly. by Sneha Bheemireddy, Ramanathan Sowdhamini, Narayanaswamy Srinivasan

“…Overall, this research contributes valuable information for understanding the intricate regulatory networks of RbpA in the context of transcription and suggests potential avenues for the development of RbpA-targeted therapeutics.…”
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Mesenchymal Stem Cells Derived from Dental Pulp: A Review by Edgar Ledesma-Martínez, Víctor Manuel Mendoza-Núñez, Edelmiro Santiago-Osorio

“…Different groups worldwide have designed and evaluated new efficient protocols for the isolation, expansion, and maintenance of clinically safe human DPSCs in sufficient numbers for various therapeutics protocols and have discussed the most appropriate route of administration, the possible contraindications to their clinical use, and the parameters to be considered for monitoring their clinical efficacy and proper biological source. …”
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Adaptation of Research Project Requirement at Pharmacy Undergraduate Studies: Students’ Perception, Attitude, and Experiences by Najia Rahim, Kiran Rafiq, Shagufta Nesar, Sadaf Naeem, Fakhsheena Anjum, Muhammad Azhar Mughal

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Pancreatic Tuberculosis or Autoimmune Pancreatitis by Ayesha Salahuddin, Muhammad Wasif Saif

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Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule. by Tingting Wang, Huaizhi Yang, Qiushuang Sheng, Ying Ding, Jian Zhang, Feng Chen, Jianfeng Wang, Lei Song, Xuming Deng

“…In conclusion, this work promotes the development of a capsule-targeted alternative therapeutic strategy for the use of the promising candidate IFA as an intervention to curb hvKP infection, particularly drug-resistant cases.…”
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Gut microbiota, mood and disorders of gut-brain axis by S. Pletikosić Tončić, G. Hauser, M. Tkalčić

“…The main objective of this review is to summarize recent studies on the role of microbiota and microbial-targeted therapeutics in symptom relief and mood regulation of IBS patients. …”
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Management Strategies and Outcomes for Hyponatremia in Cirrhosis in the Hyponatremia Registry by Samuel H. Sigal, Alpesh Amin, Joseph A. Chiodo, Arun Sanyal

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Progenitor Cell Therapy to Treat Acute Myocardial Infarction: The Promise of High-Dose Autologous CD34+ Bone Marrow Mononuclear Cells by Joseph C. Poole, Arshed A. Quyyumi

“…The need for improved post-STEMI therapies has led to a surge of novel therapeutics, especially regenerative approaches using autologous mononuclear cells. …”
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Herbal Medicines for Asthmatic Inflammation: From Basic Researches to Clinical Applications by Fang Liu, Nan-Xia Xuan, Song-Min Ying, Wen Li, Zhi-Hua Chen, Hua-Hao Shen

“…This disease has a significant impact on individuals, their families, and society. Standardized therapeutics such as inhaled corticosteroid in combination with long acting β2 agonist have been applied for asthma control; however, complementary and alternative medicines, especially herbal medicines, are still widely used all over the world. …”
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Role of extracellular vesicles in the pathogenesis of mosquito-borne flaviviruses that impact public health by Pedro Pablo Martínez-Rojas, Verónica Monroy-Martínez, Blanca H. Ruiz-Ordaz

“…This review focuses on the roles of extracellular vesicles in the pathogenesis of mosquito-borne flavivirus diseases: how they contribute to viral cycle completion, cell-to-cell transmission, and cellular responses such as inflammation, immune suppression, and evasion, as well as their potential use as biomarkers or therapeutics (antiviral or vaccines). We highlight the current findings concerning the functionality of extracellular vesicles in different models of dengue virus, Zika virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus infections and diseases. …”
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Integrated Analysis of microRNA Targets Reveals New Insights into Transcriptional–Post-Transcriptional Regulatory Cross-Talk by Simona Panni, Roberto Pizzolotto

“…Their involvement in almost all cellular processes predicts their role in diseases, and several microRNA-based therapeutics are currently undergoing clinical testing. …”
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Gene Carriers and Transfection Systems Used in the Recombination of Dendritic Cells for Effective Cancer Immunotherapy by Yu-Zhe Chen, Xing-Lei Yao, Yasuhiko Tabata, Shinsaku Nakagawa, Jian-Qing Gao

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Complementary Use of Bioluminescence Imaging and Contrast-Enhanced Micro—Computed Tomography in an Orthotopic Brain Tumor Model by Sanaz Yahyanejad, Patrick V. Granton, Natasja G. Lieuwes, Lesley Gilmour, Ludwig Dubois, Jan Theys, Anthony J. Chalmers, Frank Verhaegen, Marc Vooijs

“…Small animal models are crucial to link molecular discoveries and implementation of clinically relevant therapeutics in oncology. Using these models requires noninvasive imaging techniques to monitor disease progression and therapy response. …”
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Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives by Ricardo P. Garay

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Tumorigenic and Differentiation Potentials of Embryonic Stem Cells Depend on TGFβ Family Signaling: Lessons from Teratocarcinoma Cells Stimulated to Differentiate with Retinoic Aci... by Olga Gordeeva, Sergey Khaydukov

“…Thus, this study demonstrates that a differentiation strategy that modulates prodifferentiation and antiproliferative signaling in ES cells may be effective for eliminating tumorigenic cells and may represent a valuable tool for the development of safe stem cell therapeutics.…”
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Synthesis and crystal structure of (S,E)-4-hydroxy-3-(2-((4aR,6aS,7R,10aS,10bR)-3,3,6a,10b-tetramethyl-8-methylenedecahydro-1H-naphtho[2,1-d][1,3]dioxin-7-yl)ethylidene)dihydrofura... by Li Shi-Qing, Zhou Jian, Dong Zhang-Chao, Pan Bo Wen, Shi Yang, Zhou Ying

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Mucosal SARS-CoV-2 S1 adenovirus-based vaccine elicits robust systemic and mucosal immunity and protects against disease in animals by Najwa D. Aljehani, Levi Tamming, Muhammad Yasir Khan, Rwaa H. Abdulal, Mohamed A. Alfaleh, Aishah Ghazwani, Asalah Helal, Reem M. Alsulaiman, Mohammad A. Sanki, Khalid Alluhaybi, Farah Ayman Sukareh, Rahaf H. Alharbi, Faris H. Alyami, M-Zaki ElAssouli, Salima Shebbo, Wesam H. Abdulaal, Abdullah Algaissi, Ahmad Bakur Mahmoud, Mohammad Basabrain, Diana Duque, Jegarubee Bavananthasivam, Wangxue Chen, Lisheng Wang, Simon Sauve, Turki S. Abujamel, Tarfa Altorki, Rowa Alhabbab, Anh Tran, Xuguang Li, Anwar M. Hashem

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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…We demonstrate that this therapeutic approach has merit, is durable, and should be explored in a larger clinical trial. …”
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