Tandem repeat expansions and copy number variations as risk factors and diagnostic tools for amyotrophic lateral sclerosis by Eleonora Sabetta, Davide Ferrari, Locatelli Massimo, Sulev Kõks, Sulev Kõks

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NF2 can mediate the expression of CAMK2A in a tissue specific manner by Zhaoying Lei, Huajian Cai, Qingfeng Yan

“…Thus, targeting CAMK2A may represent a promising strategy for drug screening and the development of therapeutics for NF2-associated meningiomas and other nervous system tumors.…”
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Tea Polyphenols Regulate Key Mediators on Inflammatory Cardiovascular Diseases by Jun-ichi Suzuki, Mitsuaki Isobe, Ryuichi Morishita, Ryozo Nagai

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Toxicological Implications of Platinum Nanoparticle Exposure: Stimulation of Intracellular Stress, Inflammatory Response, and Akt Signaling In Vitro by Claudia J. Labrador-Rached, Rebecca T. Browning, Laura K. Braydich-Stolle, Kristen K. Comfort

“…Due to their distinctive physicochemical properties, platinum nanoparticles (PtNPs) have emerged as a material of interest for a number of biomedical therapeutics. However, in some instances NP exposure has been correlated to health and safety concerns, including cytotoxicity, activation of cellular stress, and modification to normal cell functionality. …”
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Successfully Climbing the “STAIRs”: Surmounting Failed Translation of Experimental Ischemic Stroke Treatments by Michael P. Kahle, Gregory J. Bix

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miRNA changes associated with differentiation of human embryonic stem cells into human retinal ganglion cells by Maryam Esmaeili, Daniel A. Smith, Ben Mead

“…The latter has led to interest in them as both biomarkers and as potential therapeutics. Retinal ganglion cells (RGC), whose axons connect the eye to the brain, are central nervous system cells of great interest, yet their study is largely restricted to animals due to the difficulty in obtaining healthy human RGC. …”
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Bioprinting approaches in cardiac tissue engineering to reproduce blood-pumping heart function by Minji Kim, Dong Gyu Hwang, Jinah Jang

“…Engineered heart tissues have been introduced to reproduce heart functions to understand the pathophysiological properties of the heart and to test and develop potential therapeutics. Although numerous studies have been conducted in various fields to increase the functionality of heart tissue to be similar to reality, there are still many difficulties in reproducing the blood-pumping function of the heart. …”
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The Drug Excipient Cyclodextrin Interacts With -Luciferin and Interferes With Bioluminescence Imaging by Jeyan S. Kumar MSc, Lisa M. Miller Jenkins PhD, Michael M. Gottesman MD, Matthew D. Hall PhD

“…As such, cyclodextrins are used as excipients for experimental therapeutics in vivo. We observed unanticipated modifications to bioluminescence imaging (BLI) signal intensity when 2-hydroxy-propyl-β-cyclodextrin (HPCD) was coinjected as an excipient. …”
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Dynamic Analysis of the Blood-Brain Barrier Disruption in Experimental Stroke Using Time Domain in Vivo Fluorescence Imaging by Abedelnasser Abulrob, Eric Brunette, Jacqueline Slinn, Ewa Baumann, Danica Stanimirovic

“…The blood-brain barrier (BBB) disruption following cerebral ischemia can be exploited to deliver imaging agents and therapeutics into the brain. The aim of this study was (a) to establish novel in vivo optical imaging methods for longitudinal assessment of the BBB disruption and (b) to assess size selectivity and temporal patterns of the BBB disruption after a transient focal ischemia. …”
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Functions and applications of RNA interference and small regulatory RNAs by Feng Xuezhu, Guang Shouhong

“…Additionally, we provide an overview of the applications of RNAi technology in biomedical research, agriculture, and therapeutics.…”
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Induced Pluripotent Stem Cells and Outer Retinal Disease by Jin Yang, Bingcui Cai, Patrick Glencer, Zhiqing Li, Xiaomin Zhang, Xiaorong Li

“…For this reason, research about exploring retinal diseases’ underlying molecular mechanisms and potential therapeutic approach using stem cell technique has been developing rapidly. …”
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Glucose metabolism impairment in major depressive disorder by Fanhao Meng, Jing Wang, Long Wang, Wei Zou

“…In addition, we briefly discussed potential pharmacological interventions for glucose metabolism to alleviate MDD, including glucagon-like peptide-1 receptor agonists, metformin, topical insulin, liraglutide, and pioglitazone, to encourage the development of new therapeutics.…”
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Alice in Wonderland Syndrome: Localising insights from right visual cortex stroke complicated by epilepsia partialis continua by Gashirai K. Mbizvo, Viraj Bharambe, Brython Hywel, Shubhabrata Biswas, Andrew J. Larner

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Opportunities for predictive proteogenomic biomarkers of drug treatment sensitivity in epithelial ovarian cancer by Trudy J. Philips, Britt K. Erickson, Stefani N. Thomas

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The implementation of genome sequencing in rare genetic diseases diagnosis: a pilot study from the Hong Kong genome projectResearch in context by Wai Kei Jacky Lam, Chak Sing Lau, Ho Ming Luk, Lisa Wing Chi Au, Gary C.P. Chan, Will Yap Hang Chan, Shirley Sze Wing Cheng, Timothy Hua Tse Cheng, Li Li Cheung, Yiu Fai Cheung, Josephine Shuk Ching Chong, Annie Tsz Wai Chu, Claudia Ching Yan Chung, Kin Lai Chung, Cheuk Wing Fung, Eva Lai Wah Fung, Yuan Gao, Stephanie Ho, Shirley Pik Ying Hue, Chi-Ho Lee, Tsz Leung Lee, Philip Hei Li, Hei Man Lo, Ivan Fai Man Lo, Herbert Ho Fung Loong, Becky Mingyao Ma, Wei Ma, Shirley Yin Yu Pang, Wai-Kay Seto, Steven Wai Kwan Siu, Ho So, Yuk Him Tam, Wenshu Tang, Rosanna Ming Sum Wong, Desmond Yat Hin Yap, Maggie Lo Yee Yau, Brian Hon Yin Chung, Su-Vui Lo

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Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation by Michael Schnoor, Pilar Alcaide, Mathieu-Benoit Voisin, Jaap D. van Buul

“…Therefore, a better understanding of the key molecules that regulate this process may help to develop novel therapeutics for treatment of inflammation-based diseases such as atherosclerosis or rheumatoid arthritis. …”
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Generation of a human induced pluripotent stem cell (iPSC) line ERPLi004-A from an Alpha-1 antitrypsin deficiency (AATD) patient with SERPINA1 mutation by Harshini Surendran, Rajani Battu, Renjitha Gopurappilly, Chethala N. Vishnuprasad, Rajarshi Pal

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Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein by Ioannis Papaioannou, J. Paul Simons, James S. Owen

“…Here, we describe atheroprotective properties of ApoE, though also potential proatherogenic actions, and the prevalence of dysfunctional isoforms, outline conventional gene transfer strategies, and then focus on gene correction therapeutics that can repair defective APOE alleles. …”
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Interaction of RECQL4 with poly(ADP‐ribose) is critical for the DNA double‐strand break response in human cells by Sunyoung Shin, Dongmin Kim, Hyemi Kim, Won‐Ho Cho, Gyungmin Kim, Joon‐Kyu Lee

“…These results suggest that the direct interaction of RECQL4 with PAR is critical for proper cellular response to DSBs and provide insights to understand PARylation‐dependent control of the DSB response and cancer therapeutics using PARylation inhibitors.…”
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Recurrent Catatonia due to Episodic Obsessive-Compulsive Disorder by Soumitra Das, Sakshi Prasad, Palak Atul Fichadia, Abhigan Babu Shrestha, Ozge C. Amuk Williams, Anil Bachu

“…Additionally, robust studies are needed in order to determine the pathophysiology of catatonia and the mechanism of ECT so that more beneficial therapeutics can be developed. A combination of ECT and antidepressants with ERP therapy for recurrent catatonia with OCD could be effective as a therapeutic modality.…”
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