Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans by Trina A. Knotts, Hyun Woo Lee, Jae Bum Kim, Pieter J. Oort, Ruth McPherson, Robert Dent, Keisuke Tachibana, Takefumi Doi, Songtao Yu, Janardan K. Reddy, Kenji Uno, Hideki Katagiri, Magdalena Pasarica, Steven R. Smith, Dorothy D. Sears, Michel Grino, Sean H. Adams

Get full text

Mechanical Properties of Surface-Charged Poly(Methyl Methacrylate) as Denture Resins by Sang E. Park, Maggie Chao, P. A. Raj

Get full text

Flexor Digitorum Accessorius Longus: Importance of Posterior Ankle Endoscopy by Jorge Pablo Batista, Jorge Javier del Vecchio, Pau Golanó, Jordi Vega

Get full text

Generation and Characterization of Erythroid Cells from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells: An Overview by Kai-Hsin Chang, Halvard Bonig, Thalia Papayannopoulou

“…In contrast to other ex vivo stem-cell-derived cellular therapeutics, tumorigenesis is not a concern, as RBCs can be irradiated without marked adverse effects on in vivo function. …”
Get full text

Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect. by Tshokey Tshokey, Ablert I Ko, Bart J Currie, Claudia Munoz-Zanzi, Cyrille Goarant, Daniel H Paris, David A B Dance, Direk Limmathurotsakul, Emma Birnie, Eric Bertherat, Gyanendra Gongal, Jackie Benschop, Jelmer Savelkoel, John Stenos, Kartika Saraswati, Matthew T Robinson, Nicholas P J Day, Stephen R Graves, Steven R Belmain, Stuart D Blacksell, Willem J Wiersinga

“…This is a call from a group of multi-institutional experts on the urgent need to directly address the circle of neglect and raise support in terms of funding, research, surveillance, diagnostics, and therapeutics to alleviate the burden of these 3 diseases.…”
Get full text

Esophageal Motility Disorders: Current Concepts of Pathogenesis and Treatment by Peter J Kahrilas

“…Instead, emphasis was placed on new developments in diagnosis, therapeutics, and practice patterns. Controlled therapeutic trials and pathophysiological observations are emphasized. …”
Get full text

St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo. by Yanxia Guo, Shikang Wang, Qun Liu, Yan Dong, Yongqing Liu

“…Drug resistance of cancers remains a major obstacle due to limited therapeutics. Lysosome targeting is an effective method for overcoming drug resistance in cancer cells. …”
Get full text

Intravitreal Devices for the Treatment of Vitreous Inflammation by John B. Christoforidis, Susie Chang, Angela Jiang, Jillian Wang, Colleen M. Cebulla

“…The eye is a well-suited organ for local delivery of therapeutics to treat vitreous inflammation as well as other pathologic conditions that induce visual loss. …”
Get full text

Barriers and facilitators of participants and non-participants of physical activity at the workplace by Antonio José Grande, Valter Silva

“…., available time at work to exercise) and promoting the factors that facilitate adhesion to this therapeutics.…”
Get full text

Artificial intelligence across oncology specialties: current applications and emerging tools by Frank Lin, Tim Rattay, John Kang, Evangelia Katsoulakis, Kyle Lafata, Ellen Kim, Christopher Yao, Harsha Nori, Christoph Ilsuk Lee

“…Oncology is becoming increasingly personalised through advancements in precision in diagnostics and therapeutics, with more and more data available on both ends to create individualised plans. …”
Get full text

Convergence of nanotechnology and artificial intelligence in the fight against liver cancer: a comprehensive review by Manjusha Bhange, Darshan Telange

“…Nanotechnology enables precise, targeted drug delivery, enhancing the efficacy of therapeutics while minimizing off-target effects. Simultaneously, AI contributes to improved diagnostic accuracy, predictive modeling, and the development of personalized treatment strategies. …”
Get full text

Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm by Andrew A. Davis, Virginia G. Kaklamani

“…Further research will facilitate the development of targeted therapeutics and programs to modify lifestyle factors to modulate the insulin-leptin-adiponectin axis for TNBC.…”
Get full text

Natural compound chaetocin induced DNA damage and apoptosis through reactive oxygen species‐dependent pathways in A549 lung cancer cells and in vitro evaluations by Qi Zhang, Feng Ruan, Maonan Yang, Qinghui Wen

“…Abstract There is an urgent need for potential pharmaceutics for lung cancer treatment due to the increased number of lung cancer deaths and the resistance of cancer cells to present therapeutics. The present work aims to discover the anticancer potential of the natural compound chaetocin as a therapeutic for lung cancer treatment. …”
Get full text

Prediction of individual patient outcomes to psychotherapy vs medication for major depression by Devon LoParo, Boadie W. Dunlop, Charles B. Nemeroff, Helen S. Mayberg, W. Edward Craighead

Get full text

Ferroptosis and pyroptosis are connected through autophagy: a new perspective of overcoming drug resistance by Peng Zhao, Shuangshuang Yin, Yuling Qiu, Changgang Sun, Haiyang Yu

Get full text

Circulating Dynamics of SARS-CoV-2 Variants between April 2021 and February 2022 in Turkey by Murat Sayan, Ayse Arikan, Murat Isbilen

“…The diagnosis of new variants and monitoring their potential effects on diagnosis, therapeutics, and vaccines by genomic sequencing is essential to manage global public crises. …”
Get full text

Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis by Imrana Jazuli, Akeela Jazeel, Lakshmi Selvaratnam, Deepa Alex, Yatinesh Kumari

“…However, diversifying therapeutic strategies is crucial for making meaningful progress. …”
Get full text

Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…Abstract Much of the therapeutic potential of mesenchymal stromal cells (MSCs) is underpinned by their secretome which varies significantly with source, donor and microenvironmental cues. …”
Get full text

Chromatographic Characterization and Method Development for Determination of Levetiracetam in Saliva: Application to Correlation with Plasma Levels by Imad I. Hamdan, Mervat Alsous, Amira Taher Masri

“…A less invasive sampling method for therapeutic drug monitoring (TDM) would be very useful particularly for children. …”
Get full text

From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies by Dong Xie, Linglin Sun, Manxiang Wu, Qiang Li

“…INMs now link materials science with advanced computing and clinical innovations to enable next-generation cancer diagnostics and therapeutics.…”
Get full text