CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance by Kayode Komolafe, Maricica Pacurari

“…The potential therapeutic benefits of pharmacological or other CXCL/CXCR axis manipulations are also discussed.…”
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Analysis of the Effect of Human Type I Collagen-Derived Peptide on Bone Regenerative Capacity and Comparison with Various Collagen Materials In Vivo by Tatsunori Asakura, Tran Thi Thuy Diep, Yuta Ueda, Aoi Yamada, Takahiro Tsuzuno, Naoki Takahashi, Masayuki Miyata, Koichi Tabeta, Masaki Nagata, Ken Matsuda

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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein by Marie-Lynn Cuypers, Tom Jaspers, Jarne Clerckx, Simon Leekens, Christopher Cawthorne, Guy Bormans, Frederik Cleeren, Nick Geukens, Bart De Strooper, Maarten Dewilde

“…The most well-studied approach to enhance brain influx of protein therapeutics, is receptor-mediated transcytosis (RMT) by targeting nutrient receptors to shuttle protein therapeutics over the blood–brain barrier (BBB) along with their endogenous cargos. …”
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Bacterial metabolism in the host and its association with virulence by Amrita Bhagwat, Tiyasa Haldar, Poonam Kanojiya, Sunil D. Saroj

“…The knowledge of crosslinked metabolic pathways of bacteria and their host will serve to develop novel potential therapeutics.…”
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Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. by Mimi Cushman-Nick, Nancy M Bonini, James Shorter

“…There are no effective therapeutics that antagonize or reverse the protein-misfolding events underpinning polyglutamine (PolyQ) disorders, including Spinocerebellar Ataxia Type-3 (SCA3). …”
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Artificial intelligence (AI) or augmented intelligence? How big data and AI are transforming healthcare: Challenges and opportunities by K Moodley

“…A transformed healthcare environment enhanced by innovation, robotics, digital technology, and improved diagnostics and therapeutics is plagued by ethical, legal and social challenges. …”
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Adjuvants for peptide-based cancer vaccines by Willem W Overwijk, Hiep Khong

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Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases by Francisco J. Garcia, Myriam Heiman

“…Abstract Many diseases and disorders of the nervous system suffer from a lack of adequate therapeutics to halt or slow disease progression, and to this day, no cure exists for any of the fatal neurodegenerative diseases. …”
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ABO Blood Groups and Cardiovascular Diseases by Hanrui Zhang, Ciarán J. Mooney, Muredach P. Reilly

“…The role of blood group antigens in the pathogenesis of various cardiovascular disorders remains a fascinating subject with potential to lead to novel therapeutics and prognostics and to reduce the global burden of cardiovascular diseases.…”
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Physiological Roles of DNA Double-Strand Breaks by Farhaan A. Khan, Syed O. Ali

“…Growing evidence points to a role of aberrant DSB physiology in human disease and an understanding of these processes may both inform the design of new therapeutic strategies and reduce off-target effects of existing drugs. …”
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Successful Treatment of Hemophagocytic Lymphohistiocytosis Associated with Lupus Nephritis by Using Mycophenolate Mofetil by Takashi Nawata, Makoto Kubo, Kosaku Shiragami, Yukinori Nakamura, Masafumi Yano

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A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. by Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx

“…Here, we describe the use of a human lung xenograft mouse model to study the permissiveness for different orthohantavirus species and to assess its utility for preclinical testing of therapeutics. Following infection of xenografted human lung tissues, distinct orthohantavirus species differentially replicated in the human lung and subsequently spread systemically. …”
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Neuromuscular diseases: genomics-driven advances by Anna Cho

“…Continued progress in gene therapy, RNA-based therapeutics, and personalized medicine holds promise for further breakthroughs in the management of these debilitating diseases.…”
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Comprehensive genome-scale CRISPR knockout screening of CHO cells by Sung Wook Shin, Su Hyun Kim, Aghiles Gasselin, Gyun Min Lee, Jae Seong Lee

“…Abstract Chinese hamster ovary (CHO) cells play a pivotal role in the production of recombinant therapeutics. In the present study, we conducted a genome-scale pooled CRISPR knockout (KO) screening using a virus-free, recombinase-mediated cassette exchange-based platform in CHO-K1 host and CHO-K1 derived recombinant cells. …”
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Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X Receptor Alpha by Yu-Jui Yvonne Wan, Mostafa Z. Badr

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Molecular glue degrader for tumor treatment by Yuhan Hu, Yan Yan, Jiehao Wang, Jiangxue Hou, Quande Lin

“…Given that molecular glue research is still in its early stage, we summarized the mechanisms of molecular glue, the promising drugs in clinical trials and diverse feasible design strategies for molecular glue therapeutics.…”
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Nanocurcumin in myocardial infarction therapy: emerging trends and future directions by Mei Lv, Qing Sun, Yilin Yu, Jinwei Bao

“…Research and clinical trials are essential for comprehensive analysis and efficacy of curcumin-based nano-therapeutics in cardiovascular condition and lowering risk of MI.…”
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An Audit of Pain Management Following Pediatric Day Surgery at British Columbia Children’s Hospital by Serena Shum, Joanne Lim, Trish Page, Elizabeth Lamb, Jennifer Gow, J Mark Ansermino, Gillian Lauder

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Excisional Biopsy of the Pyogenic Granuloma in Very High-Risk Patient by Dirceu Tavares Formiga Nery, José Ranali, Darceny Zanetta Barbosa, Helvécio Marangon Júnior, Rafael Martins Afonso Pereira, Patrícia Cristine de Oliveira Afonso Pereira

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Repository Corticotropin Injection for Treatment of Idiopathic Inflammatory Myopathies by Aarat Patel, Georgia Seely, Rohit Aggarwal

“…There are few approved therapeutics available for treatment of this group of diseases and the first-line therapy is usually corticosteroid treatment. …”
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