Derivation of induced pluripotent stem cell TUSMi013-A from a 66-year-old Chinese Han Parkinson’s disease patient carrying VPS13C and TBP mutations by Can Cui, Jian Chen, Hao Shen, Bei Zhang

“…This iPSC line offers a significant resource for the dissection of PD etiology and the innovation of novel therapeutic strategies.…”
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Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma by Jeremy Chuang, An Uche, Rohan Gupta, Kim Margolin, Phyllis Kim

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Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I by Bryan Neumann, Stephen McCarthy, Shane Gonen

“…One of the nine human NaV isoforms, NaV1.8, is a promising target for analgesics, and selective inhibitors are of interest as therapeutics. One such inhibitor, the gating-modifier peptide Protoxin-I derived from tarantula venom, blocks channel opening by shifting the activation voltage threshold to more depolarized potentials, but the structural basis for this inhibition has not previously been determined. …”
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A note on the probability structure of a doubly randomized delayed start design by Zhao Yang

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Assessment of the Alterations in Craniovertebral Angle Attributed to Continued Digital Usage as an Etiology for Temporomandibular Joint Disorders in North Indian Population: A Pilo... by Manisha Lakhanpal Sharma, Simran Kaur

“…Conclusions: TMDs should be managed using the holistic approach which incorporates a reduction in digital usage, correction of posture, therapeutics for cervicofacial muscles, and TMJ.…”
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Peroxisome proliferator–activated receptor delta and liver diseases by Tomoo Yamazaki, Edward E. Cable, Bernd Schnabl

“…This review provides an overview of PPAR-delta’s function and biology in the liver, examines its kinetics and therapeutic potential across different liver diseases, and discusses the current status of clinical trials involving its agonists.…”
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Simultaneous surgery for gastrostomy and laryngotracheal separation in a patient with Tay‒Sachs disease by Masaharu Moroto, Uda Daisuke, Tomoya Yodoi, Yoshihiro Nitta, Yohei Sugimoto, Tomohiro Chiyonobu, Hiroyuki Yamada, Kayo Ozaki, Taichi Nakatani, Norio Sakai

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Laryngeal Synovial Sarcoma: A Rare Clinical Entity by Clair Saxby, Ron Bova, Melanie Edwards

“…The presence of the diagnostic translocation, t(X;18), is being targeted and hopefully will lead to the development of new therapeutics (Guadagnolo et al., 2007). Conclusion. Laryngeal SS remains a rare and poorly understood entity. …”
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Activated neutrophils: A next generation cellular immunotherapy by Ninad Kumbhojkar, Samir Mitragotri

“…We review the conditions where activated neutrophil therapy can be therapeutically beneficial and discuss the challenges associated with their eventual translation. …”
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A Rare Cause of Hemophagocytic Lymphohistiocytosis: Fusobacterium Infection—A Case Report and Review of the Literature by Ghulam Rehman Mohyuddin, Heather J. Male

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Yoga Therapy Attenuates the Progression of Diabetes – Insights from Proteomics and Metabolomics Analysis by Babasaheb P. Sonwane, Pooja Raut, Jyotsna Chitalkar, Smita Godbole, Shanta Sabnis, Jyoti Gupta, B. Santhakumari, Mukund V. Deshpande, Mahesh J. Kulkarni

“…Objective: Diabetes management remains challenging despite advancements in therapeutics, with many subjects developing complications. …”
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Intertoe Squamous Cell Carcinoma Developed in a Patient with Rheumatoid Arthritis under Etanercept Therapy by Efstathios Rallis, Vasiliki-Kalliopi Bournia, Constantinos Verros, Alexios Iliopoulos

“…The use of tumor necrosis factor-α (TNF-α) inhibitors in the treatment of various inflammatory conditions has altered the field of medical therapeutics. Squamous cell carcinoma is the second most common cancer of the skin, usually affecting sun-exposed areas of the body. …”
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Synthesis and Antibacterial Activity of Grafted Poly(Vinyl Chloride) Polymer against Gram-Positive and Gram-Negative Bacteria by Shrajan Kotian, Sonali Gupta, Yashoda Malgar Puttaiahgowda, Sanmit Shetty

“…Antimicrobial resistance is increasing, especially among bacteria that have acquired resistance to multiple therapeutics. To fully optimize and explore the polymer’s potential and its usage, more research is needed.…”
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Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism by Alice J. Kroker, John B. Bruning

“…In contrast, partial agonists of PPARγ have been shown to retain favourable insulin sensitizing effects while exhibiting little to no side effects and thus represent a new potential class of therapeutics for the treatment of T2DM. Partial agonists have been found to not only display differences in transcriptional and cellular outcomes, but also act through distinct structural and dynamic mechanisms within the ligand binding cavity compared to full agonists.…”
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A Holistic Digital Health Framework to Support Health Prevention Strategies in the First 1000 Days by Silvia Gabrielli, Oscar Mayora Ibarra, Stefano Forti

“…The framework provides recommendations for leveraging on behavioral intervention technology and digital therapeutics solutions augmented by artificial intelligence to support the effective deployment of health prevention programs to families. …”
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Interferon-based agents for current and future viral respiratory infections: A scoping literature review of human studies. by Aldina Mesic, Emahlea K Jackson, Mathias Lalika, David M Koelle, Rena C Patel

“…Here we review the comparative efficacy, safety/tolerability, and future potential of IFN-based therapeutics. We reviewed human studies in which IFN or IFN pathway-interacting agents were used for viral respiratory infections. …”
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Novel Method of Analysis for the Determination of Residual Formaldehyde by High-Performance Liquid Chromatography by Vittoria Delbono, Christopher P. Larch, Katrina Carol Newlands, Shona Rhydderch, Thomas Craven Baddeley, John Mervyn David Storey

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Adrenal Lymphangioma Masquerading as a Catecholamine Producing Tumor by Israel Hodish, Lindsay Schmidt, Andreas G. Moraitis

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The role of radiomics in dentistry and oral radiology by Tannishtha ., Shruthi Hegde, G. Subhas Babu, Vidya Ajila, B.S. Shama

“…Technological advances in healthcare sector have led to an increasing use of new digital techniques for diagnosis and therapeutics in medical and dental professions. Artificial intelligence (AI) is one of the most commonly discussed innovations of the present era that present the capability to transform clinical practice and research. …”
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A pivotal decade for bispecific antibodies? by Marlena Surowka, Christian Klein

“…Since the discovery of mAbs and their adoption as therapeutic agents in the 1980s and 1990s, the development of bsAbs has held substantial appeal. …”
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