In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney by Toshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito, Yukiko Kamiya, Hiroyuki Asanuma, Shoichi Maruyama

“…Nucleic acid medicine encompassing antisense oligonucleotides (ASOs) has garnered interest as a potential avenue for next-generation therapeutics. However, their therapeutic application has been constrained by challenges such as instability, off-target effects, delivery issues, and immunogenic responses. …”
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Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content by Haoxiang Zhu, Ling Xu, Yinhua Lv, Juan Yang, Jihan Huang, Qingshan Zheng, Guang Ji, Lujin Li

“…Background and Aims: This study aims to conduct a comprehensive quantitative analysis of various nonalcoholic fatty liver disease (NAFLD) therapeutics, utilizing magnetic resonance (MR)-detected liver fat content (LFC) as the efficacy endpoint, and to identify biomarkers correlated with changes in LFC based on published literature. …”
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Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis by Ming Yuan, Zhiwei Zhang, Gary Tse, Xiaojin Feng, Panagiotis Korantzopoulos, Konstantinos P. Letsas, Bryan P. Yan, William K. K. Wu, Huilai Zhang, Guangping Li, Tong Liu, Yunlong Xia

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Cost Savings in Chronic Pain Patients Initiating Peripheral Nerve Stimulation (PNS) with a 60-Day PNS Treatment by David M. Dickerson, Hemant Kalia, Kevin E. Vorenkamp, Konstantin V. Slavin, Jonathan M. Hagedorn, Candace Gunnarsson, Eric L. Keuffel, Andrew J. Epstein, Mark Stultz, Nathan D. Crosby

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Development and Validation of the Digital Sensitivity Scale for Adults: Cross-Sectional Observational Study by Hae In Park, Minjeong Jeon, Ji Seon Ahn, Kyungmi Chung, Jin Young Park

“…This scale can play a pivotal role in enhancing compliance with digital therapeutics by preemptively assessing individuals’ technological literacy and competency.…”
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Frequency and Molecular Characteristics of Mismatch Repair-deficient Status among Multiple Synchronous Colorectal Cancers by Kenichi Chikatani, Noriyasu Chika, Noriko Tanabe, Yoshiko Mori, Okihide Suzuki, Takatoshi Matsuyama, Keiichiro Ishibashi, Hidetaka Eguchi, Yasushi Okazaki, Tatsuro Yamaguchi, Hideyuki Ishida

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Health recommender systems to facilitate collaborative decision-making in chronic disease management: A scoping review by Antonia Barbaric, Kenneth Christofferson, Susanne M Benseler, Chitra Lalloo, Alex Mariakakis, Quynh Pham, Joost F Swart, Rae S M Yeung, Joseph A Cafazzo

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Molecular Crosstalking among Noncoding RNAs: A New Network Layer of Genome Regulation in Cancer by Marco Ragusa, Cristina Barbagallo, Duilia Brex, Angela Caponnetto, Matilde Cirnigliaro, Rosalia Battaglia, Davide Barbagallo, Cinzia Di Pietro, Michele Purrello

“…Moreover, the pivotal role of ncRNAs as keystones of network structural integrity makes them very attractive and promising targets for innovative RNA-based therapeutics. In this review we will discuss: (1) the current knowledge on complex crosstalk among ncRNAs, with a special focus on cancer; and (2) the main issues and criticisms concerning ncRNAs targeting in therapeutics.…”
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A comparison of Bartonella henselae infection in immunocompetent and immunocompromised mice. by Rebekah L Bullard, Mercedes Cheslock, Shiva Kumar Goud Gadila, Ricardo G Maggi, Edward B Breitschwerdt, Ahmad A Saied, Monica E Embers

“…These data indicate that SCID/Beige mice can provide a model to study Bartonella infection, therapeutics, and vector dynamics in the future.…”
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iMetaOmics: Advancing human and environmental health through integrated meta‐omics by Chun‐Lin Shi, Tong Chen, Canhui Lan, Ren‐You Gan, Jun Yu, Fangqing Zhao, Yong‐Xin Liu

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Milk-derived extracellular vesicles and gut health by Barathan Muttiah, Jia Xian Law

“…This review discusses the current understanding of milk-EVs’ effects on gut health, highlighting their potential therapeutic applications and future research directions. …”
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Nongenomic Mechanisms of PTEN Regulation by Jimmie E. Fata, Shawon Debnath, Edmund C. Jenkins, Marcia V. Fournier

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Bilateral choroid plexus resection in a 9p hexasomy/tetrasomy mosaic patient by Rei Takada, Takenori Tozawa, Takumi Yamanaka, Masaharu Moroto, Tomoko Iehara, Tomohiro Chiyonobu

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PPARγ and Its Role in Cardiovascular Diseases by Mini Chandra, Sumitra Miriyala, Manikandan Panchatcharam

“…Finally, we also review the new PPARγ agonists under development as potential therapeutics with reduced or no adverse effects.…”
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors by Fersing Cyril, Mathias Fanny

“…Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). …”
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Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions by Nadia Martinez-Martin

“…Further development and application of technologies for genome-wide identification of extracellular protein interactions will be important in deciphering functional host-pathogen interaction networks, laying the foundation for development of novel therapeutics.…”
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Unique Presentation and Management Approach of Pleural Solitary Fibrous Tumor by Tarek Aridi, Ayman Tawil, Mohamad Hashem, Joe Khoury, Roy A. Raad, Pierre Youssef

“…We report a case of a young female with a large, sessile, hypervascularized SFT of the pleura presenting with cardiopulmonary shock to a rural hospital with limited therapeutic interventions. We propose, in this case report, a unique multidisciplinary approach for the management of such a critical patient and the safe resection of the tumor.…”
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Lessons from Cancer Immunoediting in Cutaneous Melanoma by Mariana Aris, María Marcela Barrio, José Mordoh

“…And finally, we will propose a rational discussion of the progress made and the future challenges in the therapeutics of Cutaneous Melanoma, taking into consideration that tumor evolution is the resulting from a continuous feedback between tumor cells and their environment, and that different combinatorial therapeutic approaches can be implemented according to the tumor stage.…”
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AMPK-Dependent Metabolic Regulation by PPAR Agonists by Woo Hyung Lee, Sang Geon Kim

“…This intriguing action of PPAR agonists may account in part for the mechanistic basis of the therapeutics in the treatment of metabolic disease. In this paper, the effects of PPAR agonists on metabolic functions were summarized with particular reference to their AMPK activity regulation.…”
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Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation by Marcia L. Moss, Dmitry Minond

“…The field of ADAM metalloproteinases is at a crossroad with many of the new potential therapeutic agents for ADAM17 advancing into the clinic. …”
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