Peptide Design for Enhanced Anti-Melanogenesis: Optimizing Molecular Weight, Polarity, and Cyclization by Putri SA, Maharani R, Maksum IP, Siahaan TJ

“…Inhibition of tyrosinase particularly by blocking its active site and preventing the binding of natural substrates such as tyrosine, can reduce melanin production, making it a promising therapeutic target for treating hyperpigmentation. Peptides have emerged as promising therapeutics to regulate melanogenesis by minimizing the side effects associated with conventional skin whitening therapeutics. …”
Get full text

Effect of Advanced Glycation End Products on Human Thyroglobulin’s Antigenicity as Identified by the Use of Sera from Patients with Hashimoto’s Thyroiditis and Gestational Diabetes... by A. Hatzioannou, I. Kanistras, E. Mantzou, E. Anastasiou, M. Peppa, V. Sarantopoulou, P. Lymberi, M. Alevizaki

Get full text

Trend of Representation of Women in Gastroenterology, Hepatology, and Endoscopy Conferences in Asia by Jalpa Devi, Tanyaporn Chantarojanasiri, Dao Viet Hang, Rashid Lui, Raja Affendi Raja Ali, Amna Subhan Butt, Rohan Raja, Trinh To Tram, Ting Ting Chan, Women in GI Focus Group, Emerging Leaders Committee, Asian Pacific Association of Gastroenterology

Get full text

Role of Nanomedicine and Nanotechnology in Dentistry – A Narrative Review by Richa Singh, M Sathya Kumar, K T Magesh, Nivedidha Manohar, Aravindhan Ravi, A Sivachandran

“…By utilizing nanoparticles and nanostructures, scientists and researchers are able to enhance the efficacy and specificity of therapeutics, improve diagnostic capabilities, and revolutionize healthcare. …”
Get full text

Editorial Expression of Concern: Addressing cancer care inequities in sub‑Saharan Africa: current challenges and proposed solutions by Olabode Omotoso, John Oluwafemi Teibo, Festus Adebayo Atiba, Tolulope Oladimeji, Oluwatomiwa Kehinde Paimo, Farid S. Ataya, Gaber El‑Saber Batiha, Athanasios Alexiou

Get full text

The Enteric Nervous System in Inflammation and Pain: The Role of Proteinase-Activated Receptors by Nathalie Vergnolle

“…Thus, PARs, together with the proteinases that activate them, represent exciting new targets for therapeutic intervention on the ENS.…”
Get full text

A + AVD for Treatment of Hodgkin Lymphoma Variant of Richter’s Transformation by Benjamin Heyman, Michael Choi, Thomas J. Kipps

Get full text

Cannabinoids for the Treatment of Pain: An Update on Recent Clinical Trials by Mark Ware, Pierre Beaulieu

“…Cannabinoid products are becoming available for research and clinical use, and pharmaceutical industry interest in the potential for cannabinoids in therapeutics is also gaining momentum. The present article summarizes recent clinical trial data in the field of pain management and suggests that the potential for cannabinoid therapy for chronic pain states is encouraging. …”
Get full text

Basic Biology and Clinical Application of Multipotent Mesenchymal Stromal Cells: From Bench to Bedside by Selim Kuçi, Reinhard Henschler, Ingo Müller, Ettore Biagi, Roland Meisel

Get full text

Insights into Viral Zoonotic Diseases: COVID-19 and Monkeypox by Alysha Kaur Sachdev, Vengadesh Letchumanan

“…This sequence of events also prompts us to scrutinize the effectiveness of existing therapeutic options, the progress of vaccines, and monitoring procedures within the healthcare sector. …”
Get full text

Mini Review of Biochemical Basis, Diagnosis and Management of Crush Syndrome by Abdulhalim Hamlah, Abd Alraouf Tarabishy, Haitham Al-Madhagi

“…In addition, diagnosis and management and the application of novel experimental therapeutics of CS are also highlighted. …”
Get full text

Mesenchymal Stem Cell Biodistribution, Migration, and Homing In Vivo by Weian Zhao, Donald G. Phinney, Dominique Bonnet, Massimo Dominici, Mauro Krampera

Get full text

A gut instinct for childhood leukemia prevention: microbiome-targeting recommendations aimed at parents and caregivers by Ersen Kameri, Ersen Kameri, Ersen Kameri, Vera Helena Jepsen, Pawel Stachura, Pawel Stachura, Nadine Rüchel, Rigveda Bhave, Leticia Benitez, Fatima Crispi, Eduard Gratacos, Nico Dragano, Stefan Janssen, Arndt Borkhardt, Arndt Borkhardt, Aleksandra Pandyra, Aleksandra Pandyra, Aleksandra Pandyra, Gesine Kögler, Gesine Kögler, Ute Fischer, Ute Fischer, Ute Fischer

Get full text

Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong by Reena Rajasuriar, Syaza Hisham, John Son Lim, Jean Yi Cheong, Wen Ying Ho, Siew Hwei Yap, Nurul Syuhada Zulhaimi, Malinee Neelamegam, Catherine Cheung, Vivian Wong, Ruhana Che Yusof, Kejal Hasmukharay, Shahrul Bahyah Kamaruzzaman, Sharifah Faridah Syed Omar, Meng Li Chong, Pui Li Wong, Grace Chung‐Yan Lui

Get full text

Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment by Takayasu Nishimaki, MD, Hitoshi Sasano, MD, PhD, Sonoko Harada, PhD, Tomohito Takeshige, MD, PhD, Yuuki Sandhu, MD, PhD, Yuki Tanabe, MD, Kei Matsuno, MD, PhD, Tetsutaro Nagaoka, MD, PhD, Jun Ito, MD, PhD, Ryo Atsuta, MD, PhD, Mayu Ohuchi, PhD, Shigehiro Yagishita, MD, PhD, Akinobu Hamada, PhD, Kazuhisa Takahashi, MD, PhD, Norihiro Harada, MD, PhD

Get full text

First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

Get full text

Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility by Vianne R. Gao, Rui Yang, Arnav Das, Renhe Luo, Hanzhi Luo, Dylan R. McNally, Ioannis Karagiannidis, Martin A. Rivas, Zhong-Min Wang, Darko Barisic, Alireza Karbalayghareh, Wilfred Wong, Yingqian A. Zhan, Christopher R. Chin, William S. Noble, Jeff A. Bilmes, Effie Apostolou, Michael G. Kharas, Wendy Béguelin, Aaron D. Viny, Danwei Huangfu, Alexander Y. Rudensky, Ari M. Melnick, Christina S. Leslie

Get full text

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy by Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li

“…Here, we summarize and analyze the role of the S1P signaling pathway in epilepsy, provide a basis for finding potential therapeutic targets and/or epileptogenic biomarkers, analyze the reasons for these controversies, and put forward our opinions. …”
Get full text

Spleen tyrosine kinase inhibitors disrupt human neutrophil swarming and antifungal functions by Alex Hopke, Adam L. Viens, Natalie J. Alexander, Seok Joon Mun, Michael K. Mansour, Daniel Irimia

“…These findings advance our understanding of swarming biology in humans while laying the foundation for developing therapeutics that enhance neutrophil function during immunosuppression.…”
Get full text

Sodium-Glucose Cotransporter-2 (SGLT-2) Attenuates Serum Uric Acid (SUA) Level in Patients with Type 2 Diabetes by Mazhar Hussain, Asim Elahi, Abid Hussain, Javed Iqbal, Lubna Akhtar, Abdul Majid

Get full text