Nonpharmacologic Interventions in Prevention and Treatment of Hypertension by Omotayo O. Erejuwa, Siew Hua Gan, Andrea M. P. Romani, Mohammad A. Kamal, Srinivas Nammi

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Standards of Care in Diabetes-2025 by P.S. Shankar, M V Jali

“…By integrating the latest advancements in research therapeutics and technology the ADA has provided a succinct comprehensive roadmap to the management of diabetic patients.…”
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Chronic obstructive pulmonary disease from the perspective of medicine based on evidence. by Gerardo Rivero González, Rolando Delgado Figueredo, Iris González Morales

“…This article made on bibliographical revision shows the main therapeutics pharmacological and non pharmacological options used in case of an acute decompensation of this disease based on the main available evidences. …”
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Atrial Fibrillation: Mechanisms and Management by Tong Liu, Gary Tse, Lilei Yu, Panagiotis Korantzopoulos, Konstantinos P. Letsas

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MicroRNAs unveiled: Nobel recognition of a revolutionary gene regulation mechanism by Junchao Xue, Gangming Zhang, Enzhi Shen

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Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons by Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough

“…Conclusions: Activation of the TRPM3/CaMKKβ/AMPK pathway promoted collateral sprouting of sensory axons, positioning TRPM3 as a promising therapeutic target for peripheral neuropathy.…”
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The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…Thus, our data identifies a novel pathway that promotes DA-neuron degeneration and suggests a potential therapeutic intervention for PD targeting the tPA-NMDAR1 interaction.…”
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Molecular Mechanisms of Memory Consolidation, Reconsolidation, and Persistence by Emiliano Merlo, Pedro Bekinschtein, Sietse Jonkman, Jorge H. Medina

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Inaudible airborne ultrasound affects emotional states in the olfactory bulbectomized rat depression model by Tsugumi Yamauchi, Kou Takahashi, Toshinori Yoshioka, Daisuke Yamada, Yoshio Nakano, Satoka Kasai, Satoshi Iriyama, Kazumi Yoshizawa, Shoichi Nishino, Satoru Miyazaki, Akiyoshi Saitoh

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Cognitive-Behavioral Therapists’ Experience on Relevance of Sleep and Sleep Disorders in Training and Clinical Practice: A Survey Study from Italy by Chiara Baglioni, Andrea Galbiati, Debora Meneo, Greta Cavadini, Francesca Gelfo, Francesco Mancini, Carlo Buonanno

“…The less familiar therapeutics were those for pediatric insomnia. Conclusions: The results of this study highlight scarce knowledge and consideration of sleep problems in CBT practice in Italy. …”
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TMEM147 Correlates with Immune Infiltration and Serve as a Potential Prognostic Biomarker in Hepatocellular Carcinoma by Sheng Cheng, Jutang Li, Ming Xu, Qun Bao, Jiaoxiang Wu, Peng Sun, Bo Han

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Enhancing Patient-Centric Drug Development: Coupling Hot Melt Extrusion with Fused Deposition Modeling and Pressure-Assisted Microsyringe Additive Manufacturing Platforms with Qual... by Dinesh Nyavanandi, Preethi Mandati, Nithin Vidiyala, Prashanth Parupathi, Praveen Kolimi, Hemanth Kumar Mamidi

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Advancing Alzheimer's Therapy: Computational strategies and treatment innovations by Jibon Kumar Paul, Abbeha Malik, Mahir Azmal, Tooba Gulzar, Muhammad Talal Rahim Afghan, Omar Faruk Talukder, Samar Shahzadi, Ajit Ghosh

“…Despite extensive research efforts, conventional treatment strategies primarily focus on symptom management, highlighting the need for innovative therapeutic approaches. This review explores the challenges of AD treatment and the integration of computational methodologies to advance therapeutic interventions. …”
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Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review by Yuriko Sasaki, Maki Kanzawa, Masaaki Yamamoto, Keitaro Kanie, Hironori Bando, Kei Yoshino, Yushi Hirota, Katsumi Shigemura, Masato Fujisawa, Wataru Ogawa, Hidenori Fukuoka

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The potential of stem cell therapy in Multiple Sclerosis treatment: a review by Sorina Amarculesei, Ava O'Meara Cushen, Cathy Brougham

“…This review reports stem cell-based therapies as potential therapeutic approaches in the treatment and management of Multiple Sclerosis. …”
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Lipid-Derived Mediators in Endogenous Anti-Inflammation and Resolution: Lipoxins and Aspirin-Triggered 15-epi-Lipoxins by Charles N. Serhan, Nan Chiang

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A Narrative Review of Prognostic Gene Signatures in Oral Squamous Cell Carcinoma Using LASSO Cox Regression by Nur Fatinazwa Mohd Faizal, Saptarsi Shai, Bansi P. Savaliya, Lee Peng Karen-Ng, Rupa Kumari, Rahul Kumar, Vui King Vincent-Chong

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Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

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Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM by Agalya Periasamy, Pamela Ornelas, Thomas Bausewein, Naomi Mitchell, Jiamin Zhao, Leonie M. Quinn, Werner Kuehlbrandt, Jacqueline M. Gulbis

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Unravelling the TCRβ repertoire: a key to unlocking the immunopathogenesis and precision medicine in SLE by Qiao Zhou, Li Zeng, Zhixin Zhang, Jian Liu, Yichen Zhang, Yang An, Lijing Yang, Tianzuo Lan, Pengming He, Xueping Wen, Shaoping Deng

“…Furthermore, we observed a reduction in TCR diversity, characterised by a lower diversity 50 value and increased clonal expansion, which correlated with disease severity.Conclusions The TCRβ repertoire is significantly altered in SLE, with potential implications for diagnostics and therapeutics. The identified hub genes may serve as novel biomarkers for SLE, and the findings contribute to the understanding of the immunopathogenesis of the disease.…”
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