Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis by Fatemeh B. Rassouli, Maryam M. Matin, Maryam M. Matin, Farzin Hadizadeh, Farzin Hadizadeh, Masoud Nejabat, Hossein Allahverdizadeh, Hamidreza Jamali, Shahin Gharedaghi, Halimeh Hassanzadeh

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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…In addition, possible future directions of this therapeutic approach are discussed.…”
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High-resolution fleezers reveal duplex opening and stepwise assembly by an oligomer of the DEAD-box helicase Ded1p by Eric M. Patrick, Rajeev Yadav, Kasun Senanayake, Kyle Cotter, Andrea A. Putnam, Eckhard Jankowsky, Matthew J. Comstock

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Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity by Dwaine F. Emerich, Jeffrey H. Kordower, Yaping Chu, Chris Thanos, Briannan Bintz, Giovanna Paolone, Lars U. Wahlberg

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Role of Artificial Intelligence in Oral Cancer by Vidhya Rekha Umapathy, Prabhu Manickam Natarajan, Bhuminathan Swamikannu, Sabarinathan Jaganathan, Suba Rajinikanth, Vijayalakshmi Periyasamy

“…Traditional diagnostic modalities, reliant on biopsy and histopathological methods, they all often exhibit constraints in expeditiousness and subjectivity, thus an alternative methodologies are needed for fostering early detection and personalized therapeutic strategies. Artificial intelligence (AI) emerges as a forefront avenue in oral cancer (OC) therapeutics, engaged in providing solutions for diagnostic augmentation, treatment optimization, and prognostic delineation. …”
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Inhibition of IAPP Aggregation and Toxicity by Natural Products and Derivatives by Amit Pithadia, Jeffrey R. Brender, Carol A. Fierke, Ayyalusamy Ramamoorthy

“…These abundantly found agents have been long used to combat diseases for many years and may serve as useful templates toward developing therapeutics against hIAPP aggregation and toxicity.…”
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Stable Long-Term Culture of Human Distal Airway Stem Cells for Transplantation by Yueqing Zhou, Yujia Wang, Dandan Li, Ting Zhang, Yu Ma, Wei Zuo

“…Taken together, the results suggested that DASC transplantation could be a promising therapeutic approach for unmet needs in respiratory medicine including the COVID-19-related diseases.…”
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Cholesterol Induces Uneven Curvature of Asymmetric Lipid Bilayers by S. O. Yesylevskyy, A. P. Demchenko, S. Kraszewski, C. Ramseyer

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Quantitative Multiparameter Evaluation of Vacuoles in Intraocular Lenses Employing a High-Magnification Digital Microscopy Method by Vincent Spiezio, Bennett N. Walker, Don Calogero, Ilko K. Ilev

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Nitric Oxide and Prostaglandins Potentiate the Liver Regeneration Cascade by Jodi M Schoen Smith, W Wayne Lautt

“…To extend this research, the hypothesis that NO and PGs are potential therapeutic targets to potentiate the liver regeneration cascade is tested. …”
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With great power, comes great responsibility: the importance of broadly measuring Fc-mediated effector function early in the antibody development process by Silvia Crescioli, Shashi Jatiani, Lenny Moise

“…The field of antibody therapeutics is rapidly growing, with over 210 antibodies currently approved or in regulatory review and ~ 1,250 antibodies in clinical development. …”
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Sound Richness of Music Might Be Mediated by Color Perception: A PET Study by Masayuki Satoh, Ken Nagata, Hidekazu Tomimoto

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Predictive Biomarkers of Bacillus Calmette-Guérin Immunotherapy Response in Bladder Cancer: Where Are We Now? by Luís Lima, Mário Dinis-Ribeiro, Adhemar Longatto-Filho, Lúcio Santos

“…The most effective therapeutic option for managing nonmuscle invasive bladder cancer (NMIBC), over the last 30 years, consists of intravesical instillations with the attenuated strain Bacillus Calmette-Guérin (the BCG vaccine). …”
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Editorial: Enhancing innate immunity in combination therapy for solid tumors by David Pejoski, David Pejoski, David Pejoski

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Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults by Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe, Yuki Azetsu, Eiji Funayama, Yuki Maruyama, Toshiaki Tsurui, Kohei Tajima, Aya Sasaki, Yoshitaka Yamazaki, Ryota Nakano, Yutaka Sano, Atsushi Ishida, Tatsuya Nakanishi, Seiji Mochizuki, Yuri Yoshizawa, Sumito Kumagai, Sakiko Yasuhara, Kakei Ryu, Tatsunori Oguchi, Atsuo Kuramasu, Kiyoshi Yoshimura, Takehiko Sambe, Sei Kobayashi, Naoki Uchida

“…Future studies should focus on ABCC11 gene polymorphisms to elucidate the pathogenesis of ear diseases and develop therapeutic methods.…”
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Nature-inspired and medicinally relevant short peptides by Maria G. Ciulla, Monica Civera, Sara Sattin, Kamal Kumar

“…However, the real challenge for in vivo application of therapeutic peptides is to overcome their low plasma availability and their fast enzymatic degradation. …”
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Targeting Herpetic Keratitis by Gene Therapy by Hossein Mostafa Elbadawy, Marine Gailledrat, Carole Desseaux, Diego Ponzin, Stefano Ferrari

“…Recurrence of the disease is likely and cornea transplantation, therefore, might not be the ideal therapeutic solution. This paper will focus on the current situation of ocular gene therapy research against herpetic keratitis, including the use of viral and nonviral vectors, routes of delivery of therapeutic genes, new techniques, and key research strategies. …”
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External low energy electromagnetic fields affect heart dynamics: surrogate for system synchronization, chaos control and cancer patient’s health by Frederico P. Costa, Jack Tuszynski, Antonio F. Iemma, Willian A. Trevizan, Bertram Wiedenmann, Eckehard Schöll

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Progress in Therapy Development for Amyotrophic Lateral Sclerosis by Kalina Venkova-Hristova, Alexandar Christov, Zarine Kamaluddin, Peter Kobalka, Kenneth Hensley

“…This review will discuss experimental therapeutics that have been tested in murine ALS models, with an emphasis on those that have progressed to human clinical trials. …”
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The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung by Matthew S. Twigg, Simon Brockbank, Philip Lowry, S. Peter FitzGerald, Clifford Taggart, Sinéad Weldon

“…To restore this balance antiproteases have been suggested as potential therapeutics or therapeutic targets. As such a number of both endogenous and synthetic antiproteases have been trialed with mixed success as therapeutics for CF lung disease.…”
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