Suggested Topics within your search.
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41
Tacrolimus Toxicity due to Biliary Obstruction in a Combined Kidney and Liver Transplant Recipient
Published 2017-01-01“…The immunosuppressant tacrolimus has a narrow therapeutic window, necessitating therapeutic drug monitoring to maintain efficacy and minimise toxicity. …”
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42
Clinical Biochemistry /
Published 2017Table of Contents: “…Biochemical investigations and quality control / David Cameron -- Automation / Tim James -- Kidney disease / Edmund Lamb -- Hyperuricaemia and gout / Joanne Marsden -- Fluid and electrolyte disorders / Tim James -- Acid-base disorders / David Tierney -- Clinical enzymology and biomarkers / Paul Collinson, Amy Lloyd -- Liver function tests / Roy Sherwood -- Abnormalities of lipid metabolism / Mike France -- Disorders of calcium, phosphate, and magnesium homeostasis / Nessar Ahmed -- Abnormal pituitary function ; Thyroid disease / Garry McDowell -- Diabetes mellitus and hypoglycaemia / Allen Yates, Ian Laing -- Adrenal disease / John Honour -- Reproductive endocrinology / Ian Laing, Julie Thornton -- Biochemical nutrition / Pat Twomey, William Simpson -- Gastrointestinal disorders and malabsorption / Garry McDowell, Gordon Brydon -- Specific protein markers / Gerald Maguire -- Cancer biochemistry and tumour markers / Joanne Adaway, Gilbert Wieringa -- Inherited metabolic disorders and newborn screening / Mary Anne Preece -- Therapeutic drug monitoring / Robin Whelpton, Nigel Brown, Robert Flanagan -- Chemical toxicology / Gwendolen Ayers.…”
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43
Clinical Biochemistry ; fundamentals of biomedical science /
Published 2017Table of Contents: “…Biochemical investigations and quality control / David Cameron -- Automation / Tim James -- Kidney disease / Edmund Lamb -- Hyperuricaemia and gout / Joanne Marsden -- Fluid and electrolyte disorders / Tim James -- Acid-base disorders / David Tierney -- Clinical enzymology and biomarkers / Paul Collinson, Amy Lloyd -- Liver function tests / Roy Sherwood -- Abnormalities of lipid metabolism / Mike France -- Disorders of calcium, phosphate, and magnesium homeostasis / Nessar Ahmed -- Abnormal pituitary function ; Thyroid disease / Garry McDowell -- Diabetes mellitus and hypoglycaemia / Allen Yates, Ian Laing -- Adrenal disease / John Honour -- Reproductive endocrinology / Ian Laing, Julie Thornton -- Biochemical nutrition / Pat Twomey, William Simpson -- Gastrointestinal disorders and malabsorption / Garry McDowell, Gordon Brydon -- Specific protein markers / Gerald Maguire -- Cancer biochemistry and tumour markers / Joanne Adaway, Gilbert Wieringa -- Inherited metabolic disorders and newborn screening / Mary Anne Preece -- Therapeutic drug monitoring / Robin Whelpton, Nigel Brown, Robert Flanagan -- Chemical toxicology / Gwendolen Ayers.…”
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44
Linezolid and tedizolid adverse effects: a review on serotonin syndrome, myelosuppression, neuropathies, and lactic acidosis
Published 2025-01-01“…Mitigation strategies, including the role of therapeutic drug monitoring, are also discussed.…”
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45
A Validated HPLC-DAD Method for Simultaneous Determination of Etodolac and Pantoprazole in Rat Plasma
Published 2014-01-01“…A simple, sensitive, and accurate HPLC-DAD method has been developed and validated for the simultaneous determination of pantoprazole and etodolac in rat plasma as a tool for therapeutic drug monitoring. Optimal chromatographic separation of the analytes was achieved on a Waters Symmetry C18 column using a mobile phase that consisted of phosphate buffer pH~4.0 as eluent A and acetonitrile as eluent B in a ratio of A : B, 55 : 45 v/v for 6 min, pumped isocratically at a flow rate of 0.8 mL min−1. …”
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46
Chromatographic Characterization and Method Development for Determination of Levetiracetam in Saliva: Application to Correlation with Plasma Levels
Published 2017-01-01“…A less invasive sampling method for therapeutic drug monitoring (TDM) would be very useful particularly for children. …”
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47
Validation of Simultaneous Quantitative Method of HIV Protease Inhibitors Atazanavir, Darunavir and Ritonavir in Human Plasma by UPLC-MS/MS
Published 2014-01-01“…The validated method can be useful in determining plasma concentration of these protease inhibitors for therapeutic drug monitoring and in high throughput clinical studies.…”
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48
Development and Validation of the Quantification Method for Hydroxychloroquine in Volumetric Absorptive Microsampling (VAMS) Using High-Performance Liquid Chromatography-Photodiode...
Published 2021-01-01“…Therefore, therapeutic drug monitoring of high dose or long-term use of hydroxychloroquine is needed. …”
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49
Fast and Simple LC-MS/MS Method for Rifampicin Quantification in Human Plasma
Published 2019-01-01“…The proposed method was successfully applied to rifampicin quantification in 340 patients’ plasma samples, thus demonstrating its suitability for both therapeutic drug monitoring and pharmacokinetic analysis.…”
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50
Conductive Composite Biosensor System for Electrochemical Indinavir Drug Detection
Published 2015-01-01“…Multidrug combination therapy and, as such, therapeutic drug monitoring (TDM) during HIV/AIDS treatment are therefore critical, to prevent adverse interactions. …”
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51
Plasma Concentrations of Benzylpenicillin and Cloxacillin in Infective Endocarditis—With Special Reference to Delayed Hypersensitivity Reactions
Published 2025-01-01“…Dose adjustments guided by therapeutic drug monitoring (TDM) could mitigate these risks while maintaining treatment efficacy. …”
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52
Development and Application of a LC-MS/MS Method for Simultaneous Quantification of Four First-Line Antituberculosis Drugs in Human Serum
Published 2020-01-01“…This method was successfully applied to the quantification of four first-line antituberculosis (anti-TB) drugs, suggesting its suitability for therapeutic drug monitoring in the clinical practices.…”
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53
Usefulness of a TDM-Guided Approach for Optimizing Teicoplanin Exposure in the Treatment of Secondary Bloodstream Infections Caused by Glycopeptide-Susceptible <i>Enterococcus faec...
Published 2025-01-01“…To assess the clinical usefulness of teicoplanin optimized by means of a therapeutic drug monitoring (TDM)-guided approach for treating secondary bloodstream infections (BSIs) caused by <i>Enterococcus faecium</i>. …”
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54
Predicting the exposure of mycophenolic acid in children with autoimmune diseases using a limited sampling strategy: A retrospective study
Published 2025-01-01“…Abstract Mycophenolic acid (MPA) is commonly used to treat autoimmune diseases in children, and therapeutic drug monitoring is recommended to ensure adequate drug exposure. …”
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55
Risk Prediction of Liver Injury in Pediatric Tuberculosis Treatment: Development of an Automated Machine Learning Model
Published 2025-01-01“…This study aims to develop an automatic machine learning (AutoML) model for predicting the risk of anti-tuberculosis drug-induced liver injury (ATB-DILI) in children.Methods: A retrospective study was performed on the clinical data and therapeutic drug monitoring (TDM) results of children initially treated for tuberculosis at the affiliated Changsha Central Hospital of University of South China. …”
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56
Innovative MOF-enhanced electroanalytical approach for sensitive sunitinib malate detection in renal carcinoma patients using CuO/lanthanum MOF-modified carbon paste electrode
Published 2025-08-01“…Moreover, the proposed methodology via modification of CPE with the synthesized MOFs tailors them to be applied for clinical analysis and therapeutic drug monitoring of SUN, providing a valuable tool for personalized medicine and improving the treatment outcomes for renal cancer patients.…”
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57
Biosimilars in Focus: Evaluating Their Role Compared to Adalimumab in Clinical Practice
Published 2025-01-01“…Key studies on pharmacokinetics, efficacy, safety, therapeutic drug monitoring (TDM), and real-world outcomes were analyzed. …”
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58
Involvement of HLADQA1*05 in Patients with Inflammatory Bowel Disease Treated with Anti-TNF Drugs
Published 2025-01-01“…<i>Methods</i>: Sixty-five paediatric IBD patients were enrolled, with therapeutic drug monitoring (TDM) of IFX and ADA, conducted using immunoenzymatic assays. …”
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59
Tacrolimus- and Mycophenolate-Mediated Toxicity: Clinical Considerations and Options in Management of Post-Transplant Patients
Published 2024-12-01“…Mycophenolate, a reversible inhibitor of inosine monophosphate dehydrogenase, frequently causes gastrointestinal disturbances, including diarrhea and colitis, as well as hematologic side effects like anemia and leukopenia, which increase infection risk. Therapeutic drug monitoring (TDM) and pharmacogenomics have emerged as essential strategies for mitigating these toxicities. …”
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60
Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients
Published 2024-04-01“…It is characterised by a narrow therapeutic index and wide interpatient variability, necessitating therapeutic drug monitoring of whole-blood concentrations. Pharmacogenetic research, although not representative of SA population groups, suggests that single-nucleotide polymorphisms within the cytochrome P450 3A5 (CYP3A5) gene contribute to the variability in tacrolimus dosing requirements. …”
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