Corticostriatal glutamate‐mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model by Xinxin Jiang, Min Sun, Yitong Yan, Yanhua Wang, Xinyu Fan, Jing Wei, Ke Wang, Peirong Liang, Zirui Wang, Jihan Wang, Xiaomin Wang, Jun Jia

“…Targeting glutamatergic neurons with EA holds promise as a non‐dopaminergic intervention for managing motor symptoms and abnormal neural activity with PD. Key points EA commonly protects dopaminergic neuronsby reducing neuroinflammation, oxidative stress, and apoptosis. …”
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miR-9-5p/HMMR regulates the tumorigenesis and progression of clear cell renal cell carcinoma through EMT and JAK1/STAT1 signaling pathway by Xinyang Niu, Dingheng Lu, Weitao Zhan, Jiazhu Sun, Yuxiao Li, Yuchen Shi, Kai Yu, Suyuelin Huang, Xueyou Ma, Xiaoyan Liu, Ben Liu

“…Abstract Background The most common malignant type of kidney cancer is clear cell renal cell carcinoma (ccRCC). …”
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Efficacy of carbonyl cyanide-3-chlorophenylhydrazone in combination with antibiotics against Mycobacterium abscessus by Jifang Zheng, Qiang Liu, Haoran Wang, Fengmin Huo, Junnan Jia, Hairong Huang, Suting Chen

“…This study aimed to determine its synergistic antimicrobial effects when combined with commonly used antibiotics. The M. abscessus reference strain and 39 clinical isolates were collected. …”
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The microbiota of cork and yellow stain as a model for a new route for the synthesis of chlorophenols and chloroanisoles from the microbial degradation of suberin and/or lignin by Marina Ruiz-Muñoz, Ignacio Ontañón, Rebeca Cobos, Carla Calvo-Peña, Rebeca Otero-Suárez, Vicente Ferreira, Jordi Roselló, Juan José R. Coque

“…Phenol could be efficiently chlorinated in vitro to produce 2,4,6-trichlorophenol by a fungal chloroperoxidase, an enzymatic activity commonly found in filamentous fungi isolated from cork. …”
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Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…ObjectiveIntracerebral hemorrhage (ICH) is a common cerebrovascular disease characterized by high mortality and disability rates. …”
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Clinical characteristics and outcomes of patients with chondroblastoma undergoing surgery with various adjuvant procedures: a retrospective study of 59 cases by Toru Hirozane, Tetsuya Sekita, Eisuke Kobayashi, Tomoaki Mori, Naofumi Asano, Toru Udaka, Takashi Tajima, Rumi Nakagawa, Kazutaka Kikuta, Akira Yoshiyama, Hideo Morioka, Itsuo Watanabe, Ukei Anazawa, Michiro Susa, Keisuke Horiuchi, Yoshihisa Suzuki, Takeshi Morii, Robert Nakayama

“…Methods This retrospective study examined 59 patients followed up at our hospitals for ≥ 1 year after surgery during 1990–2020. The most common lesion site was the epiphyses of long bones (42 cases, 71%), including the femur, tibia, and humerus. …”
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Restorative Neurostimulation Therapy Compared to Optimal Medical Management: A Randomized Evaluation (RESTORE) for the Treatment of Chronic Mechanical Low Back Pain due to Multifid... by Frank Schwab, Nagy Mekhail, Kiran V. Patel, Meredith Langhorst, Robert D. Heros, Jonathan Gentile, Sherif Costandi, Gregory Moore, Christopher Gilmore, Smith Manion, Krishnan Chakravarthy, S. Craig Meyer, Justin V. Bundy, Jordan L. Tate, Rebecca Sanders, Sandeep Vaid, Oszkar Szentirmai, Johnathan Goree, Vikas V. Patel, Jeff Lehmen, Mehul J. Desai, Jason E. Pope, Anthony Giuffrida, Salim Hayek, Sohrab Singh Virk, Richard Paicius, William R. Klemme, Robert Levy, Christopher Gilligan, the RESTORE investigators

“…Abstract Introduction Many interventional strategies are commonly used to treat chronic low back pain (CLBP), though few are specifically intended to target the distinct underlying pathomechanisms causing low back pain. …”
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Identification and validation of a novel autoantibody biomarker panel for differential diagnosis of pancreatic ductal adenocarcinoma by Metoboroghene O. Mowoe, Metoboroghene O. Mowoe, Hisham Allam, Joshua Nqada, Marc Bernon, Karan Gandhi, Sean Burmeister, Urda Kotze, Miriam Kahn, Christo Kloppers, Suba Dharshanan, Zafirah Azween, Pamela Maimela, Paul Townsend, Eduard Jonas, Jonathan M. Blackburn, Jonathan M. Blackburn

“…Autoantibodies (AAbs) in principle make attractive biomarkers as they arise early in disease, report on disease-associated perturbations in cellular proteomes, and are static in response to other common stimuli, yet are measurable in the periphery, potentially well in advance of the onset of clinical symptoms.MethodsHere, we used high-throughput, custom cancer antigen microarrays to identify a clinically relevant autoantibody biomarker combination able to differentially detect PDAC. …”
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High-throughput methylation sequencing reveals novel biomarkers for the early detection of renal cell carcinoma by Wenhao Guo, Weiwu Chen, Jie Zhang, Mingzhe Li, Hongyuan Huang, Qian Wang, Xiaoyi Fei, Jian Huang, Tongning Zheng, Haobo Fan, Yunfei Wang, Hongcang Gu, Guoqing Ding, Yicheng Chen

“…Abstract Purpose Renal cell carcinoma (RCC) is a common malignancy, with patients frequently diagnosed at an advanced stage due to the absence of sufficiently sensitive detection technologies, significantly compromising patient survival and quality of life. …”
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Fractionated robotic radiosurgery for unfavorable nonfunctioning pituitary macroadenoma: 5-year outcomes from a single institution protocol by Akrita Bhatnagar, Monica Pernia Marin, Jonathan W. Lischalk, Min Ji Koh, Siviero Agazzi, Simeng Suy, Brent T. Harris, Susmeeta T. Sharma, Edward Aulisi, Amjad Anaizi, Mohamed H. Khattab, Walter C. Jean, Walter C. Jean, Sean P. Collins, Brian T. Collins

“…ObjectiveNonfunctioning macroadenoma is a commonly diagnosed pituitary tumor. Resection is the favored treatment, with radiosurgery often utilized for residual or progressing disease. …”
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Social-ecological perspective on the suicidal behaviour factors of early adolescents in China: a network analysis by Xueying Zhang, Yuan Li, Juan Chen, Peiying Li, Mengyuan Yuan, Yonghan Li, Gengfu Wang, Puyu Su

“…Firstly, this study highlighted the importance of joint interventions across multiple departments. Secondly, the common risk factors of suicidal ideation, plans and attempts were elucidated. …”
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Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy by Francesco Bruno, Francesco Bruno, Patrizia Spadafora, Ida Veltri, Mario L. Cuconati, Francesca Condino, Annamaria Cerantonio, Selene De Benedittis, Beatrice M. Greco, Beatrice M. Greco, Gemma Di Palma, Olivier Gallo, Luigi Citrigno, Antonio Qualtieri, Maurizio Cundari, Maurizio Cundari, Maurizio Cundari, Francesca Cavalcanti

“…IntroductionTemporal lobe epilepsy is the most common form of focal epilepsy, often associated with cognitive impairments, particularly in memory functions, and depression. …”
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The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis by Denise Vianna Machado Ayres, Sabrina Saemy Tome Uchiyama, Andréa Oliveira Prates, Rosana Aparecida Freitas Lopes, Antenor Bispo Santos Silva, Denise Rodrigues Tsukimoto, Rosimeire Alves Amorim, Taynah Souza Ribeiro, Artur Cesar Aquino Santos, André Tadeu Sugawara, André Tadeu Sugawara, Marcos Montagnini, Linamara Rizzo Battistella, Linamara Rizzo Battistella, Marta Imamura, Marta Imamura

“…BackgroundKnee osteoarthritis (KOA) is the most common form of arthritis in adults and a leading cause of years lived with disability, representing a significant burden on healthcare worldwide.ObjectiveDescribe the structure and educational elements of the Knee-SCHOOL, a brief patient-centered multidisciplinary educational program for patients with KOA.DesignObservational prospective study.SettingAcademically affiliated rehabilitation outpatient center in Brazil.MethodsThe program consisted of three in-person educational sessions (4.5 hr each) for 55 community dwelling adults, aged ≥50 years, with primary KOA-related pain. …”
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Influence of cervical muscle strength and pain severity on functional balance and limits of stability in elderly individuals with chronic nonspecific neck pain: a cross-sectional s... by Shaker Hassan S. Alshehri, Ravi Shankar Reddy, Mohammad A. ALMohiza, Mastour Saeed Alshahrani, Batool Abdulelah Alkhamis, Hani Hassan Alnakhli, Ghada Mohammed Koura, Ajay Prashad Gautam, Debjani Mukherjee, Raee S. Alqhtani, Saeed Y. Al Adal, Abdullah Mohammed Alyami, Faisal M. Alyazedi

“…Abstract Background Chronic nonspecific neck pain (CNSNP) is a common musculoskeletal disorder, particularly in the elderly, leading to reduced cervical muscle strength, impaired functional balance, and decreased postural stability. …”
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Mark loss can strongly bias estimates of demographic rates in multi-state models: a case study with simulated and empirical datasets by Touzalin, Frédéric, Petit, Eric J., Cam, Emmanuelle, Stagier, Claire, Teeling, Emma C., Puechmaille, Sébastien J.

“…To fill this knowledge gap, we employed a wide range of simulation scenarios that reflect commonly encountered real case studies, drawing inspiration from the survival rates of 700 vertebrate species. …”
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The Performance of Equations That Estimate Glomerular Filtration Rate against Measured Urinary Creatinine Clearance in Critically Ill Patients by Hasan M. Al-Dorzi, Abdulmajeed A. Alsadhan, Ayman S. Almozaini, Ali M Alamri, Hani Tamim, Musharraf Sadat, Lolowa Al-Swaidan, Elwaleed Elhassan, Yaseen M. Arabi

“…The sensitivity of equations to correctly classify CrCl24h-urine 30–59.9 ml/min/1.73 m2 was 17.2% for CGactual-wt, 30.0% for CGideal-wt, 31.0% for CGadjusted-wt, 31.0% for MDRD-4, 39.1% for MDRD-6, 13.8% for CKD-EPI, and 34.5% for Jelliffe equation. Conclusions. Commonly used GFR-estimating equations had limited ability to properly estimate CrCl24h-urine and to correctly classify GFR into clinically relevant ranges that usually determine dosing of medications.…”
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The walnut tree as a source of progesterone for reproductive control in goats by P. Chemineau, A.L. Lainé, D. Gennetay, C. Porte, D. Chesneau, C. Laclie, G. Goudet, M. Meunier, M. Delmas, M.L. Greil, P. Liere, A. Pianos, A. Bernard, E. Dirlewanger, J.A. Delgadillo, M. Keller

“…We found a very high concentration of P4, specifically in the leaves of the three most common French varieties (∼100 mg/kg of DM) but not in flowers, fruits, septa, husk, oil or cake. …”
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Prevalence of abnormal bone mineral density and its influencing factors among adult residents in Jiangsu province: a cross-sectional survey by Weihao WANG, Huijing HE, Yaoda HU, Xingming CHEN, Tan XU, Ji TU, Ang LI, Binbin LIN, Qihang LIU, Zhiming LU, Tianshu XI, Haibo HUANG, Da XU, Zhili CHEN, Zichao WANG, Guangliang SHAN

“…Age and education level are common factors influencing abnormal BMD in both male and female adult residents in the region.…”
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New insights into the immunomodulatory potential of sialic acid on monocyte-derived dendritic cells by Zélia Silva, João Amorim Rabaça, Vanessa Luz, Rita Adubeiro Lourenço, Mariolina Salio, Alexandra Couto Oliveira, Pedro Bule, Sebastian Springer, Paula Alexandra Videira

“…Our investigation juxtaposes this novel approach with the conventional cytokine-based maturation regimen commonly employed in clinical settings. Notably, C. perfringens sialidase remarkably increased MHC-I levels compared to other sialidases having different specificities, supporting the idea that higher MHC-I is due to the cleavage of specific sialoglycans on cell surface proteins. …”
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The miR-1269a/PCDHGA9/CXCR4/β-catenin pathway promotes colorectal cancer invasion and metastasis by Haitao Mei, Qingshan Luo, Junyong Weng, Jialing Hao, Jinfeng Cai, Runkai Zhou, Ce Bian, Yingzi Ye, Shengzheng Luo, Yugang Wen

“…Abstract Background Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. …”
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