Demographic and Clinical Characteristics of Patients with Corneal Ectasia at Multiple Medical Centers in Saudi Arabia: A Hospital-based Study by Waleed Alghamdi, Sulaiman Aldakhil, Saif Hassan Alrasheed, Kareem Allinjawi, Mustafa Abdu, Raghda F. Mutwaly, Khaled Al Rashah, Hani M. Ghazal, Ghassan H. Radwan, Naveen Kumar Challa

“…Corneal rigid gas permeable contact lens was most used in treatment of 176 (40.9%) eyes followed by glasses in155 (36. 0%), while corneal cross-linking was the common surgical intervention (10.9%), followed by penetrating keratoplasty (3.0%). …”
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Impact of hearing loss and vestibular decline on cognition in Alzheimer’s disease: a prospective longitudinal study protocol (Gehoor, Evenwicht en Cognitie, GECkO) by Patrick Cras, Vincent Van Rompaey, Joyce Bosmans, Cathérine Jorissen, Angelique Van Ombergen, Sebastiaan Engelborghs, Annick Gilles, Eline Princen, Julie Moyaert, Griet Mertens

“…Alzheimer’s disease (AD) is the most common cause of dementia. Previous research investigated the link between hearing loss and cognition, and the effect of vestibular dysfunction on cognition. …”
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Does a complex intervention targeting communities, health facilities and district health managers increase the utilisation of community-based child health services? A before and af... by Joanna Schellenberg, Della Berhanu, Lars Åke Persson, Muluemebet Abera Wordofa, Araya Abrha Medhanyie, Fisseha Ashebir Gebregizabher, Habtamu Beyene, Ephrem Tekle Lemango, Abebe Bekele, Theodros Getachew, Mezgebu Yitayal, Yemisrach Behailu Okwaraji, Atkure Defar, Fitsum W/Gebriel, Alem Desta, Dawit Wolde Daka, Alemayehu Hunduma, Tigist Getahun, Amare Tariku Woldemariam, Desta Wolassa

“…We report the intervention’s effectiveness on care utilisation for common childhood illnesses.Methods We included a representative sample of 5773 households with 2874 under-five children at baseline (December 2016 to February 2017) and 10 788 households and 5639 under-five children at endline surveys (December 2018 to February 2019) in intervention and comparison areas. …”
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The effect of anterior disc displacement with polycystic ovarian syndrome on adolescent condylar bone remodeling by Jiali Sun, Chuyao Wang, Jieyun Zhao, Xin Nie, Chuan Lu, Xiang Ye, Dongmei He

“…Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that disrupts bone metabolism. …”
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Women’s experiences of gender-based violence supports through an intersectional lens: a global scoping review by Amaya Perez-Brumer, Beverley M Essue, Cyndirela Chadambuka, Isabel Arruda-Caycho, Danielle Tocallino, Rebecca Balasa, Prossy Kiddu Namyalo, Carmina Ravanera, Sarah Kaplan

“…Findings reflected intersectional differences in women’s experiences of accessing GBV services across contexts and lived experiences. Common findings indicate that seeking GBV support was motivated and enabled by informal supports and positive prior experiences in accessing services. …”
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Causal associations between osteoporosis and HBV infection across Asian and European populations: evidence from Mendelian randomization and colocalization analysis by Zhengnan Li, Jiarui Cao, Ke Li, Yixin Wu, Zhanpeng Luo, Rui Cao, Zhiheng Cheng, Zhendong Tian, Yiyang Han, Yuping Lai, Bangqi Wang, Shen Chen

“…Bayesian co-localization (coloc) analysis was also applied to calculate the posterior probability of causal variants and to identify common genetic variants between HBV infection and osteoporosis.ResultsMR analysis indicated that HBV infection increased the risk of osteoporosis onset in two East Asian cohort (IVW, OR = 1.058, 95% CI = 1.021 to 1.097, P = 0.002 and OR = 1.067, 95% CI = 1.029 to 1.106, P < 0.001). …”
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Low-Dose Ketamine Infusion for Perioperative Pain Management in Patients Undergoing Laparoscopic Gastric Bypass: A Prospective Randomized Controlled Trial by Mitchell T. Seman, Shawn H. Malan, Matthew R. Buras, Richard J. Butterfield, Kristi L. Harold, James A. Madura, David M. Rosenfeld, Andrew W. Gorlin

“…Introduction. Obesity is a common comorbidity seen in the perioperative setting and is associated with many diseases including cardiovascular disease and obstructive sleep apnea. …”
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Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies by Prathibha Babu Chandraprabha, Manoj Kumar K. Azhagiri, Vigneshwaran Venkatesan, Wendy Magis, Kirti Prasad, Sevanthy Suresh, Aswin Anand Pai, Srujan Marepally, Alok Srivastava, Kumarasamypet Murugesan Mohankumar, David I. K. Martin, Saravanabhavan Thangavel

“…Methods We employed Cas9 RNP-ssODN-mediated homology-directed repair (HDR) gene editing to mimic two naturally occurring HBG promoter point mutations; -175T > C, associated with high HbF levels, and −158 C > T, a common polymorphism in the Indian population that induces HbF under erythropoietic stress, in HSPCs. …”
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Enhancement of systemic and lung-localized CD4⁺ T-cell immune responses by truncation of NS1 protein of a seasonal live influenza vaccine strain by Polina I. Prokopenko, Ekaterina A. Stepanova, Victoria A. Matyushenko, Alexandra Ya. Rak, Anna K. Chistyakova, Arina D. Kostromitina, Tatyana S. Kotomina, Igor V. Kudryavtsev, Artem A. Rubinstein, Alexey S. Komlev, Larisa G. Rudenko, Irina N. Isakova-Sivak

“…There is a large variety of licensed influenza vaccines worldwide, but their common limitation is rather narrow specificity and inability to protect against antigenic-drift variants of influenza virus. …”
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Effectiveness of a home-based computerized cognitive training in Parkinson's disease: a pilot randomized cross-over study by Serena Tagliente, Brigida Minafra, Simona Aresta, Simona Aresta, Paola Santacesaria, Andrea Buccoliero, Cinzia Palmirotta, Gianvito Lagravinese, Davide Mongelli, Christian Gelao, Luigi Macchitella, Stefania Pazzi, Domenico Scrutinio, Paola Baiardi, Petronilla Battista

“…IntroductionCognitive symptoms are common in Parkinson's Disease (PD), and digital interventions like telerehabilitation other an accessible way to manage these symptoms. …”
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Larvicidal activity of Bacillus thuringiensis strains against Aedes aegypti and Culex quinquefasciatus mosquitoes by Prakai Rajchanuwong, Sawaporn Peaboon, Ratchadawan Ngoen-Klan, Atsalek Rattanawannee, Atirat Noosidum, Boonhiang Promdonkoy, Jariya Chanpaisaeng, Theeraphap Chareonviriyaphap

“…Organophosphates, carbamates and synthetic pyrethroids are commonly used in Thailand to control mosquito vectors; however, long-term use of insecticides in vector control has led to the rapid development of insecticide resistance. …”
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Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials by Haoyang Guo, Juan Yang, Jihan Huang, Ling Xu, Yinghua Lv, Yexuan Wang, Jiyuan Ren, Yulin Feng, Qingshan Zheng, Lujin Li

“…There was a significant negative correlation in the exponential pattern between age and weight reduction effect, whereas baseline weight and BMI had no significant impact. Common adverse events of GLP-1RAs, reported in the literature include nausea, vomiting, diarrhea, and constipation, with a significantly higher incidence of nausea than that of placebo. …”
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Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study by Samuel Smith, Peter Sasieni, William Cross, Richard Bryant, Steven Kennish, James Catto, Rachel Hubbard, Simon Faulkner, Rohit Chahal, Mohantha Dooldeniya, Marcus Cumberbatch, Bernard North, Alastair D Lamb, Roseann Kealy, Selina Bhattrai

“…Background Prostate cancer (PCa) is the most common male malignancy in the western world. Many men (40%) are diagnosed with localised low or intermediate-risk PCa, which is suitable for active surveillance (AS). …”
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Application of trichloroisocyanuric acid in controlling kiwifruit bacterial canker disease demonstrates its promising potential as an eco-friendly bactericide by Jianyou Gao, Jiewei Li, Cuixia Liu, Hongjuan Gong, Beibei Qi, Rongxiang Zhu, Liming Xia, Li Li, Shibiao Liu, Qiaosheng Jiang, Kaiyu Ye, Faming Wang

“…Trichloroisocyanuric acid (TCCA), a cost-effective and relatively safe industrial oxidant commonly used for disinfection, has shown potential for plant disease management. …”
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Enhanced Control Efficacy of Different Insecticides Mixed with Mineral Oil Against Asian Citrus Psyllid, <i>Diaphorina citri</i> Kuwayama, Under Varying Climates by Wei Hu, Kejing Wang, Xiaoyue Zhong, Pei Jiang, Shunchang Zhang, Zhanjun Lu, Zhixiang Zhang, Long Yi, Ning Zhang

“…Currently, chemical control remains the most effective strategy for ACP management. Mineral oils are commonly used as insecticides or adjuvants in integrated pest management (IPM) practices. …”
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The implementation and side effect management of immune checkpoint inhibitors in gynecologic oncology: a JAGO/NOGGO survey by Maximilian Riedel, Helene Herrmann, Thomas Bartl, Anna-Maria Rossner, Anna Tatzber, Chiara Flethe, Dario Zocholl, Barbara Schmalfeldt, Jalid Sehouli, Klaus Pietzner

“…When asked which irAEs they had observed “frequently” or “very frequently”, respondents most commonly reported thyroiditis (37.2%), followed by skin reactions (23.6%), and pneumonitis (10.6%). …”
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The association of RBP4 with chronic kidney diseases in southern Chinese population by Tong Chen, Tong Chen, Tong Chen, Yu Liu, Yu Liu, Shiquan Wu, Siyu Long, Ling Feng, Wenqian Lu, Wenya Chen, Guoai Hong, Li Zhou, Fang Wang, Yuechan Luo, Hequn Zou, Hequn Zou, Weihua Liu

“…ROC analysis showed that RBP4 as a single index, AUC (0.666) was superior to Scr, FBG, Log HOMA-IR, WC, TG, VLDL-C, UA, HDL-C, LDL-C, and that combining RBP4 indicator and other common risk factors of CKD can improve the accuracy for predicting CKD.ConclusionThis study found that the RBP4 was strongly correlated with CKD, RBP4 may become a valuable marker and have strong power for predicting CKD.…”
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Assessment of Attentional Functioning in Health Professionals of a Brazilian Tertiary Referral Hospital for COVID-19 by Eelco van Duinkerken, Guilherme J. Schmidt, Ana Lúcia Taboada Gjorup, Carolina Ribeiro Mello, André Casarsa Marques, Áureo do Carmo Filho, Paula Regina Yuri Fukusawa, Simone Gonçalves de Assis, Júlio Cesar Tolentino, Sergio L. Schmidt

“…This cut-off was based on the clear division between professionals working and not working with COVID-19 patients and considered that 12-hour and 24-hour daily shifts are common for hospital employees in Brazil. A MANCOVA was performed to examine between-group differences, using age, sleep quality, sex, education level, previous COVID-19 infection, and profession as covariates. …”
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AutoLDP: An accurate and efficient artificial intelligence-based tool for automatic labeling of digital pathology by Yingnan Zhao, Huifen Ye, Jing Yang, Su Yao, Maohua Lv, Zhihong Chen, Yunrui Ye, Qingru Hu, Cheng Lu, Zaiyi Liu, Ke Zhao, Zhihua Chen

“…We compared the proposed model with several commonly used text detection and recognition models including ABinet, CRNN, TRBA, and Vitstr. …”
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Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain by Michaela Berankova, Jiri Holoubek, Vaclav Hönig, Zuzana Matusova, Martin Palus, Jiri Salat, Imtissal Krayem, Jarmila Vojtiskova, Pavel Svoboda, Veronika Pranclova, Lukas Valihrach, Peter Demant, Marie Lipoldova, Daniel Ruzek

“…Abstract Background Tick-borne encephalitis (TBE) is the most common tick-borne viral infection in Eurasia. Outcomes range from asymptomatic infection to fatal encephalitis, with host genetics likely playing a role. …”
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