The efficacy and safety of half-dose glucocorticoids combined with rituximab versus high-dose glucocorticoids for initial treatment of minimal change disease: a single-center exper... by Xueting Li, Peng Yan, Lu Zhang, Wei Qiao, Zhengbiao Xue, Xiangdong Fang, Ben Ke, Shuying Zhu

“…BackgroundMinimal change disease (MCD) is a podocytopathy more commonly seen in children, but it also accounts for 10%–25% of adult nephrotic syndrome. …”
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Smoking and secondhand smoke exposure and carotid intima-media thickness: Baseline data from the Aidai Cohort Study in Japan by Makoto Saito, Yoshihiro Miyake, Keiko Tanaka, Chisato Nagata, Hidenori Senba, Yasuko Hasebe, Toyohisa Miyata, Takashi Higaki, Eizen Kimura, Bunzo Matsuura, Osamu Yamaguchi, Ryuichi Kawamoto

“…The greatest CIMT measurement in the left or right common carotid artery was considered the maximum CIMT, and a maximum CIMT >1.0 mm was indicative of carotid wall thickening. …”
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Value of routine blood count surveillance in detecting relapse in acute lymphoblastic leukemia by Sarah AlHarbi, Sarah AlHarbi, Areej Taha, Areej Taha, Ahmed Ashi, Ahmed Ashi, Naglla Elimam, Naglla Elimam, Sami Althubaiti, Sami Althubaiti, Sami Althubaiti

“…Clinical and complete blood count (CBC) assessments are commonly used surveillance methods to detect relapses. …”
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A stratified two-stage tumor molecular profiling algorithm to identify clinically actionable molecular alterations in pancreatic cancer☆ by S. Hussung, D. Akhoundova, C. Pistoni, D. Lenggenhager, A. Töpfer, C. Pauli, B. Pestalozzi, C. Britschgi, M. Zoche, M. Rechsteiner, H. Moch, A. Weber, R. Fritsch

“…Stage 1 comprised immunohistochemistry for mismatch repair deficiency and targeted sequencing employing a 33-gene next-generation sequencing panel covering common PC drivers and DNA damage response genes. Based on pre-specified events (KRAS wild type, mismatch repair deficiency, molecular tumor board recommendation), subsequent comprehensive molecular testing was carried out (stage 2). …”
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Effects of Dietary Inclusion of Canthaxanthin- and α-Tocopherol-Loaded Liposomes on Growth and Muscle Pigmentation of Rainbow Trout (Oncorhynchus mykiss) by Tran Quoc Toan, Viet Anh Dang, Quoc Long Pham, Phi Hung Nguyen, Thu Huong Trinh, Thuy Ha Tran, Van Thinh Do, Van Khoi Le, Xuan Luong Ngo, Tri Nhut Pham, Hai Ha Pham Thi, Manh Do Van, Duy Chinh Nguyen, Thanh Duong Nguyen

“…Dietary inclusion of canthaxanthin, a common carotenoid pigment, has been long practiced in aquaculture to give the favorable flesh color in farmed salmonids. …”
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High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…Studies of patient-derived brain tissues have concluded that these inclusions are associated with Parkinson’s disease, the second most common neurodegenerative disorder, and other synuclein-related diseases called synucleinopathies. …”
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Is routine preoperative head ultrasound screening before congenital cardiac surgery mandatory? by Shawana Farooq, Hanan Rashid Abu Hassan, Omai Mohammed AlSassi, Tarek Alfawzan, Abdullah Eltayeb, Seifeldin Mohamed, Suffura Rafique, Ghaida Mohammed Ali, Tarek Jamal Alanezi, Ali Hussain Alharbi, Brahim Tabarki, Abdullah Al Wadai

“…There were no differences in the baseline characteristics between patients with normal and abnormal HUS. The most common abnormality reported by HUS was intraventricular hemorrhage (IVH) (n = 65, 47.45%). …”
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Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs) by Jeffrey J. Yu, Daniel B. Azzam, Marilyn Chwa, Kevin Schneider, Jang-Hyeon Cho, Chinhui Hsiang, Henry Klassen, M. Cristina Kenney, Jing Yang

“…While several treatment options exist for the exudative form of AMD, there are currently no FDA-approved treatments for the more common nonexudative (atrophic) form. Mounting evidence suggests that mitochondrial damage and retinal pigment epithelium (RPE) cell death are linked to the pathogenesis of AMD. …”
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Evaluation of three-dose fosfomycin tromethamine in the treatment of patients with urinary tract infections: an uncontrolled, open-label, multicentre study by Shan Chen, Yong Yang, Bo Yang, Ming Chen, Kai Zhang, Yi Wang, Lu-Dong Qiao, Bo Zheng, Hong-Feng Guo, Yuan-Jie Niu, Ben-Kang Shi, Wei-Min Yang, Xiao-Kun Zhao, Xiao-Feng Gao

“…The overall efficacy rates (day 15) were 95.29% (81/85), 77.78% (28/36) and 64.52% (20/31), respectively. 20/356 (5.6%) patients reported drug-related AEs, the most common being diarrhoea. No serious drug-related AEs were reported.Conclusions This fosfomycin tromethamine dosing regimen showed clinical and microbiological efficacy with some AEs and good tolerability in patients with acute uncomplicated cystitis, recurrent lower urinary tract infection and complicated lower urinary tract infection.…”
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Research progress of combined treatment of western medicine in children with allergic purpura (儿童过敏性紫癜西药联合治疗的研究进展) by HU Yuan (胡园), CHEN Xiuying (陈秀英), LIU Lili (刘莉莉)

“…At present, there is no specific medicine for children allergic purpura clinically, but a number of scholars found that the combined use of common drugs such as monoculist sodium and glucocorticoid has a good effect. …”
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Chinese patent medicine tongxinluo capsule as a supplement to treat chronic coronary syndromes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials by Shi-Bing Liang, Shi-Bing Liang, Shi-Bing Liang, Yi-Fei Wang, Yi-Fei Wang, Yi-Fei Wang, Zhen-Chao Niu, Zhen-Chao Niu, Yu-Fei Li, Hui-Min Zheng, Hui-Min Zheng, Jia-Ming Huan, Jie Yuan, Nicola Robinson, Nicola Robinson, Jian-Ping Liu, Yun-Lun Li, Yun-Lun Li, Yun-Lun Li

“…BackgroundChronic coronary syndromes (CCS) is a common clinical condition that increases the risk of cardiovascular events at any time. …”
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Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Background: Reports indicate that depression is a common mental health issue following traumatic brain injury (TBI). …”
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Frequency, demographics, diagnoses and consultation patterns associated with low-acuity attendances in German emergency departments: a retrospective routine healthcare data analysi... by Patrik Dröge, Anna Slagman, Felix Greiner, Martin Möckel, Liane Schenk, Anna Schneider, Thomas Keil, Stephanie Roll, Rainer Röhrig, Felix Walcher, Reinhard Busse, Johannes Drepper, David Legg, Ryan King, Thomas Reinhold, Thomas Ruhnke, Antje Fischer-Rosinský, Yves-Noel Wu, Natalie Baier, Maike Below, Cornelia Henschke, Björn Kreye, Christian Lüpkes, Burgi Riens, Marie-Luise Rosenbusch, Felix Stäps, Kristin Schmieder, Daniel Schreiber, Dominik von Stillfried, Grit Zimmermann

“…The highest proportion of low-acuity presentations was observed during the weekend (average of 18.6% per day), compared with an average of 12.5% on weekdays. The most common diagnoses (back pain, abdominal and pelvic pain) were similar in both low-acuity and high-acuity groups.Conclusion Our study provides further evidence that younger age is associated with low-acuity presentation in German EDs. …”
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Prevalence, Characterization, and Proteomic Relatedness Among β-Lactam-Resistant Bacteria Throughout the Poultry Production Chain in Greece by Anestis Tsitsos, Alexandros Damianos, Konstantinos Kiskinis, Vasilios Tsiouris, Ilias Tirodimos, Nikolaos Soultos, Anna Papa, Vangelis Economou

“…Extended-spectrum-β-lactamase (ESBL) and carbapenemase-producing <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i> and <i>Acinetobacter</i> spp. are associated with hospital-acquired infections and are commonly isolated across the poultry food production chain. …”
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High, but variable prevalence of Sarcocystis cruzi infections in farm-raised American bison (Bison bison) beef destined for human consumption by Larissa S. de Araujo, Aditya Gupta, Marianne Dias Papadopoulos, Doaa Naguib, Jacquin Battle, Oliver Kwok, Asis Khan, Benjamin Rosenthal, Jitender P. Dubey

“…Abstract Background Bison (Bison bison) and cattle (Bos taurus) are closely related (can interbreed) and they also share many parasites. Cattle are commonly infected with one or more of the eight named Sarcocystis species: Sarcocystis hirsuta, S. cruzi, S. hominis, S. bovifelis, S. heydorni, S. bovini, S. sigmoideus and S. rommeli. …”
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Feasibility pilot of a novel coaching intervention to optimize cannabis use for chronic pain management among Veterans by Kevin F. Boehnke, Gabrielle Bowyer, Jenna McAfee, Tristin Smith, Catherine Klida, Vivian Kurtz, Evangelos Litinas, Poonam Purohit, Anne Arewasikporn, Dana Horowitz, Laura Thomas, Jennifer Eckersley, Mia Railing, David A. Williams, Daniel J. Clauw, Kelley M. Kidwell, Amy S. B. Bohnert, Rachel S. Bergmans

“…Abstract Introduction Chronic pain is common among Veterans, some of whom use cannabis for pain. …”
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Telomere Length Is Associated With Adverse Atrial Remodeling in Patients With Atrial Fibrillation by Kabita Pradhan, Balram Neupane, Paul Niehues, Martin Kirschner, Fabian Beier, Chao‐Chung Kuo, Erika Anneliese Hilbold, Christian Bär, Oana‐Maria Thoma, Maximilian Waldner, Margherita Vieri, Tim H. Brümmendorf, Vithurithra Tharmapalan, Wolfgang Wagner, Michael Kleines, Mahdi Emrani, Matthias Daniel Zink, Andreas Napp, Nikolaus Marx, Michael Gramlich

“…Background Atrial fibrillation (AF) is the most common cardiac arrhythmia with a massive burden on global health. …”
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The real-world efficacy and toxicity of first-line paclitaxel and cisplatin with bevacizumab in platinum-naïve primary stage IVB cervical cancer by Junhwan Kim, Eun-Byul Park, Shin-Wha Lee, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Ju-Hyun Kim

“…Patients received a median of 9 (range, 2−30) cycles of paclitaxel-cisplatin-bevacizumab. The most common adverse event (all grades) during treatment was azotemia (80.3 %). …”
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Children’s emerging concepts of resilience: insights from using body mapping in an East London cohort sample of 7-10-year-old children by Aisling Murray, Dominie Mahala Smith Scott, Milena Nikolajeva, Daniele Porricelli, Francois van Loggerenberg, Dennis Ougrin, Jennifer Y. F. Lau

“…Of the body categories colored (n = 51), the most common were the head, hands and abdomen/stomach.ConclusionChildren expressed dominant and abstract symbols of resilience and identified factors that contributed to resilience. …”
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Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy (PPOIT) in inducing desensitisation or toleran... by Michael O’Sullivan, Michael S Gold, Francesca Orsini, Adriana Chebar Lozinsky, Paxton Loke, Susan L. Prescott, Patrick Quinn, Audrey DunnGalvin, Mimi LK Tang, Anne-Louise Ponsoby, Ee Lyn Su, Marnie Robinson, Dean Tey, Kuang-Chih Hsiao, Molly O’Sullivan, Christine Axelrad, Sigrid Pitkin, Jessica Metcalfe, Susan Fahy-Scheer, Thalayasingam Meera, Jovanka King, Fuad Abass, Abigail Cheung, Rachel Wallace, Samara Baldwin

“…Introduction Peanut allergy is the the most common cause of life-threatening food-induced anaphylaxis. …”
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