甲型H1N1流感病毒神经氨酸酶基因遗传进化分析

“…【目的】 了解季节性H1N1流感病毒与2009年新型H1N1流感病毒神经氨酸酶(NA)基因的遗传进化关系,探讨甲型H1N1流感病毒的遗传变异规律65377;【方法】 分别从2006年和2009年流感病人标本中分离并鉴定出季节性HIN1流感病毒和新型H1N1流感病毒,用RT-PCR技术扩增了病毒NA基因全序列,并对其分子进化和重要功能位点的遗传变异进行了分析65377; 【结果】 2009年新型H1N1流感病毒与2006年季节性HIN1流感病毒比较,NA基因的同源性较低(77.9% ~ 78.8 %),与世界各地不同年代代表株及WHO推荐的1979 ~ 2010年季节性流感疫苗株比较,NA基因的同源性也较低(78.1% ~ 79.3%),但与WHO推荐的2009年新型H1N1流感疫苗株比较同源性则高达99%以上;系统进化分析结果表明,2009年新型H1N1流感病毒NA基因与欧亚猪流感病毒株A/swine/Belgium/1/1983的亲缘关系最近;并发现自2005年以来季节性H1N1流感病毒NA基因的某些抗原位点和神经氨酸酶活性位点已发生了变异65377;【结论】 2009年新型H1N1流感病毒NA基因可能来源于欧亚猪流感病毒;接种季节性流感疫苗不能对本次流行的新型流感产生有效的免疫保护作用;季节性H1N1流感病毒在流行过程中NA基因已发生了一定的变异,有必要持续跟踪和监测病毒的变异情况65377;…”
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Traumatic peripheral nerve injuries in young Korean soldiers: a recent 10-year retrospective study by Chul Jung, Jae-hyun Yun, Eun Jin Kim, Jaechan Park, Jiwoon Yeom, Kyoung-Eun Kim

“…Methods A list of enlisted soldier patients who were discharged from military service due to PNI over a 10-year period (2012–2021) was obtained, and their medical records were reviewed. …”
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Neonatal outcomes in offspring of mothers with pregestational diabetes: a hospital-based multicentre prospective cohort study protocol by Manu Raj, Vishnu Renjith, Renjitha Bhaskaran, Anju Philip Thurkkada, Radhamany Kunjukutty, Sobha S Nair, Annie Soman, Sethulakshmi Ramachandran

“…Those who will have a miscarriage, an abortion or twin pregnancies will be excluded from the study. …”
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Surgical treatment of obesity and excess risk of developing heart failure in a controlled cohort study by Christina E. Lundberg, Shabbar Jamaly, Martin Adiels, Jesper Lagergren, Carl Johan Svensson, Lena Björck, Annika Rosengren

“…The obesity cohort was divided into two groups: 27 882 patients who had undergone gastric bypass surgery within 2 years of obesity diagnosis and 39 564 patients who had not undergone such surgery. …”
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‘Everyone should know what they’re on’: a qualitative study of attitudes towards and use of patient held lists of medicines among patients, carers and healthcare professionals in p... by Caitriona Cahir, Kathleen E Bennett, Sheena M Mc Hugh, Ciara Kirke, Muriel Pate, Bernadine O'Donovan

“…Objectives Managing multiple medicines can be challenging for patients with multimorbidity, who are at high risk of adverse outcomes, for example, hospitalisation. …”
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Chest CT Scan Features to Predict COVID-19 Patients’ Outcome and Survival by Mohammad-Mehdi Mehrabi Nejad, Aminreza Abkhoo, Faeze Salahshour, Mohammadreza Salehi, Masoumeh Gity, Hamidreza Komaki, Shahriar Kolahi

“…The patients who did not die and were equivalent in terms of demographics and other clinical features to cases were considered as the control (survivors) group. …”
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RELAPSES AFTER RADICAL SUBCUTANEOUS/SKIN-SPARING MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION IN BREAST CANCER by A. D. Zikiryakhodzhayev, E. A. Rasskazova, A. Yu. Tukmakov, I. M. Shirokikh

“…To evaluate 3‑year disease-free survival in patients with breast cancer who underwent radical subcutane­ous/skin-sparing mastectomy with simultaneous reconstruction.Patients and methods. …”
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Psychosocial and pharmacologic interventions for problematic methamphetamine use: Findings from a scoping review of the literature. by Mona Hersi, Kim Corace, Candyce Hamel, Leila Esmaeilisaraji, Danielle Rice, Nicole Dryburgh, Becky Skidmore, Gary Garber, Amy Porath, Melanie Willows, Paul MacPherson, Beth Sproule, Jorge Flores-Aranda, Chandlee Dickey, Brian Hutton

“…Studies involving individuals who use methamphetamine, including key subgroups (e.g. those with mental health comorbidities; adolescents/youths; gay, bisexual, and other men who have sex with men) were sought. …”
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The impact of gestational age limits on abortion-related outcomes: a synthesis of legal and health evidence by Fiona de Londras, Amanda Cleeve, Maria I. Rodriguez, Alana Farrell, Magdalena Furgalska, Antonella F. Lavelanet

“…GLs impact most on people who are least able to access abortion because of later detection of pregnancy, lack of access to abortion provision, and lack of access to the resources required to avail of abortion. …”
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Availability and use of institutional support programs for emergency department healthcare personnel during the COVID-19 pandemic. by Karin F Hoth, Patrick Ten Eyck, Karisa K Harland, Anusha Krishnadasan, Robert M Rodriguez, Juan Carlos C Montoy, Linder H Wendt, William Mower, Kelli Wallace, Scott Santibañez, David A Talan, Nicholas M Mohr, Project COVERED Emergency Department Network

“…Program use did not significantly differ for HCP who reported symptoms of anxiety and/or stress compared to those who did not.…”
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Prevalence, risk factors, and cardiovascular disease outcomes associated with persistent blood pressure control: The Jackson Heart Study. by Gabriel S Tajeu, Calvin L Colvin, Shakia T Hardy, Adam P Bress, Bamba Gaye, Byron C Jaeger, Gbenga Ogedegbe, Swati Sakhuja, Mario Sims, Daichi Shimbo, Emily C O'Brien, Tanya M Spruill, Paul Muntner

“…This analysis included 1,604 participants who were taking antihypertensive medication at Visit 1 and had BP data at Visits 1 (2000-2004), 2 (2005-2008), and 3 (2009-2013). …”
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HIV status and contraceptive use in Zimbabwe among sexually active adolescent girls and women: Secondary analysis of Zimbabwe Demographic Health survey data by G Musuka, G Murewanhema, Z Mukandavire, I Chingombe, D Cuadros, F Mutenherwa, T Dzinamarira, R Eghtessadi, N Malunguza, M Mapingure

“…Statistically significant differences were noted in the use of condoms, with those who are HIV-positive having a higher use of condoms compared with those who are HIV-negative. …”
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The long-term outcome of children with VP shunt and hydrocephalus: motor developmental outcome and QOL of patients with hydrocephalus is associated with the number of revisional pr... by Danielle S. Wendling-Keim, Hannah Luz, Elena Kren, Oliver Muensterer, Markus Lehner

“…The significance level was set at p ≤ 0.05.ResultsQuestionnaires were sent to 81 patients who were treated at our institution over a mean retrospective study period of 18 years. …”
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Multimodality Treatment Including Triplet Regimen as First-Line Chemotherapy May Improve Prognosis of Serum AFP-Elevated Gastric Cancer with Liver Metastasis by Yakun Wang, Lin Shen, Ming Lu, Zhi Ji, Xiaotian Zhang

“…Moreover, for patients of the AFP ≥ 20 ng/ml group, those who reached PR had a longer survival period (15.4 m versus 9.4 m, P=0.017), and combined with local treatment for liver metastasis also seemed to improve prognosis (19.2 m versus 8.4 m, P=0.003). …”
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Compliance of healthcare workers with the infection prevention and control guidance in tertiary care hospitals: quantitative findings from an explanatory sequential mixed-methods s... by Syed Shariful Islam, Syed Moniruzzaman, M Atiqul Haque, Sarmin Sultana, Marium Salwa, Mohammad Tanvir Islam, Md Maruf Haque Khan

“…Compliance with IPC guidance was 0.061 times greater among participants who reported low perceived barriers compared with those with high perceived barriers.Conclusion Overall, compliance with IPC guidance among HCWs was unsatisfactory. …”
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Adults with reading difficulties demonstrate selective impairments in the fine neural tuning for print by Tongjie Zhuang, Yaowen Li, Yufei Tan, Jiuju Wang, Xiuyue Yue, Licheng Xue, Jing Zhao, Jing Zhao

“…Although many adults also experience reading difficulties, relatively few studies have examined whether such impairments exist in adults, particularly those who read Chinese, which differs markedly in visual and linguistic characteristics from alphabetic scripts.MethodsTo fill this gap, we assessed 20 high-level and 16 low-level adult readers who were the two extremes of the best and poorest readers of a database, which consisted of 308 college students. …”
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Mean arterial pressure at the initiation of continuous renal replacement therapy as a prognostic indicator in patients with acute kidney injury by Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan

“…This study investigated the relationship between mean arterial pressure (MAP) and 28- and 90-day mortality in critically ill AKI patients treated with CRRT.Methods This secondary analysis of a bicenter, retrospective, observational study included patients with AKI who were treated with CRRT from January 2009 to September 2016. …”
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Reduction effect of oral pravastatin on the acute phase response to intravenous zoledronic acid: protocol for a real-world prospective, placebo-controlled trial by Qi Liu, Min Zhang, Liyuan Tao, Chunli Song, Haiyan Li, Gengyu Han, Runting Li, Dongwei Fan, Guohong Du, Dongyang Liu

“…Introduction Zoledronic acid (ZA) has been used as a first-line treatment in patients with osteoporosis (OP) who receive an annual injection of 5 mg. However, side effects of bone pain and fever, known as the acute phase response (APR), have often been observed after clinical usage. …”
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Using waist circumference as a predictor of hypertension in Manzese, Dar es Salaam: a community-based cross-sectional study, 2023 by Godbless Henry Mfuru, James N. Allan, Agnes Njau, Omary Ubuguyu, Khadija Y. Malima

“…Data were collected using WHO STEPwise Approach to Chronic Disease Risk Factor Surveillance questionnaire. …”
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Association between the Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio and Carotid Atherosclerosis: A Retrospective Study by Xiangming Hu, Wei Li, Chenyang Wang, Haotian Zhang, Haoyu Lu, Guang Li, Yingling Zhou, Haojian Dong

“…In this retrospective study, we enrolled 1304 patients who had multiple cardiovascular risk factors or symptoms of suspected coronary artery disease. cIMT and carotid artery plaque were measured using ultrasonography. …”
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