LRRK2 Mutations and Asian Disease-Associated Variants in the First Parkinson’s Disease Cohort from Kazakhstan by Rauan Kaiyrzhanov, Akbota Aitkulova, Chingiz Shashkin, Nazira Zharkinbekova, Mie Rizig, Elena Zholdybayeva, Zharkyn Jarmukhanov, Vadim Akhmetzhanov, Gulnaz Kaishibayeva, Talgat Khaibullin, Altynay Karimova, Serik Akshulakov, Askhat Bralov, Nurlan Kissamedenov, Zhanar Seidinova, Anjela Taskinbayeva, Aliya Muratbaikyzy, Henry Houlden

“…One early-onset PD subject was homozygous for p.Ala419Val who developed fast progression and severe dyskinesias. p.Ala419Val was associated with early-onset PD. …”
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Towards person-centred maternal and newborn care in Ethiopia: a mixed method study of satisfaction and experiences of care by Tigist Eshetu, Eshcolewyine Fekadu, Ahmed Abdella, Adiyam Mulushoa, Girmay Medhin, Merga Belina, Atalay Alem, Roxanne Keynejad, Tanya Robbins, Nadine Seward, Andrew Shennan, Louise M. Howard, Martin Prince, Jane Sandall, Charlotte Hanlon

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'Giustizia fatta': observations sur un registre des condamnés à mort (1471–1764) de la bibliothèque de Beccaria by Pierre Musitelli

“…Reading this manuscript reminds us that this judicial rite echoes through the works of Pietro Verri (Osservazioni sulla tortura, Storia di Milano), Alessandro Manzoni (I promessi sposi, Storia della colonna infame) and even Leonardo Sciascia, who was inspired by this text to write one of his last stories (La Strega e il capitano). …”
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Efficacy of first-line chemotherapy combined with immunotherapy or anti-angiogenic therapy in advanced KRAS-mutant non-small cell lung cancer by Huiping Qiang, Yue Wang, Yao Zhang, Jingwen Li, Lincheng Zhang, Huawei Du, Xuxinyi Ling, Shuhui Cao, Yan Zhou, Runbo Zhong, Hua Zhong

“…Among the 203 patients who received first-line chemotherapy combined with immunotherapy, PD-L1 positive NSCLC patients responded better than PD-L1 negative patients (mPFS: 11.0 months vs. 4.0 months, P = 0.0004; mOS: 21.0 months vs. 11.0 months, P = 0.0005). …”
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Prolonged use of selective immunosuppressants in glacoma drainage surgery: experimental in vivo study by V.N. Germanova, E.V. Karlova, L.T. Volova, N.N. Sarbaeva, I.F. Nefedova, M.V. Radaykina

“…</i> </p> <p> <i><b>Results</b>: better characteristics of filtering blebs and lower IOP values were seen among the animals who underwent surgical procedures with immunosuppressants compared to the control group even in the early post-op period. …”
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A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease by Handong Ding, Handong Ding, Handong Ding, Fei Zhang, Fei Zhang, Fei Zhang, Jinbiao Zhong, Jinbiao Zhong, Jinbiao Zhong, Jiashan Pan, Jiashan Pan, Jiashan Pan, Yiding Chen, Yiding Chen, Yiding Chen, Ji Zhang, Ji Zhang, Ji Zhang, Qin Wang, Guiyi Liao, Guiyi Liao, Guiyi Liao, Zongyao Hao, Zongyao Hao, Zongyao Hao

“…Herein, we evaluated the predictive value of the combined score of these parameters.MethodsData from 370 patients with newly diagnosed ESRD who underwent routine echocardiography and electrocardiography between May 2016 and May 2017 were retrospectively evaluated. …”
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Efficacy of 5 µg and 10 µg Dexmedetomidine as Adjuvants to 3 mL 0.5% Hyperbaric Bupivacaine in Pelvic and Lower Limb Orthopaedic Surgeries: A Randomised Clinical Study by Jigisha Bharatbhai Mehta, Shreya Jatin Patel, Nilesh Vrajmohan Shah, Dinesh K Chauhan, Sara Mary Thomas

“…Materials and Methods: This randomised clinical and single-blind study study was conducted at the Operation Theatre (OT) complex of Dheeraj Hospital, SBKS, and MIRC, Sumandeep Vidyapeeth, Vadodara, Gujarat, India in the Department of Anaesthesia over a period of 18 months, from September 2022 to March 2024 and total of 82 patients scheduled for lower limb and pelvic orthopaedic surgery who were to receive spinal anaesthesia were divided into Group D1 and D2. …”
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Study protocol for the COPE study: COVID-19 in Older PEople: the influence of frailty and multimorbidity on survival. A multicentre, European observational study by Thomas Lee, Sandeep Singh, Phyo Kyaw Myint, Sheila Jones, Ben Carter, Susan Moug, Terry Quinn, Michael Thomas, Emma Bhatti, Angeline Price, Fenella Barlow-Pay, Siobhan Duffy, Lyndsay Pearce, Arturo Vilches-Moraga, Michael Stechman, Philip Braude, Emma Mitchell, Alessia Verduri, Kathryn McCarthy, Jonathan Hewitt, Charlotte Davey, Kiah Lunstone, Alice Cavenagh, Charlotte Silver, Thomas Telford, Rebecca Simmons, Dolcie Paxton, Francis Rickard, Mark Holloway, James Hesford, Tarik Jichi, Norman Galbraith, Jenny Edwards, Carly Bisset, Ross Alexander, Abigail Ingham, Roxanna Short, Aine McGovern, Jemima Collins, Eilidh Bruce, Alice Einarsson, Enrico Clini, Giovanni Guaraldi, Madeline Garcia, Shefali Sangani, Thomas Kneen, George Kyriakopoulos, Denise Tan

“…All patients receiving inpatient hospital care &gt;18 years who receive a diagnosis of COVID-19 are eligible for inclusion. …”
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Sport participation as an educational tool and a means of promoting physical, mental, and social well-being by Francesco Sgrò

“…The natural consequence of this scenario is the development of limited interest in sports among those who have not yet developed or consolidated a competitive attitude and skills. …”
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Development of the destination branding model based on tourism industry nostalgia by parinaz masoumi, vahidreza mirabi, jalal HaghighatMonfared, Ahmad Vedadi

“…Research shows that people who have the desire to visit tourist destinations and buy from these destinations are more knowledgeable about tourist destinations than ordinary people. …”
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Role of the Perceived Social Responsibility of the Company and the Psychological Mechanisms to Achieve the Employees' Creative Behavior (Case Study: Electro Kavir Company of Yazd) by Marziyeh Dehghanizadeh, Fatemeh Keshavarzi Hedesh

“…Therefore, this research in Yazd Electro Desert Company, which needs the creative behavior of employees to achieve a competitive advantage; tries to investigate whether the employees' understanding of the social responsibility of Electro Desert Company has increased the emotional commitment of the employees, and whether this increase in commitment has caused a compassionate behavior among the employees, and whether this has led to an increase in the internal motivation of the employees who want to behave creatively without external expectations. …”
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Assessment of hemodynamic disturbances and impaired ventricular filling in asymptomatic fontan patients: A 4D flow CMR study by Li-Wei Hu, Xiaodan Zhao, Shuang Leng, RongZhen Ouyang, Qian Wang, Ai-Min Sun, Yi-Man Liu, Wei Dong, Liang Zhong, Yu-Min Zhong

“…Consequently, long-term follow-up of individuals who have undergone the asymptomatic Fontan procedure is essential. …”
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Comparación de un hemoglobinómetro portátil (Verio Q Red) con los resultados del laboratorio clínico en la práctica clínica habitual by Boris Trenado-Luengo, Rosa García-Sierra, Verónica Moreno Gómez, Marina Montenegro Calvo, Jordi Anguita Lapido, Pere Torán-Monserrat

“…Participants: Random selection of participants who attended routine blood tests. Over 18 years old. …”
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Hypertension Subtypes among Thai Hypertensives: An Analysis of Telehealth-Assisted Instrument in Home Blood Pressure Monitoring Nationwide Pilot Project by Sakolwat Montrivade, Pairoj Chattranukulchai, Sarawut Siwamogsatham, Yongkasem Vorasettakarnkij, Witthawat Naeowong, Patchaya Boonchayaanant, Anut Sakulsupsiri, Aekarach Ariyachaipanich, Vorarit Lertsuwunseri, Voravut Rungpradubvong, Sudarat Satitthummanid, Sarinya Puwanant, Somchai Prechawat, Suphot Srimahachota, Jarkarpun Chaipromprasit, Wacin Buddhari, Smonporn Boonyaratavej, Surapun Sitthisook, Peera Buranakitjaroen, Apichard Sukonthasarn, Somkiat Sangwatanaroj

“…A multicenter, observational study included adult hypertensives who had been diagnosed for at least 3 months based on CBP without the adoption of HBP monitoring. …”
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Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital by Jin Won Kim, Hee Young Na, Sejoon Lee, Ji-Won Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jaihwan Kim, Jin-Hyeok Hwang, Kihwan Hwang, Chae-Yong Kim, Yong Beom Kim, Soomin Ahn, Kyu Sang Lee, Hyojin Kim, Hye Seung Lee, So Yeon Park, Gheeyoung Choe, Jee Hyun Kim, Jin-Haeng Chung

“…Of 32 patients with measurable lesions who received NGS-based therapy, 12 (37.5%) achieved a partial response, and 11 (34.4%) achieved stable disease. …”
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Germline Human Leukocyte Antigen Status is Associated With Immunotherapy-Induced Pneumonitis and Treatment Response in Patients With Non–Small Cell Lung Cancer With High Programmed... by Alvin H.K. Cheung, MBBS, PhD, Zeta Mui, MPhil, Walter W. Yeung, PhD, Chit Chow, PhD, Mandy F. Yu, BSc, Olivia H. Chen, MD, PhD, Kit-Yee Wong, MPhil, Fuda Xie, MPhil, Yat Ming Lau, MBBS, Alfred S-L. Cheng, PhD, Wei Kang, PhD, Ka-Fai To, MBChB, Tony S. Mok, MD, Molly S.C. Li, MBBS

“…Importantly, all patients (7/7 patients) who developed pneumonitis in our cohort expressed the HLA-DPB1∗02 allele, and the incidence of pneumonitis was 31.8% (7/22 patients) in patients expressing this allele compared with 0% (0/20 patients) in those without this allele (p = 0.009). …”
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Efficacy and safety of the Russian protease inhibitor narlaprevir at treatment-naive and earlier treated noncirrhotic patients with the 1st genotype chronic hepatitis C (PIONEER st... by M. V. Mayevskaya, V. T. Ivashkin, O. O. Znoyko, Ye. A. Klimova, D. T. Abdurakhmanov, I. G. Bakulin, P. O. Bogomolov, E. Z. Burnevich, M. Yu. Galushko, N. I. Geyvandova, K. V. Zhdanov, Ye. V. Esaulenko, S. N. Kizhlo, D. Yu. Konstantinov, N. I. Mironova, V. G. Morozov, Ye. A. Strebkova, I. G. Nikitin, M. F. Osipenko, V. D. Pasechnikov, O. I. Sagalova, I. M. Khayertynova, V. P. Chulanov, A. A. Yakovlev, I. A. Vasyutin, Ye. P. Tarkhova, E. N. Krasavina, M. Yu. Samsonov

“…In treatment-naïve patients from the main group SVR24 was achieved in 90.8% at initial METAVIR F0-F2 liver fibrosis stage and in 75% at F3 liver fibrosis stage. In those who were previously treated by peg-IFN/RBV, in the main group SVR-24 was attained in 72.6% at liver fibrosis stage F0-F2 and in 53.3% with F3 liver fibrosis stage. …”
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Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Lev... by Fabiana Corsi-Zuelli, Gary Donohoe, Siân Lowri Griffiths, Cristina M. Del-Ben, Andrew J. Watson, Tom Burke, Paris A. Lalousis, Declan McKernan, Derek Morris, John Kelly, Colm McDonald, Saahithh R. Patlola, Carmine Pariante, Nicholas M. Barnes, Golam M. Khandaker, John Suckling, Bill Deakin, Rachel Upthegrove, Maria R. Dauvermann

“…Future work identifying elevated levels of inflammation in larger samples may allow stratification and personalized intervention by subgroups who are at risk of poor outcomes.…”
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Comparison on the effect of different dressings on poor wound healing after surgery via posterior midline approach (不同敷料对后正中手术入路切口愈合不良的影响差异研究)... by ZHANG Tingting (张婷婷), ZHANG Hongyang (张宏扬), ZHU Ruifang (朱瑞芳)

“…Methods A total of 60 patients who underwent surgery via posterior midline approach in the pediatric ward of Neurosurgery Center of Tiantan Hospital were included as research objects. …”
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Influence of Exposure to Different Green Rooftop Spaces on Stress Restoration of College Students by Zhixiong ZHUO, Liang DONG

“…The volunteers are in good health without any adverse symptoms, who are asked to eat a healthy diet and get enough sleep before the experiment. …”
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