Liver Elastography for Liver Fibrosis Stratification: A Comparison of Three Techniques in a Biopsy-Controlled MASLD Cohort by Antonio Liguori, Giorgio Esposto, Maria Elena Ainora, Irene Mignini, Raffaele Borriello, Linda Galasso, Mattia Paratore, Maria Cristina Giustiniani, Laura Riccardi, Matteo Garcovich, Antonio Gasbarrini, Luca Miele, Maria Assunta Zocco

“…<b>Methods:</b> This prospective study included 75 consecutive patients with MASLD who underwent liver biopsy for suspected MASH. All patients underwent S-Shearwave Imaging by Samsung and 2D-SWE with SSI on the same day of liver biopsy. …”
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A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

“…Abstract This is a randomized, double-blind, placebo-controlled phase 3 clinical trial (ClinicalTrials.gov, NCT04878016) conducted in 54 hospitals in China. Adults who were histologically diagnosed and never treated for extensive-stage small cell lung cancer (ES-SCLC) were enrolled. …”
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Gestational weight gain and increased risk of cesarean delivery across body mass index categoriesAJOG Global Reports at a Glance by Pearl A. McElfish, PhD, Britni L. Ayers, PhD, Nicola L. Hawley, PhD, Aaron Caldwell, PhD, Austin Porter, DrPh, Michael D. Macechko, MD, Donya Watson, MD, Jennifer A. Callaghan-Koru, PhD, James P. Selig, PhD, Jennifer A. Andersen, PhD, Nirvana Manning, MD, Lanita White, PharmD, Enrique Gomez-Pomar, MD, Clare C. Brown, PhD

“…Only low-risk births were included (singleton, term-gestation [≥37 weeks], cephalic presentation, and first birth to exclude women who had a prior cesarean delivery). We used the rate of gestational weight gain (lb/wk) measured as both a categorical and continuous variable. …”
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Epilepsy care pathway: The Finnish model by Reetta Kälviäinen, Zakarya Hadj‐Allal, Jarkko Kirjavainen, Reina Roivainen, Tarja Linnankivi, Jukka Peltola, Kai Eriksson, Salla Lamusuo, Tuire Lähdesmäki, Johanna Annunen, Päivi Vieira, Virpi Tarkiainen, Leena Jutila, Anni Saarela, Leena Kämppi, Liisa Metsähonkala, Eija Gaily, Niina Lähde, Jaana Antinmaa, Sini Erme, Anna‐Leena Pirttisalo, Jari Virolainen, Milla Ylijoki, Laura Kela, Jonna Komulainen‐Ebrahim, Paula Sorjonen, Finnish Severe Epilepsy Coordination Group

“…They must align with the WHO Global Action Plan on Epilepsy, ensuring best practices and cost‐effective management. …”
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Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study by Rui Zhang, Hao Wang, Chenxi Song, Rui Fu, Kefei Dou, Shuai Liu, Qianqian Liu, Xiaohui Bian, Weida Liu, Chengang Zhu, Jingjing Gao, Sheng Yuan, Xinming Cui, Sijia Qin, Yumeng Li

“…Notably, the predictive performance of NT-proBNP for 1-year mortality was greater in patients receiving surgery than conservative treatment (between-cohorts difference in area under the curve 0.13, Delong’s test p=0.04).Conclusion NT-proBNP provides incremental prognostic information for mortality in patients with acute type A aortic dissection who underwent surgical repairment, which could aid in risk stratification as a pragmatic and versatile biomarker in this critically ill population while having limited prognostic value for those receiving conservative treatment.…”
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THE RIGHT TO GOOD ADMINISTRATION AS A CONSTITUTIONAL RIGHT OF THE PERSON: EU EXPERIENCE by Tetyana Kaganovska, Vitalii Serohin

“…This right applies not only to EU citizens, but to any person who contacts the relevant institutions. There is no clear definition of the principle of proper administration in EU legislation. …”
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Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group by Guadalupe Oñate, Ana Garrido, Montserrat Arnan, Helena Pomares, Ester Alonso, Mar Tormo, Marina Diaz-Beya, Susana Vives, Lurdes Zamora, Antonia Sampol, Rosa Coll, Olga Salamero, Marta Cervera, Antoni Garcia, Ferran Vall-Llovera, Sara Garcia-Avila, Joan Bargay, Xavier Ortin, Eva Iranzo, Francisca Guijarro, Marta Pratcorona, Josep F. Nomdedeu, Jordi Esteve, Jorge Sierra

“…Abstract Given the heterogeneity of acute myeloid leukemia patients, it is necessary to identify patients considered fit for intensive therapy but who will perform poorly, and in whom alternative approaches deserve investigation. …”
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Women's experiences and acceptability of self-administered, home delivered, intravaginal 5-Fluorouracil cream for cervical precancer treatment in Kenya by Konyin Adewumi, Aparna Ghosh Kachoria, Everlyn Adoyo, Mercy Rop, Mercy Rop, Antony Owaya, Jennifer H. Tang, Jennifer H. Tang, Lisa Rahangdale, Lisa Rahangdale, Lisa Rahangdale, Chemtai Mungo, Chemtai Mungo, Chemtai Mungo

“…To understand women's experiences with self-administered 5FU, we evaluated the acceptability of this intervention among trial participants.MethodsAll 12 participants from the Phase I trial completed a structured questionnaire and in-depth semi-structured interviews in their preferred language, focusing on their experiences with 5FU self-administration, challenges faced, and overall acceptability of the intervention, including whether they would use it again or recommend it to someone who needed it. Quantitative data were analyzed using descriptive statistics. …”
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Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

“…Methods We conducted a secondary analysis of the Broadening the Reach, Impact, and Delivery of Genetic Services (BRIDGE) trial at University of Utah Health and NYU Langone Health, involving 2,760 unaffected patients meeting genetic testing criteria for inherited cancer susceptibility and who were initially randomized to either an automated chatbot or an enhanced standard of care (SOC) genetic services delivery model. …”
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Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

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Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs by Thiago Fellipe Ortiz de Camargo, Thiago Fellipe Ortiz de Camargo, Guilherme Alberto Sousa Ribeiro, Guilherme Alberto Sousa Ribeiro, Maria Carolina Bueno da Silva, Luan Oliveira da Silva, Pedro Paulo Teixeira e Silva Torres, Denise do Socorro Rodrigues da Silva, Mayler Olombrada Nunes de Santos, William Salibe Filho, Marcela Emer Egypto Rosa, Magdala de Araujo Novaes, Thiago Augusto Massarutto, Osvaldo Landi Junior, Elaine Yanata, Marcio Rodrigues da Cunha Reis, Gilberto Szarf, Pedro Vieira Santana Netto, Joselisa Peres Queiroz de Paiva

“…This study evaluates a deep learning algorithm designed for CXR interpretation, focusing on its utility for non-specialists in thoracic radiology physicians.PurposeTo assess the performance of a Convolutional Neural Networks (CNNs)-based AI algorithm in interpreting CXRs and compare it with a team of physicians, including thoracic radiologists, who served as the gold-standard.MethodsA retrospective study from January 2021 to July 2023 evaluated an algorithm with three independent models for Lung Abnormality, Radiological Findings, and Tuberculosis. …”
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Effect of Traditional Chinese Medicine enema combined with injection via gastric tube in the treatment of gastrointestinal dysfunction in ICU patients (中药胃肠联合治疗ICU患者胃肠功能障碍的效果观察)... by ZHONG Yongjian (钟永建)

“…Methods Totally70 critically ill patients with gastrointestinal dysfunction who were hospitalized in the Department of Critical Care Medicine from January 2022 to December 2022 were selected. …”
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Angiographic Complete versus Clinical Selective Incomplete Percutaneous Revascularization in Heart Failure Patients with Multivessel Coronary Disease by Chieh-Yu Chang, Chun-Chi Chen, I-Chang Hsieh, Ming-Jer Hsieh, Cheng-Hung Lee, Dong-Yi Chen, Ming-Lung Tsai, Ming-Yun Ho, Jih-Kai Yeh, Yu-Chang Huang, Yu-Ying Lu, Chao-Yung Wang, Shang-Hung Chang, Ming-Shien Wen

“…During a mean follow-up period of 3.7 ± 1.9 years, there was no significant difference in 5-year MACEs between selective IR and successful angiographic CR in HF patients with MVD. However, patients who failed CR had a significantly greater incidence of 5-year MACEs than those in the other two groups (failed CR: 46.4% vs. selective IR: 27.7% vs. successful CR: 27.8%, p<0.001). …”
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A pelvis MR transformer-based deep learning model for predicting lung metastases risk in patients with rectal cancer by Yin Li, Yin Li, Yin Li, Shuang Li, Shuang Li, Ruolin Xiao, Ruolin Xiao, Xi Li, Yongju Yi, Yongju Yi, Liangyou Zhang, Liangyou Zhang, You Zhou, You Zhou, Yun Wan, Chenhua Wei, Liming Zhong, Liming Zhong, Wei Yang, Wei Yang, Lin Yao, Lin Yao, Lin Yao

“…This study aims to develop and validate a transformer-based deep learning (DL) model based on pelvic MR images, integrated with clinical features, to predict RCLM.MethodsA total of 819 patients with histologically confirmed rectal cancer who underwent preoperative pelvis MRI and carcinoembryonic antigen (CEA) tests were enrolled. …”
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Construction of feature selection and efficacy prediction model for transformation therapy of locally advanced pancreatic cancer based on CT, 18F-FDG PET/CT, DNA mutation, and CA19... by Liang Qi, Xiang Li, Jiayao Ni, Yali Du, Qing Gu, Baorui Liu, Jian He, Juan Du

“…Methods We retrospectively collected data from 70 patients with locally advanced pancreatic cancer who had undergone a biopsy for pathological diagnosis. …”
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Clinical study on the treatment of chronic heart failure with a novel D‐shant atrium shunt device by Xiaoke Shang, Mei Liu, Yucheng Zhong, Xueli Wang, Song Chen, Xiaojuan Fu, Ming Sun, Mingxing Xie, Yuhe Ke, Ying Guan, Changdong Zhang, Nianguo Dong

“…Methods and results From May 2020 to September 2020, six patients who were diagnosed with chronic heart failure and completed percutaneous D‐shant atrium shunt device implantation in the Department of Cardiovascular Surgery, Union Hospital, were retrospectively included. …”
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Intratumoral oncolytic virus OH2 injection in patients with locally advanced or metastatic sarcoma: a phase 1/2 trial by Lu Zhang, Shu Li, Jing Huang, Yan Wu, Liang Han, Tian Gao, Qingxia Fan, Suxia Luo, Binlei Liu, Lixin Zhou, Xinyu Wang, Ling Jia, Jianhua Shi, Zhichao Tan, Zhengfu Fan, Sijuan Ding, Chujie Bai, Ruifeng Xue, Jiayong Liu

“…Here, we examined the safety and efficacy of OH2 as a single agent or in combination with HX008, an NMPA-approved PD-1 inhibitor, in locally advanced or metastatic sarcoma patients.Methods This multicenter, phase 1/2 trial enrolled patients with injectable sarcoma lesions, who had failed at least 1 or more lines of standard treatment. …”
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Efficacy of PARPi re-maintenance therapy for recurrent ovarian cancer by Yulin Wang, Yunjie Yang, Binghong Guo, Binghong Guo, Xiaoyan Li, Renakezi Tuersun, Ye Cao, Jundong Li, Jihong Liu, Su Li, Tao Liu, Yongwen Huang

“…This study aims to investigate the efficacy and associated factors of PARPi re-maintenance therapy in PSROC patients in China.MethodsIn this study, there were 201 patients with PSROC who had received maintenance therapy previously and achieved complete or partial response after platinum-based chemotherapy upon recurrence. …”
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Impact of liver graft steatosis on long-term post-transplant hepatic steatosis and fibrosis via magnetic resonance quantification by Lung-Yi Mak, Lung-Yi Mak, James Fung, James Fung, James Fung, James Fung, Gladys Lo, Christine Shing-Yen Lo, Trevor Kwan-Hung Wu, Matthew Shing-Hin Chung, Tiffany Cho-Lam Wong, Tiffany Cho-Lam Wong, Wai-Kay Seto, Wai-Kay Seto, Albert Chi-Yan Chan, Albert Chi-Yan Chan, Man-Fung Yuen, Man-Fung Yuen

“…This study aimed to characterize PTHS and ≥ F3 using magnetic resonance imaging (MRI) in patients who underwent LT for non-MASLD indications and to examine their relationship with SLG.MethodsPost-LT patients with implant biopsy fat content data were recruited for MRI assessments. …”
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Analysis of early efficacy and immune reconstitution after autologous hematopoietic stem cell transplantation in multiple myeloma by Kaili Chen, Huixin Liang, Zezhong Yu, Guangyao Guo, Huijian Zheng, Yun Huang, Liping Liu, Jie Lin, Jinlan Long, Renyao Pan, Xi Chen, Changgui Wang, Wenjie Zhang, Zhenshu Xu

“…Ninety-four MM patients who underwent initial parallel sequential auto-HSCT were selected. …”
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