Circulating Isthmin-1 Levels and Their Relationship with Diabetes and Metabolic Diseases in Kuwaiti Adults by Eman Alshawaf, Sulaiman K. Marafie, Mohamed Abu-Farha, Ahmed N. Albatineh, Tahani Alramah, Aldana Albuhairi, Yafa Al Qassar, Reem Zinoun, Rawan Shalabi, Sarah Behbehani, Dalal Mohammed, Fahad Alajmi, Mohammed A. Abdalla, Ebaa Al-Ozairi, Mohammad Shehab, Muhammad Abdul-Ghani, Fahd Al-Mulla, Jehad Abubaker

“…The primary outcomes of this study are obesity, insulin resistance, MAFLD, and T2D, while the secondary outcome is hypertension; Methods: This is a cross-sectional study involving 450 participants, who were divided based on their obesity status into people with obesity (n = 182) and those without obesity (n = 265). …”
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Comparative analysis of clinical efficacy of unilateral biportal endoscopic and open transforaminal lumbar interbody fusion in the treatment of lumbar degenerative by Tao Ma, Xiaoshuang Tu, Junyang Li, Yongcun Geng, Yongcun Geng, Jingwei Wu, Senlin Chen, Dengming Yan, Dengming Yan, Ming Jiang, Ming Jiang, Gongming Gao, Luming Nong

“…In recent years, unilateral biportal endoscopic lumbar interbody fusion (ULIF) has gained increasing application.MethodsWe recorded the basic information of patients who underwent single-segment ULIF or TLIF for the first time in our hospital from May 2021 to November 2022, including age, gender, BMI, diagnosis, and surgical segment. …”
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Exploring the Interaction between Local Communities and Environmental Policies: A Qualitative Study of Conflicts between Natives and Rangers around the Protected Areas of Bojaq Nat... by Yaser Khoshsirat Salimi, Ali Ruhani, Hossein Afrasiabi, Sadegh Salehi

“…The locals argued that instead of addressing seawater pollution and regulating the Fisheries Organization and military entities that contributed to a challenging natural environment for local wildlife, the environmental organization had focused on controlling hunters, who used to engage in limited harvesting. When regulatory institutions fail to make substantial and foundational decisions, their capacity for environmental protection becomes restricted, often targeting the weakest links in the chain of culpability, thereby further depleting resources. …”
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Contrastive learning with transformer for adverse endpoint prediction in patients on DAPT post-coronary stent implantation by Fang Li, Zenan Sun, Ahmed abdelhameed, Tiehang Duan, Laila Rasmy, Xinyue Hu, Jianping He, Yifang Dang, Jingna Feng, Jianfu Li, Yichen Wang, Tianchen Lyu, Naomi Braun, Si Pham, Michael Gharacholou, DeLisa Fairweather, Degui Zhi, Jiang Bian, Cui Tao

“…., DeepSurv, DeepHit, and SurvTrace.ResultsThe final cohort comprised 19,713 adult patients who underwent DES implantation with more than 1 month of records after coronary stenting. …”
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Heart failure with mildly reduced ejection fraction: retrospective study of ejection fraction trajectory risk by Robert J.H. Miller, Majid Nabipoor, Erik Youngson, Gynter Kotrri, Nowell M. Fine, Jonathan G. Howlett, Ian D. Paterson, Justin Ezekowitz, Finlay A. McAlister

“…We assessed whether left ventricular ejection fraction (LVEF) trajectory can be used to identify groups of patients with HFmrEF who have different clinical outcomes in a large retrospective study of patients with serial imaging. …”
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Case report: Atypical young case of MV1 Creutzfeldt-Jakob disease with unusually long survival by Lucie Yeongran Ahn, Mark L. Cohen, Mark L. Cohen, Ignazio Cali, Ignazio Cali, Tia Russell, Jessica Ludwig, Xun Jia, Alberto Bizzi, Lawrence B. Schonberger, Ryan A. Maddox, Rohini Paul, Tania C. Ghazarian, Jaspreet Garcha, Mostafa Hammoudi, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby, Brian Stephen Appleby

“…Here, we present a 21-year-old female who died with a sporadic prion disease. She presented with psychiatric symptoms followed by a rapidly progressive neurocognitive and motor decline. …”
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Evaluation of Bone Mineral Metabolism in Pre-Dialysis Chronic Kidney Disease: Quantitative Computed Tomography vs. Dual-Energy Absorptiometry and Correlation with Bone Turnover Mar... by Aydan Mutis Alan, Zehra Sezer, Ahmet Oz, Cebrail Karaca, Mevlüt Tamer Dinçer, Ahmet Murt, Fatma Beyza Sag, Selma Alagoz, Serdar Sahin, Mustafa Sait Gonen, Elif Güzel, Sinan Trabulus, Nurhan Seyahi

“…<i>Results</i>: Data from 38 participants (patient group: 18; control group: 20) who underwent QCT and/or DXA were evaluated. Thirty-three subjects were assessed using both QCT and DXA (patient group: 14; control group: 19). …”
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Effectiveness and safety profile of mesenchymal stem cell secretome as a treatment for severe cases of COVID-19: a randomized controlled trial [version 2; peer review: 1 approved,... by Hary Sakti Muliawan, Erlina Burhan, Mia Elhidsi, Heri Wibowo, Triya Damayanti, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem, Ismail Hadisoebroto Dilogo, Mira Yulianti, Adityo Susilo, Irandi Putra Pratomo, Raden Rara Diah Handayani, Rahyussalim -, Murdani Abdullah, Cosphiadi Irawan, Robert Sinto, Dita Aditianingsih

“…We also found that most of the subjects who received placebo had high levels of IL-6 and ferritin (p=0.043) on the seventh day after the intervention. …”
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Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China’s two-child policy by SiQin Xiu, Li Tang, Chengjie Qin, Di Tian, Yuhong Chen, Lingling Gu, Liu Yang, Yuhao Sun, Xinghui Liu, Yonghong Lin, Yumei Wang

“…Methods We conducted a retrospective cohort study of 23,899 pregnant women who delivered between January 1, 2017 and December 31, 2019 at Chengdu Women’s and Children’s Central Hospital and West China Second Hospital of Sichuan University. …”
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Modified minimally invasive chevron osteotomy versus traditional incision chevron osteotomy by Run Tang, Jie Yang, Xiao Jun Liang, Yi Li, JunHu Wang, MiaoLuo Jin, Yang Du, Tong Lu, YiXiang Hao

“…Methods This retrospective study enrolled 42 patients (60 feet) with mild to moderate hallux valgus deformities who were treated with modified MIC osteotomy or TIC osteotomy between January 2020 and June 2021. …”
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The effect of the MyBFF@school program on cardiorespiratory fitness in overweight and obese primary schoolchildren: a cluster randomized controlled trial by Abdul Halim Mokhtar, Muhammad Ashaari Kamarudin, Alston Choong, Lakvinder Singh, Vinotha Genisan, Abqariyah Yahya, Ruziana Mona Wan Mohd Zin, Fuziah Md. Zain, Rusidah Selamat, Zahari Ishak, Muhammad Yazid Jalaludin

“…Schoolchildren aged 9–11 years with a body mass index (BMI) z-score greater than + 1 SD (WHO) were eligible for the study. The intervention group participated in the MyBFF@school program while the control followed the existing standard curriculum. …”
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The practice and exploration of SPOC-based online-offline mixed teaching mode in Traditional Chinese Medicine nursing teaching (基于SPOC的线上-线下混合式教学模式在中医护理教学中的实践与探索)... by WANG Li (王黎), MA Xueling (马雪玲), WANG Zhen (王臻), CHEN Hong (陈宏), WENG Zhiwen (翁志文), WANG Junxiang (王俊翔)

“…In addition, interview was conducted to several students who were taught with online-offline mixed teaching mode, which means the effects of online-offline mixed teaching mode were evaluated from both subjective and objective perspectives. …”
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Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma (FiTNEss (UK-MRA Myeloma XIV Trial)): a study protocol for a randomised phase III... by Roger Owen, John Jones, David Meads, David A Cairns, Christopher Parrish, Gordon Cook, Neil Rabin, Matthew Jenner, Martin Kaiser, Kevin Boyd, Graham Jackson, Catherine Olivier, Amy Beth Coulson, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Jennifer Bird, Stella Bowcock, Ruth de Tute, Hayley Gardner, Bryony Dawkins, Rowena Henderson, Phillip Best, Bhuvan Kishore, Mark Drayson

“…However, this is less apparent in older, less fit patients, who are ineligible for stem cell transplant. Research is required in this patient group, taking into account frailty and aiming to improve: treatment tolerability, clinical outcomes and quality of life.Methods and analysis Frailty-adjusted therapy in Transplant Non-Eligible patients with newly diagnosed Multiple Myeloma is a national, phase III, multicentre, randomised controlled trial comparing standard (reactive) and frailty-adjusted (adaptive) induction therapy delivery with ixazomib, lenalidomide and dexamethasone (IRD), and to compare maintenance lenalidomide to lenalidomide+ixazomib, in patients with newly diagnosed multiple myeloma not suitable for stem cell transplant. …”
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Survey on the Status and Training Demands of Capabilities for Diagnosing and Treating Common Diseases of Primary Care General Practitioners in Hunan Province by LI Lingqi, GAO Yinyan, ZHANG Yuqin, SUN Dingkui, WU Xinyin, ZHANG Weiru

“…Methods From April to May 2023, a convenience sampling method was used to recruit primary care general practitioners who participated in the residency training or general practitioner transfer training at Xiangya Hospital, Central South University. …”
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Disability, comorbidities and risk determinants at end of TB treatment in Kenya, Uganda, Zambia and Zimbabwe by The Kenya, Uganda, Zambia, and Zimbabwe TB Disability Study Group (members listed here in alphabetical order):, S.A. Adakun, F.M. Banda, A. Bloom, M. Bochnowicz, J. Chakaya, A. Chansa, H. Chiguvare, R. Chimzizi, C. Colvin, J.P. Dongo, A. Durena, C. Duri, R. Edmund, A.D. Harries, I. Kathure, F.N. Kavenga, Y. Lin, H. Luzze, I. Mbithi, M. Mputu, A. Mubanga, D. Nair, M. Ngwenya, B. Okotu, P. Owiti, A. Owuor, P. Thekkur, C. Timire, S. Turyahabwe, E. Tweyongyere, M. YaDiul, R. Zachariah, K. Zimba

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Examining the therapeutic potential and side effects of calcium channel blockers in mortality and morbidity of patients with stroke: A systematic review of pre-clinical and clinica... by Sevak Hatamian, Asad Abdi, Fatemeh Sadat Seyedi Asl, Armin Tafazolimoghadam, Arian Tavasol, Seyed Ali Mousavi Nejad, Reza Madadi, Zohre Tajabadi, Mina Dehghani, Najmeh Ahmadpoor, Mobina Fathi, Mohammadreza Hajiesmaeili, Navid Nooraei

“…Two studies did not report the number of patients who underwent treatment with CCBs. Among 24 studies, 11 reported favorable outcomes following CCB administration, and two studies reported neuroprotective effects for CCBs without any adverse outcome in stroke patients. …”
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Multifaceted Assessment of Chronic Gastritis: A Study of Correlations between Serological, Endoscopic, and Histological Diagnostics by Toshitatsu Takao, Takeshi Ishikawa, Takashi Ando, Madoka Takao, Tsuguhiro Matsumoto, Yutaka Isozaki, Mika Okita, Yasuyuki Nagao, Hirokazu Oyamada, Keiichi Yokoyama, Atsushi Tatebe, Kazuhiko Uchiyama, Osamu Handa, Tomohisa Takagi, Nobuaki Yagi, Satoshi Kokura, Yuji Naito, Toshikazu Yoshikawa

“…Subjects comprised 319 patients who had provided informed consent. Serological assessment of chronic gastritis was based on the pepsinogen test method. …”
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Contribution of flood early warning response measures in reducing flood effects in Kilosa District, Tanzania by Japhet Ringo, Shadrack Sabai, Anesi Mahenge

“…The responders to these warnings are the people in flood-prone areas at the individual and community (collective) levels, who then have to take voluntary or mandatory measures before and during flood events (onset time). …”
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3D-printed constructs deliver bioactive cargos to expedite cartilage regeneration by Rong Jiao, Xia Lin, Jingchao Wang, Chunyan Zhu, Jiang Hu, Huali Gao, Kun Zhang

“…Finally, clinical applications and future development of simulated cartilage printing are introduced, which are expected to provide new insights into this field and guide other researchers who are engaged in cartilage repair.…”
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Feasibility study of ‘Triple-Low’ technique for coronary artery computed tomography angiography (CCTA) by Shaochuan Wang, Zhengwen Sun, Yihong Zeng, Xinyu Xu, Yan Wang, Xueqin Liu, Yonggui Yang

“…We prospectively collected data from 90 patients who underwent CCTA at our hospital between 2021 and 2024. …”
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