Clinical utility and predictive value of cerebrospinal fluid cell-free DNA profiling in non-small cell lung cancer patients with leptomeningeal metastasis by Sheng-Kai Liang, Wei-Yu Liao, Jin-Yuan Shih, Chia-Lin Hsu, Ching-Yao Yang, Shang-Gin Wu, Yen-Ting Lin, Yueh-Feng Wen, Lun-Che Chen, Yen-Fu Chen, Ya-Fang Chen, Yen-Heng Lin, Chong-Jen Yu

“…We conducted a study from February 2022 to April 2023 involving patients from five hospitals in Taiwan who had recurrent or advanced NSCLC with LM. These patients underwent CSF cfDNA analysis using a 118-gene targeted panel for NGS, with comprehensive clinical data collected. …”
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Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2 by Naota Taura, Tatsuki Ichikawa, Hisamitsu Miyaaki, Yoshiko Kadokawa, Takuya Tsutsumi, Shotaro Tsuruta, Yuji Kato, Osami Inoue, Noboru Kinoshita, Kazuo Ohba, Hiroyuki Kato, Kazuyuki Ohata, Junichi Masuda, Keisuke Hamasaki, Hiroshi Yatsuhashi, Kazuhiko Nakao

“…A total of 100 chronic hepatitis C patients with HCV genotype 2 who received peg-IFN alfa-2b and ribavirin therapy were consecutively enrolled. …”
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Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis by Bin Yang, Leizhen Xia, Rufei Deng, Liping Wu, Zhiqin Zhang, Xingwu Wu, Tao Ding, Yan Zhao, Jialyu Huang, Jialyu Huang, Zhihui Huang

“…Additionally, we assessed whether DFI had a potential impact on long-term maternal and neonatal complications.MethodsA total of 5,271 women who underwent IVF treatment for the first time between October 1, 2020, and July 31, 2023, were included from an academic fertility center. …”
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Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium by V. A. Ivanisenko, N. V. Basov, A. A. Makarova, A. S. Venzel, A. D. Rogachev, P. S. Demenkov, T.  V. Ivanisenko, M. A. Kleshchev, E. V. Gaisler, G. B. Moroz, V. V. Plesko, Y. S. Sotnikova, Y. V. Patrushev, V. V. Lomivorotov, N. A. Kolchanov, A. G. Pokrovsky

“…The analysis revealed four significantly different sphingomyelin contents in patients with POD compared to those who did not develop POD (control group). Employing gene network reconstruction, we perceived a set of 82 regulatory enzymes affiliated with the genetic coordination of the sphingolipid metabolism pathway. …”
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Factors Affecting Influenza and Pneumococcal Vaccination Rates in Hemodialysis Patients: A Multicenter Study by Selen T, Merhametsiz Ö, Öneç K, Ercan Z, İslam M, Altun G, Pınar M, Demir ME

“…There were 220 patients (20.1%) who had knowledge about both vaccines. Among the patients, 95 (17.3%) had received the pneumococcal vaccine, with 41.1% of them having received it five years ago or more. …”
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Incidence of unintended pregnancies and pregnancy experience among adolescents living with perinatally-acquired HIV in West Africa: a mixed-method study by Désiré Lucien Dahourou, Clément Tisseron, Caroline Yonaba, Joël Djaha, Marie-Sylvie N’Gbeche, Corinne Moh, Kouakou Kouadio, Patricia Nindjin, François Eboua, Belinda Bouah, Karen Malateste, Jean-Claude Azani, Eulalie Kangah, Elisabeth Thio, Philippe Msellati, Julie Jesson, Valériane Leroy, for the IeDEA West-African Collaboration

“…In Abidjan, semi-structured interviews were also conducted with eight adolescents who became pregnant since their inclusion to report their pregnancy experience. …”
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Geospatial Access to Emergency Obstetric Surgery in Indonesia: Is Travel Time for Access Too Long? by Brahmana Askandar Tjokroprawiro, Hanif Ardiansyah Sulistya, Farizal Rizky Muharram, Renata Alya Ulhaq, Alifina Izza, Budi Prasetyo, Khoirunnisa Novitasari, Budi Wiweko, Pandu Hanindito Habibie, Arya Ananda Indrajaya Lukmana, Muhammad Muhibuddin Hilmy Asari

“…In this study, we aimed to quantify the percentage of Indonesian women of reproductive age (WRA) who can access a hospital with emergency obstetric and gynecological services within this time frame. …”
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Impact of corticosteroids on the efficacy of CD19/22 CAR-T cell therapy in pediatric patients with B-ALL: a single-center study by Jing Yang, Jing Zhang, Xinyu Wan, Jiaoyang Cai, Jiaoyang Cai, Tianyi Wang, Xiaomin Yang, Wenjie Li, Lixia Ding, Lili Song, Yan Miao, Xiang Wang, Yani Ma, Chengjuan Luo, Jingyan Tang, Longjun Gu, Jing Chen, Jun Lu, Yanjing Tang, Benshang Li

“…After eliminating the effect of consolidative transplantation on the prognosis, the EFS of the patients who did not use steroids was better (p = 0.037) in the LDB group, but the difference was not significant in the HDB group. …”
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The natural immune molecules urinary Tamm–Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control study by Zongping Li, Yingru Xu, Qian Wang, Gang Yuan, Jing Shu, Shiwei Liu, Xuezhong Gong

“…Despite this, predicting the risk of recurrence and the degree of immune compromise in patients who have had one urinary tract infection remains challenging. …”
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Faktor Risiko dan Faktor Pencetus yang Mempengaruhi Kejadian Asma pada Anak di RSUP Dr. M. Djamil Padang by Isnaniyah Usman, Eva Chundrayetti, Oea Khairsyaf

“…The study was conducted by interview to respondents who had been designated as a research subject. The subjects were all pediatric patients both inpatient and outpatient care that have been diagnosed as asthma by a physician in the hospital of Dr. …”
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High-dependency unit care after carotid endarterectomy for asymptomatic stenosis by Beatriz Guimarães, Andreia Coelho, Marina Dias-Neto, Ricardo Castro-Ferreira, João Peixoto, Luís Fernandes, Roberto Boal, Marta Machado, Francisco Basílio, Patrícia Carvalho, Armando Mansilha, Alexandra Canedo

“…CONCLUSIONS: In this analysis, the risk for CO development was consistently increased in patients who developed high MAP intra-operatively, highlighting the need for scrupulous BP management to reduce potential complications. …”
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An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene by Zita Reisz, Rita Pereira, Smitha Nevis, Alan Mackay, Leena Bhaw, Yura Grabovska, Ross Laxton, Valeria Molinari, Anna Burford, Barnaby Clark, Cristina Bleil, Bassel Zebian, Erika Pace, Annette Weiser, Fernando Carceller, Lynley Marshall, Andrew King, Istvan Bodi, Safa Al-Sarraj, Chris Jones, Matthew Clarke

“…Abstract Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), H3 K27-altered, diffuse hemispheric glioma (DHG), H3 G34-mutant). The WHO classification recognises in exceptional cases, these mutations co-occur. …”
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The effect of irrigation practice and water consumption using aqua-crop by M.D. Teweldebrihan, M.O. Dinka

“…This finding holds particular relevance in areas where water resources are limited.CONCLUSION: The Food Agriculture Organization’s aqua-crop is a useful tool for farmers who have limited access to water. Aqua-crop is a computer-based model that replicates the growth of crops in different irrigation scenarios. …”
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Effects of intradermal acupuncture in relieving the non-incisional pain and promoting anal exhaust and defecation after gynecological laparoscopy (皮内针在缓解妇科腹腔镜术后非切口疼痛及促进排气排便中的效果观察)... by LIU Xiaoyu (刘晓宇), XU Daoli (徐道立), LIU Ying (刘颖), LU Yin (卢英)

“…Methods A total of 152 patients who underwent laparoscopic surgery were selected and divided into a control group(n=60) and a treatment group(n=80). …”
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Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcino... by Lei Yu, Lan Zhang, Xin Xu, Zheng Wang, Jian Zhou, Jia Fan, Wentao Wang, Zhenggang Ren, Lixing Li, Peiran Huang

“…The study aims to evaluate the efficacy and safety of this treatment strategy for such patients.Methods In this single-arm, prospective, phase II study, we enrolled eligible patients with HCC who were treated with TACE plus programmed cell death protein 1 (PD-1) inhibitors (sintilimab) from April 2021 to February 2023. …”
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A Novel Point-of-Care Prediction Model for Steatotic Liver Disease: Expected Role of Mass Screening in the Global Obesity Crisis by Jeayeon Park, Goh Eun Chung, Yoosoo Chang, So Eun Kim, Won Sohn, Seungho Ryu, Yunmi Ko, Youngsu Park, Moon Haeng Hur, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim

“…Methods: We retrospectively analyzed the clinical data of 28,506 adults who had routine health check-ups in South Korea from January to December 2022. …”
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Inappropriate medication prescribing, polypharmacy, potential drug-drug interactions and medication regimen complexity in older adults attending three referral hospitals in Asmara,... by Nuru Abdu, Saleh Idrisnur, Hanae Said, Lude Kifle, Natnael Habte, Semira Ghirmai, Tomas Tewelde, Senai Mihreteab Siele, Eyasu H. Tesfamariam

“…Methods A cross-sectional study was conducted among older adults (aged 65 years and above) who visited three referral hospitals in Asmara, Eritrea, between June and August, 2023. …”
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MANIFESTATION OF COVID-19 IN THE SECOND TRIMESTER OF PREGNANCY: FEATURES OF GESTATION, OBSTETRIC AND PERINATAL OUTCOMES by Людмила Станиславовна Ищенко, Екатерина Евгеньевна Воропаева, Элла Алексеевна Казачкова, Евгений Леонидович Казачков, Татьяна Николаевна Шамаева, Елена Романовна Вейсенборн, Юлия Сергеевна Ищенко

“…Patients of the main group, depending on the severity of COVID-19, were divided into 4 groups: with a mild course (n = 137) – group 1, with a moderate course (n = 259) – group 2, with a severe course (n = 50) – 3 group with extremely severe infection (n = 10) – group 4. 90 women in the third trimester of gestation who had no history of COVID-19 during this pregnancy – a comparison group. …”
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Implementation of model-informed precision dosing for tamoxifen therapy in patients with breast cancer: A prospective intervention study by Ruben Y.M. van Nijnatten, Sanne M. Buijs, Bram C. Agema, Raphaël M.J. Fischer, Inge Ghobadi Moghaddam-Helmantel, Caroline M.E. Contant, Felix E. de Jongh, Auke M.T. Huijben, Manon Kop, Annemieke van der Padt-Pruijsten, Hanneke J.M. Zuetenhorst, Ron H.N. van Schaik, Birgit C.P. Koch, A. Jager, Stijn L.W. Koolen, Ron H.J. Mathijssen

“…This may partly be explained by a larger proportion of patients who were recommended to switch to an aromatase inhibitor (AI) in the intervention cohort. …”
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Effect of anastomotic reinforcement with barded suture on anastomotic leakage prevention following laparoscopic low anterior resection for rectal cancer: a retrospective single-cen... by Xinyu Qi, Kai Xu, Maoxing Liu, Fei Tan, Pin Gao, Chuanyong Zhou, Zhendan Yao, Nan Zhang, Hong Yang, Chenghai Zhang, Jiadi Xing, Ming Cui, Xiangqian Su

“…Methods During the period from November 1, 2018 to November 1, 2023, a total of 725 consecutive patients who had underwent laparoscopic LAR for rectal cancer were enrolled in this study. …”
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