Empagliflozin-based quadruple oral therapy for type 2 diabetes: a prospective cohort study by Fatemeh Moosaie, Shiva Abedinzadeh, Soghra Rabizadeh, Kimia Daneshvar, Mohammadamin Noorafrooz, Fatemeh Alsadat Mojtahedi, Niloofar Deravi, Seyede Marzie Fatemi Abhari, Akam Ramezani, Alipasha Meysamie, Marzieh Hajibabaei, Sahar Karimpour Reyhan, Mahsa Abbaszadeh, Manouchehr Nakhjavani, Alireza Esteghamati

“…This prospective cohort study aimed to assess the effectiveness of Empagliflozin as part of a quadruple OHA regimen over a 7-year follow-up period in 575 adult patients with uncontrolled T2DM on a triple OHA regimen and who were unwilling to initiate insulin therapy. …”
Get full text

Case report: The case of T-cell acute lymphoblastic leukemia treated with chemotherapy followed by anti-CD7 CAR-T cells using retroviral vector by Huanhuan Zhou, Wenxiang Zhu, Qihong Ma, Ning Liu, Mengdi Jin, Yaru Feng, Lijun Zhao, Rui Sun, Rongyou Li, Huaxiu Li, Yuanyuan Shi, Jianxun Wang, Liqiong Liu, Zhi Guo, Zhi Guo, Zhi Guo

“…In this study, we reported a case of a 34-year-old male patient with T-ALL who finally developed multi-line drug resistance and refractoriness after multiple lines of high-intensity chemotherapy. …”
Get full text

Representation of Hispanic Patients in Clinical Trials for Respiratory Failure: A Systematic Review by Emily A. Harlan, MD, MA, MSc, Kaitlin Malley, BS, Grecia Quiroga, MD, Eman Mubarak, MD, Pema Lama, BS, Amanda Schutz, PhD, Adolfo Cuevas, PhD, Catherine L. Hough, MD MSc, Theodore J. Iwashyna, MD PhD, Mari Armstrong-Hough, PhD, Thomas S. Valley, MD, MSc

“…Exclusion of participants who do not speak English may represent a barrier to trial enrollment.…”
Get full text

Efficacy and Safety of Low-Dose Lenvatinib and Toripalimab in Patients With Recurrent Platinum-Resistant Ovarian Cancer: Study Protocol of a Multicenter, Open-Label, Single-Arm, Ph... by Su H, Shang X, Liu H, Wang Y, Yu Y, Xu Y, Jiang K, Feng F

“…Patients with recurrent epithelial ovarian cancer who have disease progression either during or within 6 months after completion of platinum-based therapy will be included. …”
Get full text

Occupational Radiation Exposure during Endoscopic Retrograde Cholangiopancreatography and Usefulness of Radiation Protective Curtains by Tomoyuki Minami, Tamito Sasaki, Masahiro Serikawa, Michihiro Kamigaki, Masanobu Yukutake, Takashi Ishigaki, Yasutaka Ishii, Teruo Mouri, Satoshi Yoshimi, Akinori Shimizu, Tomofumi Tsuboi, Keisuke Kurihara, Yumiko Tatsukawa, Eisuke Miyaki, Kazuaki Chayama

“…We studied medical staff members who had assisted in 80 consecutive therapeutic endoscopic retrograde cholangiopancreatography (ERCP) procedures. …”
Get full text

Linking weather and climate information services (WCIS) to Climate-Smart Agriculture (CSA) practices by Tafadzwanashe Mabhaudhi, Tinashe Lindel Dirwai, Cuthbert Taguta, Aidan Senzanje, Wuletawu Abera, Ajit Govid, Elliott Ronald Dossou-Yovo, Ermias Aynekulu, Vimbayi Grace Petrova Chimonyo

“…Results: The results revealed that seasonal forecasts were the main WCIS available to farmers who utilised them to plan predominantly for irrigation and water harvesting activities. …”
Get full text

Types of electronic nicotine delivery systems (ENDS) used by people of different age and smoking status groups: results from a US nationally representative survey by Lucy Popova, Robert T Fairman, David L Ashley, Zachary B Massey, Bai Cham, Ruiyan Luo, Mohammed Alqahtani, Scott Weaver

“…This study sought to identify differences in the use of ENDS device type based on age and cigarette use status to inform policy about regulating ENDS.Design This was a cross-sectional study.Setting Data was derived from a national survey conducted in 2021 in the USA.Participants Participants include 2369 US youth and adults (13 years or older) who reported past 30-day ENDS use.Outcome measures Past 30-day fairly regular use (i.e., several times a week or more) of ENDS device types, namely cigalikes, disposables, refillable tank/box mods, closed pods, refillable pods and drippers. …”
Get full text

Comorbidities and neurosurgical interventions in a cohort with connective tissue disorders by Ilene S. Ruhoy, Paolo A. Bolognese, Jared S. Rosenblum, Randall A. Dass, Navdeep S. Nayyer, Navdeep S. Nayyer, Jeffrey D. Wood, Jeffrey D. Wood, John B. Biggins, John B. Biggins

“…Of the total cohort, 426 (59%) were diagnosed with Chiari I Malformation, which shared a significant overlap with hEDS. Of those who elected to undergo surgery (n = 612), 61% required craniocervical fusion (CCF). …”
Get full text

Comparative cardiometabolic safety and effectiveness of aripiprazole in people with severe mental illness: A target trial emulation. by Alvin Richards-Belle, Alvin Richards-Belle, Naomi Launders, Sarah Hardoon, Al Richards, Kenneth K C Man, Neil M Davies, Elvira Bramon, Joseph F Hayes, David P J Osborn

“…., bipolar disorder, schizophrenia, and other non-organic psychoses) who were prescribed a new antipsychotic between 2005 and 2017, with a 2-year follow-up to 2019. …”
Get full text

Xen 63 versus Preserflo MicroShunt implant in patients with primary open-angle glaucoma by José María Martínez-de-la-Casa, Antonio Pascual-Santiago, Laura Morales-Fernandez, Federico Saez-Frances, Sofia Garcia-Saenz, Noemi Guemes-Villahoz, Ruben Sanchez-Jean, Carmen Mendez, Julian Garcia-Feijoo

“…It is a retrospective and single-center study conducted on consecutive on patients with medically uncontrolled POAG who underwent either a standalone Xen 63 or a standalone Preserflo and had a 12-month follow-up visit. …”
Get full text

IOP-lowering effect and tolerability of prostaglandin analogues in primary open-angle glaucoma and ocular hypertension as risk factors for glaucoma progression by A.V. Belogurova, E.N. Eskina, Zh.G. Oganezova

“…<br> The article reviews the data on IOP-lowering effect and tolerability of preservative-free tafluprost 0.0015% in patients with POAG and ocular hypertension who have switched from preservative-containing prostaglandin analogues. …”
Get full text

Does tocilizumab eliminate inflammation in GCA? A cohort study on repeated temporal artery biopsies by Chiara Marvisi, Francesco Muratore, Carlo Salvarani, Pierluigi Macchioni, Pamela Mancuso, Luigi Boiardi, Stefania Croci, Paolo Giorgi Rossi, Alberto Cavazza, Annibale Versari, Rexhep Durmo, Caterina Ricordi, Martina Bonacini, Giuseppe Malchiodi

“…We aimed to evaluate the histological impact of adding tocilizumab (TCZ) to GCs.Methods We enrolled all consecutive GCA patients with an inflammed TAB at diagnosis who were treated with TCZ and GCs for ≥6 months and followed from December 2017 to December 2023. …”
Get full text

Preparation of Nutmeg Gel and Evaluation of its Efficacy as Local Drug Delivery in Stage II Grade A Periodontitis Patients: A Prospective Interventional Study by Vazeeha Afrin Syed, AS Pavithra, Arvina Rajasekar, Rajeshkumar Shanmugam

“…Followed by in-vitro analysis, 40 patients with stage II grade A periodontitis patients who reported between June 2023 and September 2023 to the Department of Periodontology were enrolled. …”
Get full text

Comparison of Intraoperative and Postoperative Outcomes of Sleeve and Dorsal Slit Technique of Circumcision: A Prospective Interventional Study by N Snigdha, R Lakshmana, Das Debarath, Natarjan Soorya, A Pravindhas, M Malar Mannan

“…Sixty patients diagnosed with phimosis, balanoposthitis, paraphimosis and patients who requested circumcision for religious reasons were randomly assigned to undergo either the sleeve technique (Group A) or the dorsal slit technique (Group B). …”
Get full text

Negative childbirth experience in Dutch women: A socio-ecological analysis of individual, interpersonal, and organisational factors from the birth experience study by Tamool A.S. Muhamed, Viola Angelini, Laura Viluma, Hazel Keedle, L. Lilian Peters

“…Aim: To examine differences between women who reported positive and negative childbirth experience and detangle the complexity of negative childbirth experience by building a socio-ecological model that includes individual, interpersonal, and organisational factors. …”
Get full text

Association of Time in Target Range of Resting Heart Rate With Adverse Clinical Outcomes in Patients With Acute Coronary Syndromes After Percutaneous Coronary Intervention by Jianmei Zheng, Cen Chen, Zhongcai Fan, Qiang Ye, Yi Zhong, Jinsong Li, Hao Huang, Jianping Deng, Jinghong Zhao, Tinglin Xiong, Wenjie Tian, Xuemei Zhang

“…A total of 1455 ACS patients who underwent percutaneous coronary intervention (PCI) and were admitted to 22 hospitals between 2019 and 2022 were enrolled and followed up for 12 months. …”
Get full text

Effect of Lamotrigine on Refractory Epilepsy: Clinical Outcomes and EEG Changes by Li Z, Wu P, Chen Q, Tong X, Yang Q

“…Lamotrigine, with its proven efficacy and tolerability, offers potential benefits when combined with traditional medications like valproate, though its comprehensive impact on clinical outcomes and neurological markers requires further study.Objective: To analyze the improvement effect of combined application of lamotrigine on refractory epilepsy patients and its impact on patients’ EEG and neurological function.Methods: This retrospective cohort study analyzed the clinical data of 93 patients with refractory epilepsy who were admitted to our hospital between January 2023 and June 2024. …”
Get full text

Real World Experience of Chronic Hepatitis C Retreatment with Genotype Specific Regimens in Nonresponders to Previous Interferon-Free Therapy by Dorota Zarębska-Michaluk, Iwona Buczyńska, Krzysztof Simon, Magdalena Tudrujek-Zdunek, Ewa Janczewska, Dorota Dybowska, Marek Sitko, Beata Dobracka, Jerzy Jaroszewicz, Paweł Pabjan, Jakub Klapaczyński, Łukasz Laurans, Włodzimierz Mazur, Łukasz Socha, Olga Tronina, Miłosz Parczewski, Robert Flisiak

“…We demonstrated moderate effectiveness of genotype specific rescue therapy in failures due to virologic reason and high in those who discontinued primary therapy. Therefore rescue therapy with genotype specific regimens should be considered always if more potent regimens are not available.…”
Get full text

Common mental disorders and associated factors among adult patients admitted in non-psychiatric wards of public hospitals in Harari regional State, Eastern Ethiopia by Hirko Assefa, Tilahun Ali, Ibsa Mussa, Tadesse Misgana, Dawit Abdi, Abinet Zewudie, Abdi Temesgen

“…The study suggested that patients who are admitted to non-psychiatric wards should be screened for common mental disorders and its associated factors as part of routine inpatient care.…”
Get full text

Factors associated with decreased anal sphincter tone and the accuracy of forced anal examinations to detect individuals having receptive anal intercourse: an observational study by John A Schneider, Alan G Nyitray, Derek Smith, Michael W Ross, Elizabeth Y Chiao, Timothy J Ridolfi, Bridgett Brzezinski, B R Simon Rosser, Aniruddha Hazra, Jenna Nitkowski, Sandrine Sanos, Ever Mkonyi, Lucy Mgopa

“…Compared with individuals having always/mostly insertive anal intercourse, individuals having always/mostly receptive anal intercourse were associated with decreased RT, but not ST, while those equally preferring both insertive and receptive anal intercourse were not associated with decreased RT or ST.Conclusion Decreased sphincter tone is uncommon among SGM who prefer receptive anal intercourse. Given virtually no accuracy, a finger inserted into the anus has no utility to detect individuals practising receptive anal intercourse and thus should not be used as such.Trial registration number NCT04090060.…”
Get full text