Association between DNA methylation levels of thioredoxin-interacting protein (TXNIP) and changes in glycemic traits: a longitudinal population-based study by Keisuke Maeda, Ryosuke Fujii, Hiroya Yamada, Eiji Munetsuna, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Hiroaki Ishikawa, Koji Ohashi, Yoshiki Tsuboi, Yuji Hattori, Yuya Ishihara, Nobuyuki Hamajima, Shuji Hashimoto, Koji Suzuki

“…We therefore examined the association between TXNIP DNAm levels and longitudinal changes in glycemic traits by conducting a longitudinal study involving 169 subjects who underwent two health checkups in 2015 and 2019. …”
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2-Aminothiophene Derivatives—New Drug Candidates Against Leishmaniasis: Drug Design, Synthesis, Pharmacomodulation, and Antileishmanial Activity by Rodrigo Santos Aquino de Araújo, Vitória Gaspar Bernardo, Robert da Silva Tibúrcio, Danilo Cesar Galindo Bedor, Michel Leandro de Campos, Roberto Pontarolo, Julyanne Maria Saraiva de Sousa, Klinger Antonio da Franca Rodrigues, Marcus Tullius Scotti, Anuraj Nayarisseri, Pascal Marchand, Francisco Jaime Bezerra Mendonça-Junior

“…<b>Background/Objectives</b>: Leishmaniasis is one of the 20 Neglected Tropical Diseases according to the WHO, affecting approximately 12 million people in four continents, generating serious public health problems. …”
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Unraveling the Role of Oxygen Pulse Variability in Endurance Exercise Training in Individuals with COPD: A Novel Approach to Response of Oxygen Pulse and Quality of Life in Pulmona... by Huang SY, Hsieh PC, Huang KL, Yang MC, Jao LY, Tzeng IS, Lan CC, Wu YK

“…Cardiopulmonary exercise testing (CPET) measures oxygen pulse (O2P), an indicator of stroke volume, yet the impact of baseline O2P on PR effectiveness remains unclear.Methods: This retrospective study included 97 participants with COPD who had received PR, of whom 48 were classified as Group 1 (normal O2P) and 49 as Group 2 (low O2P). …”
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Efficacy of Moringa oleifera Seed Husk as Adsorptive Agent for Trihalomethanes from a Water Treatment Plant in Southwestern, Nigeria by Aderonke Adetutu Okoya, Olasunkanmi Olalekan Olaiya, Abimbola Bankole Akinyele, Nnenneh Oruada Ochor

“…Moringa oleifera (MO) has found wide acceptance by many people in Nigeria who have used it for food for both humans and fauna, for health purposes, and as a coagulant for water treatment. …”
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The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model by Changjing Xu, Junlong Zhu, Kun Tu, Hui Tang, Xinxin Zhou, Qiuyu Li, Kun Chen, Xuping Yang, Yilan Huang

“…This study aimed to explore the risk factors and developed a nomogram model for predicting the risk of coagulopathy in patients undergoing CPZ/SAM treatment.MethodsA total of 1719 patients who underwent CPZ/SAM in the Affiliated Hospital of Southwest Medical University from August 2018 to August 2022, were recruited as the training cohort. …”
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Efficacy, safety, and biomarker analysis of TACE combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a real-world study by Lingzhan Meng, Hu Li, Yingjie Ji, Peng Yu, Zizheng Wang, Li Cao, Bin Shi, Yanling Shao, Jin Yan, Yinjie Gao, Zhenyu Zhu

“…Methods Unresectable HCC patients who received TACE in combination with sintilimab plus Lenvatinib as first-line treatment from 1 January 2020 to 31 March 2023 were included for the analysis. …”
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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…The study will recruit 90 participants who will undergo serial clinical assessment over 12 months with advanced cardiovascular imaging (CMR scans with automated analysis at baseline, 6 and 12 months), cardiac biomarker measurement (six time points over 12 months), plus complete heart failure QoL and medication disutility questionnaires. …”
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Clinical characteristics and frailty status in heart failure with preserved vs. reduced ejection fraction by Tomoyuki Hamada, Toru Kubo, Kazuya Kawai, Yoko Nakaoka, Toshikazu Yabe, Takashi Furuno, Eisuke Yamada, Hiroaki Kitaoka, Kochi YOSACOI study

“…Patients for whom left ventricular ejection fraction data were not available (n = 19), patients with heart failure with mildly reduced ejection fraction (n = 172), and patients who were not assessed by the J‐CHS criteria (n = 225) were excluded. …”
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Perceived stress and family adaptability in head and neck cancer patients receiving radiotherapy: the chain-mediated effect of social support and family resilience by Xiaoru Li, Xiaoru Li, Xiaoru Li, Yu Zhu, Yu Zhu, Yu Zhu, Hongwei Wan, Hongwei Wan, Hongwei Wan

“…The aim of the present study was to investigate the relationship between perceived stress and family adaptability in patients with head and neck tumors and to analyze whether social support and family resilience play a mediating role in this relationship.MethodsThe convenience sample approach was utilized to recruit 316 patients with head and neck tumors who received radiation. Self-developed general information questionnaires, the Chinese Perceived Stress Scales, Social Support Rating Scale, the Shortened Chinese Version of the Family Resilience Assessment Scale, and Family Adaptability Scale were used to collect data. …”
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Self-Management Strategies for Low Back Pain Among Horticulture Workers: Protocol for a Type II Hybrid Effectiveness-Implementation Study by Kim Dunleavy, Heidi Liss Radunovich, Jason M Beneciuk, Boyi Hu, Yang Yang, Janeen McCormick Blythe, Kelly K Gurka

“…ObjectiveThis study will (1) investigate the effectiveness of self-management strategies for nursery and landscape workers by comparing within-subject control and intervention periods and (2) determine if adoption and effectiveness differs between participants randomly assigned to review self-management videos only and those who also receive multimodal implementation support. …”
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Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia by Anna Alari, Otavio Ranzani, Carles Milà, Sergio Olmos, Xavier Basagaña, Payam Dadvand, Talita Duarte-Salles, Mark Nieuwenhuijsen, Cathryn Tonne

“…Conclusions: Long-term exposure to air pollution was positively associated with hospital admission for lower respiratory infections. Individuals who were older than 65 years, hypertensive or male were most vulnerable.…”
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Iron Overload in Transfusion-Dependent Indonesian Thalassemic Patients by Pandji Irani Fianza, Anita Rahmawati, Sri Hudaya Widihastha, Shofura Afifah, Mohammad Ghozali, Andre Indrajaya, Dilli Marayuzan Akbar Pratama, Dimmy Prasetya, Teddy Arnold Sihite, Mas Rizky A. A. Syamsunarno, Djatnika Setiabudi, Suthat Fucharoen, Ramdan Panigoro

“…Additionally, youth and adult TDT patients whose serum ferritin >5000 ng/mL had significantly lower tricuspid annular plane systolic excursion (TAPSE) when compared with those who had serum ferritin <2500 ng/mL. Similarly, TAPSE in patients with moderate cardiac siderosis based on cardiac T2∗ MRI was significantly lower than those without cardiac siderosis. …”
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The appearance of scalp high‐frequency oscillations is associated with poor seizure control in pediatric epilepsy patients by Keisuke Maeda, Nami Hosoda, Himari Tsuboi, Honoka Naito, Chiaki Kudo, Junichi Fukumoto, Shiho Fujita, Naohiro Ichino, Keisuke Osakabe, Keiko Sugimoto, Shunta Yamaguchi, Naoko Ishihara

“…Plain Language Summary This study analyzed scalp high‐frequency oscillations and spikes in pediatric patients with various types of epilepsy who were being treated using ASMs. The results showed that an increased risk of scalp HFO appearance was observed in patients with poor seizure control compared to those with good seizure control. …”
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Prevalence and determinants of clustering of adverse lifestyle behaviors among 35 – 75 years old residents at high cardiovascular disease risk in Hebei province: an analysis of dat... by Yuejing QIAO, Yuhuan LIU, Lijuan TANG, Dongsheng JIANG, Xiaoli LIU, Ze CUI

“…MethodsInformation on 29 721 residents aged 35 – 75 years who were considered at high risk of CVD was collected from the datasets of the CVD Early Detection and Comprehensive Intervention Project, which was conducted in 11 sites in Hebei province from 2018 to 2021. …”
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Accuracy of noninvasive total haemoglobin measurement for detecting anaemia in infants: a cross-sectional study in a well-child care clinic, Khon Kaen, Thailand by Leelawadee Techasatian, Rattapon Uppala, Suchaorn Saengnipanthkul, Chamaiporn Tawiangnan, Prapassara Sirikarn, Sakuntala Supasai, Phanthila Sitthikarnkha

“…This study evaluated the accuracy of noninvasive total haemoglobin (Hb) spot-check monitoring as part of anaemia screening in healthy infants, compared with the conventional laboratory method.Design A cross-sectional study was conducted using a consecutive sampling technique.Setting The study was carried out at the Well-Child Clinic, Khon Kaen University, Thailand.Participants Healthy, full-term infants aged 6–12 months who were scheduled for vaccination. Spectrophotometric haemoglobin (SpHb) was measured using Masimo Rad-67 with Rainbow DCI-mini Sensor. …”
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Factors associated with thermal injury of abdominal skin in focused ultrasound ablation of uterine fibroids by Tang Chendian, Huang Guohua, Zhibiao Wang, Liu Fang, Shuang Luo, Xiaofang Liu, Qiuling Shi

“…Objective To investigate the factors which may cause thermal injury of abdominal skin in patients with uterine fibroids (UFs) who underwent ultrasound-guided focused ultrasound ablation surgery (FUAS).Method A total of 123 patients were enrolled in the injury group. …”
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ADAPTIVE COMFORT PADA GRAND STUDIO PROGRAM STUDI ARSITEKTUR FAKULTAS TEKNIK UNIVERSITAS MALIKUSSALEH by Atthaillah Atthaillah, Eri Saputra, Muhammad Iqbal

“…The thermal sensation of the space was uncomfortable both for students and lecturers who had used the studio.  Thisinvestigation of this study is to prove the subjective of uncomfortable sensation that can become responsible objective using measurement of adaptive comfort.  …”
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A qualitative research on health education needs of pregnant women with gestational diabetes mellitus (妊娠期糖尿病孕产妇健康教育需求的质性研究) by TAN Minjing (覃敏静), YANG Miaomiao (杨苗苗), WANG Kaihua (王凯华), LUO Chunmiao (罗春苗), ZHOU Jinchang (周金嫦)

“…Methods From October to December 2020, the purposive sampling was adopted to select 12 pregnant women with diabetes mellitus who gave birth in our hospital as the research objects. …”
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Meta Analysis on Rehabilitation Effect of Proprioception Training on Ankle Sprainof Athletes by Yuxiao CHEN, Jiaojiao LIU, Changsong Yi, Mengguang CHAI, Qing WANG, Lei JIANG

“…Objective:To explore the effects of proprioception training on the incidence of athletes' ankle sprains, dynamic neuromuscular control, postural stability and joint position perception.Methods:Data were searched from the databases of PubMed, Cochrane Library, EMbase, China National Knowledge Infrastructure(CNKI), Wanfang Database(Wangfang Data), Chinese Journal Full-text Database(VIP), China Biomedical Literature Database(CBMdisc).Athletes were included in the randomized controlled trials(RCTs)who were treated with proprioception training to improve the function of athlete's ankle joint.The retrieval time for each database was from the establishment of the database to December 31, 2019, and the references of related documents were traced.Two researchers independently searchered the literature, extracted data, and evaluated the quality of the literature.RevMan5.3 software was used to analyze the data.According to the systematic review manual provided by the Cochrane Collaboration Network, the continuous variables use mean difference(<italic>MD</italic>)and 95%confidence interval(<italic>CI</italic>)as indicators, and binary variables use risk ratio(RR)and 95%<italic>CI</italic> as indicators.The statistical heterogeneity was judged comprehensively by chi-square test(χ²test)and the Heterogeneity test(<italic>I</italic>²test).If <italic>P</italic>≥0.1 and <italic>I</italic>²≤50%, a fixed effects model would be used.In contrast, if <italic>P</italic>&lt;0.1 or <italic>I</italic>²&gt;50%, a random effects model would be used.Results:A total of 11 RCTs and 1 776 athletes were included.The results of Meta analysis showed that compared with the control group, the incidence of ankle sprains in the experimental group was significantly reduced after proprioceptive training[<italic>RR</italic>=0.61, 95%<italic>CI</italic>(0.41, 0.90), <italic>P</italic>=0.01]; compared with the control group, the posterolateral and posterior medical maximum extension distances of the experimental group increased significantly after proprioception training[<italic>MD</italic>=4.44, 95%<italic>CI</italic>(3.66, 5.23), <italic>P</italic>&lt;0.00 001;<italic>MD</italic>=4.21, 95%<italic>CI</italic>(3.18, 5.24), <italic>P</italic>&lt;0.00 001]and the difference was statistically significant;but there was no significant difference in the improvement effect of the anterior maximum extension distance, and the difference was not statistically significant(<italic>P</italic>&gt;0.05).The postural sway of the affected ankle joint in the experimental group was significantly lower than that in the control group;the athletes in the experimental group had better position perception ability in the ankle joint plantar flexion, dorsiflexion, middle and lateral directions than the control group.Conclusion:Proprioceptive training can effectively reduce the incidence of athletes' ankle sprains, improve dynamic neuromuscular control, improve postural stability, and enhance ankle joint position perception, which is worthy of clinical application.However, the absolute effect is not yet clear, so large samples and high-quality randomized controlled trials are still needed to further verify the efficacy of proprioception training, so as to provide more reliable evidence-based evidence for clinical rehabilitation.…”
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A Novel Artificial Intelligence–Enhanced Digital Network for Prehospital Emergency Support: Community Intervention Study by Ji Hoon Kim, Min Joung Kim, Hyeon Chang Kim, Ha Yan Kim, Ji Min Sung, Hyuk-Jae Chang

“…However, for patients with fever or respiratory symptoms, the group using the system showed a statistically significant reduction in outlier cases (36.5%-30.1%, P=.01). For patients who received real-time acceptance signals from the hospital, the reduction in the percentage of 75% outliers was statistically significant compared with those without the system (27.5%-19.6%, P=.02). …”
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