Efficacy and safety of filgotinib in patients with rheumatoid arthritis: week 156 interim results from a long-term extension study by Hendrik Schulze-Koops, Tsutomu Takeuchi, Daniel Aletaha, Maya H Buch, Yoshiya Tanaka, Ricardo Blanco, Paul Emery, Jacques-Eric Gottenberg, Bernard G Combe, Roberto Caporali, Patrick Verschueren, Vijay Rajendran, Anna Zubrzycka-Sienkiewicz, Edmund V Ekoka Omoruyi, Francesco De Leonardis

“…Efficacy assessments up to week 156 include American College of Rheumatology 20% response (ACR20), Disease Activity Score 28 using C-reactive protein of <2.6, Clinical Disease Activity Index of ≤2.8, Simplified Disease Activity Index of ≤3.3 and Boolean remission (1.0 and 2.0) with non-responder imputation.Results In patients with an inadequate response to methotrexate, 60.2% and 54.6% receiving de novo filgotinib 200 mg and 100 mg had an ACR20 at week 156, respectively, as did 67.3% and 59.5% of those who continued filgotinib 200 mg and 100 mg. At week 156, Boolean remission 1.0 was achieved by 18.8% and 15.4% of patients treated with de novo filgotinib 200 mg and 100 mg, respectively, and by 21.1% and 18.5% when Boolean 2.0 criteria were applied. …”
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Autistic and transgender/gender diverse people’s experiences of health and healthcare by Kate Green, Elizabeth Weir, Lily Wright, Carrie Allison, Simon Baron-Cohen

“…As our sample was biased towards white individuals, UK residents, relatively highly educated individuals, those assigned female at birth, and those who currently identify as female, our findings may be less applicable to individuals of differing demographics. …”
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Unveiling the pathways: identifying the multifaceted determinants of low birth weight among neonates in low-income countries: a case-control study by Dube Jara, Angefa Ayele, Dukele Boneya, Jitu Beka, Miesa Gelchu, Alo Edin

“…Background Low birth weight, as defined by the WHO, refers to the weight of a neonate below 2500 g at birth and is a significant public health concern globally, with both short- and long-term consequences. …”
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Seizure prevalence in children aged up to 3 years: a longitudinal population-based cohort study in Japan by Kandai Nozu, Masahiro Nishiyama, Hiroshi Yamaguchi, Yusuke Ishida, Kazumi Tomioka, Hiroki Takeda, Noriyuki Nishimura, Hiroki Mishina, Kazumoto Iijima, Hiroaki Nagase

“…Objective To investigate the prevalence of seizures/febrile seizures in children up to 3 years of age and examine the effects of gestational age at birth on the risk for febrile seizures.Design Retrospective longitudinal population-based cohort study.Setting Kobe City public health center, Kobe, Japan, from 2010 to 2018.Participants Children who underwent a medical check-up at 3 years of age.Methods Information regarding seizures was collected from the parents of 96 014 children. …”
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Baseline Smartphone App Survey Return in the Electronic Framingham Heart Study Offspring and Omni 1 Study: eCohort Study by Jian Rong, Chathurangi H Pathiravasan, Yuankai Zhang, Jamie M Faro, Xuzhi Wang, Eric Schramm, Belinda Borrelli, Emelia J Benjamin, Chunyu Liu, Joanne M Murabito

“…MethodsFramingham Heart Study Offspring and Omni (multiethnic cohort) participants who owned a smartphone were invited to download this study’s app that contained a range of survey types to report on different aspects of health including self-reported measures from the Patient-Reported Outcomes Measurement Information System (PROMIS). iPhone users also completed 4 tasks including 2 cognitive and 2 physical function testing tasks. …”
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A Pragmatic Clinical Trial to Compare the Real-World Effectiveness of V-Go versus Standard Delivery of Insulin in Patients with Advanced Type 2 Diabetes by Mark J. Cziraky, Scott Abbott, Matt Nguyen, Kay Larholt, Elizabeth Apgar, Thomas Wasser, Poul Strange, Leon Shi, H. Courtenay Harrison, Beverly Everitt, Lynn Nowak

“…A cost of therapy analysis was completed on patients who had received comparable baseline T2DM treatment with multiple daily basal-bolus insulin injections (MDI). …”
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A Histopathological Study of Skin Lesions in Individuals with Oculocutaneous Albinism in Togo in 2019 by Bayaki Saka, Julienne Noude Teclessou, Sefako Abla Akakpo, Piham Gnossike, Kwamé Doh, Saliou Adam, Abas Mouhari-Toure, Garba Mahamadou, Panawé Kassang, Yvette Elegbede Moise, Tchin Darre, Koussake Kombate, Palokinam Pitché

“…The 54 skin carcinomas were diagnosed in 33 (41.8%) of the 79 patients who underwent skin biopsies/excisional biopsies. …”
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Significance of Early Postoperative Arterial Lactic Acid, Inferior Vena Cava Variability, and Central Venous Pressure in Hypovolemic Shock by Wei Lin, Xingsheng Lin, Yingfeng Zhuang, Xiaobin Pan, Chao Wu, Shujuan Zhang, Lihui Zhang, Jian Lin, Songjing Shi, Songchang Shi

“…This is a retrospective study of patients who underwent surgical resuscitation in the Department of Critical Care Medicine. …”
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Paramedic Recognition of Sepsis in the Prehospital Setting: A Prospective Observational Study by Robert S. Green, Andrew H. Travers, Edward Cain, Samuel G. Campbell, Jan L. Jensen, David A. Petrie, Mete Erdogan, Gredi Patrick, Ward Patrick

“…Accurate paramedic recognition of sepsis is important to initiate care promptly for patients who arrive by Emergency Medical Services. Methods. …”
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Geographic and socioeconomic variation of sodium and potassium intake in Italy: results from the MINISAL-GIRCSI programme by Simona Giampaoli, Francesco P Cappuccio, Chen Ji, Luigi Palmieri, Diego Vanuzzo, Chiara Donfrancesco, Renato Ippolito, Pasquale Strazzullo

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Efficacy and Acceptability of a Mobile App for Monitoring the Clinical Status of Patients With Chronic Obstructive Pulmonary Disease Receiving Home Oxygen Therapy: Randomized Contr... by Anisbed Naranjo-Rojas, Luis Ángel Perula-de Torres, Freiser Eccehomo Cruz-Mosquera, Guillermo Molina-Recio

“…At the end of the follow-up, the Borg dyspnea scale was significantly lower in patients who used the mobile app for HO therapy monitoring (mean 0.6, SD 0.8 vs mean 4.1, SD 1.4; P=.001). …”
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Ratio of Skeletal Muscle Mass to Visceral Fat Area Is a Useful Marker for Assessing Left Ventricular Diastolic Dysfunction among Koreans with Preserved Ejection Fraction: An Analys... by Jin Kyung Oh, Yuri Seo, Wonmook Hwang, Sami Lee, Yong-Hoon Yoon, Kyupil Kim, Hyun Woong Park, Jae-Hyung Roh, Jae-Hwan Lee, Minsu Kim

“…Methods : In total, 1,070 participants with preserved left ventricular ejection fraction who underwent comprehensive health examinations, including transthoracic echocardiography and bioimpedance body composition analysis, were enrolled. …”
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Survey of medication history of patients with stroke after discharge from an acute hospital ward: a case series study by Yuko Fukuda, Risa Ito, Misaki Kakihana, Tsutomu Takahashi, Tetsuji Kanemoto, Toshiyuki Sahara, Masahiko Tsujikawa, Mitsuko Onda

“…Methods We enrolled patients who were discharged from an acute ward between June 11, 2022, and March 31, 2023, after receiving inpatient care at the Japan Community Healthcare Organization, Hoshigaoka Medical Center for acute stroke, and transferred to other outpatient hospitals. …”
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Evaluation of Two Different Solvents for Azolla pinnata Extracts on Chemical Compositions and Larvicidal Activity against Aedes albopictus (Diptera: Culicidae) by Rajiv Ravi, Nor Shaida Husna Zulkrnin, Nurul Nadiah Rozhan, Nik Raihan Nik Yusoff, Mohd Sukhairi Mat Rasat, Muhammad Iqbal Ahmad, Zulhazman Hamzah, Intan H. Ishak, Mohamad Faiz Mohd Amin

“…Next, larvicidal test following WHO guidelines was tested against late 3rd instar to early 4th instar larvae of Ae. albopictus mosquitoes. …”
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Geographical Differences in the Safety and Efficacy of Tofacitinib Versus TNFi: A Post Hoc Analysis of ORAL Surveillance by Bogdan Batko, Slawomir Jeka, Piotr Wiland, Agnieszka Zielińska, Maria Stopińska-Polaszewska, Marcin Stajszczyk, Magdalena Kosydar-Piechna, Mary Jane Cadatal, Jose L. Rivas

“…Methods Patients with RA in ORAL Surveillance (NCT02092467), who were aged ≥ 50 years with ≥ 1 additional CV risk factor, received tofacitinib 5 or 10 mg twice daily or TNFi; 45.9% were from either Poland or North America. …”
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Assessing customer satisfaction: the case of test prescribers at the clinical biology laboratory of Centre Muraz/ Institut National de Santé Publique, Burkina Faso by Dame Yenyetou, Issouf Sanou, Chérileila Thiombiano, Bakary Diamoutany Sogodogo, Adama Sanou, Soufiane D. Sanou, Mamoudou Cisse, Amariane M. M. Kone, Aline R. Ouoba, Dramane Kania, Michel K. Gomgnimbou, Ibrahim Sangare, Abdoul-Salam Ouedraogo

“…The questionnaire was distributed to the laboratory's prescribers, who were contacted ahead of time and consented. …”
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Digital Frequency Customized Relieving Sound for Chronic Subjective Tinnitus Management: Prospective Controlled Study by Dongmei Tang, Yuzhu Peng, Dantong Gu, Yongzhen Wu, Huawei Li

“…In this nonrandomized concurrent controlled trial, a total of 107 participants were assigned to listen to personalized DFCRS through our developed app, while the other 77 participants who did not want to download and use the app were assigned to listen to unmodified music (UM). …”
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Effect of Situational Interactive Respiratory Training System on Patients with Respiratory Dysfunction after Stroke by TAN Lishuang, WANG Na, ZHAO Xiaoxue, DU Tianshu, ZHANG Yan

“…ObjectiveTo explore the effect of situational interactive respiratory training system on respiratory function, swallowing function and activities of daily living of patients with respiratory dysfunction after stroke.MethodsA total of 60 patients with respiratory dysfunction after stroke who were treated in the Rehabilitation Center of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from September 2018 to September 2020, which were randomly divided to the the control group and the observation group, with 30 cases in each group. …”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…BackgroundUpadacitinib, a Janus kinase inhibitor, has been increasingly used over the past few years to treat moderate to severe ulcerative colitis and Crohn’s disease in patients who are insufficiently responsive or intolerant to tumor necrosis factor (TNF) antibodies, demonstrating notable clinical efficacy. …”
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Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…The complement system has been implicated in the etiopathogenesis of RA.ObjectiveTo evaluate the effect of systemic IL-6 inhibition on complement pathways functional activity in RA patients treated with TCZ.DesingProspective non-interventional study.MethodsTwenty-seven RA patients included in the TOCRIVAR study who received TCZ (8mg/kg IV/q4w) were evaluated at baseline and at weeks 12, 24 and 52 of treatment. …”
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