Traditional Chinese acupuncture versus minimal acupuncture for mild-to-moderate knee osteoarthritis: a protocol for a randomised, controlled pilot trial by Guang-Xia Shi, Cun-Zhi Liu, Ning Sun, Yi Du, Jian-Feng Tu, Yong-Ting Li, Li-Wen Zhang, Yan Cao, Jing-Jie Zhao, Da-Chang Xiong, Hai-Kun Hou

“…Our objective is to evaluate the efficacy of traditional Chinese acupuncture for pain relief and function improvement in mild-to-moderate knee osteoarthritis (TCAKOA) participants.Methods/analysis 42 patients will be recruited who have been diagnosed with mild-to-moderate KOA and randomly allocated in equal proportions to traditional Chinese acupuncture or minimal acupuncture. …”
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Insulin therapy adherence and its associated factors among diabetic patients in a Ghanaian primary care hospital. by Israel Abebrese Sefah, Michael Mensah, Araba Ata Hutton-Nyameaye, Emmanuel Sarkodie, Johanna C Meyer, Brian Godman, Varsha Bangalee

“…<h4>Method</h4>This was a cross-sectional survey among adult (≥18 years) diabetic patients who are currently using insulin, either alone or in combination with an oral antidiabetic regimen, and seeking primary care at Kwame Nkrumah University of Science and Technology Hospital in Ghana. …”
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Intestinal obstruction caused by disseminated mycobacterium avium complex disease following solid organ transplantation: a case report by Akane Mita, Sho Nakakubo, Yusuke Nishimura, Hideki Shima, Masaaki Watanabe, Tsuyoshi Shimamura, Satoshi Konno

“…Case presentation A 76-year-old woman, who had undergone living-donor liver transplantation 15 years earlier for primary biliary cirrhosis, presented with persistent fever and vomiting three months before admission. …”
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Utility of Ascitic Fluid Adenosine Deaminase Levels in the Diagnosis of Tuberculous Peritonitis in General Medical Practice by Ayako Kumabe, Shuji Hatakeyama, Naoki Kanda, Yu Yamamoto, Masami Matsumura

“…A retrospective cohort of 181 adult patients who underwent ascitic fluid ADA level examination at Jichi Medical University Hospital between January 2006 and December 2015 were included. …”
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Correlation between Cortical Excitability and Hand Function in Patients with Subacute Cerebral Infarction by Ling CHEN, Junling WANG, Dongfeng HUANG

“…Objective:To observe the cortical activation characteristics of cerebral motor prediction in patients with subacute cerebral infarction in the palm grasping task, and to explore the correlation between cortical excitability and hand function in patients with cerebral infarction.Methods:A total of twenty-five patients with subacute cerebral infarction who were hospitalized in the first affiliated hospital of Sun Yat-sen University from January 2017 to March 2018 were selected as the experimental group, and twenty-five healthy individuals matched with the gender and age of the experimental group were selected as the control group.Event related potentials were used to collect the electroencephalogram signals of the two groups in the palm grasping task, and then analyzed the latencies and amplitudes of the contingent negative variation(CNV)in the cerebral cortex before motor activation.Action Research Arm Test(ARAT)was used to assess the function of hand, and the correlation between CNV amplitude and ARAT score was analyzed.Results:Compared with the control group, the CNV latencies in the midline region of the experimental group were significantly shorter during the left hand grasp and right hand grasp, and the CNV amplitude were statistically significantly increased in the midline, bilateral frontal lobe and primary motor area(M1)(<italic>P</italic>&lt;0.05).There was no significant difference in CNV latency between left hand grasp and right hand grasp in the experimental group(<italic>P</italic>&gt;0.05), with the CNV amplitude of Cz electrode in midline statistically significantly greater than that of C4 electrode in contralateral M1(<italic>P</italic>&lt;0.05).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during right hand grasp in the experimental group(F4: <italic>r</italic>=0.510; C4: <italic>r</italic>=0.442; Fz: <italic>r</italic>=0.428).There was moderate correlation between the CNV amplitude and ARAT in the non-lesioned frontal lobe, M1 and midline during left hand grasp in the experimental group(F4: <italic>r</italic>=0.422; C4: <italic>r</italic>=0.496; Fz: <italic>r</italic>=0.446).Conclusion:The neural mechanism of motor anticipation in patients with subacute cerebral infarction is abnormal, the time of brain motor preparation is prolonged, and the non-lesioned frontal lobe and M1 are hyperactivity compensatory during motor anticipation.There was moderate correlation between the cortical excitability and hand dysfunction.Therefore, CNV may be a neural indicator of the severity of hand dysfunction in patients with cerebral infarction.…”
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Effect of Donor Sperm on Quality of Life in Patients with Severe Oligoasthenosperm After ICSI Failure by Wang K, Xu Y, Qin N, Guo Y, Bai J, Li Z

“…Ke Wang,1– 3,&ast; Yan Xu,2,3,&ast; Ningxin Qin,1 Yi Guo,1 Jie Bai,3 Zheyuan Li4 1Center of Reproductive Medicine, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 2Department of Nursing, Shanghai Sanda University, Shanghai, 201209, People’s Republic of China; 3School of Medicine, Tongji University, Shanghai, 200092, People’s Republic of China; 4Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ningxin Qin, Email ningxinqin@51mch.comObjective: To explore the effects of donor sperm on reproductive quality of life, sleep quality and erectile function in patients with severe oligoasthenospermia after the failure of intracytoplasmic sperm injection (ICSI), and to provide targeted reference for intervention.Methods: From January 2021 to December 2023, patients with severe oligoasthenospermia who received assisted pregnancy treatment in Obstetrics and Gynecology Hospital Affiliated to Tongji University were selected as the study objects. …”
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BIMSSA: enhancing cancer prediction with salp swarm optimization and ensemble machine learning approaches by Pinakshi Panda, Sukant Kishoro Bisoy, Amrutanshu Panigrahi, Abhilash Pati, Bibhuprasad Sahu, Zheshan Guo, Haipeng Liu, Prince Jain

“…According to the World Health Organization (WHO), 9.9 million people died from cancer in 2020. …”
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Intracranial otogenic complications in adults: new factors that influenced its onset, frequency and nature by Małgorzata Wierzbicka, Michalina Staśkiewicz, Oskar Rosiak, Katarzyna Karmelita-Katulska, Witold Szyfter, Wojciech Gawęcki

“…We consulted extensively with the Bioethics Committee at Poznan University of Medical Sciences who determined that our study did not need ethical approval. …”
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The survey of the status of self-stigma of depression and its relationship with demographic factors in Gonabad, Iran by Hadi Tehrani, Hadi Tehrani, Fatemehzahra Naddafi, Mahbobeh Nejatian, Alireza Jafari

“…Individuals with a history of mental disorder had higher SSD (p = 0.011) and help-seeking inhibition (p = 0.004). People who did not obtain information related to mental illness had more help-seeking inhibition (p = 0.001). …”
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Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study by Tong Liu, Wenqiang Li, Sarah Tan Siyin, Nan Yao, Ning Duan, Guoshuai Xu, Jun Qu, Siqing Liu

“…We prospectively investigated hs-CRP in relation to the occurrence of GSD based on the Kailuan study.Study design Prospective cohort study.Setting The Kailuan cohort study was conducted in Tangshan City in northern China.Participants 95 319 participants who were free from GSD were recruited in this study. …”
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Concurrent Renorrhaphy During Renal Mass Excision in Laparoscopic Nephron-Sparing Surgery: A Novel Surgical Technique by Nurullah Hamidi, Tuncel Uzel

“…Written informed consent was obtained from the patients who agreed to take part in the study. Results: The total operative and renorraphy time was 85 and 10 minutes, respectively. …”
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Association between herpes simplex virus infection and Alzheimer’s disease biomarkers: analysis within the MAPT trial by Morgane Linard, Isabelle Garrigue, Bruno Vellas, Nicola Coley, Henrik Zetterberg, Kaj Blennow, Nicholas James Ashton, Pierre Payoux, Anne-Sophie Salabert, Jean-François Dartigues, Joachim Mazere, Sandrine Andrieu, Catherine Helmer

“…Our sample included 182 participants at risk of cognitive decline from the Multidomain Alzheimer Preventive Trial who had HSV-1 plasma serology and an amyloid PET scan. …”
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Correlation Between Spinopelvic Parameters, Body Mass Index, Waist Circumference, and Chronic Non-Specific Low Back Pain by Daphne Butzen, Yannick Smolders, Tom Stroobants, Gino Verleye, Dieter Thijs, Erik Van de Kelft

“…Methods: Adult patients presenting to the outpatient neurosurgery clinic with non-specific chronic low back pain who had undergone full spine radiography were included. …”
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Use of Tramadol or Other Analgesics in Patients Treated in the Emergency Department as a Risk Factor for Opioid Use by Jorge Enrique Machado-Alba, Laura Sofía Serna-Echeverri, Luis Fernando Valladales-Restrepo, Manuel Enrique Machado-Duque, Andrés Gaviria-Mendoza

“…Based on a medication dispensation database, patients over 18 years of age treated in different clinics in Colombia who for the first time received tramadol, dipyrone, or a nonsteroidal anti-inflammatory drug (NSAID) in the emergency room between January and December 2018 were identified. …”
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HER2-related biomarkers predict clinical outcomes with trastuzumab deruxtecan treatment in patients with HER2-expressing metastatic colorectal cancer: biomarker analyses of DESTINY... by Salvatore Siena, Kanwal Raghav, Toshiki Masuishi, Kensei Yamaguchi, Tomohiro Nishina, Elena Elez, Javier Rodriguez, Ian Chau, Maria Di Bartolomeo, Hisato Kawakami, Fumitaka Suto, Makito Koga, Koichiro Inaki, Yusuke Kuwahara, Issey Takehara, Daniel Barrios, Kojiro Kobayashi, Axel Grothey, Takayuki Yoshino

“…Baseline circulating tumor DNA (ctDNA) analysis suggests antitumor activity of T-DXd in patients who had baseline activating RAS, PIK3CA, or HER2 mutations detected in ctDNA.…”
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The Role of Serum Vitamin D Levels and Vitamin D Receptor (<i>VDR</i>) Gene Variants on Dental Caries by Ece Şengün Berber, Feyza Umay Koç, Ayça Aykut, Burcu Barutçuoğlu, Fahinur Ertuğrul, Merve Tosyalı, Mert Pekerbaş, Arzu Aykut Yetkiner

“…Methods: This study included 128 3–6-year-old children who were divided into 64 caries-free and 64 carious children. …”
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Effect of Isoniazid Preventive Therapy on the Incidence of Tuberculosis among Seropositive Children Attending HIV/AIDS Care in Two General Hospitals, Northwest Ethiopia, 2021 by Fassikaw Kebede, Birhanu Kebede, Tsehay Kebede, Melaku Agmasu

“…Missed IPT (AHR = 7.45, 95% CI: 2.96, 18.74, P<0.001), missed cotrimoxazole preventive therapy (CPT) (AHR = 2.4, 95% CI: 1.84–4.74, P<0.022), age ≥ 11 years (AHR = 4.2, 95% CI: 1.04–7.03, P<0.048), MUAC ≤ 11.5 cm (AHR = 4.36, 95% CI: 1.97–9.97, P<0.001), WHO stages III and IV (AHR = 2.04, 95% CI: 1.12–3.74, P<0.022), and CD4 count ≤100 cells/μl (AHR = 3.96, 95% CI: 1.52–10.34, P<0.005) were significantly associated with TB incidence. …”
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An Ontology for Digital Medicine Outcomes: Development of the Digital Medicine Outcomes Value Set (DOVeS) by Benjamin Rosner, Matthew Horridge, Guillen Austria, Tiffany Lee, Andrew Auerbach

“…MethodsFrom a starting point of a 4-generation–deep hierarchical taxonomy developed by ADviCE, we developed DOVeS using the Web Ontology Language through the open-source ontology editor Protégé, and data from 185 vendors who had submitted structured product information to ADviCE. …”
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Characterization of Cannabis usage in individuals with non-cancer chronic pain in the state of Maine using the Behavioral Risk Factor Surveillance System (BRFSS) by Rachel Bordonaro, Elizabeth N. Bean, Ling Cao

“…Methods We identified individuals with chronic pain as those that reported having a rheumatoid condition diagnosis, and controls as those who reported no such conditions. To focus on non-cancer chronic pain, we excluded individuals that had previous cancer diagnoses. …”
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Recognizing and addressing burnout among healthcare workers in rural Nepal: a proof-of-concept study using Kern’s six-step theoretical framework by Raj Kumar Dangal, Eva Studer, Tula Krishna Gupta, Kristin Nguyen, Amit Suneja, Karuna Khadka, Shailina Bata Shrestha, Bibhav Acharya

“…We then developed learning objectives for knowledge, attitude, and skills domains based on the World Health Organization (WHO) definition of burnout. Then, we created animated educational videos designed to meet the learning objectives. …”
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