General practitioners’ clinical decision-making in patients that could have cancer: a vignette study comparing the Baltic states with four Nordic countries by Alexander Rosendahl, Anet Vanaveski, Liina Pilv-Toom, Jānis Blumfelds, Vija Siliņa, Mette Brekke, Tuomas Koskela, Aurimas Rapalavičius, Hans Thulesius, Peter Vedsted, Michael Harris

“…This study investigated the likelihood of General Practitioners (GPs) investigating or referring patients with a low but significant risk of cancer in these two regions, and how this was affected by GP demographics.Design A survey of GPs using clinical vignettes.Setting General Practice in Denmark, Estonia, Finland, Latvia, Lithuania, Norway, and Sweden.Subjects General Practitioners.Outcome measures A regional comparison of GPs’ stated immediate diagnostic actions (whether or not they would perform a key diagnostic test and/or refer to a specialist) for patients with a low but significant risk of cancer (between 1.2 and 3.6%).Results Of the 427 GPs that completed the questionnaire, those in the Baltic states, and GPs that were more experienced, were more likely to arrange a key diagnostic test and/or refer their patient to a specialist than those in Nordic Countries or who were less experienced (p < 0.001 for both measures). …”
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A Scoping Review of Factors Associated with Delayed Extubation in Post Cardiac Surgery Patients by Kumalasari RI, Kosasih CE, Priambodo AP

“…Consequently, further research focusing on DE is essential, particularly in patients who have undergone cardiac surgery.Keywords: cardiac surgery, delayed extubation, mechanical ventilation…”
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Analysis of the Relationship Between Body Mass Index (BMI) and Dento-Skeletal Maturation: A Cross-Sectional Case-Control Study by Alessio Verdecchia, Inmaculada Coronado de la Torre, Ivan Menéndez Diaz, Veronica García Sanz, Yolanda García Mesa, Teresa Cobo, Vanessa Paredes Gallardo

“…These findings may be of interest for orthodontists, who should consider weight status when performing orthodontic treatment in children and adolescents.…”
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The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma by Wenhui Wang, Fuyuan Wu, Zhe Wu, Mengfan Zhang, Qiang Lu

“…Finally, AZD5582 drug toxicity was detected to confirm its feasibility.ResultsXIAP protein expression is significantly increased in recurrent hepatocellular carcinoma tissues of patients who previously received microwave ablation therapy. …”
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Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients by YongWei Jiang, Liang Ma, ChengWu Han, Qian Liu, Xiao Cong, YaPing Xu, TingTing Zhao, Ping Li, YongTong Cao

“…We studied 845 diabetic patients who were divided into DN group (n=429) and control group (n=416). …”
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Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…Eligible participants are those who are at least 18 years old, have a diagnosis of active moderate to severe CD and have failed to respond to or tolerate at least two prior lines of standard medication. …”
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Comparing Clinical Outcomes of Five-Strand Hamstring Tendon Autograft and Quadrupled Hamstring Tendon Autograft for Single Bundle Anterior Cruciate Ligament Reconstruction in Filip... by Albert Ian Villegas, Emmanuel Roy Mata, Jose Antonio San Juan, John Rey Go, Vick Roland Ladica

“…Methodology: This ambi-directional cohort study involved Asian Filipino patients aged 18–50 with unilateral ACL tears who underwent single-bundle ACL reconstruction with either quadrupled or five-strand hamstring autografts between January 2022 and August 2023. …”
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Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…Twenty-eight patients with coronary artery disease and who underwent DES implantations were randomly assigned to pioglitazone (30 mg/d; PIO) or placebo (control; Con) treatment in addition to optimal standard therapy. …”
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Advanced heart failure: guideline‐directed medical therapy, diuretics, inotropes, and palliative care by Daniela Tomasoni, Julie K.K. Vishram‐Nielsen, Matteo Pagnesi, Marianna Adamo, Carlo Mario Lombardi, Finn Gustafsson, Marco Metra

“…Patients with severe HF who received omecamtiv mecarbil experienced a significant treatment benefit, whereas patients without severe HF did not (P = 0.005 for interaction). …”
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Spontaneous tumor regression following COVID-19 vaccination by Hui Dai, Renata Ferrarotto, Myrna Godoy, Diana Bell, Shiaw-Yih Lin, Daniel J McGrail, Luana Guimaraes de Sousa, Kaiyi Li, Mario L Marques-Piubelli, Cipriano Gonzalez, Sammy Ferri-Borgogno, Jared Burks

“…Here, we report spontaneous regression of metastatic salivary gland myoepithelial carcinoma in a patient who experienced grade 3 systemic reactogenicity, following vaccination with the mRNA-1273 COVID-19 vaccine. …”
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Detection of Mycobacterium tuberculosis DNA in intraocular fluid of 11 suspected tuberculous uveitis patients by multiplex PCR by Huirong Xu, Min Xu, Fang Chen, Hong Chen, Wei Du, Jing Yu

“…The results of multiplex PCR tests were correlated with intraocular fluid findings and clinical profiles of patients clinically diagnosed with tuberculous uveitis who underwent standard antituberculosis therapy. …”
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Does therapy with immunosuppressive drugs improve gastrointestinal symptoms in patients with systemic sclerosis? by Oliver Distler, Cosimo Bruni, Suzana Jordan, Carina Mihai, Muriel Elhai, Rucsandra Dobrota, Alexandru Garaiman, Mike Oliver Becker, Lea Stamm, Sherif Ismail, Norina Zampatti, Aurora Maria Tatu

“…We aimed to identify an association between immunosuppressive therapy and the the severity of GI symptoms, measured by the University of California at Los Angeles/Scleroderma Clinical Trial Consortium Gastro-Intestinal Tract instrument 2.0 (GIT).Methods We selected patients with SSc who had at least two visits (further referred to as ‘baseline’ and ‘follow-up’) with completed GITs, within an interval of 12±3 months. …”
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Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion by Zheng Huang, Xialin Li, Weihong Yi, Junfeng Gong, Yue Zhou, Yu Tang

“…Methods: This single-center retrospective study reviewed the medical records of 96 patients who underwent single-level PELIF for degenerative pathologies between 2018 and 2020. …”
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A novel approach for managing the incisions of tibial plateau fractures with soft tissue swelling by Yang Zhang, Yangyang Zhao, Shuanggong Liu, Zihan Yao, Zikang Jin, Wanli Ma

“…We retrospectively enrolled 64 patients with TPFs who underwent surgery at the Second Hospital of Shandong University. …”
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Role of the very low frequencies of the renal oxygen saturation signal in acute kidney injury in newborns with perinatal asphyxia by Daniel Botero-Rosas, Sergio Agudelo-Pérez, Sergio Agudelo-Pérez, Gloria Troncoso, Maria C. Gómez, Eduardo Tuta-Quintero

“…This component demonstrated good predictive ability for AKI (ROC curve 0.77, 95% CI 0.63–0.90).ConclusionAmong neonates with perinatal asphyxia who developed AKI, a lower power of the very-low-frequency component in FFT (approximately 0.01 Hz) was observed on the second day of therapeutic hypothermia. …”
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Care Burden and Coping Strategies among Caregivers of Paediatric HIV/AIDS in Northern Uganda: A Cross-Sectional Mixed-Method Study by Ibrahim Mujjuzi, Paul Mutegeki, Sarah Nabuwufu, Ashim Wosukira, Fazirah Namata, Patience Alayo, Sharon Bright Amanya, Richard Nyeko

“…This places an enormous demand and care burden on the caregivers who often struggle to cope in various ways, some of which may be maladaptive. …”
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Short-term follow-up of antibiotic-loaded calcium sulfate in treating chronic periprosthetic joint infection during two-stage revision by Xiao Sun, Jun Tan, Lijuan Zhan, Mingkui Sheng, Zhongxin Tang, Lingxiao Wu, Jianzhong Xu, Haijun Ma

“…This study aimed to evaluate the efficacy and safety of treating chronic knee PJI with and without antibiotic-loaded calcium sulfate during two-stage revision surgery.MethodsThis retrospective study analyzed 94 patients with TKA infections who underwent two-stage revision between May 2017 and January 2022 at the First Affiliated Hospital of Zhengzhou University. …”
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Do Increased Doses to Stem-Cell Niches during Radiation Therapy Improve Glioblastoma Survival? by Sebastian Adeberg, Semi Ben Harrabi, Nina Bougatf, Denise Bernhardt, Angela Mohr, Juliane Rieber, Christian Koelsche, Stefan Rieken, Juergen Debus

“…Conventionally fractionated patients (n=54) who received higher doses (Dmean ≥ 40 Gy) to the IL SVZ showed improved PFS (8.5 versus 5.2 months; p=0.013). …”
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Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population by Kai Fang, Pei Gao, Jun Tian, Xueying Qin, Wenzhen Yu, Juan Li, Qing Chen, Lvzhen Huang, Dafang Chen, Yonghua Hu, Xiaoxin Li

“…In addition, based on the method to measure the departure from the additivity model, the synergy index (S) was 2.63 (1.09–6.38) and the attributable proportion due to interaction (AP) was 55.7% (21.4%–89.9%), which suggested that a common pathway may exist for these genes for nAMD. Those who carried CC for rs3793917 and TC/CC for rs1061170 were at the highest risk of nAMD (OR: 9.76, 95% CI: 4.65–20.51). …”
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Association between Bioelectrical Impedance Parameters, Magnetic Resonance Imaging Muscle Parameters, and Fatty Liver Severity in Children and Adolescents by Kyungchul Song, Eun Gyung Seol, Eunju Lee, Hye Sun Lee, Hana Lee, Hyun Wook Chae, Hyun Joo Shin

“…Methods: Children and adolescents who underwent BIA and liver magnetic resonance imaging between September 2022 and November 2023 were included. …”
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