Novel NOTCH3 mutation c.1564 T > A (p.Cys522Ser) presenting with early-onset Parkinsonism and white matter lesions by Nicola Rifino, Silvia Baratta, Esteban Zacarias, Isabella Canavero, Benedetta Storti, Mario Stanziano, Emanuela Maderna, Gianluca Marucci, Franco Taroni, Anna Bersano

“…This report presents a novel NOTCH3 c.1564 T > A (p.Cys522Ser) mutation associated with early-onset parkinsonism and significant white matter lesions. We describe a patient who presented with early-onset parkinsonism, characterized by bradykinesia and rigidity, alongside extensive white matter lesions observed through neuroimaging. …”
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Efficacy of high-dose steroids versus low-dose steroids in the treatment of immune checkpoint inhibitor-associated myocarditis: a case series and systematic review by Xiuyue Man, Hong Wang, Chen Chen, Xiaofeng Cong, Lemeng Sun, Xueru Sun, Chen Chen, Jing Zhang, Lei Yang

“…Additionally, the clinical treatment process was more straightforward in the high-dose group, with treatment efficacy surpassing that observed in patients who received an initial methylprednisolone (mPSL) dose of less than 1 g/day. …”
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Case report: The Montgomery T tube may be the preferred transition option for achieving a smooth extubation after tracheotomy when complicating airway pathology is present by Jieqiong Wang, Xun Li, Weihua Xu, Nenghui Jiang, Bo Yang, Ming Chen

“…A 44-year-old male patient, who had undergone tracheostomy due to underlying disease, demonstrated substantial recovery following rehabilitation and was poised for tracheostomy tube extraction. …”
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Real-World Experience with AGA Guidelines in the Management of Crohn’s Disease following Ileocolonic Resection: A Retrospective Cohort Study by Shasha Tang, Wei Liu, Weilin Qi, Tunan Yu, Qian Cao, Xiaolong Ge, Wei Zhou

“…The majority of CD patients who undergo surgery in clinical practice may be at a high risk of disease recurrence. …”
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Progress towards 90-90-90 and 95-95-95 strategy implementations and HIV positivity trends in the City of Johannesburg by J C Y Nyasulu, I Maposa

“…There were significant steady increases in the number of people who knew their HIV status (slope = 0.044, p<0.001) and initiating on antiretroviral therapy (ART) (slope = 0.001, p<0.001), and significant decreases for overall HIV positivity rate (slope = –0.016, p<0.001), adolescent positivity rate (slope = –0.0087, p<0.001) and antenatal care HIV positivity rate (slope = –0.013, p<0.001). …”
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Monitoring for 5-aminosalicylate nephrotoxicity in adults with inflammatory bowel disease: prognostic model development and validation using data from the Clinical Practice Researc... by Abhishek Abhishek, Richard D Riley, Christian D Mallen, Guruprasad P Aithal, Georgina Nakafero, Matthew J Grainge, Maarten W Taal, Tim Card, Matthew D Stevenson

“…Model performance was assessed in terms of calibration and discrimination.Results 13 728 and 7318 participants who contributed 40 378 and 20 679 person-years follow-up formed the development and validation cohorts with 170 (1.2%) and 98 (1.3%) outcome events respectively. …”
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Prevalence of HPV in a Peruvian Healthcare Network: A Descriptive Cross-Sectional Study by Jhajaira M. Araujo MSc, Maria Ramon-Cotrina Br, Rosa Quispe-Martinez MD, Mayra Rios-Rios Br, Maribel Quispe-Gonzaga Br, Carlos O. Saldaña-Reyes Br, Paula Medina PhD, Melanie Cornejo PhD, Joseph A. Pinto MSc, Richard Dyer MD

“…A de-identified database of HPV-positive women who underwent the BD Onclarity™ HPV Assay between December 2018 and December 2021 at Auna clinics was analyzed. …”
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Impact of parathyroidectomy on inflammatory and cardiovascular risk parameters in primary hyperparathyroidism: a retrospective analysis by Nese Bulbul, Suat Sen, Fettah Acibucu

“…Methods We retrospectively analyzed PHPT patients who visited the outpatient clinic between 2015 and 2020. …”
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Pengaruh Public Service Motivation terhadap Organizational Citizenship Behavior: Peran Moderasi Service Climate by Dimas Prafi Al Mauludin, Reza Lidia Sari

“…This research uses a cross-sectional study approach with a survey method and involves 105 state civil apparatus employees in East Java Province who serve for at least one year. The sample was drawn using accidental sampling technique. …”
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Impact of Saharan dust on particulate matter characteristics in an urban and a natural locality in Central Europe by Jan Loskot, Daniel Jezbera, Martina Nalezinková, Adéla Holubová Šmejkalová, Danilo Fernandes, Jan Komárek

“…PM10 concentrations during the Saharan dust event were about 6–8 times higher than under normal atmospheric conditions, exceeding WHO guidelines by up to 2 times. Terrain and altitude may have influenced the local concentrations of Saharan dust. …”
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Cost-effectiveness analysis of pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in the Chinese healthcare system by Wenwang Lang, Yulong He, Changchun Hou, Hua Li, Qinling Jiang, Liuyong Mei

“…PSA indicated probabilities of cost-effectiveness for pembrolizumab plus chemotherapy at 0.55%, 69.41%, and 0.14% for the entire population and the non-epithelioid and epithelioid subgroups, respectively.ConclusionIn the Chinese healthcare system, the combination of pembrolizumab and chemotherapy did not prove to be more cost-effective than chemotherapy alone as an initial treatment for untreated advanced pleural mesothelioma, with the exception of patients who have non-epithelioid histology.…”
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The characteristics and clinical outcomes of trauma patients transferred by a physician-staffed helicopter emergency medical service in Korea: a retrospective study by Myung Jin Jang, Woo Sung Choi, Jung Nam Lee, Won Bin Park

“…Methods This study retrospectively reviewed data from the Korean Trauma Data Bank of trauma patients who arrived at a regional trauma center through doctor helicopters from January 1, 2014, to December 31, 2022. …”
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Air Quality of Bursa: Temporal and Spatial Evaluation of PM10, PM2.5, NO2 and SO2 Pollutants Using IDW Geostatistical Technique by Duygu Arıkan İspir, Ferruh Yıldız

“…The pollution maps were analyzed based on the criteria outlined in the World Health Organization (WHO) report, as well as the limit values set by the European Union and the national regulations. …”
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Genie oder kein Genie, ist nicht die Frage. Perspektiven auf Clara Wieck Schumanns Kompetenzerwerb by Janina Klassen

“…The assumed naturalness of female inequality in medical and anthropological discourses of the nineteenth century reinforced the idea of a natural-born heroic genius who produces original ideas without effort and preconditions. …”
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The TikTok Addiction Scale: Development and validation by Petros Galanis, Aglaia Katsiroumpa, Ioannis Moisoglou, Olympia Konstantakopoulou

“…Our study population included 429 adults who have been TikTok users for at least the last 12 months. …”
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CT Imaging Findings after Stereotactic Radiotherapy for Liver Tumors by Olga R. Brook, Eavan Thornton, Mishal Mendiratta-Lala, Anand Mahadevan, Vassilious Raptopoulos, Alexander Brook, Robert Najarian, Robert Sheiman, Bettina Siewert

“…In this IRB-approved, HIPAA-compliant study CTs of 68 consecutive patients who underwent stereotactic radiotherapy for liver tumors between 01/2006 and 01/2010 were retrospectively reviewed. …”
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The Prognostic Value of Echocardiographic Wall Motion Score Index in ST-Segment Elevation Myocardial Infarction by Michael L. Savage, Karen Hay, Bonita Anderson, Gregory Scalia, Darryl Burstow, Dale Murdoch, Isuru Ranasinghe, Owen Christopher Raffel

“…When compared to left ventricular ejection fraction (LVEF), previous studies have suggested the superiority of wall motion score index (WMSI) in predicting cardiac events in patients who have suffered acute myocardial infarction. However, there are limited studies assessing WMSI and mortality in ST-segment elevation myocardial infarction (STEMI). …”
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Perspectives, benefits and challenges of a live OSCE during the COVID-19 pandemic in a cross-sectional study by Anne Herrmann-Werner, Teresa Loda, Rebecca Sarah Erschens, Stephan Zipfel, Andrew B Nevins

“…When compared the students’ results to previous students’ results who completed the OSCE before the pandemic, the results indicated that students felt less prepared than under non-pandemic circumstances; however, their performances on this OSCE were not lower.…”
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THE EDUCATION AND SOCIALIZATION CONCEPT OF THE DEFENDANTS IN RUSSIAN CORRECTIONAL INSTITUTIONS by Vyacheslav T. Volov, Vsevolod V. Volov

“…Modern penal system instead of resocialization initiates person desocialization, i.e. isolation of the people who have offended against the law, does not promote their rehabilitation and reeducation. …”
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Cancer patients’ sense of coherence – psycho-oncological consultations and therapeutic alliance as salutogenic factors by Natalia Cecon-Stabel, Ibrahim Demirer, Holger Pfaff, Antje Dresen

“…Participants and procedure Patients who received PC were surveyed twice (after 3 and 12 months) about their care experiences, including therapeutic alliance and SoC. …”
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