Plasma miRNAs in polycystic ovary syndrome drive endometrial cancer progression: insights into molecular pathways and therapeutic targets by Xuedan Lai, Ling Wu, Peihong Lin, Lijiao You, Jianwen Ye

“…Two-sample Mendelian randomization analysis identified potential causal relationships between AURKA gene expression and PCOS or UCEC. Testosterone and estradiol might have adverse roles in UCEC, while drugs like troglitazone, valproic acid, retinoic acid, and progesterone demonstrated various effects on gene expression and cellular processes. …”
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The dual impact: physiological and psychological effects of rapid weight loss in wrestling by Barış Sarıakçalı, Fatma Neşe Şahin, Burhan Başoğlu, Levent Ceylan, Özkan Güler, Bade Yamak, Gökhan Arıkan, Gizem Ceylan Acar, Gülşah Sekban, Mehmet Vakıf Durmuşoğlu, Sezen Çimen Polat, Hamza Küçük

“…Levels of creatine, BUN, sodium, hematocrit, hemoglobin, LDH, and cortisol increased, while albumin, testosterone, and FSH levels decreased. There were no significant differences in potassium, ALT, AST, TSH levels. …”
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Characterisation of Chemical Constitutes and Spermatogenic Activity of Ushir (Vetiveria Zizanioides Linn) versus Ikshu (Saccharum Officinarum Linn) in Male Wistar Rats: A Research... by Akshay Sudhir Pargaonkar, Jaymala Jadhav, Bhagyashree Ratan Jibkate, Minakshi Urkude

“…Parameters that will be assessed include sperm morphology, sperm motility, pH, agglutination, sperm count, serum testosterone levels and histopathology. The experimental study will be conducted as per Organisation for Economic Cooperation and Development (OECD) guidelines. …”
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Microplastics: A threat to Fetoplacental unit and Reproductive systems by Abass Toba Anifowoshe, Md Noor Akhtar, Abisola Majeed, Asem Sanjit Singh, Toyyibah Funmilayo Ismail, Upendra Nongthomba

“…They also bioaccumulate in testes, altering spermatogenesis, spermatozoa morphology, testosterone production, body weights, and inflammation as reported in mice. …”
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Male Central Precocious Puberty: Serum Profile of Anti-Müllerian Hormone and Inhibin B before, during, and after Treatment with GnRH Analogue by Romina P. Grinspon, Luz Andreone, Patricia Bedecarrás, María Gabriela Ropelato, Rodolfo A. Rey, Stella M. Campo, Ignacio Bergadá

“…After GnRHa withdrawal, AMH declined concomitantly with the rise in serum testosterone. At diagnosis, inhibin B was elevated and decreased throughout therapy, remaining in the upper normal prepubertal range. …”
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The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials by Xiaoshuai Zhang, Yang Zheng, Yanan Guo, Zhiwen Lai

“…The primary outcomes included the changes in BMI, homeostatic model assessment for insulin resistance (HOMA-IR), and blood lipids, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), follicle-stimulating hormone (FSH), luteotropic hormone (LH), total testosterone (T), and sex hormone-binding globulin (SHBG). …”
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Woxuanzhongzhou formula improves DHEAS and high-fat diet-induced IR and anovulatory mice via AMPK/PGC1- α/Irisin pathway by Haijuan Liu, Guohua Wang, Conglu Sui, Yanan Guo, Xiangyu He

“…Significant reductions were observed in body weight, serum testosterone, luteinizing hormone, luteinizing hormone/ follicle-stimulating hormone ratio, FINS, and HOMA-IR. …”
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Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages by Hiroki Yamazaki, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Yusuke Nakatsu, Takako Kikuchi, Sunao Kaneko, Hirotoshi Tanaka, Tomoichiro Asano

“…Notably, these effects of SHBG were not altered by coaddition of large amounts of testosterone or estradiol. In conclusion, SHBG suppresses inflammation and lipid accumulation in macrophages and adipocytes, which might be among the mechanisms underlying the protective effect of SHBG, that is, its actions which reduce the incidence of metabolic syndrome.…”
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Post-treatment of rat aflatoxicosis by camel milk and silymarin by Nahla H. Hassaneen, Shabaan A. Hemeda, Abeer F. El Nahas, Ghadeer M. Albadrani, Muath Q. Al-Ghadi, Zuhair M. Mohammedsaleh, Sabreen E. Fadl, Eman M. El-Diasty, Hader I. Sakr, Hader I. Sakr

“…The evaluation was done through measuring leukocyte count, liver function tests, carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), ferritin, and testosterone. Moreover, the histopathology of the liver and testes was done along with expression levels of specific genes in the liver and testes.ResultsThe outcomes showed that the post-treatment with silymarin and camel milk improved biochemical markers in serum and ability to reproduce.ConclusionIn conclusion, post-treatment with camel milk and silymarin could mitigate the negative effect of AFB1 on rats.…”
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<i>Broussonetia papyrifera</i> Extract Can Be Used as a Raw Material Source for a Sterility Agent for <i>Microtus fortis</i> by Shuangye Wang, Tian Lan, Yunlin Zhao, Wanfu Liu, Tian Huang, Meiwen Zhang, Zhiyuan Hu, Zhenggang Xu

“…The results show that the growth of sex organs was inhibited, and the males’ testosterone levels and sperm quality were reduced. Though there were some positive effects on females, the reproductive parameters of coupled voles were inferior; the most treated couple exhibited an increased reproductive time, fetal counts, and reduced weight. …”
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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses by Ye Ma, Fang Wu, Zeming Yu, Lu Yang

“…Furthermore, it was determined that the causal associations between these lipidome profiles and FRDs were independent of BMI, obesity, diabetes, smoking, alcohol use, physical activity, inflammation, depression, waist-hip ratio, vitamin D, dehydroepiandrosterone sulphate, sex hormone binding globulin, and testosterone levels. Most outcomes passed consistent tests without evidence of heterogeneity, pleiotropy, or reverse causality. …”
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The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages by Hui juan Zhu, Su juan Li, Hui Pan, Naishi Li, Dian xi Zhang, Lin jie Wang, Hong bo Yang, Qinyong Wu, Feng ying Gong

“…A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. …”
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Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male by Silvia Migliaccio, Davide Francomano, Roberto Bruzziches, Emanuela A. Greco, Rachele Fornari, Lorenzo M. Donini, Andrea Lenzi, Antonio Aversa

“…Evidence from male rodents suggests that OSCA may also regulate testosterone (T) synthesis. Using a cross-sectional design, we evaluated OSCA, 25(OH) vitamin D, T, 17β-estradiol (E2), homeostasis model assessment of insulin resistance (HOMA-IR), and body composition in 86 obese (mean BMI = 34) male subjects (18–69 yr old). …”
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Study on the effects of Mogroside V in inhibiting NLRP3-mediated granulosa cell pyroptosis and insulin resistance to improve PCOS by Wenqin Yang, Yujie Ma, Yafei Wu, Xiaocan Lei, Jing Zhang, Meixiang Li

“…Results The PCOS group exhibited elevated serum testosterone (T), luteinizing hormone (LH), insulin, and fasting glucose levels, along with increased insulin resistance (HOMA-IR) and decreased estradiol (E2), which were reversed by MV treatment. …”
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Relationship between CCL25/CCR9 Levels in Follicular Fluid and High Ovarian Response in Patients with Polycystic Ovary Syndrome by Yongxin Hao, Qianqian Yin, Fangfang Hu, Xiaoyan Liu, Yaru Yang, Fang Sun, Xiaonan Yan

“…Similarly, the two groups observed no statistically significant differences in the baseline levels of luteinizing hormone (LH), progesterone (P), estradiol (E2), basal prolactin (PRL), and testosterone (T). Compared to the NOR group, HOR patients exhibit markedly elevated levels of anti-Müllerian hormone (AMH), antral follicle count (AFC), basal follicle-stimulating hormone (FSH), and HOMA-IR (all p < 0.05). …”
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Finger Length Ratios in Serbian Transsexuals by Svetlana Vujović, Srdjan Popović, Ljiljana Mrvošević Marojević, Miomira Ivović, Milina Tančić-Gajić, Miloš Stojanović, Ljiljana V. Marina, Marija Barać, Branko Barać, Milena Kovačević, Dragana Duišin, Jasmina Barišić, Miroslav L. Djordjević, Dragan Micić

“…There is evidence that the 2nd and 4th digit ratio (2D : 4D) associates negatively with prenatal testosterone and positively with estrogens. The aim was to assess the difference in 2D : 4D between female to male transsexuals (FMT) and male to female transsexuals (MFT) and controls. …”
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Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites by Yexun Zhou, Yexun Zhou, Liang Chen, Hui Han, Hui Han, Bohui Xiong, Ruqing Zhong, Yue Jiang, Lei Liu, Haiqing Sun, Jiajian Tan, Xiaowei Cheng, Martine Schroyen, Yang Gao, Yong Zhao, Hongfu Zhang

“…TAX increased the blood concentration of testosterone derivatives, antioxidants such as melatonin and betaine, unsaturated fatty acids such as DHA, and beneficial amino acids such as proline. …”
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Dietary supplementation with Epimedium contributes to the improvement of hormone levels, gut microbiota, and serum metabolite composition in the Chinese forest musk deer (Moschus b... by Shan Xie, Shan Xie, Qinlin Yang, Zaixiang Ying, Zaixiang Ying, Mingcheng Cai, Wenqiao Fan, Hanyu Gao, Hanyu Gao, Xiaolan Feng, Yongjiang Wu

“…The results indicated that the inclusion of Epimedium in the diet increased dry matter intake (DMI) and improved the ratio of feed to gain (F/G), with an increase in fecal testosterone levels (p &lt; 0.05). 16S rDNA sequencing analysis revealed that Epimedium enhanced the richness and diversity of the gut microbiota in the Chinese forest musk deer, increasing the relative abundance of beneficial bacteria such as Firmicutes, while reducing the relative abundance of the potentially pathogenic Proteobacteria (p &lt; 0.05). …”
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Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases by Xing Li, Mingyu Liao, Rufei Shen, Linlin Zhang, Hua Hu, Jun Wu, Xiuli Wang, Hua Qu, Shaodong Guo, Min Long, Hongting Zheng

“…Asprosin in PCOS subjects was also higher than in healthy subjects (P<0.001) but lower than in T2DM subjects (P<0.05), and it was positively correlated with FBG, HbA1c, HOMA-IR, LDL-c, APOB, APOE, and testosterone (P<0.05). The BMI-categorized subgroups of PCOS subjects also showed correlations of asprosin with metabolic profiles and sex-related hormones. …”
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Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia by Agnieszka Zachurzok, Grazyna Deja, Aneta Gawlik, Agnieszka Drosdzol-Cop, Katarzyna Klimek, Ewa Malecka-Tendera

“…Triglycerides and LDL/HDL ratio were (R2=0.7, p<0.0001, R2=0.6, p<0.0003 resp.) related to testosterone, FAI, WHR, and mean HbA1c. Conclusion. Lipid profile in diabetic adolescent girls is adversely influenced by the androgens level, particularly in the group with higher WHR and poorer glycemic control.…”
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