RANKL-Targeted Therapies: The Next Frontier in the Treatment of Male Osteoporosis by Alicia K. Morgans, Matthew R. Smith

“…Thousands of men with prostate cancer are treated with androgen deprivation therapy, a treatment that dramatically reduces serum testosterone and causes severe hypogonadism. Men treated with androgen deprivation therapy experience a decline in bone mineral density and have an increased rate of fracture. …”
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Ne plus se laisser prendre à leurs Jeux. by Anaïs Bohuon, Lucie Pallesi

“…In the 2010s, a more assertive form of activism emerged with the mobilization of legal tools from athletes challenging the rules of federations restricting their participation, in particular the maximum testosterone levels imposed in the women’s category.…”
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Age- and sex-specific differences in myocardial sympathetic tone and left ventricular remodeling following myocardial injury by Achi Haider, Susan Bengs, Angela Portmann, Sandro Fröhlich, Dominik Etter, Monika Maredziak, Geoffrey I. Warnock, Alexander Akhmedov, Sebastian Kozerke, Claudia Keller, Fabrizio Montecucco, Bruno Weber, Linjing Mu, Ronny R. Buechel, Vera Regitz-Zagrosek, Philipp A. Kaufmann, Giovanni G. Camici, Simon M. Ametamey, Catherine Gebhard

“…Female animals showed an age-dependent increase in MSA (p = 0.011), which was absent in males. Conclusion Testosterone associates with an increase in sympathetic tone, contributing to adverse cardiac remodeling following MI. …”
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Association between sex steroid hormones and α-klotho: Results from the NHANES 2013-2016 and Mendelian randomization study by Andong Guo, Pengcheng Chen, Jishuang Cao, Chenrui Wu, Sentai Ding

“…Results: In men, significant positive correlations with α-Klotho were consistent across both unadjusted and fully adjusted models for total testosterone (TT), bio-available testosterone (Bio-T), estradiol (E2) and sex hormone-binding globulin (SHBG) (Model 3: TT: β = 3.54, 95 % CI: 1.63–5.44, P = 0.0003; Bio-T: β = 1.74, 95 % CI: 0.73–2.74, P = 0.0007; E2: β = 0.25, 95 % CI: 0.11–0.38, P = 0.0003; SHBG: β = 0.95, 95 % CI: 0.63–1.27, P < 0.0001); In premenopausal women, we detected a potential nonlinear relationship between TT levels and α-Klotho, with α-Klotho levels rising to a peak at a TT level of 72.2 ng/mL, after which they declined. …”
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Masculinization of Nile tilapia (Oreochromis niloticus) by administration of bull testes meal by Muslim Muslim, M. Zairin Junior, Nur Bambang Priyo Utomo

“…The use of synthetic testosterone hormone is not recommended in Indonesia. …”
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Management of Zinner’s Syndrome Associated with Contralateral Seminal Vesicle Hypoplasia: A Case Report by Mehdi Kardoust Parizi, Nasser Shakhssalim

“…Hormone workup (LH, FSH, prolactin, and testosterone) was normal. Sperm analysis showed oligoasthenozoospermia and low ejaculate volume. …”
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Biochemical Bone Turnover Markers and Osteoporosis in Older Men: Where Are We? by Pawel Szulc

“…Limited data from the cohort studies suggest that BTM measurement does not improve the prediction of fragility fractures in older men in comparison with age, BMD, history of falls and fragility fractures. Testosterone replacement therapy (TRT) decreases bone resorption. …”
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‘Scrotal “Sack” – A Bag of Worms’: Scrotal Arteriovenous Malformation by Shruti Thakur, Suresh Kumar Thakur, Anupam Jhobta, Charu Smita Thakur

“…He had oligospermia on semen analysis with a normal testosterone level and no history of testicular infection or scrotal surgery. …”
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Towards an inclusive city? The effects of aesthetic-corporeal changes among transmasculine men by Sofía Luciana Santillán

“…Such changes are the result of procedures of hormone therapy, through the periodic administration of testosterone, and the adjustment of particular practices associated with masculinity. …”
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A Rare Case of Adolescent Girl with Beard-PCOS with a Difference: “HAIR-AN Syndrome” by Payal S. Kubsad, Vani Hebbal Nagarajappa, Dhanya Soodhana Mohan

“…Biochemical investigations showed highly elevated serum insulin with elevated testosterone and normal blood glucose.A multidisciplinary approach with lifestyle modifications combined with hormonal medications like oral contraceptive pills with metformin and spironolactone were required to control the disease and prevent the systemic manifestation and decrease the degree of virilization. …”
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Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization by Lea F. Surrey, Ashesh A. Thaker, Paul J. Zhang, Giorgos Karakousis, Michael D. Feldman

“…We report the first case of a testosterone producing an extra-adrenal adrenocortical oncocytoma accompanied by a myelolipoma. …”
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Adaptive Treatment of Metastatic Prostate Cancer Using Generative Artificial Intelligence by Youcef Derbal

“…The case explores the design of GPT-supported adaptive intermittent therapy for mPC. Testosterone and prostate-specific antigen (PSA) are assumed to be repeatedly monitored while treatment may involve a combination of androgen deprivation therapy (ADT), androgen receptor-signalling inhibitors (ARSI), chemotherapy, and radiotherapy. …”
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Assessment of Body Composition, Bone Density, and Biochemical Markers of a Natural Bodybuilder During Contest Preparation by Konstantinos Michailidis, Nikolaos Zaras, Dimitrios Balampanos, Alexandra Avloniti, Theodoros Stampoulis, Maria Protopapa, Dimitrios Pantazis, Nikolaos-Orestis Retzepis, Ilias Smilios, Athanasios Chatzinikolaou

“…At the beginning (W31), in the middle (W18), and one week before the contest (W1), measurements included body composition via DEXA, testosterone and cortisol hormonal concentrations, and lipid, blood, and liver biochemical markers via an automated hematology analyzer. …”
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Beta-HCG Secretion by a Pulmonary Choriocarcinoma in a Male Patient by Brecht Devos, Cedric Willemse, Mira Sterckx, Johan Debruyne, Inge Stappaerts, Tom Van den Mooter, Marjan Hertoghs, Pascale Abrams

“…A 65-year-old man presented with bilateral gynaecomastia with abnormally high levels of β-hCG and elevated oestradiol, progesterone, and testosterone levels on April 7, 2023. After excluding testicular malignancy, CT scan of the chest and abdomen revealed bilateral pulmonary lesions. …”
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Endocrine Actions of Osteocalcin by Aurora Patti, Luigi Gennari, Daniela Merlotti, Francesco Dotta, Ranuccio Nuti

“…Recent provocative data from experimental observations in mice showed that the circulating undercarboxylated fraction of osteocalcin increases insulin secretion and sensitivity, lowers blood glucose, and decreases visceral fat in both genders, while it enhances testosterone production by the testes in males. Moreover, both total and undercarboxylated osteocalcins increase following physical activity with potential positive effects on glucose tolerance. …”
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Oxidative Stress and Autophagy: Unraveling the Hidden Threat to Boars’ Fertility by Ruizhi Hu, Xizi Yang, Jianhua He, Shusong Wu

“…This disruption results in diminished sperm quality, impaired testosterone synthesis, and compromised integrity of the blood–testis barrier. …”
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Pathology of single dose cadmium toxicity and investigations of protective effect of simultaneous chlorpromazine administrations in rats by Tuna Erdem, Fatih Hatipoğlu

“…Corresponding to these changes significant decreases in serum testosterone levels were also observed and the spermatic granulomas were seen in the epididymis. …”
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Prevalence of Osteoporosis and Its Associated Factors among Older Men with Type 2 Diabetes by Hai-ling Chen, Li-li Deng, Ju-fen Li

“…Although no differences in age, blood pressure, waist-to-hip ratio, body mass index (BMI), and testosterone levels were observed, the prevalence of low BMD was significantly higher in the T2DM group compared to the control group. …”
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Multiomics unravels the complexity of male obesity: a prospective observational study by Georgios E. Papadakis, Lucie Favre, Yassine Zouaghi, Nathalie Vionnet, Nicolas J. Niederländer, Michela Adamo, James S. Acierno, Dassine Berdous, Alexia Boizot, Jenny Meylan, Julijana Ivanisevic, Emmanuelle Paccou, Hector Gallart-Ayala, Tim Reyns, Elise Van Caeneghem, Bruno Lapauw, Jérôme Pasquier, Yasser Aleman, Styliani Mantziari, Olivier Salamin, Raul Nicoli, Tiia Kuuranne, Tom Fiers, Patric Hagmann, Federico Santoni, Andrea Messina, Nelly Pitteloud

“…Following RYGB-induced substantial weight loss, testosterone levels markedly increased in both obese individuals with and without HH, challenging the current definition of hypogonadism. …”
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Immunization with OPN5 increased seasonal degradation of reproductive activity in Magang ganders by Jianqiu Pan, Xu Shen, Hongjia Ouyang, Junfeng Sun, Sui Liufu, Danli Jiang, Wenjun Chen, Siyue Peng, Danning Xu, Yunbo Tian, Yunmao Huang, Jianhua He

“…Moreover, the concentration of testosterone and LH decreased significantly while PRL increased. …”
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