Do Anabolic Androgenic Steroids Really Cause Harm? A Comprehensive Examination of Adverse Effects by Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Jakub Kurasz, Wojciech Maj, Wiktoria Tomaszewska, Wiktoria Podlasiewicz, Katarzyna Pala, Piotr Dudziak, Anna Nowak, Maria Golińska

“… Anabolic steroids, synthetic derivatives of testosterone, are frequently employed in clinical settings to address hormonal deficiencies and, controversially, in athletic contexts to augment physical performance. …”
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Ocular Surface Disease Severity in Polycystic Ovary Syndrome: is This Really Significant in Daily Life? by Demet Yabanoglu, Funda Gode

“…In group I, Ocular Surface Disease Index scores were significantly positively correlated with free testosterone, while tear osmolarity was significantly positively correlated with estradiol levels but significantly negatively correlated with dehydroepiandrosterone sulfate levels (p<0.05). …”
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Effect of Metformin on Anthropometric Measurements and Hormonal and Biochemical Profile in Patients with Prediabetes by Mustafa Safiah, Dana Hyassat, Yousef Khader, Oraib Farahid, Anwar Batieha, Mohammed El-Khateeb, Kamel Ajlouni

“…Metformin use resulted in significant increase in luteinizing hormone (LH) and progesterone levels in males, while it was associated with significant increase in prolactin, follicular stimulating hormone (FSH), and dehydroepiandrostenedione-sulphate (DHEA-S) levels and significant decrease in total testosterone level in females. Conclusion. Metformin treatment in females with prediabetes reduces BMI, waist circumference, fasting blood glucose, and HbA1c. …”
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Activation of PPAR𝛾 by Rosiglitazone Does Not Negatively Impact Male Sex Steroid Hormones in Diabetic Rats by Mahmoud Mansour, Elaine Coleman, John Dennis, Benson Akingbemi, Dean Schwartz, Tim Braden, Robert Judd, Eric Plaisance, Laura Ken Stewart, Edward Morrison

“…Peroxisome proliferator-activated receptor gamma (PPAR𝛾) activation decreased serum testosterone (T) in women with hyperthecosis and/or polycystic ovary syndrome and reduced the conversion of androgens to estradiol (E2) in female rats. …”
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Gestational Exposure to Synthetic Steroid Hormones Impaired Sperm Quantity and Quality in Wistar Rats by Samy Ismail Ahmed, Aamir Magzoub, Mohammed Saeed Zayed Al-Ayed, Gamal Ali Attia, Basel A. Abdel-Wahab, Masood M. Khateeb, Asim M. Abdalla, Heitham M. Mohammed, Aymen N. Eldeen A. Elkareem, Ali Gadkarim A. Salih

“…The reproductive hormonal assay revealed significantly lower serum testosterone and higher levels of FSH and LH among the test groups compared to the control (p<0.05 for all). …”
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The association between melatonin hormone and reproductive hormones in polycystic ovary syndrome: A case–control study by Ban Jabir Edan, Zahid Mohammed-Ali Kadhim

“…There was a significant adverse correlation between melatonin and testosterone hormone in PCOS patients (P < 0.05). Melatonin level showed an AUC of 0.755 at a cutoff point of 20 ng/mL and more, giving a sensitivity (78%) and specificity (75%). …”
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Fluoride-induced testicular and ovarian toxicity: evidence from animal studies by Seyedeh Fahimeh Talebi, Mohammad Seify, Ramji Kumar Bhandari, Hamed Shoorei, Shahram Dabiri Oskuei

“…In males, F exposure at different doses has been associated with reduced testis weight, reduced sperm quality in terms of count, motility, and viability, as well as abnormal sperm morphology and disruption of seminiferous tubules by altering hormone levels (especially testosterone), impairing spermatogenesis, and inducing oxidative stress and zinc deficiency. …”
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Assessment of Cardiovascular Risk Factors in Women Having Female Pattern Hair Loss by Damini Verma, Vibhu Mendiratta, Taru Garg, Smita Tripathi, Shaili Tomer

“…The objective was to measure carotid intima-media thickness (CIMT) by doppler ultrasound, Body mass index (BMI), waist circumference, lipid profile, fasting blood sugar (FBS), insulin, testosterone, Sex hormone binding globulin (SHBG), hs-CRP, ESR and fibrinogen, in pre-menopausal women having FPHL and to correlate these parameters with severity of FPHL. …”
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Bioanthropological and Biomechanical Perspectives on Skeletal Senescence Variation by Sayf Muhammad Alaydrus, Muhamad Andri Jauhari

“…The loss of sex hormones is related to skeletal senescence, especially in females, while the effects of testosterone on skeletal senescence are under-researched. …”
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The Effect of Long-Term Exercise on the Production of Osteoclastogenic and Antiosteoclastogenic Cytokines by Peripheral Blood Mononuclear Cells and on Serum Markers of Bone Metabol... by J. Kelly Smith, Rhesa Dykes, David S. Chi

“…We also measured lymphocyte phenotypes and serum markers of bone formation (osteocalcin), bone resorption (C-terminal telopeptides of Type I collagen), and bone homeostasis (25 (OH) vitamin D, estradiol, testosterone, parathyroid hormone, and insulin-like growth factor 1). …”
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A Study of Serum Adiponectin Levels in Patients with Polycystic Ovarian Syndrome and its Correlation with Various Cardiometabolic Risk Markers by G. Surendra Prasad, Uma Kaimal Saikia, Ashok Krishna Bhuyan, Abhamoni Baro

“…Materials and Methods: All the included subjects underwent detailed clinical, biochemical and hormonal evaluation, including lipid profile, 75 g oral glucose tolerance test, fasting serum insulin, fasting serum adiponectin, oxLDL, total testosterone and anti-Mullerian hormone. Statistical Analysis Used: Appropriate statistical methods were performed using SPSS (version 21) and Microsoft Excel (2019). …”
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Formulation Study of a Poly(amino methacrylate) Film-Forming Solution for Transdermal Administration by Chiara G. M. Gennari, Antonella Casiraghi, Francesca Selmin, Francesco Cilurzo

“…The in vitro skin permeation studies were conducted on formulations containing caffeine and testosterone. Results: The FFS, consisting of EuE and PEG400 in isopropyl alcohol and ethanol (80:20, <i>v</i>/<i>v</i>), exhibited rapid film formation within about 5 min and the dried film allowed a high skin permeability compared to other formulations due to the ability to increase the thermodynamic activity of both drugs. …”
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The causal relationship between steroid hormones and risk of stroke: evidence from a two-sample Mendelian randomization study by Yang Zhang, Miaowen Jiang, Di Wu, Ming Li, Xunming Ji

“…Through genome-wide association meta-analysis, the genetic variants of steroid hormones, including testosterone/17β-estradiol (T/E2) ratio, aldosterone, androstenedione, progesterone, and hydroxyprogesterone, were acquired as instrumental variables. …”
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Biotin interference with laboratory test results by Strilić David Z., Stanimirov Bojan G., Đanić Maja P.

“…Topic: This review addresses the risk of biotin interference in various immunoassays, particularly its impact on thyroid function tests (TSH, FT3, FT4), parathyroid hormone (PTH), testosterone, human chorionic gonadotropin (hCG), and cardiac markers including troponin. …”
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Therapeutic Effect of Stem Cells on Male Infertility in a Rat Model: Histological, Molecular, Biochemical, and Functional Study by Sally S. Mohammed, Mona F. Mansour, Noha A. Salem

“…Group 2 showed significant histological changes, decreased free testosterone level, decrease in stem cell factor expression, and dysfunction of the oxidation state. …”
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Protective effects of Euphorbia heterophylla against testicular degeneration in streptozotocin-induced diabetic rats in relation to phytochemical profile. by Ahmed M Nagy, Heba A Fahmy, Mohamed F Abdel-Hameed, Rehab F Taher, Alaa M Ali, Mohamed M Amin, Sherif M Afifi, Tuba Esatbeyoglu, Mohamed A Farag, Abdelsamed I Elshamy

“…Treatment with EH-EtOH effectively mitigated the damage caused by STZ, as evidenced by restored testosterone (T4) levels and antioxidant capacity, reduced expression of pro-inflammatory cytokines, improved testicular microcirculation, and inhibition of apoptosis in the testes.…”
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The Correlation between Hormonal Disturbance in PCOS Women and Serum Level of Kisspeptin by Razaw O. Ibrahim, Shirwan H. Omer, Chro N. Fattah

“…Kisspeptin correlated with serum free testosterone level (r=0.26). In healthy women, preovulatory kisspeptin levels were higher than follicular kisspeptin levels (P<0.05), while this difference was insignificant in PCOS patients. …”
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SPERM QUALITY IN RATS PREDISPOSED TO THE MANIFESTATION OF CATATONIC REACTIONS by M. A. Kleshchev, T. A. Alekhina, L. V. Osadchuk

“…It has been assumed that the changes of spermatogenic parameters in response to selection for catatonia are caused by changing the ontogenic pattern of testosterone secretion. In conclusion, the hereditary predisposition to catatonic reaction is associated with impaired sperm parameters in adult rats that reduces their chance to reproduction. …”
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Compared to Fishmeal, Dietary Soybean Meal Improves the Reproductive Performance of Female Yellow Catfish (Pelteobagrus fulvidraco) Broodstock by Zheng Chen, Shuzhan Fei, Cui Liu, Yuanhui Duan, Haokun Liu, Dong Han, Junyan Jin, Yunxia Yang, Xiaoming Zhu, Shouqi Xie

“…In addition, SBM and RSM diets resulted in higher estradiol (E2), vitellogenin (VTG), luteinizing hormones (LH), and lower follicle-stimulating hormone (FSH) and testosterone (T) in plasma (P<0.05) of female broodstock. …”
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Muscular Dystrophies at Different Ages: Metabolic and Endocrine Alterations by Oriana del Rocío Cruz Guzmán, Ana Laura Chávez García, Maricela Rodríguez-Cruz

“…In addition, endocrine disturbances such as hypogonadism, low levels of testosterone, and growth hormone have been reported. …”
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