X-linked Dyskeratosis Congenita Case with Mutation 1058C>T(p.Ala353Val) in Dyskerine Gene by Ayse Oktem, Pelin Kocyigit, Timur Tuncalı, Ulviyye Kahraman, Sumeyra Ozbolat

“…Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome and telomere biology disorder, usullay consisting of a triad of oral leucoplakia, dystrophic nails, reticular skin pigmentation. …”
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Chemical Biology of G-quadruplex and i-motif DNA: use of topologically constrained DNA by Dejeu, Jérôme, Defrancq, Eric

“…They are indeed involved in many biological processes including translation regulation, pre-mRNA processing, mRNA targeting, telomere maintenance, etc. We have developed chemical tools named TASQ (Template-Assembled Synthetic Quadruplex) to address the following scientific goals: (i) identify unambiguous (i.e., affine and specific) G4- and i-DNA-interacting ligands, (ii) identify proteins interacting with those structures and determine their cellular relevance and (iii) select specific antibodies for G4 and i-DNA. …”
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“One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles by Anton Granzhan, David Monchaud, Nicolas Saettel, Aurore Guédin, Jean-Louis Mergny, Marie-Paule Teulade-Fichou

“…A two-step selection procedure based on the FRET-melting assay was carried out enabling identification of macrocycles of high affinity (ΔT1/2 up to 30°C) and high selectivity for the human telomeric G-quadruplex. The four selected hits possess sophisticated architectures, more particularly the presence of a pendant side-arm as well as the existence of a particular topological arrangement appear to be strong determinants of quadruplex binding. …”
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Assessment of Transformed Properties In Vitro and of Tumorigenicity In Vivo in Primary Keratinocytes Cultured for Epidermal Sheet Transplantation by A. Thépot, A. Desanlis, E. Venet, L. Thivillier, V. Justin, A. P. Morel, F. DeFraipont, M. Till, V. Krutovskikh, M. Tommasino, O. Damour, P. Hainaut

“…Keratinocytes from four different human donors were investigated for molecular and cellular parameters indicative of transformation status, including (i) karyotype, (ii) telomere length, (iii) proliferation rate, (iv) epithelial-mesenchymal transition, (v) anchorage-independent growth potential, and (vi) tumorigenicity in nude mice. …”
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Extension of Chronological Lifespan by Hexokinase Mutation in Kluyveromyces lactis Involves Increased Level of the Mitochondrial Chaperonin Hsp60 by Lisa Rizzetto, Elena Zanni, Daniela Uccelletti, Ileana Ferrero, Paola Goffrini

“…Oxidative damage, mitochondrial dysfunction, genomic instability, and telomere shortening represent all molecular processes proposed as causal factors in aging. …”
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Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence by Shan Geng, Xin-Yi Mu, Xiong-Bin Chen, Ji-Ying Hou, Dao-Yong Jia, Chun-Yan Xu, Ya-Ping Wang

“…In accordance with that, the senescence of HSPCs also started from the middle age, since the self-renewal and differentiation ability remarkably decreased, and senescence-associated markers SA-β-GAL increased in the 6-month-old and the older groups. Interestingly, the telomere length and telomerase activity increased to a certain degree in the 6-month-old group. …”
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Sirtuins, Bioageing, and Cancer by D. McGuinness, D. H. McGuinness, J. A. McCaul, P. G. Shiels

“…Here, we discuss the current understanding of the role of Sirtuins in age-related diseases while taking a closer look at their roles and functions in maintaining genomic stability and their influence on telomerase and telomere function.…”
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The synthesis and research of the naphthalimide G-quadruplex probe targeting hybrid G4s by Lilin Gan, Wenzheng Luo, Qian Cheng, Shanke Wan, Min Wu, Mingqi Wang, Enming Luo, Xianjin Luo, Shuo Li

“…The human C-MYC promoter and telomere G4 DNA structures were widely recognized as promising targets for cancer therapy. …”
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Proteomic profiling of iPSC and tissue-derived MSC secretomes reveal a global signature of inflammatory licensing by Margeaux Hodgson-Garms, Matthew J. Moore, Mikaël M. Martino, Kilian Kelly, Jessica E. Frith

“…Overall, resting secretomes were defined by extracellular matrix (ECM) and pro-regenerative proteins, while licensed secretomes were enriched in chemotactic and immunomodulatory proteins. iMSC and UC.MSC secretomes contained proteins indicating proliferative potential and telomere maintenance, whereas adult tissue-derived secretomes contained fibrotic and ECM-related proteins. …”
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Finding the Correct Partner: The Meiotic Courtship by Tomás Naranjo

“…Reduction of spacing between homologues makes possible the occurrence of chromosomal interactions leading to homology detection and the formation of bivalents. In many organisms, telomere-led chromosome movements are generated that bring homologues together. …”
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Genomic characterization of chronic lymphocytic leukemia in patients of African ancestry by Cecilia Bonolo de Campos, Chantal E. McCabe, Laura A. Bruins, Daniel R. O’Brien, Sochilt Brown, Renee C. Tschumper, Cristine Allmer, Yuan Xiao Zhu, Kari G. Rabe, Sameer A. Parikh, Neil E. Kay, Huihuang Yan, James R. Cerhan, John N. Allan, Richard R. Furman, J. Brice Weinberg, Danielle M. Brander, Diane F. Jelinek, Marta Chesi, Susan L. Slager, Esteban Braggio

“…We sequenced 59 putative driver genes and found an increased frequency of high-impact mutations in AA CLL, including genes of the DNA damage repair (DDR) pathway. Telomere erosion was also increased in AA CLL, amplifying the notion of increased genomic instability in AA CLL. …”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…Sirtuin 6 (SIRT6), a sirtuin family member, is pivotal in genome and telomere stability, inflammation regulation, and metabolic processes. …”
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Our journey with François Gros by Butler-Browne, Gillian, Mouly, Vincent

“…Together, they demonstrated the impact of the limit in proliferation of the precursor cells on the regenerative capacity of human skeletal muscle, and their group developed models to evaluate the regenerative potential of skeletal muscle in vitro, measuring the telomeric erosion, and identified the involvement of a stress pathway in the proliferative arrest of muscle progenitors. …”
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SAMHD1 shapes deoxynucleotide triphosphate homeostasis by interconnecting the depletion and biosynthesis of different dNTPs by Claudia McCown, Corey H. Yu, Dmitri N. Ivanov

“…The regulatory relationship between the biosynthesis and depletion of different dNTPs sheds light on the emerging role of SAMHD1 in the biology of dNTP homeostasis with implications for HIV/AIDS, innate antiviral immunity, T cell disorders, telomere maintenance and therapeutic efficacy of nucleoside analogs.…”
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Evolution of CpG-islands by means of tandem duplications by V. N. Babenko, Y. L. Orlov, Zh. T. Isakova, D. A. Antonov, M. I. Voevoda

“…Intergenic CpGi duplication mediates through CG-rich telomeric satellites, as well as elements of the SINE. …”
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Association of urban green and blue space with accelerated ageing: A cohort Study in the UK Biobank by YiNi Wang, XinYu Shi, Fei Yang, ShengYuan Wang, TianShu Han, Kun Ma

“…General linear models and logistics models assessed links between UGBS and accelerated ageing (Klemera-Doubal method, telomere length and frailty). Mediation analysis examined the role of pollution and other factors. …”
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Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging by Wei Liu, Le Zhang, Wenhui Liao, Huiguo Liu, Wukaiyang Liang, Jinhua Yan, Yi Huang, Tao Jiang, Qian Wang, Cuntai Zhang, Peifang Wei

“…This review examines the molecular and cellular features common to both OSAHS and VA, highlighting decreased melatonin secretion, impaired autophagy, increased apoptosis, increased inflammation and pyroptosis, increased oxidative stress, accelerated telomere shortening, accelerated stem cell depletion, metabolic disorders, imbalanced protein homeostasis, epigenetic alterations, and dysregulated neurohormonal signaling. …”
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Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes by Luca Pangrazzi, Andreas Meryk

“…Recent advances in molecular biology have shed light on the underlying mechanisms of immunosenescence, including telomere attrition, epigenetic alterations, mitochondrial dysfunction, and changes in key signaling pathways such as NF-κB and mTOR. …”
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The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment by Tao Huang, Gang Zhu, Fan Chen

“…HNRNPA2B1 is a member of the HNRNP family, which is associated with telomere function, mRNA translation, and splicing, and plays an important role in tumor development. …”
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Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice by Yan Peng, Rui Chi, Gang Liu, Weijie Tian, Jun Zhang, Rihui Zhang

“…Aerobic exercise (AE) enhances learning and memory, improves cognitive impairment, increases telomere binding protein expression, and decreases apoptosis regulators, but it remains unclear whether it can improve cognitive impairment caused by neuronal apoptosis in AD. …”
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